Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5502-5505

  Youngsaye, Willmen ^a   Vincent, Benjamin ^b,c   Hartland, Cathy L ^a   Morgan, Barbara J ^a   Buhrlage, Sara J ^a   Johnston, Stephen ^a   Bittker, Joshua A ^a   MacPherson, Lawrence ^a   Dandapani, Sivaraman ^a   Palmer, Michelle ^a   Whitesell, Luke ^b   Lindquist, Susan ^b,c   Schreiber, Stuart L ^a   Munoz, Benito ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Antifungal; Candida albicans; Chemosensitizer; Fluconazole; Molecular Libraries Probe Production Centers Network (MLPCN)

Indexed keywords

FLUCONAZOLE; PIPERAZINYL QUINOLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGUS ISOLATION; NONHUMAN;

ANTIFUNGAL AGENTS; CALCINEURIN; CANDIDA ALBICANS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUCONAZOLE; HSP90 HEAT-SHOCK PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINOLINES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA; CANDIDA ALBICANS;

EID: 80051946140     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.105     Document Type: Article

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