Self-disturbances as a possible premorbid indicator of schizophrenia risk: A neurodevelopmental perspective

Schizophrenia Research

Volumn 152, Issue 1, 2014, Pages 73-80

  Brent, Benjamin K ^a,b,c,d   Seidman, Larry J ^a,b,c,d   Thermenos, Heidi W ^a,b,c,d   Holt, Daphne J ^b,d   Keshavan, Matcheri S ^a,c,d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Genetic high risk; Neurodevelopment; Premorbid; Schizophrenia; Self disturbances

Indexed keywords

ADOLESCENCE; ARTICLE; BEHAVIOR DISORDER; CHILD DEVELOPMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC RISK; HIGH RISK POPULATION; HUMAN; IMAGE ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; SELF DISTURBANCE; BRAIN CELL; BRAIN CORTEX; BRAIN FUNCTION; BRAIN REGION; CELL MIGRATION; CHILD BEHAVIOR; DISEASE SEVERITY; FUNCTIONAL ASSESSMENT; GENETIC ASSOCIATION; HIGH RISK PATIENT; INFERIOR PARIETAL LOBULE; LATERAL CORTEX; MEDIAL PREFRONTAL CORTEX; MENTAL DISEASE; MORBIDITY; NEUROANATOMY; PERINATAL PERIOD; RISK FACTOR; SUPERIOR TEMPORAL SULCUS; TEMPORAL CORTEX;

GENETIC HIGH-RISK; NEURODEVELOPMENT; PREMORBID; SCHIZOPHRENIA; SELF-DISTURBANCES;

BRAIN; HUMANS; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SELF CONCEPT;

EID: 84891627154     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.07.038     Document Type: Article

References (142)

1. Akbarian S., Bunney W.E., Potkin S.G., Wigal S.B., Hagman J.O., Sandman C.A., Jones E.G. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch. Gen. Psychiatry 1993, 50(3):169-177.
2. Amminger G.P., Pape S., Rock D., Roberts S.A., Ott S.L., Squires-Wheeler E., Kestenbaum C., Erlenmeyer-Kimling L. Relationship between childhood behavioral disturbance and later schizophrenia in the New York High-Risk Project. Am. J. Psychiatry 1999, 156(4):525-530.
3. Amodio D.M., Frith C.D. Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 2006, 7(4):268-277.
4. Bedford N.J., Surguladze S., Giampietro V., Brammer M.J., David A.S. Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight. BMC Psychiatry 2012, 12:106.
5. Bhojraj T.S., Francis A.N., Rajarethinam R., Eack S., Kulkarni S., Prasad K.M., Montrose D.M., Dworakowski D., Diwadkar V., Keshavan M.S. Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia. Schizophr. Res. 2009, 115(2-3):202-208.
6. Bhojraj T.S., Francis A.N., Montrose D.M., Keshavan M.S. Grey matter and cognitive deficits in young relatives of schizophrenia patients. NeuroImage 2011, 54(Suppl. 1):S287-S292.
7. Bhojraj T.S., Sweeney J.A., Prasad K.M., Eack S., Rajarethinam R., Francis A.N., Montrose D.M., Keshavan M.S. Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients. J. Psychiatr. Res. 2011, 45(2):205-212.
8. Bhojraj T.S., Sweeney J.A., Prasad K.M., Eack S.M., Francis A.N., Miewald J.M., Montrose D.M., Keshavan M.S. Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology. NeuroImage 2011, 54(Suppl. 1):S272-S279.
9. Blackwood N.J., Bentall R.P., Ffytche D.H., Simmons A., Murray R.M., Howard R.J. Persecutory delusions and the determination of self-relevance: an fMRI investigation. Psychol. Med. 2004, 34(4):591-596.
10. Blakemore S.J. Development of the social brain in adolescence. J. R. Soc. Med. 2012, 105(3):111-116.
11. Bora E., Pantelis C. Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: systematic review and meta-analysis. Schizophr. Res. 2013, 144(1-3):31-36.
