Relearning the lessons of genomic stability of human cells during expansion in culture: Implications for clinical research

Stem Cells

Volumn 30, Issue 6, 2012, Pages 1051-1052

  Prockop, Darwin J ^a   Keating, Armand ^b  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LIVE VACCINE;

CARCINOGENICITY; CELL CLONING; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL THERAPY; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CLINICAL RESEARCH; CLINICAL TRIAL (TOPIC); COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; DIPLOIDY; EMBRYONIC STEM CELL; FIBROBLAST; FOLLOW UP; GENE EXPRESSION; GENOME ANALYSIS; GENOMIC INSTABILITY; HUMAN; KARYOTYPING; LETTER; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; NEURAL STEM CELL; NONHUMAN; OSTEOSARCOMA CELL; PLURIPOTENT STEM CELL; PRENATAL DIAGNOSIS; STEM CELL TRANSPLANTATION;

CELLS, CULTURED; GENOMIC IMPRINTING; GENOMIC INSTABILITY; HUMANS; MESENCHYMAL STROMAL CELLS;

EID: 84861840324     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1103     Document Type: Letter

References (10)

1. Ben-David U, Mayshar Y, Benvenisty N. Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells. Cell Stem Cell 2011;9:97-102.
2. Hayflick L, Perkins F, Stevenson RE. Human diploid cell strains. Science 1964;143:976.
3. Report of Ad Hoc Committee on karyological controls of human cell substrates. J Biol Stand 1979;7:397-404.
4. Rosolowsky M, McKee R, Nichols W et al. Chromosomal characterization of MRC-5 cell banks utilizing G-banding technique. Dev Biol Stand 1998;93:109-117.
5. Strassberg M, Fruhman G, Van den Veyver IB. Copy-number changes in prenatal diagnosis. Expert Rev Mol Diagn 2011;11:579-592.
6. Petricciani JC, Horaud FN. Karyology and tumorigenicity testing requirements: Past, present and future. Dev Biol Stand 1998;93: 5-13.
7. Dass CR, Ek ET, Choong PF. Human xenograft osteosarcoma models with spontaneous metastasis in mice: Clinical relevance and applicability for drug testing. J Cancer Res Clin Oncol 2007;133: 193-198. (Pubitemid 46144095)
8. Romanov SR, Kozakiewicz BK, Holst CR et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001;409:633-637. (Pubitemid 32154817)
9. Prockop DJ, Brenner M, Fibbe WE et al. Simmons PJ, Sensebe L, Keating A. Defining the risks of mesenchymal stromal cell therapy. Cytotherapy 2010;12:576-578.
10. Casiraghi F, Remuzzi G, Abbate M et al. Multipotent mesenchymal stromal cell therapy and risk of malignancies. Stem Cell Rev 2012 [Epub ahead of print].