메뉴 건너뛰기




Volumn 68, Issue 1, 2014, Pages 111-125

The Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Simvastatin in a Rat Model of Liver Fibrosis

Author keywords

Liver fibrosis; Mesenchymal stem cells; Rats; Simvastatin

Indexed keywords

ANIMALIA; RATTUS;

EID: 84891628507     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-013-9698-1     Document Type: Article
Times cited : (46)

References (73)
  • 1
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis-From bench to bedside
    • Friedman, S. L. (2003). Liver fibrosis-From bench to bedside. Journal of hepatology, 38(Suppl 1), S38-S53.
    • (2003) Journal of Hepatology , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 4
    • 34047121535 scopus 로고    scopus 로고
    • Expression of MMPs and TIMPs in liver fibrosis-A systematic review with special emphasis on anti-fibrotic strategies
    • Hemmann, S., Graf, J., Roderfeld, M., & Roeb, E. (2007). Expression of MMPs and TIMPs in liver fibrosis-A systematic review with special emphasis on anti-fibrotic strategies. Journal of Hepatology, 46, 955-975.
    • (2007) Journal of Hepatology , vol.46 , pp. 955-975
    • Hemmann, S.1    Graf, J.2    Roderfeld, M.3    Roeb, E.4
  • 5
    • 70349308483 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review)
    • Consolo, M., Amoroso, A., Spandidos, D., & Mazzarino, M. (2009). Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review). International Journal of Molecular Medicine, 24, 143-152.
    • (2009) International Journal of Molecular Medicine , vol.24 , pp. 143-152
    • Consolo, M.1    Amoroso, A.2    Spandidos, D.3    Mazzarino, M.4
  • 6
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock, K., Plaks, V., & Werb, Z. (2010). Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell, 141, 52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 12
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang, O. Y., Lee, J. S., Lee, P. H., & Lee, G. (2005). Autologous mesenchymal stem cell transplantation in stroke patients. Annals of Neurology, 57, 874-882.
    • (2005) Annals of Neurology , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 13
    • 56549119921 scopus 로고    scopus 로고
    • Autotransplantation of purified mesenchymal stem cells in a patient with acute myocardial infarction: A case study
    • Zhang, Z. X., Zhang, Y. Z., Guan, L. X., Zhou, Y. J., Zhao, X. X., Cai, Y. H., et al. (2007). Autotransplantation of purified mesenchymal stem cells in a patient with acute myocardial infarction: A case study. Journal of Stem Cells, 2, 185-189.
    • (2007) Journal of Stem Cells , vol.2 , pp. 185-189
    • Zhang, Z.X.1    Zhang, Y.Z.2    Guan, L.X.3    Zhou, Y.J.4    Zhao, X.X.5    Cai, Y.H.6
  • 14
    • 43549106847 scopus 로고    scopus 로고
    • A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury
    • Zhang, Z. X., Guan, L. X., Zhang, K., Zhang, Q., & Dai, L. J. (2008). A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury. Cytotherapy, 10, 134-139.
    • (2008) Cytotherapy , vol.10 , pp. 134-139
    • Zhang, Z.X.1    Guan, L.X.2    Zhang, K.3    Zhang, Q.4    Dai, L.J.5
  • 15
    • 0036106054 scopus 로고    scopus 로고
    • Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
    • Schwartz, R. E., Reyes, M., Koodie, L., Jiang, Y., Blackstad, M., Lund, T., et al. (2002). Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. The Journal of Clinical Investigation, 109, 1291-1302.
    • (2002) The Journal of Clinical Investigation , vol.109 , pp. 1291-1302
    • Schwartz, R.E.1    Reyes, M.2    Koodie, L.3    Jiang, Y.4    Blackstad, M.5    Lund, T.6
  • 16
    • 10644283018 scopus 로고    scopus 로고
    • In vitro hepatic differentiation of human mesenchymal stem cells
    • Lee, K. D., Kuo, T. K., Whang-Peng, J., Chung, Y. F., Lin, C. T., Chou, S. H., et al. (2004). In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology, 40, 1275-1284.