12. Bora E., Sehitoglu G., Aslier M., Atabay I., Veznedaroglu B. Theory of mind and unawareness of illness in schizophrenia: is poor insight a mentalizing deficit?. Eur. Arch. Psychiatry Clin. Neurosci. 2007, 257(2):104-111.
13. Brahmbhatt S.B., Haut K., Csernansky J.G., Barch D.M. Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings. Schizophr. Res. 2006, 87(1-3):191-204.
14. Brent B. Mentalization-based psychodynamic psychotherapy for psychosis. J. Clin. Psychol. 2009, 65(8):803-814.
15. Brent B.K., Holt D.J., Keshavan M.S., Seidman L.J., Fonagy P. Mentalization-based treatment for psychosis: linking an attachment-based model to the psychotherapy for impaired mental state understanding in people with psychotic disorders. Isr. J. Psychiatry Relat. Sci. 2013, (accepted for publication).
16. Brune M., Lissek S., Fuchs N., Witthaus H., Peters S., Nicolas V., Juckel G., Tegenthoff M. An fMRI study of theory of mind in schizophrenic patients with "passivity" symptoms. Neuropsychologia 2008, 46(7):1992-2001.
17. Brunet E., Sarfati Y., Hardy-Bayle M.C., Decety J. Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia. Neuropsychologia 2003, 41(12):1574-1582.
18. Buckner R.L., Andrews-Hanna J.R., Schacter D.L. The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 2008, 1124:1-38.
19. Bunney W.E., Bunney B.G. Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia. Brain Res. Brain Res. Rev. 2000, 31(2-3):138-146.
20. Byun M.S., Kim J.S., Jung W.H., Jang J.H., Choi J.S., Kim S.N., Choi C.H., Chung C.K., An S.K., Kwon J.S. Regional cortical thinning in subjects with high genetic loading for schizophrenia. Schizophr. Res. 2012, 141(2-3):197-203.
21. Cannon T.D., van Erp T.G., Bearden C.E., Loewy R., Thompson P., Toga A.W., Huttunen M.O., Keshavan M.S., Seidman L.J., Tsuang M.T. Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schizophr. Bull. 2003, 29(4):653-669.
22. Cermolacce M., Naudin J., Parnas J. The "minimal self" in psychopathology: re-examining the self-disorders in the schizophrenia spectrum. Conscious. Cogn. 2007, 16(3):703-714.
23. Choi J.S., Park J.Y., Jung M.H., Jang J.H., Kang D.H., Jung W.H., Han J.Y., Choi C.H., Hong K.S., Kwon J.S. Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia. Schizophr. Bull. 2012, 38(6):1189-1199.
24. D'Argembeau A., Cassol H., Phillips C., Balteau E., Salmon E., Van der Linden M. Brains creating stories of selves: the neural basis of autobiographical reasoning. Soc. Cogn. Affect. Neurosci. 2013, (in press).
25. Delawalla Z., Csernansky J.G., Barch D.M. Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia. Biol. Psychiatry 2008, 63(5):490-497.
26. Diwadkar V.A., Montrose D.M., Dworakowski D., Sweeney J.A., Keshavan M.S. Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30(2):230-238.
27. Diwadkar V.A., Pruitt P., Zhang A., Radwan J., Keshavan M.S., Murphy E., Rajan U., Zajac-Benitez C. The neural correlates of performance in adolescents at risk for schizophrenia: inefficiently increased cortico-striatal responses measured with fMRI. J. Psychiatr. Res. 2012, 46(1):12-21.
28. Diwadkar V.A., Wadehra S., Pruitt P., Keshavan M.S., Rajan U., Zajac-Benitez C., Eickhoff S.B. Disordered corticolimbic interactions during affective processing in children and adolescents at risk for schizophrenia revealed by functional magnetic resonance imaging and dynamic causal modeling. Arch. Gen. Psychiatry 2012, 69(3):231-242.
29. Eack S., Greenwald D.P., Hogarty S.S., Cooley S.J., DiBarry A.L., Montrose D.M., Keshavan M. Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial. Psychiatr. Serv. 2009, 60:1468-1476.
