Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: Evidence for isoform specific activation by ciguates

Biochemical Pharmacology

Volumn 80, Issue 11, 2010, Pages 1676-1683

  Haase, Nadine ^a   Haase, Tobias ^a   Kraehling, Jan Robert ^a   Behrends, Soenke ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

CGMP; Ciguates; Enzymology; Guanylyl cyclase; Nitric oxide

Indexed keywords

4 [[4 CARBOXYBUTYL[2 [(4 PHENETHYLBENZYL)OXY]PHENETHYL]AMINO]METHYL]BENZOIC ACID; ATACIGUAT; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; HEME; HETERODIMER; HMR 1766; ISOENZYME; NITRIC OXIDE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1; BENZOIC ACID DERIVATIVE; CELL RECEPTOR; CINACIGUAT; PROTEIN BINDING; PROTEIN SUBUNIT; SOLUBLE GUANYLYL CYCLASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIGUATERA; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STOICHIOMETRY; ANIMAL; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; SPODOPTERA;

ANIMALS; BENZOIC ACIDS; CELLS, CULTURED; ENZYME ACTIVATION; GUANYLATE CYCLASE; ISOENZYMES; NITRIC OXIDE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPODOPTERA; BENZOATES;

EID: 77957906338     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.08.007     Document Type: Article

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