    • (2004) Hepatology , vol.40 , pp. 1275-1284
    • Lee, K.D.1    Kuo, T.K.2    Whang-Peng, J.3    Chung, Y.F.4    Lin, C.T.5    Chou, S.H.6
  • 17
    • 4143114744 scopus 로고    scopus 로고
    • Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice
    • Fang, B., Shi, M., Liao, L., Yang, S., Liu, Y., & Zhao, R. C. (2004). Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation, 78, 83-88.
    • (2004) Transplantation , vol.78 , pp. 83-88
    • Fang, B.1    Shi, M.2    Liao, L.3    Yang, S.4    Liu, Y.5    Zhao, R.C.6
  • 18
    • 34547866073 scopus 로고    scopus 로고
    • Effects of statins on liver fibrosis reversibility and activities of lysosomal exoglycosidases
    • Oxana Lukivskaya, M. K., Dudzik, D., Borzym-Kluczyk, M., Lis, R., Buko, V., & Zwierz, K. (2007). Effects of statins on liver fibrosis reversibility and activities of lysosomal exoglycosidases. E&C Hepatology, 3, 14-17.
    • (2007) E&C Hepatology , vol.3 , pp. 14-17
    • Oxana Lukivskaya, M.K.1    Dudzik, D.2    Borzym-Kluczyk, M.3    Lis, R.4    Buko, V.5    Zwierz, K.6
  • 19
    • 38049175023 scopus 로고    scopus 로고
    • Statins: A new insight into their mechanisms of action and consequent pleiotropic effects
    • Jasinska, M., Owczarek, J., & Orszulak-Michalak, D. (2007). Statins: A new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacological Reports, 59, 483-499.
    • (2007) Pharmacological Reports , vol.59 , pp. 483-499
    • Jasinska, M.1    Owczarek, J.2    Orszulak-Michalak, D.3
  • 23
    • 2142768218 scopus 로고    scopus 로고
    • Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    • Chalasani, N., Aljadhey, H., Kesterson, J., Murray, M. D., & Hall, S. D. (2004). Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology, 126, 1287-1292.
    • (2004) Gastroenterology , vol.126 , pp. 1287-1292
    • Chalasani, N.1    Aljadhey, H.2    Kesterson, J.3    Murray, M.D.4    Hall, S.D.5
  • 24
    • 0032956961 scopus 로고    scopus 로고
    • Natural statins and stroke risk
    • Furberg, C. D. (1999). Natural statins and stroke risk. Circulation, 99, 185-188.
    • (1999) Circulation , vol.99 , pp. 185-188
    • Furberg, C.D.1
  • 25
    • 4544359550 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Isolation and therapeutics
    • Alhadlaq, A., & Mao, J. J. (2004). Mesenchymal stem cells: Isolation and therapeutics. Stem Cells and Development, 13, 436-448.
    • (2004) Stem Cells and Development , vol.13 , pp. 436-448
    • Alhadlaq, A.1    Mao, J.J.2
  • 27
    • 21044434501 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats
    • Zhao, D. C., Lei, J. X., Chen, R., Yu, W. H., Zhang, X. M., Li, S. N., et al. (2005). Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World Journal of Gastroenterology, 11, 3431-3440.
    • (2005) World Journal of Gastroenterology , vol.11 , pp. 3431-3440
    • Zhao, D.C.1    Lei, J.X.2    Chen, R.3    Yu, W.H.4    Zhang, X.M.5    Li, S.N.6
  • 28
    • 77049204706 scopus 로고
    • A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum
    • Karmen, A. (1955). A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum. The Journal of Clinical Investigation, 34, 131-133.
    • (1955) The Journal of Clinical Investigation , vol.34 , pp. 131-133
    • Karmen, A.1
  • 29
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • Reitman, S., & Frankel, S. (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology, 28, 56-63.
    • (1957) American Journal of Clinical Pathology , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 30
    • 77049203740 scopus 로고
    • Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine
    • Kind, P. R., & King, E. J. (1954). Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of Clinical Pathology, 7, 322-326.