30. Ernst M., Mueller S.C. The adolescent brain: insights from functional neuroimaging research. Dev. Neurobiol. 2008, 68(6):729-743.
31. Fair D.A., Cohen A.L., Power J.D., Dosenbach N.U., Church J.A. Functional brain networks develop from a "local to distributed" organization. PLoS Comput. Biol. 2009, 5(5):e1000381.
32. Fett A.K., Viechtbauer W., Dominguez M.D., Penn D.L., van Os J., Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci. Biobehav. Rev. 2011, 35(3):573-588.
33. Fisher M., McCoy K., Poole J.H., Vinogradov S. Self and other in schizophrenia: a cognitive neuroscience perspective. Am. J. Psychiatry 2008, 165:1465-1472.
34. Fonagy P., Gergely G., Jurist E., Target M. Affect Regulation, Mentalization, and the Development of the Self 2002, Other Press, New York, New York.
35. Frankenberger K.D. Adolescent egocentrism: a comparison among adolescents and adults. J. Adolesc. 2000, 23(3):343-354.
36. Frith C.D., Corcoran R. Exploring 'theory of mind' in people with schizophrenia. Psychol. Med. 1996, 26(3):521-530.
37. Frith U., Frith C.D. Development and neurophysiology of mentalizing. Philos. Trans. R. Soc. Lond. 2003, 358:459-473.
38. Gallagher H.L., Happe F., Brunswick N., Fletcher P.C., Frith U., Frith C.D. Reading the mind in cartoons and stories: an fMRI study of 'theory of mind' in verbal and nonverbal tasks. Neuropsychologia 2000, 38(1):11-21.
39. Giedd J.N., Blumenthal J., Jeffries N.O., Castellanos F.X., Liu H., Zijdenbos A., Paus T., Evans A.C., Rapoport J.L. Brain development during childhood and adolescence: a longitudinal MRI study. Nat. Neurosci. 1999, 2(10):861-863.
40. Gogtay N., Sporn A., Clasen L.S., Greenstein D., Giedd J.N., Lenane M., Gochman P.A., Zijdenbos A., Rapoport J.L. Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia. Am. J. Psychiatry 2003, 160(3):569-571.
41. Gogtay N., Giedd J.N., Lusk L., Hayashi K.M., Greenstein D., Vaituzis A.C., Nugent T.F., Herman D.H., Clasen L.S., Toga A.W., Rapoport J.L., Thompson P.M. Dynamic mapping of human cortical development during childhood through early adulthood. Proc. Natl. Acad. Sci. U. S. A. 2004, 101(21):8174-8179.
42. Gogtay N., Greenstein D., Lenane M., Clasen L., Sharp W., Gochman P., Butler P., Evans A., Rapoport J. Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia. Arch. Gen. Psychiatry 2007, 64(7):772-780.
43. Greicius M.D., Menon V. Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation. J. Cogn. Neurosci. 2004, 16(9):1484-1492.
44. Greicius M.D., Krasnow B., Reiss A.L., Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(1):253-258.
45. Gusnard D.A., Akbudak E., Shulman G.L., Raichle M.E. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(7):4259-4264.
46. Gusnard D.A., Raichle M.E., Raichle M.E. Searching for a baseline: functional imaging and the resting human brain. Nat. Rev. Neurosci. 2001, 2(10):685-694.
47. Harms M.P., Wang L., Campanella C., Aldridge K., Moffitt A.J., Kuelper J., Ratnanather J.T., Miller M.I., Barch D.M., Csernansky J.G. Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings. Br. J. Psychiatry J. Ment. Sci. 2010, 196(2):150-157.
48. Harris J.M., Whalley H., Yates S., Miller P., Johnstone E.C., Lawrie S.M. Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia?. Biol. Psychiatry 2004, 56(3):182-189.
49. Harter S. The Construction of the Self: a Developmental Perspective 1999, Guilford Press, New York, New York.
50. Harter S., Monsour A. Developmental analysis of conflict caused among adolescents and adults. J. Adolesc. 1992, 28:251-260.
51. Harter S., Bresnick S., Bouchey H.A., Whitesell N.R. The development of multiple role-related selves during adolescence. Dev. Psychopathol. 1997, 9(4):835-853.
