Biotransformation of bde-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6

Environmental Health Perspectives

Volumn 121, Issue 4, 2013, Pages 440-446

  Feo, Maria Luisa ^a,b   Gross, Michael S ^a   Mcgarrigle, Barbara P ^c   Eljarrat, Ethel ^b   Barceló, Damià ^b,d   Aga, Diana S ^a   Olson, James R ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^c UNIVERSITY AT BUFFALO   (United States)

^d CATALAN INSTITUTE FOR WATER RESEARCH ICRA   (Spain)

Author keywords

BDE metabolites; BDE 47; CYP2B6; Human liver microsomes; Hydroxylated metabolites; PBDE metabolism

Indexed keywords

2,2 ,4,4 TETRABROMODIPHENYL ETHER; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450; DIAZOMETHANE; DICHLOROMETHANE; ETHER DERIVATIVE; HEXANE; POLYBROMINATED DIPHENYL ETHER; TOXIN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; BACULOVIRUS; CONTROLLED STUDY; DRUG METABOLISM; GAS CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN DENATURATION; TANDEM MASS SPECTROMETRY;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FLAME RETARDANTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALOGENATED DIPHENYL ETHERS; HUMANS; KINETICS; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

TETRA;

EID: 84875908735     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.120544     Document Type: Article

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