    • (1954) Journal of Clinical Pathology , vol.7 , pp. 322-326
    • Kind, P.R.1    King, E.J.2
  • 31
    • 0015195627 scopus 로고
    • Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine
    • Belfield, A., & Goldberg, D. M. (1971). Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme, 12, 561-573.
    • (1971) Enzyme , vol.12 , pp. 561-573
    • Belfield, A.1    Goldberg, D.M.2
  • 34
    • 10444248938 scopus 로고    scopus 로고
    • Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    • Wang, H. S., Hung, S. C., Peng, S. T., Huang, C. C., Wei, H. M., Guo, Y. J., et al. (2004). Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells, 22, 1330-1337.
    • (2004) Stem Cells , vol.22 , pp. 1330-1337
    • Wang, H.S.1    Hung, S.C.2    Peng, S.T.3    Huang, C.C.4    Wei, H.M.5    Guo, Y.J.6
  • 35
    • 0042967962 scopus 로고    scopus 로고
    • Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection
    • Wu, G. D., Tuan, T. L., Bowdish, M. E., Jin, Y. S., Starnes, V. A., Cramer, D. V., et al. (2003). Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection. Transplantation, 76, 609-614.
    • (2003) Transplantation , vol.76 , pp. 609-614
    • Wu, G.D.1    Tuan, T.L.2    Bowdish, M.E.3    Jin, Y.S.4    Starnes, V.A.5    Cramer, D.V.6
  • 36
    • 34447558272 scopus 로고    scopus 로고
    • Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis
    • Abdel Aziz, M. T., Atta, H. M., Mahfouz, S., Fouad, H. H., Roshdy, N. K., Ahmed, H. H., et al. (2007). Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clinical Biochemistry, 40, 893-899.
    • (2007) Clinical Biochemistry , vol.40 , pp. 893-899
    • Abdel Aziz, M.T.1    Atta, H.M.2    Mahfouz, S.3    Fouad, H.H.4    Roshdy, N.K.5    Ahmed, H.H.6
  • 38
    • 0029778988 scopus 로고    scopus 로고
    • An algorithm for the grading of activity in chronic hepatitis C
    • The METAVIR Cooperative Study Group
    • Bedossa, P., Poynard, T., & The METAVIR Cooperative Study Group. (1996). An algorithm for the grading of activity in chronic hepatitis C. Hepatology, 24, 289-293.
    • (1996) Hepatology , vol.24 , pp. 289-293
    • Bedossa, P.1    Poynard, T.2
  • 40
    • 0031047691 scopus 로고    scopus 로고
    • Endoglin, a transforming growth factor-beta-binding protein, is upregulated in chronic progressive renal disease
    • Roy-Chaudhury, P., Simpson, J. G., & Power, D. A. (1997). Endoglin, a transforming growth factor-beta-binding protein, is upregulated in chronic progressive renal disease. Experimental Nephrology, 5, 55-60.
    • (1997) Experimental Nephrology , vol.5 , pp. 55-60
    • Roy-Chaudhury, P.1    Simpson, J.G.2    Power, D.A.3
  • 42
    • 0026646785 scopus 로고
    • Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    • Cheifetz, S., Bellon, T., Cales, C., Vera, S., Bernabeu, C., Massague, J., et al. (1992). Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. The Journal of Biological Chemistry, 267, 19027-19030.
    • (1992) The Journal of Biological Chemistry , vol.267 , pp. 19027-19030
    • Cheifetz, S.1    Bellon, T.2    Cales, C.3    Vera, S.4    Bernabeu, C.5    Massague, J.6
  • 44
    • 33646691720 scopus 로고    scopus 로고
    • Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells
    • Wiercinska, E., Wickert, L., Denecke, B., Said, H. M., Hamzavi, J., Gressner, A. M., et al. (2006). Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Hepatology, 43, 1032-1041.
    • (2006) Hepatology , vol.43 , pp. 1032-1041
    • Wiercinska, E.1    Wickert, L.2    Denecke, B.3    Said, H.M.4    Hamzavi, J.5    Gressner, A.M.6
  • 45
    • 38549127166 scopus 로고    scopus 로고
    • Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: Engraftment and hepatocyte differentiation versus profibrogenic potential
    • di Bonzo, L. V., Ferrero, I., Cravanzola, C., Mareschi, K., Rustichell, D., Novo, E., et al. (2008). Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: Engraftment and hepatocyte differentiation versus profibrogenic potential. Gut, 57, 223-231.