52. Herwig U., Kaffenberger T., Schell C., Jancke L., Bruhl A.B. Neural activity associated with self-reflection. BMC Neurosci. 2012, 13:52.
53. Holt D.J., Cassidy B.S., Andrews-Hanna J.R., Lee S.M., Coombs G., Goff D.C., Gabrieli J.D., Moran J.M. An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection. Biol. Psychiatry 2011, 69(5):415-423.
54. Innocenti G.M., Ansermet F., Parnas J. Schizophrenia, neurodevelopment and corpus callosum. Mol. Psychiatry 2003, 8(3):261-274.
55. Irani F., Platek S.M., Panyavin I.S., Calkins M.E., Kohler C., Siegel S.J., Schacter M., Gur R.E., Gur R.C. Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr. Res. 2006, 88(1-3):151-160.
56. Jang J.H., Jung W.H., Choi J.S., Choi C.H., Kang D.H., Shin N.Y., Hong K.S., Kwon J.S. Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia. Schizophr. Res. 2011, 127(1-3):58-65.
57. Jardri R., Pins D., Lafargue G., Very E., Ameller A., Delmaire C., Thomas P. Increased overlap between the brain areas involved in self-other distinction in schizophrenia. PLoS One 2011, 6(3):e17500.
58. Jenkins A.C., Mitchell J.P. Medial prefrontal cortex subserves diverse forms of self-reflection. Soc. Neurosci. 2011, 6(3):211-218.
59. Job D.E., Whalley H.C., Johnstone E.C., Lawrie S.M. Grey matter changes over time in high risk subjects developing schizophrenia. NeuroImage 2005, 25(4):1023-1030.
60. Job D.E., Whalley H.C., McIntosh A.M., Owens D.G., Johnstone E.C., Lawrie S.M. Grey matter changes can improve the prediction of schizophrenia in subjects at high risk. BMC Med. 2006, 4:29.
61. Johns L.C., Gregg L., Allen P., McGuire P.K. Impaired verbal self-monitoring in psychosis: effects of state, trait and diagnosis. Psychol. Med. 2006, 36(4):465-474.
62. Karbasforoushan H., Woodward N.D. Resting-state networks in schizophrenia. Curr. Top. Med. Chem. 2012, 12:2404-2414.
63. Keefe R.S., Arnold M.C., Bayen U.J., McEvoy J.P., Wilson W.H. Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources. Schizophr. Res. 2002, 57(1):51-67.
64. Kelley W.M., Macrae C.N., Wyland C.L., Caglar S., Inati S., Heatherton T.F. Finding the self? An event-related fMRI study. J. Cogn. Neurosci. 2002, 14(5):785-794.
65. Keshavan M.S., Bhojraj T. Gray matter alterations in schizophrenia: are they reversible. Schizophrenia: the Final Frontier: a Festscrift for Robin M. Murray 2011, Psychology Press, Hove, United Kingdom. A.S. David, S. Kapur, P. McGuffin (Eds.).
66. Keshavan M.S., Hogarty G.E. Brain maturational processes and delayed onset in schizophrenia. Dev. Psychopathol. 1999, 11(3):525-543.
67. Keshavan M.S., Anderson S., Pettegrew J.W. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J. Psychiatr. Res. 1994, 28(3):239-265.
68. Keshavan M.S., Diwadkar V.A., Spencer S.M., Harenski K.A., Luna B., Sweeney J.A. A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Prog. Neuropsychopharmacol. Biol. Psychiatry 2002, 26(6):1143-1149.
69. Keshavan M.S., Diwadkar V.A., Montrose D.M., Rajarethinam R., Sweeney J.A. Premorbid indicators and risk for schizophrenia: a selective review and update. Schizophr. Res. 2005, 79(1):45-57.
70. Keshavan M., Montrose D.M., Rajarethinam R., Diwadkar V., Prasad K., Sweeney J.A. Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments. Schizophr. Res. 2008, 103(1-3):114-120.
