Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity

Molecular and Cellular Biology

Volumn 33, Issue 23, 2013, Pages 4660-4671

  Teng, Teng ^a   Mercer, Carol A ^a   Hexley, Philip ^b   Thomas, George ^a,c   Fumagalli, Stefano ^d  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

^c BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METHIONINE; PROTEIN P53; RIBOSOMAL PROTEIN L11; RIBOSOMAL PROTEIN L5; RIBOSOME PROTEIN; SMALL INTERFERING RNA; SULFUR 35; UNCLASSIFIED DRUG; CCNA2 PROTEIN, HUMAN; CCNE1 PROTEIN, HUMAN; CYCLIN A2; CYCLIN E; ONCOPROTEIN; RIBOSOMAL PROTEIN L5, HUMAN; TP53 PROTEIN, HUMAN;

ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISOTOPE LABELING; LUNG FIBROBLAST; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; GENE SILENCING; GENETICS; METABOLISM; PROTEIN SYNTHESIS; TUMOR CELL LINE;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A2; CYCLIN E; GENE KNOCKDOWN TECHNIQUES; HUMANS; ONCOGENE PROTEINS; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEINS; RIBOSOMES; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891677296     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01174-13     Document Type: Article

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