    • (2008) Gut , vol.57 , pp. 223-231
    • di Bonzo, L.V.1    Ferrero, I.2    Cravanzola, C.3    Mareschi, K.4    Rustichell, D.5    Novo, E.6
  • 46
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn, T. A. (2008). Cellular and molecular mechanisms of fibrosis. The Journal of Pathology, 214, 199-210.
    • (2008) The Journal of Pathology , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 47
    • 20644471364 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats
    • Xu, X., Xu, Z., Xu, Y., & Cui, G. (2005). Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coronary Artery Disease, 16, 245-255.
    • (2005) Coronary Artery Disease , vol.16 , pp. 245-255
    • Xu, X.1    Xu, Z.2    Xu, Y.3    Cui, G.4
  • 49
    • 56549113250 scopus 로고    scopus 로고
    • The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis
    • Dai, L. J., Li, H. Y., Guan, L. X., Ritchie, G., & Zhou, J. X. (2009). The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis. Stem Cell Research, 2, 16-25.
    • (2009) Stem Cell Research , vol.2 , pp. 16-25
    • Dai, L.J.1    Li, H.Y.2    Guan, L.X.3    Ritchie, G.4    Zhou, J.X.5
  • 51
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird, T., Stabile, E., Burnett, M. S., Shou, M., Lee, C. W., Barr, S., et al. (2004). Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation, 109, 1543-1549.
    • (2004) Circulation , vol.109 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3    Shou, M.4    Lee, C.W.5    Barr, S.6
  • 52
    • 19944432052 scopus 로고    scopus 로고
    • Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    • Silva, G. V., Litovsky, S., Assad, J. A., Sousa, A. L., Martin, B. J., Vela, D., et al. (2005). Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation, 111, 150-156.
    • (2005) Circulation , vol.111 , pp. 150-156
    • Silva, G.V.1    Litovsky, S.2    Assad, J.A.3    Sousa, A.L.4    Martin, B.J.5    Vela, D.6
  • 53
    • 6944235074 scopus 로고    scopus 로고
    • Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor
    • Matsuda-Hashii, Y., Takai, K., Ohta, H., Fujisaki, H., Tokimasa, S., Osugi, Y., et al. (2004). Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor. Experimental Hematology, 32, 955-961.
    • (2004) Experimental Hematology , vol.32 , pp. 955-961
    • Matsuda-Hashii, Y.1    Takai, K.2    Ohta, H.3    Fujisaki, H.4    Tokimasa, S.5    Osugi, Y.6
  • 55
    • 0037183512 scopus 로고    scopus 로고
    • Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
    • Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., et al. (2002). Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery. Neurology, 59, 514-523.
    • (2002) Neurology , vol.59 , pp. 514-523
    • Li, Y.1    Chen, J.2    Chen, X.G.3    Wang, L.4    Gautam, S.C.5    Xu, Y.X.6
  • 56
    • 0033847886 scopus 로고    scopus 로고
    • Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation
    • Trim, N., Morgan, S., Evans, M., Issa, R., Fine, D., Afford, S., et al. (2000). Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. The American Journal of Pathology, 156, 1235-1243.
    • (2000) The American Journal of Pathology , vol.156 , pp. 1235-1243
    • Trim, N.1    Morgan, S.2    Evans, M.3    Issa, R.4    Fine, D.5    Afford, S.6
  • 58
    • 0031026475 scopus 로고    scopus 로고
    • The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood
    • Aiuti, A., Webb, I. J., Bleul, C., Springer, T., & Gutierrez-Ramos, J. C. (1997). The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. The Journal of Experimental Medicine, 185, 111-120.