71. Kim H.S., Shin N.Y., Jang J.H., Kim E., Shim G., Park H.Y., Hong K.S., Kwon J.S. Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophr. Res. 2011, 130(1-3):170-175.
72. Kircher T.T., Leube D.T. Self-consciousness, self-agency, and schizophrenia. Conscious. Cogn. 2003, 12(4):656-669.
73. Klosterkotter J., Hellmich M., Steinmeyer E.M., Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Arch. Gen. Psychiatry 2001, 58(2):158-164.
74. Koren D., Seidman L.J., Poyurovsky M., Goldsmith M., Viksman P., Zichel S., Klein E. The neuropsychological basis of insight in first-episode schizophrenia: a pilot metacognitive study. Schizophr. Res. 2004, 70(2-3):195-202.
75. Koren D., Reznik N., Adres M., Scheyer R., Apter A., Steinberg T., Parnas J. Disturbances of basic self and prodromal symptoms among non-psychotic help-seeking adolescents. Psychol. Med. 2012, 1-12.
76. Langdon R., Michie P.T., Ward P.B., McConagh N., Catts S.V., Coltheart M. Defective self and/or other mentalizing in schizophrenia: a cognitive neuropsychological approach. Cogn. Neuropsychiatry 1997, 2:167-193.
77. Li X., Branch C.A., Ardekani B.A., Bertisch H., Hicks C., DeLisi L.E. fMRI study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk. Schizophr. Res. 2007, 96(1-3):14-24.
78. Li X., Branch C.A., Bertisch H.C., Brown K., Szulc K.U., Ardekani B.A., DeLisi L.E. An fMRI study of language processing in people at high genetic risk for schizophrenia. Schizophr. Res. 2007, 91(1-3):62-72.
79. Li X., Alapati V., Jackson C., Xia S., Bertisch H.C., Branch C.A., Delisi L.E. Structural abnormalities in language circuits in genetic high-risk subjects and schizophrenia patients. Psychiatry Res. 2012, 201(3):182-189.
80. Lymer G.K., Job D.E., William T., Moorhead J., McIntosh A.M., Owens D.G., Johnstone E.C., Lawrie S.M. Brain-behaviour relationships in people at high genetic risk of schizophrenia. NeuroImage 2006, 33(1):275-285.
81. Lysaker P.H., Carcione A., Dimaggio G., Johannesen J.K., Nicolo G., Procacci M., Semerari A. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatr. Scand. 2005, 112(1):64-71.
82. Lysaker P.H., Buck K.D., Ringer J. The recovery of metacognitive capacity in schizophrenia across thirty two months of individual psychotherapy: a case study. Psychother. Res. 2007, 17:713-720.
83. Lysaker P.H., Dimaggio G., Carcione A., Procacci M., Buck K.D., Davis L.W., Nicolo G. Metacognition and schizophrenia: the capacity for self-reflectivity as a predictor for prospective assessments of work performance over six months. Schizophr. Res. 2010, 122(1-3):124-130.
84. Mattai A.A., Weisinger B., Greenstein D., Stidd R., Clasen L., Miller R., Tossell J.W., Rapoport J.L., Gogtay N. Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry 2011, 50(7):697-704.
85. McGlashan T.H., Hoffman R.E. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch. Gen. Psychiatry 2000, 57(7):637-648.
86. McIntosh A.M., Owens D.C., Moorhead W.J., Whalley H.C., Stanfield A.C., Hall J., Johnstone E.C., Lawrie S. Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis. Biol. Psychiatry 2011, 69:953-958.
87. McIntosh A.M., Owens D.C., Moorhead W.J., Whalley H.C., Stanfield A.C., Hall J., Johnstone E.C., Lawrie S.M. Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis. Biol. Psychiatry 2011, 69(10):953-958.
88. Mitchell J.P. Social psychology as a natural kind. Trends Cogn. Sci. 2009, 13(6):246-251.
89. Morin A., Hamper B. Self-reflection and the inner voice: activation of the left inferior frontal gyrus during perceptual and conceptual self-referential thinking. Open Neuroimaging J. 2012, 6:78-89.
