Plasma acylated ghrelin levels are higher in patients with chronic atrophic gastritis

Clinical Endocrinology

Volumn 67, Issue 5, 2007, Pages 761-766

  Campana, Davide ^a   Nori, Francesca ^a   Pagotto, Uberto ^a   De Iasio, Rosaria ^a   Morselli Labate, Antonio Maria ^a   Pasquali, Renato ^a   Corinaldesi, Roberto ^a   Tomassetti, Paola ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN; GHRELIN;

ADULT; AGED; ARTICLE; ATROPHIC GASTRITIS; BACTERIAL INFECTION; CLINICAL ARTICLE; COMPENSATION; CONTROLLED STUDY; CORRELATIONAL STUDY; DIGESTIVE TRACT ENDOSCOPY; FEMALE; GASTROINTESTINAL BIOPSY; HELICOBACTER PYLORI; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; STOMACH FUNDUS; STOMACH PH;

ACYLATION; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; GASTRIC MUCOSA; GASTRINS; GASTRITIS, ATROPHIC; GHRELIN; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; SEX FACTORS;

EID: 35448934891     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.02959.x     Document Type: Article

References (36)

1. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H. Kangawa, K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656 660.
2. Hosoda, H., Kojima, M., Matsuo, H. Kangawa, K. (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. Journal of Biological Chemistry, 275, 21995 22000.
3. Hosoda, H., Kojima, M., Matsuo, H. Kangawa, K. (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemical and Biophysical Research Communications, 279, 909 913.
4. Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M.S., Suganuma, T., Matsukura, S., Kangawa, K. Nakazato, M. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology, 141, 4255 4261.
5. Dornonville, C.C., Bjorkqvist, M., Sandvik, A.K., Bakke, I., Zhao, C.M., Chen, D. Hakanson, R. (2001) A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regulatory Peptides, 99, 141 150.
6. Rindi, G., Necchi, V., Savio, A., Torsello, A., Zoli, M., Locatelli, V., Raimondo, F., Cocchi, D. Solcia, E. (2002) Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochemistry and Cell Biology, 117, 511 519.
7. Volante, M., Allia, E., Gugliotta, P., Funaro, A., Broglio, F., Deghenghi, R., Muccioli, G., Ghigo, E. Papotti, M. (2002) Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. Journal of Clinical Endocrinology and Metabolism, 87, 1300 1308.
8. Date, Y., Nakazato, M., Hashiguchi, S., Dezaki, K., Mondal, M.S., Hosoda, H., Kojima, M., Kangawa, K., Arima, T., Matsuo, H., Yada, T. Matsukura, S. (2002) Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 51, 124 129.
9. Korbonits, M., Kojima, M., Kangawa, K. Grossman, A.B. (2001) Presence of ghrelin in normal and adenomatous human pituitary. Endocrine, 14, 101 104.
10. Kanamoto, N., Akamizu, T., Hosoda, H., Hataya, Y., Ariyasu, H., Takaya, K., Hosoda, K., Saijo, M., Moriyama, K., Shimatsu, A., Kojima, M., Kangawa, K. Nakao, K. (2001) Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. Journal of Clinical Endocrinology and Metabolism, 86, 4984 4990.
11. Cone, R.D., Cowley, M.A., Butler, A.A., Fan, W., Marks, D.L. Low, M.J. (2001) The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. International Journal of Obesity and Related Metabolic Disorders, 25 (Suppl. 5 S63 S67.
12. Lu, S., Guan, J.L., Wang, Q.P., Uehara, K., Yamada, S., Goto, N., Date, Y., Nakazato, M., Kojima, M., Kangawa, K. Shioda, S. (2002) Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neuroscience Letters, 321, 157 160.
13. Volante, M., Fulcheri, E., Allia, E., Cerrato, M., Pucci, A. Papotti, M. (2002) Ghrelin expression in fetal, infant, and adult human lung. Journal of Histochemistry and Cytochemistry, 50, 1013 1021.
14. Gaytan, F., Barreiro, M.L., Caminos, J.E., Chopin, L.K., Herington, A.C., Morales, C., Pinilla, L., Paniagua, R., Nistal, M., Casanueva, F.F., Aguilar, E., Dieguez, C. Tena-Sempere, M. (2004) Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. Journal of Clinical Endocrinology and Metabolism, 89, 400 409.
15. Gaytan, F., Barreiro, M.L., Chopin, L.K., Herington, A.C., Morales, C., Pinilla, L., Casanueva, F.F., Aguilar, E., Dieguez, C. Tena-Sempere, M. (2003) Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. Journal of Clinical Endocrinology and Metabolism, 88, 879 887.
