Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline, mediated by cDNA-expressed human CYP1A2

Drug Metabolism and Disposition

Volumn 28, Issue 11, 2000, Pages 1297-1302

  Miranda, Cristobal L ^a   Yang, Yea Huey ^a   Henderson, Marilyn C ^a   Stevens, Jan F ^a   Santana Rios, Gilberto ^b   Deinzer, Max L ^a   Buhler, Donald R ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 8 PRENYLNARINGENIN; CARCINOGEN; CHALCONE DERIVATIVE; COMPLEMENTARY DNA; CYTOCHROME P450; DNA; FLAVANONE DERIVATIVE; FLAVONOID; HETEROCYCLIC AMINE; ISOXANTHOHUMOL; PHENACETIN O DEETHYLASE; PRENYLFLAVONOID DERIVATIVE; PROTEIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; XANTHOHUMOL;

AMES TEST; ARTICLE; BEER; CANCER; CANCER PREVENTION; CONTROLLED STUDY; COOKING; COVALENT BOND; ENZYME INHIBITION; INSECT; METABOLIC ACTIVATION; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BIOTRANSFORMATION; CARCINOGENS; CATALYSIS; CYTOCHROME P-450 CYP1A2; DNA, COMPLEMENTARY; FLAVONOIDS; HUMANS; MUTAGENICITY TESTS; PLANTS; PROTEIN BINDING; QUINOLINES; RATS; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SPODOPTERA;

HUMULUS LUPULUS; INSECTA; SALMONELLA;

EID: 0033790505     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

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