    • (1997) The Journal of Experimental Medicine , vol.185 , pp. 111-120
    • Aiuti, A.1    Webb, I.J.2    Bleul, C.3    Springer, T.4    Gutierrez-Ramos, J.C.5
  • 59
    • 80053893866 scopus 로고    scopus 로고
    • Age-related changes in rat bone-marrow mesenchymal stem cell plasticity
    • Asumda, F. Z., & Chase, P. B. (2011). Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biology, 12, 44.
    • (2011) BMC Cell Biology , vol.12 , pp. 44
    • Asumda, F.Z.1    Chase, P.B.2
  • 60
    • 0038555527 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    • Rombouts, K., Kisanga, E., Hellemans, K., Wielant, A., Schuppan, D., & Geerts, A. (2003). Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. Journal of Hepatology, 38, 564-572.
    • (2003) Journal of Hepatology , vol.38 , pp. 564-572
    • Rombouts, K.1    Kisanga, E.2    Hellemans, K.3    Wielant, A.4    Schuppan, D.5    Geerts, A.6
  • 61
    • 0033919245 scopus 로고    scopus 로고
    • Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I
    • Rosenbloom, J., Saitta, B., Gaidarova, S., Sandorfi, N., Rosenbloom, J. C., Abrams, W. R., et al. (2000). Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I. Arthritis and Rheumatism, 43, 1624-1632.
    • (2000) Arthritis and Rheumatism , vol.43 , pp. 1624-1632
    • Rosenbloom, J.1    Saitta, B.2    Gaidarova, S.3    Sandorfi, N.4    Rosenbloom, J.C.5    Abrams, W.R.6
  • 62
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein, J. L., & Brown, M. S. (1990). Regulation of the mevalonate pathway. Nature, 343, 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 63
    • 0037155865 scopus 로고    scopus 로고
    • Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB
    • Holstein, S. A., Wohlford-Lenane, C. L., & Hohl, R. J. (2002). Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB. The Journal of Biological Chemistry, 277, 10678-10682.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 10678-10682
    • Holstein, S.A.1    Wohlford-Lenane, C.L.2    Hohl, R.J.3
  • 64
    • 33646355930 scopus 로고    scopus 로고
    • Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin
    • Louneva, N., Huaman, G., Fertala, J., & Jimenez, S. A. (2006). Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis and Rheumatism, 54, 1298-1308.
    • (2006) Arthritis and Rheumatism , vol.54 , pp. 1298-1308
    • Louneva, N.1    Huaman, G.2    Fertala, J.3    Jimenez, S.A.4
  • 65
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs, U., & Liao, J. K. (1998). Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. The Journal of Biological Chemistry, 273, 24266-24271.
    • (1998) The Journal of Biological Chemistry , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 66
    • 33644694919 scopus 로고    scopus 로고
    • Rho GTPases, statins, and nitric oxide
    • Rikitake, Y., & Liao, J. K. (2005). Rho GTPases, statins, and nitric oxide. Circulation Research, 97(12), 1232-1235.
    • (2005) Circulation Research , vol.97 , Issue.12 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 67
    • 33750717503 scopus 로고    scopus 로고
    • Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat
    • Jeong, W. I., Do, S. H., Jeong, D. H., Hong, I. H., Park, J. K., Ran, K. M., et al. (2006). Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Anticancer Research, 26, 3517-3526.
    • (2006) Anticancer Research , vol.26 , pp. 3517-3526
    • Jeong, W.I.1    Do, S.H.2    Jeong, D.H.3    Hong, I.H.4    Park, J.K.5    Ran, K.M.6
  • 69
  • 70
    • 36348987648 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    • Lewis, J. H., Mortensen, M. E., Zweig, S., Fusco, M. J., Medoff, J. R., & Belder, R. (2007). Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Hepatology, 46, 1453-1463.
    • (2007) Hepatology , vol.46 , pp. 1453-1463
    • Lewis, J.H.1    Mortensen, M.E.2    Zweig, S.3    Fusco, M.J.4    Medoff, J.R.5    Belder, R.6
  • 72
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: Focus on patients with fatty liver
    • Chalasani, N. (2005). Statins and hepatotoxicity: Focus on patients with fatty liver. Hepatology, 41, 690-695.
    • (2005) Hepatology , vol.41 , pp. 690-695
    • Chalasani, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.