16. van der Lely, A.J., Tschop, M., Heiman, M.L. Ghigo, E. (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews, 25, 426 457.
17. Masuda, Y., Tanaka, T., Inomata, N., Ohnuma, N., Tanaka, S., Itoh, Z., Hosoda, H., Kojima, M. Kangawa, K. (2000) Ghrelin stimulates gastric acid secretion and motility in rats. Biochemical and Biophysical Research Communications, 276, 905 908.
18. Date, Y., Nakazato, M., Murakami, N., Kojima, M., Kangawa, K. Matsukura, S. (2001) Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochemical and Biophysical Research Communications, 280, 904 907.
19. Sibilia, V., Pagani, F., Guidobono, F., Locatelli, V., Torsello, A., Deghenghi, R. Netti, C. (2002) Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats. Neuroendocrinology, 75, 92 97.
20. Dornonville, C.C., Lindstrom, E., Norlen, P. Hakanson, R. (2004) Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regulatory Peptides, 120, 23 32.
21. Brzozowski, T., Konturek, P.C., Konturek, S.J., Kwiecien, S., Drozdowicz, D., Bielanski, W., Pajdo, R., Ptak, A., Nikiforuk, A., Pawlik, W.W. Hahn, E.G. (2004) Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regulatory Peptides, 120, 39 51.
22. Arnold, M., Mura, A., Langhans, W. Geary, N. (2006) Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. Journal of Neuroscience, 26, 11052 11060.
23. Trudel, L., Tomasetto, C., Rio, M.C., Bouin, M., Plourde, V., Eberling, P. Poitras, P. (2002) Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. AJP - Gastrointestinal and Liver Physiology, 282, G948 G952.
24. Kitazawa, T., De Smet, B., Verbeke, K., Depoortere, I. Peeters, T.L. (2005) Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut, 54, 1078 1084.
25. Peeters, T.L. (2005) Ghrelin: a new player in the control of gastrointestinal functions. Gut, 54, 1638 1649.
26. Gokcel, A., Gumurdulu, Y., Kayaselcuk, F., Serin, E., Ozer, B., Ozsahin, A.K. Guvener, N. (2003) Helicobacter pylori has no effect on plasma ghrelin levels. European Journal of Endocrinology, 148, 423 426.
27. Nwokolo, C.U., Freshwater, D.A., O'Hare, P. Randeva, H.S. (2003) Plasma ghrelin following cure of Helicobacter pylori. Gut, 52, 637 640.
28. Osawa, H., Nakazato, M., Date, Y., Kita, H., Ohnishi, H., Ueno, H., Shiiya, T., Satoh, K., Ishino, Y. Sugano, K. (2005) Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori. Journal of Clinical Endocrinology and Metabolism, 90, 10 16.
29. Isomoto, H., Ueno, H., Saenko, V.A., Mondal, M.S., Nishi, Y., Kawano, N., Ohnita, K., Mizuta, Y., Ohtsuru, A., Yamashita, S., Nakazato, M. Kohno, S. (2005) Impact of helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans. American Journal of Gastroenterology, 100, 1711 1720.
30. Pagotto, U., Gambineri, A., Vicennati, V., Heiman, M.L., Tschop, M. Pasquali, R. (2002) Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. Journal of Clinical Endocrinology and Metabolism, 87, 5625 5629.
31. Pirazzoli, P., Lanari, M., Zucchini, S., Gennari, M., Pagotto, U., De Iasio, R., Pasquali, R., Cassio, A., Cicognani, A. Cacciari, E. (2005) Active and total ghrelin concentrations in the newborn. Journal of Pediatric Endocrinology and Metabolism, 18, 379 384.
32. Rindi, G., Torsello, A., Locatelli, V. Solcia, E. (2004) Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system. Experimental Biology and Medicine, 229, 1007 1016.
33. Suzuki, H., Masaoka, T., Hosoda, H., Nomura, S., Ohara, T., Kangawa, K., Ishii, H. Hibi, T. (2004) Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio - a possible novel and non-invasive marker for gastric atrophy. Hepatogastroenterology, 51, 1249 1254.
34. Masaoka, T., Suzuki, H., Imaeda, H., Hosoda, H., Ohara, T., Morishita, T., Ishii, H., Kangawa, K. Hibi, T. (2005) Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication. Hepatogastroenterology, 52, 1 4.
35. Mori, M., Suzuki, H., Masaoka, T., Imaeda, H., Nomoto, Y., Hosoda, H., Nishizawa, T., Kangawa, K. Hibi, T. (2006) Intravenous ghrelin administration enhances gastric acid secretion - evaluation using wireless pH capsule. Alimentary Pharmacology & Therapeutics, 24, 96 103.
36. Akamizu, T., Shinomiya, T., Irako, T., Fukunaga, M., Nakai, Y., Nakai, Y. Kangawa, K. (2005) Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. Journal of Clinical Endocrinology and Metabolism, 90, 6 9.