Gastrin mediated down regulation of ghrelin and its pathophysiological role in atrophic gastritis

Journal of Physiology and Pharmacology

Volumn 64, Issue 6, 2013, Pages

  Rau, T T ^a   Sonst, A ^a   Rogler, A ^a   Burnat, G ^a   Neumann, H ^a   Oeckl, K ^a   Neuhuber, W ^a   Dimmler, A ^b   Faller, G ^b   Brzozowski, T ^c   Hartmann, A ^a   Konturek, P C ^d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b St Vincentius Hospital   (Germany)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Autoimmune gastritis; Enterochromaffin like cells; Gastric cancer; Gastrin; Gastrin cholecystokinin receptor; Ghrelin; Helicobacter pylori

Indexed keywords

CHOLECYSTOKININ RECEPTOR; GASTRIN; GHRELIN;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ARTICLE; ATROPHIC GASTRITIS; CELL HYPERPLASIA; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INFANT; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH BIOPSY;

EID: 84891704403     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Chen D, Aihara T, Zhao CM, Hakanson R, Okabe S. Differentiation of the gastric mucosa. I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes. Am J Physiol Gastrointest Liver Physiol 2006; 291: G539-G544.
2. Rau TT, Rogler A, Frischauf M, et al. Methylation-dependent activation of CDX1 through NF-kappaB: a link from inflammation to intestinal metaplasia in the human stomach. Am J Pathol 2012; 181: 487-498.
3. Konturek SJ, Konturek PC, Bielanski W, et al. Serum progastrin and its products, gastric acid secretion and serum pepsinogen I in gastric cancer. Digestion 2003; 68: 169-177.
4. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
5. Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-4261.
6. Dornonvillede la Cour C, Lindqvist A, Egecioglu E, et al. Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice. Gut 2005; 54: 907-913.
7. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-1719.
8. Perez-Tilve D, Nogueiras R, Mallo F, Benoit SC, Tschoep M. Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine 2006; 29: 61-71.
9. Fukumoto K, Nakahara K, Katayama T, Miyazatao M, Kangawa K, Murakami N. Synergistic action of gastrin and ghrelin on gastric acid secretion in rats. Biochem Biophys Res Commun 2008; 374: 60-63.
10. Konturek PC, Brzozowski T, Pajdo R, Nikiforuk A, Kwiecien S, Harsch I, et al. Ghrelin-a new gastroprotective factor in gastric mucosa. J Physiol Pharmacol 2004; 55: 325-336.
11. Konturek PC, Brzozowski T, Walter B, et al. Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide. Eur J Pharmacol 2006; 536: 171-181.
12. Pawlik MW, Obuchowicz R, Biernat J, et al. Effects of peripherally and centrally applied ghrelin in the pathogenesis of ischemia-reperfusion induced injury of the small intestine. J Physiol Pharmacol 2011; 62: 429-439.
13. Prinz C, Sachs G, Walsh JH, Coy DH, Wu SV. The somatostatin receptor subtype on rat enterochromaffinlike cells. Gastroenterology 1994; 107: 1067-1074.
14. Huggett JF, Foy CA, Benes V, et al. The digital MIQE guidelines: minimum information for Publication of Quantitative Digital PCR Experiments. Clin Chem 2013; 59: 892-902.
15. Murray CD, Kamm MA, Bloom SR, Emmanuel AV. Ghrelin for the gastroenterologist: history and potential. Gastroenterology 2003; 125: 1492-1502.
16. Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988.
17. Konturek PC, Burnat G, Rau T, Hahn EG, Konturek S. Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line. Dig Dis Sci 2008; 53: 597-605.
18. Kawashima J, Ohno S, Sakurada T, et al. Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. J Gastroenterol 2009; 44: 1046-1054.
19. Weis VG, Goldenring JR. Current understanding of SPEM and its standing in the preneoplastic process. Gastric Cancer 2009; 12: 189-197.
20. Campana D, Nori F, Pagotto U, et al. Plasma acylated ghrelin levels are higher in patients with chronic atrophic gastritis. Clin Endocrinol (Oxf) 2007; 67: 761-766.
21. Checchi S, Montanaro A, Pasqui L, et al. Serum ghrelin as a marker of atrophic body gastritis in patients with parietal cell antibodies. J Clin Endocrinol Metab 2007; 92: 4346-4351.
22. Srivastava A, Kamath A, Barry SA, Dayal Y. Ghrelin expression in hyperplastic and neoplastic proliferations of the enterochromaffin-like (ECL) cells. Endocr Pathol 2004; 15: 47-54.
23. Corbetta S, Peracchi M, Cappiello V, et al. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 2003; 88: 3117-3120.
24. Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E. Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 2001; 86: 5052-5059.
25. Tsolakis AV, Portela-Gomes GM, Stridsberg M, et al. Malignant gastric ghrelinoma with hyperghrelinemia. J Clin Endocrinol Metab 2004; 89: 3739-3744.
26. Dornonvillede la Cour C, Bjorkqvist M, et al. A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul Pept 2001; 99: 141-150.
27. Stenstrom B, Zhao CM, Tommeras K, Arum CJ, Chen D. Is gastrin partially responsible for body weight reduction after gastric bypass? Eur Surg Res 2006; 38: 94-101.
28. Zub-Pokrowiecka A, Rembiasz K, Konturek PC, et al. Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy. World J Gastroenterol 2011; 17: 449-458.
29. Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 2002; 146: 241-244.
30. Konturek PC, Brzozowski T, Konturek SJ, et al. Role of histamine in ghrelin-induced gastroprotection against acute gastric lesions. Inflamm Res 2007; 56(Suppl. 1): S25-S26.
31. Strickertsson JA, Dossing KB, Aabakke AJ, Nilsson HO, Hansen TV, Knigge U, et al. Interferon-gamma inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism. World J Gastroenterol 2011; 17: 3117-3125.
32. Szlachcic A, Majka J, Strzalka M, et al. Experimental healing of preexisting gastric ulcers induced by hormones controlling food intake ghrelin, orexin-A and nesfatin-1 is impaired under diabetic conditions. A key to understanding the diabetic gastropathy? J Physiol Pharmacol 2013; 64: 625-637.
33. Friis-Hansen L. Lessons from the gastrin knockout mice. Regul Pept 2007; 139: 5-22.
34. Konturek PC, Brzozowski T, Konturek SJ. Gut clock: implication of circadian rhythms in the gastrointestinal tract. J Physiol Pharmacol 2011; 62: 139-150.