Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 476-484

  Busker, Mareike ^a   Neidhardt, Inga ^a   Behrends, Sönke ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; FORSTER RESONANCE ENERGY TRANSFER; NITRIC OXIDE; PORPHYRINS;

ACTIVATED CONFORMATION; CONFORMATIONAL CHANGE; FUNCTIONAL DOMAINS; HEME-BINDING DOMAINS; NITRIC OXIDE-SENSITIVE; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES; TRYPTOPHAN RESIDUES;

AMINO ACIDS;

GUANYLATE CYCLASE; NITRIC OXIDE; TRYPTOPHAN; CELL RECEPTOR; HEME; SOLUBLE GUANYLYL CYCLASE;

ALPHA HELIX; ARTICLE; BETA HELIX; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE ANALYSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEME BINDING DOMAIN; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ENZYME ACTIVATION; GUANYLATE CYCLASE; HEME; HUMANS; NITRIC OXIDE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84891692632     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.504472     Document Type: Article

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