90. Murphy E.R., Brent B.K., Benton M., Pruitt P., Diwadkar V., Rajarethinam R.P., Keshavan M.S. Differential processing of metacognitive evaluation and the neural circuitry of the self and others in schizophrenia: a pilot study. Schizophr. Res. 2010, 116(2-3):252-258.
91. Nelson B., Fornito A., Harrison B.J., Yucel M., Sass L.A., Yung A.R., Thompson A., Wood S.J., Pantelis C., McGorry P.D. A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiology. Neurosci. Biobehav. Rev. 2009, 33(6):807-817.
92. Nelson B., Thompson A., Yung A.R. Basic self-disturbance predicts psychosis onset in the ultra high risk for psychosis "prodromal" population. Schizophr. Bull. 2012, 38(6):1277-1287.
93. Newen A., Vogeley K. Self-representation: searching for a neural signature of self-consciousness. Conscious. Cogn. 2003, 12(4):529-543.
94. Niznikiewicz M., Donnino R., McCarley R.W., Nestor P.G., Iosifescu D.V., O'Donnell B., Levitt J., Shenton M.E. Abnormal angular gyrus asymmetry in schizophrenia. Am. J. Psychiatry 2000, 157(3):428-437.
95. Parnas J. Self and Schizophrenia: a Phenomenological Perspective 2003, Cambridge University Press, Cambridge.
96. Parnas J., Handest P., Saebye D., Jansson L. Anomalies of subjective experience in schizophrenia and psychotic bipolar illness. Acta Psychiatr. Scand. 2003, 108(2):126-133.
97. Parnas J., Handest P., Jansson L., Saebye D. Anomalous subjective experience among first-admitted schizophrenia spectrum patients: empirical investigation. Psychopathology 2005, 38(5):259-267.
98. Pauly K., Finkelmeyer A., Schneider F., Habel U. The neural correlates of positive self-evaluation and self-related memory. Soc. Cogn. Affect. Neurosci. 2013, (in pess).
99. Paus T., Keshavan M., Giedd J.N. Why do many psychiatric disorders emerge during adolescence?. Nat. Rev. Neurosci. 2008, 9(12):947-957.
100. Pfeifer J.H., Blakemore S.J. Adolescent social cognitive and affective neuroscience: past, present, and future. Soc. Cogn. Affect. Neurosci. 2012, 7(1):1-10.
101. Poulton R., Caspi A., Moffitt T.E., Cannon M., Murray R., Harrington H. Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch. Gen. Psychiatry 2000, 57(11):1053-1058.
102. Power J.D., Barnes K.A., Snyder A.Z., Schlaggar B.L., Petersen S.E. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. NeuroImage 2012, 59(3):2142-2154.
103. Prasad K.M., Sanders R., Sweeney J., Montrose D., Diwadkar V., Dworakowski D., Miewald J., Keshavan M. Neurological abnormalities among offspring of persons with schizophrenia: relation to premorbid psychopathology. Schizophr. Res. 2009, 108(1-3):163-169.
104. Prasad K.M., Goradia D., Eack S., Rajagopalan M., Nutche J., Magge T., Rajarethinam R., Keshavan M.S. Cortical surface characteristics among offspring of schizophrenia subjects. Schizophr. Res. 2010, 116(2-3):143-151.
105. Raichle M.E., MacLeod A.M., Snyder A.Z., Powers W.J., Gusnard D.A., Shulman G.L. A default mode of brain function. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(2):676-682.
106. Rajarethinam R., Venkatesh B.K., Peethala R., Phan K.L., Keshavan M. Reduced activation of superior temporal gyrus during auditory comprehension in young offspring of patients with schizophrenia. Schizophr. Res. 2011, 130(1-3):101-105.
107. Repovs G., Csernansky J.G., Barch D.M. Brain network connectivity in individuals with schizophrenia and their siblings. Biol. Psychiatry 2011, 69(10):967-973.
108. Rosso I.M., Makris N., Thermenos H.W., Hodge S.M., Brown A., Kennedy D., Caviness V.S., Faraone S.V., Tsuang M.T., Seidman L.J. Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study. Schizophr. Res. 2010, 123(1):15-21.
