Structural optimization of berberine as a synergist to restore antifungal activity of fluconazole against drug-resistant Candida albicans

ChemMedChem

Volumn 9, Issue 1, 2014, Pages 207-216

  Liu, Hong ^b   Wang, Liang ^a   Li, Yan ^a   Liu, Jiang ^d   An, Maomao ^c   Zhu, Shaolong ^a   Cao, Yongbing ^a   Jiang, Zhihui ^a   Zhao, Mingzhu ^a   Cai, Zhan ^a   Dai, Li ^a   Ni, Tingjunhong ^a   Liu, Wei ^c   Chen, Simin ^c   Wei, Changqing ^a   Zang, Chengxu ^a   Tian, Shujuan ^a   Yang, Jingyu ^d   Wu, Chunfu ^d   Zhang, Dazhi ^a   Liu, Hua ^b   Jiang, Yuanying ^a   more..

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

antifungal agents; berberine; Candida albicans; drug resistance; structure activity relationships

Indexed keywords

[N (2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL) 2 (2 FLUROPHENYL)ACETAMIDE]; BERBERINE; BERBERINE DERIVATIVE; FLUCONAZOLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDA ALBICANS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACOPHORE; PICTET SPENGLER REACTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIFUNGAL AGENTS; BERBERINE; CANDIDA ALBICANS; DRUG RESISTANCE; STRUCTURE-ACTIVITY RELATIONSHIPS;

ACETAMIDES; ANTIFUNGAL AGENTS; BERBERINE; CANDIDA ALBICANS; CELL SURVIVAL; DIOXOLES; DRUG RESISTANCE, FUNGAL; DRUG SYNERGISM; FLUCONAZOLE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891740399     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300332     Document Type: Article

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