Experimental healing of preexisting gastric ulcers induced by hormones controlling food intake ghrelin, orexin-and nesfatin-1 is impaired under diabetic conditions. A key to understanding the diabetic gastropathy?

Journal of Physiology and Pharmacology

Volumn 64, Issue 5, 2013, Pages 625-637

  Szlachcic, A ^a   Majka, J ^a   Strzalka, M ^a   Szmyd, J ^a   Pajdo, R ^a   Ptak Belowska, A ^a   Kwiecien, S ^a   Brzozowski, T ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Appetite hormones; Calcitonin gene related peptide; Diabetes mellitus; Gastric blood flow; Gastric ulcers; Ghrelin; Nesfatin 1; Nitric oxide; Orexin A; Prostaglandins; Ulcer healing

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CAPSAZEPINE; GHRELIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; N(G) NITROARGININE; NESFATIN 1; OREXIN A; PEPTIDE HORMONE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; FOOD INTAKE; GENE EXPRESSION; HORMONE ACTION; HUNGER; HYPEREMIA; NERVE INJURY; NONHUMAN; RAT; RECEPTOR BLOCKING; SATIETY; SENSORY NERVE; STOMACH BLOOD FLOW; STOMACH MUCOSA; STOMACH ULCER; TISSUE REGENERATION; ULCER HEALING;

ACETIC ACID; ANIMALS; ANTI-ULCER AGENTS; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DNA-BINDING PROTEINS; EATING; GASTRIC MUCOSA; GHRELIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; STOMACH ULCER;

