Regional flexibility in the S4–S5 linker regulates hERG channel closed-state stabilization

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 10, 2014, Pages 1911-1919

  Hull, Christina M ^a   Sokolov, Stanislav ^a   Van Slyke, Aaron C ^a   Claydon, Tom W ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

hERG; Mode shift; S4 S5 linker; Voltage clamp fluorimetry; Voltage sensor

Indexed keywords

ERG1 POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG;

AMINO ACID SEQUENCE; ANIMAL; CHANNEL GATING; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; XENOPUS;

EID: 84891724820     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1431-9     Document Type: Article

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