The synergy of honokiol and fluconazole against clinical isolates of azole-resistant Candida albicans

Letters in Applied Microbiology

Volumn 51, Issue 3, 2010, Pages 351-357

  Jin, J ^a   Guo, N ^a   Zhang, J ^b   Ding, Y ^a   Tang, X ^c   Liang, J ^a   Li, L ^a   Deng, X ^a   Yu, L ^a  

^a JILIN UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

Candida albicans; honokiol; synergy

Indexed keywords

ANIMALS; IMPACT RESISTANCE; STRAIN;

ALBICANS; ANTAGONISTIC ACTIVITY; ANTI-FUNGAL ACTIVITY; CANDIDA ALBICANS; CLINICAL ISOLATES; COLONY FORMING UNITS; COMBINATION THERAPY; DRUG-RESISTANCE; E-MODEL; FLUCONAZOLE; HONOKIOL; IN-VITRO; IN-VIVO; INHIBITORY CONCENTRATION; MICRODILUTION; POSITIVE INTERACTION; RESISTANT STRAINS; SELECTED STRAINS; SYNERGISTIC ACTIVITY; SYNERGY; THERAPEUTIC METHOD;

YEAST;

FLUCONAZOLE; HONOKIOL;

ANTIMICROBIAL ACTIVITY; COLONY; CONCENTRATION (COMPOSITION); DISEASE CONTROL; DISEASE TREATMENT; DRUG RESISTANCE; ECOLOGICAL MODELING; FUNGAL DISEASE; INHIBITOR; ORGANIC COMPOUND; RODENT;

ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BROTH DILUTION; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG POTENTIATION; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; OPTICAL DENSITY; SPECTROPHOTOMETRY;

ANIMALIA; CANDIDA ALBICANS; MUS;

EID: 77955788310     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2010.02900.x     Document Type: Article

References (25)

1. Ahn, K.S., Sethi, G., Shishodia, S., Sung, B., Arbiser, J.L. Aggarwal, B.B. (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol Cancer Res 4, 621 633.
2. Bang, K.H., Kim, Y.K., Min, B.S., Na, M.K., Rhee, Y.H., Lee, J.P. Bae, K.H. (2000) Antifungal activity of magnolol and honokiol. Arch Pharm Res 23, 46 49.
3. Choi, N.H., Choi, G.J., Min, B.S., Jang, K.S., Choi, Y.H., Kang, M.S., Park, M.S., Choi, J.E. et al. (2009) Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi. J Appl Microbiol 106, 2057 2063.
4. Guo, Q., Sun, S., Yu, J., Li, Y. Cao, L. (2008) Synergistic activity of azoles with amiodarone against clinically resistant Candida albicans tested by chequerboard and time-kill methods. J Med Microbiol 57, 457 462.
5. Guo, N., Wu, X., Yu, L., Liu, J., Meng, R., Jin, J., Lu, H., Wang, X. et al. (2009) In vitro and in vivo interactions between fluconazole and allicin against clinical isolates of fluconazole-resistant Candida albicans determined by alternative methods. FEMS Immunol Med Microbiol 58, 193 201.
6. Klepser, M.E, Wolfe, E.J., Jones, R.N., Nightingale, C.H. Pfaller, M.A. (1997) Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans. Antimicrob Agents Chemother 41, 1392 1395.
7. Li, Y., Sun, S., Guo, Q., Ma, L., Shi, C., Su, L. Li, H. (2008) In vitro interaction between azoles and cyclosporin A against clinical isolates of Candida albicans determined by the chequerboard method and time-kill curves. J Antimicrob Chemother 61, 577 585.
8. Marchetti, O., Moreillon, P., Glauser, M.P.J., Bille, J. Sanglard, D. (2000) Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrob Agents Chemother 44, 2373 2381.
9. Meletiadis, J., Mouton, J.W., Meis, J.F. Verweij, P.E. (2003) In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Antimicrob Agents Chemother 47, 106 117.
10. Mukherjee, P.K., Sheehan, D.J., Hitchcock, C.A. Ghannoum, M.A. (2005) Combination treatment of invasive fungal infections. Clin Microbiol Rev 18, 163 194.
11. Munroe, M.E., Arbiser, J.L. Bishop, G.A. (2007) Honokiol, a Natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis1. J Immunol 179, 753 763.
12. Naglik, J.R., Challacombe, S.J. Hube, B. (2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67, 400 428.
13. National Committee for Clinical and Laboratory Standards (1997) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Document M27A.
14. Odds, F.C. (2003) Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother 52, 1.
15. Prichard, M.N., Prichard, L.E. Shipman, C. Jr. (1993) Strategic design and three-dimensional analysis of antiviral drug combinations. Antimicrob Agents Chemother 37, 540 545.
16. Quan, H., Cao, Y.Y., Xu, Z., Zhao, J.X., Gao, P.H., Qin, X.F. Jiang, Y.Y. (2006) Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole. Antimicrob Agents Chemother 50, 1096 1099.
17. Sanati, H., Ramos, C.F., Bayer, A.S. Ghannoum, M.A. (1997) Combination therapy with amphotericin B and fluconazole against invasive candidiasis in neutropenic-mouse and infective-endocarditis rabbit models. Antimicrob Agents Chemother 41, 1345 1348.
18. Seneviratne, C.J., Jin, L.J., Samaranayake, Y.H. Samaranayake, L.P. (2008) Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms. Antimicrob Agents Chemother 52, 3259 3266.
19. Sun, S., Li, Y., Guo, Q., Shi, C., Yu, J. Ma, L. (2008) In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. Antimicrob Agents Chemother 52, 409 417. (Pubitemid 351170807)
20. Syu, W.J., Shen, C.C., Lu, J.J., Lee, G.H. Sun, C.M. (2004) Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis. Chem Biodivers 1, 530 537.
21. Te Dorsthorst, D.T., Verweij, P.E., Meis, J.F., Punt, N.C. Mouton, J.W. (2004) In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models. Antimicrob Agents Chemother 48, 2007 2013.
22. Watanabe, K., Watanabe, H.Y., Goto, Y., Yamamoto, N. Yoshizaki, M. (1975) Studies on the active principles of magnolia bark. Centrally acting muscle relaxant activity of magnolol and honokiol. Jpn J Pharmacol 25, 605 607.
23. White, T.C., Holleman, S., Dy, F., Mirels, L.F. Stevens, D.A. (2002) Resistance mechanisms in Clinical Isolates of Candida albicans. Antimicrob Agents Chemother 46, 1704 1713.
24. Wolf, I., O'Kelly, J., Wakimoto, N., Nguyen, A., Amblard, F., Karlan, B.Y., Arbiser, J.L. Koeffler, H.P. (2007) Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. Int J Oncol 30, 1529 1537.
25. Yan, L., Li, M., Cao, Y., Gao, P., Cao, Y., Wang, Y. Jiang, Y. J. (2009) The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility. J Antimicrob Chemother 64, 764 773.