EID: 84888270744     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008; 135: 41-60.
2. Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 2005; 56(Suppl 5): 33-55.
3. Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992; 27: 649-655.
4. Wozniak-Holecka J, Josko J, Tyrpien M, Kasperczyk J, Steplewska K, Holecki T. Influence of vascular endothelial growth factor (VEGF) on gastroprotection in stress-induced gastric mucosal ulcers in rats. Methods Find Exp Clin Pharmacol 2009; 31: 523-531.
5. Whittle BJ, Lopez-Bolmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990; 99: 607-611.
6. Bado A, Levasseur S, Attoub S, et al. The stomach is a source of leptin. Nature 1998; 394: 790-793.
7. Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 1998; 18: 559-572.
8. Brzozowski T, Konturek PC, Pajdo R, et al. Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. Eur J Pharmacol 1999; 374: 263-276.
9. Brzozowski T, Konturek PC, Pajdo R, et al. Brain-gut axis gastroprotection by leptin and cholecystokinin against ischemia-reperfusion induced gastric lesions. J Physiol Pharmacol 2001; 52: 583-602.
10. Schneider R, Bornstein SR, Chrousos G P, Boxberger S, Ehninger G, Breidert M. Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor. Horm Metab Res 2001; 33: 1-6.
11. Lundberg JM, Tatemoto K, Terenius L, et al. Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci USA 1982; 79: 4471-4475.
12. Kawakubo K, Yang H, Tache I. Gastric protective effects of peripheral PYY through PYY preferring receptors in anesthetized rats. Am J Physiol Gastrointest Liver Physiol 2002; 283: G1035-G1041.
13. Guo YS, Fujimura M, Lluis F, Tsong Y, Greeley GH, Thompson JC. Inhibitory action of peptide YY on gastric acid secretion. Am J Physiol 1987; 253: G298-G302.
14. Sakurai T, Amemiya A, Ishii M, et al. Orexin and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
15. Nakabayashi M, Suzuki T, Takahashi K, et al. Orexin-A expression in human peripheral tissues. Mol Cell Endocrinol 2003; 205: 43-50.
16. Nowak KW, Mackowiak P, Switonska MM, Fabis M, Malendowicz LK. Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci 2000; 66: 449-454.
17. Takahashi N, Okumura T, Yamada H, Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 1999; 254: 632-637.
18. Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T. A selective orexin-1 receptor antagonist, SB 334867, blocks2-DG-induced gastric acid secretion in rats. Neurosci Lett 2005; 376: 137-142.
19. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
20. Friis-Hansen L, Wierup N, Rehfeld JF, Sundler F. Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice. Endocrinology 2005; 146: 4464-4471.
21. Ariyasu H, Takaya K, Tagami T, et al. Stomach in a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001; 86: 4753-4758.
22. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-1719.
23. Date Y, Kojima M, Hosoda A, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-4261.
24. Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanol-induced ulcers in rats: studies on the mechanisms of action. Endocrinology 2003; 144: 353-359.
25. Brzozowski T, Konturek PC, Konturek SJ, et al. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120; 39-51.
26. Brzozowski T, Konturek PC, Sliwowski Z, et al. Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury. J Pharmacol Exp Ther 2006; 319: 477-487.
27. Konturek PC, Brzozowski T, Walter B, et al. Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide. Eur J Pharmacol 2006; 536: 171-181.
28. Szlachcic A, Brzozowski T, Majka J, et al. Involvement of orexigenic peptides in the mechanism of gastric mucosal integrity and healing of chronic gastric ulcers. Curr Pharm Des 2010; 16: 1214-1223.
29. Gil K, Bugajski A, Thor P. Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet. J Physiol Pharmacol 2011; 62: 637-646.
30. Ohi S, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443: 709-712.
31. Shimizu H, Ohi S, Hashimoto K, et al. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 2009; 150: 662-671.
32. Foo KS, Brismar H, Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008; 156: 563-579.
33. Brailoiu GC, Dun SL, Brailoiu E, et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology 2007; 148: 5088-5094.
34. Stengel A, Goebel M, Yakubov I, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009; 150: 232-238.
35. Fort P, Salvert D, Hanriot L, et al. The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat. Neuroscience 2008; 155: 174-181.
36. Kohno D, Nakata M, Maejima Y, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 2008; 149: 1295-1301.
37. Szlachcic A, Sliwowski Z, Krzysiek-Maczka G, et al. New satiety hormone nesfatin-1 protects gastric mucosa against stress-induced injury: mechanistic roles of prostaglandins, nitric oxide, sensory nerves and vanilloid receptors. Peptides 2013; 49C: 9-20.
38. Stengel A, Tache Y. Gastric peptides and their regulation of hunger and satiety. Curr Gastroenterol Rep 2012; 14: 480-488.
39. Brzozowski T, Konturek PC, Sliwowski Z, et al. Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide. Regul Pept 2008; 148: 6-20.
40. Brzozowski T, Konturek PC, Sliwowski Z, et al. Neural aspects of ghrelin-induced gastroprotection against mucosal injury induced by noxious agents. J Physiol Pharmacol 2006; 57(Suppl 6): 63-76.
41. Pawlik MW, Obuchowicz R, Biernat J, et al. Effects of peripherally and centrally applied ghrelin in the pathogenesis of ischemia-reperfusion induced injury of the small intestine. J Physiol Pharmacol 2011; 62: 429-439.
42. Stengel A, Hofmann T, Goebel-Stengel M, et al. Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects. Histochem Cell Biol 2013; 139: 909-918.
43. Tashima K, Fujita A, Takeuchi K. Aggravation of ischemia/reperfusion-induced gastric lesions in streptozotocin-diabetic rats. Life Sci 2000; 67: 1707-1718.
44. Korolkiewicz R, Tashima K, Kubomi M, Kato S, Takeuchi K. Increased susceptibility of diabetic rat gastric mucosa to food deprivation during cold stress. Digestion 1999; 60: 528-537.
45. Konturek PC, Brzozowski T, Burnat G, et al. Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats. J Physiol Pharmacol 2010; 61: 429-436.
46. Brzozowska I, Targosz A, Sliwowski Z, et al. Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. J Physiol Pharmacol 2004; 55: 773-790.
47. Okabe S, Roth IL, Pfeiffer CJ. A method for experimental penetrating gastric and duodenal ulcers in rats. Observations on normal healing. Am J Dig Dis 1971; 16: 277-284.
48. Brzozowska I, Konturek PC, Brzozowski T, et al. Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. J Pineal Res 2002; 32: 149-162.
49. Kawahara Y, Nakase Y, Isomoto Y, et al. Role of macrophage colony-stimulating factor (M-CSF)-dependent macrophages in gastric ulcer healing in mice. J Physiol Pharmacol 2011; 62: 441-448.
50. Goldin E, Ardite E, Elizalde JI, et al. Gastric mucosal damages in experimental diabetes in rats: role of endogenous glutathione. Gastroeneterology 1997; 112: 855-863.
51. Takeuchi K, Takehara K, Tajima K, Kato S, Hirata T. Impaired healing of gastric lesions in streptozotocin-induced diabetic rats: effect of basic fibroblast growth factor. J Pharmacol Exp Ther 1997; 281: 200-207.
52. Tashima K, Korolkiewicz R, Kubomi M, Takeuchi K. Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats role of capsaicin-sensitive sensory fibers. Br J Pharmacol 1998; 124: 1359-1402.
53. Tashima K, Fujita A, Umeda M, Takeuchi K. Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. Life Sci 2000; 67: 1639-1652.
54. Pietzsch M, Theuer S, Haase G, Plath F, Kayser M, Riethling AK. Results of systematic screening for serious gastrointestinal bleeding associated with NSAIDs in Rostock Hospitals. Int J Pharmacol Ther 2002; 40: 111-115.
55. Szabo S, Vincze A, Sandor Z, et al. Vascular approach to gastro-duodenal ulceration. Dig Dis Sci 1998; 43(Suppl. 9): 40S-45S.
56. Sakowicz-Burkiewicz M, Pawelczyk T. Recent advances in understanding the relationship between adenosine metabolism and the function of T and B lymphocytes in diabetes. J Physiol Pharmacol 2011; 62: 505-512.
57. Matsui Y, Mitsuyama K, Tomiyasu N, Toyomaga A, Sata M. Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury. Digestion 2002: 66: 99-105.
58. Harsch IA, Brzozowski T, Bazela K, et al. Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines. Eur J Pharmacol 2003; 481: 249-260.