Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: Engraftment and hepatocyte differentiation versus profibrogenic potential

Gut

Volumn 57, Issue 2, 2008, Pages 223-231

  Valfre Di Bonzo L ^a   Ferrero, I ^a   Cravanzola, C ^a   Mareschi, K ^a   Rustichell, D ^a   Novo, E ^a   Sanavio, F ^a   Cannito, S ^a   Zamara, E ^a   Bertero, M ^a   Davit, A ^a   Francica, S ^a   Novelli, F ^a,b   Colombatto, S ^a   Fagioli, F ^a   Parola, Maurizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; CARBON TETRACHLORIDE; CYTOKERATIN 18; CYTOKERATIN 19;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; FIBROGENESIS; IRRADIATION; LIVER CELL; LIVER GRAFT; LIVER INJURY; LIVER REGENERATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE;

ANIMALS; BONE MARROW CELLS; CARBON TETRACHLORIDE; GENE EXPRESSION; GRAFT SURVIVAL; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER REGENERATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED NOD; MICE, SCID; REGENERATIVE MEDICINE;

EID: 38549127166     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.111617     Document Type: Article

References (49)

1. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999;284:1168-70.
2. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000;31:235-40.
3. Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from non-hepatic adult stem cells. Nature 2000;406:257.
4. Lagasse E, Connors H, Al-Dhalimy M, et al. Purified HSC can differentiate into hepatocytes in vivo. Nature Med 2000;6:1229- 34.
5. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology 2000;32:11-16.
6. Korbling M, Katz RL, Khanna A, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral blood stem cells. New Engl J Med 2002;346:738-46.
7. Fogt F, Beyser KH, Poremba C, et al. Recipient-derived hepatocytes in liver transplants: a rare event in sex-mismatched transplants. Hepatology 2002;36:173-6.
8. Wang X, Ge S, McNamara G, et al. Albumin expressing hepatocyte-like cells develop in the livers of immune deficient mice that received transplant of highly purified HSC. Blood 2003;101:4201-8.
9. Hove WR, van Hoek B, Bajema IM, et al. Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium and hepatocytes. Liver Transpl 2003;9:552-6.
10. Ng IO, Chan K, Shek W, et al. High frequency of chimerism in transplanted livers. Hepatology 2003;38:989-98.
11. Thorgeirsson SS, Grisham JW. Haemopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 2006;43:2-8.
12. Jang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-9.
13. - progenitors. J Haematotherapy Stem Cell Res 2003;12:603-13.
14. Willenbring H, Bailey AS, Foster M, et al. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nature Med 2004;10:744-8.
15. Almeida-Porada G, Porada CD, Chamberlain J, et al. Formation of human hepatocytes by human HSC in sheep. Blood 2004;104:2582-90.
16. Sato Y, Araki H, Kato J, et al. Human mesenchymal stem cells xenografted directly to rat liver differentiated into hepatocytes without fusion. Blood 2005;106:756-63.
17. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
18. Pereira RF, Halford KW, O'Hara MO, et al. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci USA 1995;92:4857-61.
19. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1α. J Cell Physiol 1996;166:585-92.
20. Yoo JU, Barthel TS, Nishimura K, et al. The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg Am 1998;80:1745-57.
21. Park SR, Oreffo RO, Triffitt JT. Interconversion potential of cloned human marrow adipocytes in vitro. Bone 1999;24:549-54.
22. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995;18:1417-26.
23. Lee KD, Kuo TK, Whang-Pheng J, et al. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004;40:1275-84.
24. Fang B, Shi M, Liao L, et al. Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004;78:83-8.
25. Lange C, Bassler P, Lioznov MV, et al. Hepatocytic gene expression in cultured rat mesenchymal stem cells. Transplant Proc 2005;37:276-9.
26. Hong SH, Gang EJ, Jeong JA, et al. In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 2005;330:1153- 61.
27. Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 2005;328:258-64.
28. Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002;109:1291-302.
29. 4-injured rats. J Hepatol 2006;44:742-8.
30. Mareschi K, Ferrero I, Rustichelli D, et al. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem 2006;97:744-54.
31. Mareschi K, Biasin E, Piacibello W, et al. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica 2001;86:1099-100.
32. Robino G, Parola M, Marra F, et al. Interaction between 4-hydroxy-2,3-alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signaling in hepatic stellate cells. J Biol Chem 2000;275:40561-7.
33. Aleffi S, Petrai I, Bertolani C, et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 2005;42:1339-48.
34. Parola M, Robino G, Marra F, et al. HNE interacts directly with JNK isoforms in human hepatic stellate cells. J Clin Invest 1998;102:1942-50.
35. Novo E, Marra F, Zamara E, et al. Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells. Gut 2006;55:90-7.
36. Novelli F, D'Elios MM, Bernabei P, et al. Expression and role in apoptosis of the alpha- and beta-chains of IFN-gamma receptor on human TM and Th2 clones. J Immunol 1997;159:206-13.
37. Neuss S, Becher E, Wöltje M, et al. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair and wound healing. Stem Cells 2004;22:405-14.
38. Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 2005;106:419-27.
39. Charo IF, Richard M, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. New Engl J Med 2006;354:610-21.
40. Marra F. Chemokines in liver inflammation and fibrosis. Front Biosci 2002;7:1899-914.
41. Simpson KJ, Henderson NC, Bone-Larson CL, et al. Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles. Clin Sci 2003;104:47-63.
42. Shackel N, Rockey D. In pursuit of the "Holy Grail" - stem cells, hepatic injury, fibrogenesis and repair. Hepatology 2005;41:16-18.
43. Simonsen S, Gurdon JB. Changing cell fate by nuclear reprogramming. Cell Cycle 2005;4:513-15.
44. Rideout III WM, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293:1093-8.
45. Fuchs E, Tumbar T, Guasch G. Socializing with neighbours: stem cells and their niche. Cell 2004;116:769-78.
46. Ohlstein B, Kai T, Decotto E, et al. The stem cell niche: theme and variations. Curr Opin Cell Biol 2004;16:693-9.
47. Aurich I, Mueller LP, Audrich H, et al. Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut 2007;56:405-15.
48. Russo FP, Alison MR, Bigger BW, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006;130:1807-21.
49. Kucia M, Reca R, Campbell FR, et al. A population of very small embryonic- like (VSEL) CXCR4+, SSEA-1+, 0ct-4+ stem cells identified in adult bone marrow. Leukemia 2006;20:857-69.