109. Russell T.A., Rubia K., Bullmore E.T., Soni W., Suckling J., Brammer M.J., Simmons A., Williams S.C., Sharma T. Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution. Am. J. Psychiatry 2000, 157(12):2040-2042.
110. Salvatore G., Lysaker P.H., Gumley A., Popolo R., Mari J., Dimaggio G. Out of illness experience: metacognition-oriented therapy for promoting self-awareness in individuals with psychosis. Am. J. Psychother. 2012, 66:85-106.
111. Sass L.A., Parnas J. Schizophrenia, consciousness, and the self. Schizophr. Bull. 2003, 29(3):427-444.
112. Saxe R., Kanwisher N. People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind". NeuroImage 2003, 19(4):1835-1842.
113. Saxe R., Carey S., Kanwisher N. Understanding other minds: linking developmental psychology and functional neuroimaging. Annu. Rev. Psychol. 2004, 55:87-124.
114. Schiffman J., Lam C.W., Jiwatram T., Ekstrom M., Sorensen H., Mednick S. Perspective-taking deficits in people with schizophrenia spectrum disorders: a prospective investigation. Psychol. Med. 2004, 34(8):1581-1586.
115. Schmitz T.W., Kawahara-Baccus T.N., Johnson S.C. Metacognitive evaluation, self-relevance, and the right prefrontal cortex. NeuroImage 2004, 22(2):941-947.
116. Schneider K. Psychopathology 1959, Grune and Stratton, New York, New York.
117. Schultze-Lutter F. Subjective symptoms of schizophrenia in research and the clinic: the basic symptom concept. Schizophr. Bull. 2009, 35(1):5-8.
118. Sebastian C., Burnett S., Blakemore S.J. Development of the self-concept during adolescence. Trends Cogn. Sci. 2008, 12(11):441-446.
119. Seidman L.J., Thermenos H.W., Poldrack R.A., Peace N.K., Koch J.K., Faraone S.V., Tsuang M.T. Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory. Schizophr. Res. 2006, 85(1-3):58-72.
120. Shaw P., Kabani N.J., Lerch J.P., Eckstrand K., Lenroot R., Gogtay N., Greenstein D., Clasen L., Evans A., Rapoport J.L., Giedd J.N., Wise S.P. Neurodevelopmental trajectories of the human cerebral cortex. J. Neurosci. Off. J. Soc. Neurosci. 2008, 28(14):3586-3594.
121. Smollar J., Youniss J. Adolescent Self-concept Development 1985, Academic Press, New York, NY.
122. Sowell E.R., Trauner D.A., Gamst A., Jernigan T.L. Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study. Dev. Med. Child Neurol. 2002, 44(1):4-16.
123. Sowell E.R., Thompson P.M., Toga A.W. Mapping changes in the human cortex throughout the span of life. Neuroscientist 2004, 10(4):372-392.
124. Stephan K.E., Friston K.J., Frith C.D. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophr. Bull. 2009, 35(3):509-527.
125. Stone W.S., Faraone S.V., Seidman L.J., Olson E.A., Tsuang M.T. Searching for the liability to schizophrenia: concepts and methods underlying genetic high-risk studies of adolescents. J. Child Adolesc. Psychopharmacol. 2005, 15(3):403-417.
126. Subramaniam K., Luks T.L., Fisher M., Simpson G.V., Nagarajan S., Vinogradov S. Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia. Neuron 2012, 73:842-853.
127. Summerfield J.J., Hassabis D., Maguire E.A. Cortical midline involvement in autobiographical memory. NeuroImage 2009, 44(3):1188-1200.
128. Sun D., Phillips L., Velakoulis D., Yung A., McGorry P.D., Wood S.J., van Erp T.G., Thompson P.M., Toga A.W., Cannon T.D., Pantelis C. Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals. Schizophr. Res. 2009, 108(1-3):85-92.
129. Tarbox S.I., Pogue-Geile M.F. Development of social functioning in preschizophrenia children and adolescents: a systematic review. Psychol. Bull. 2008, 134(4):561-583.
130. Thermenos H.W., Keshavan M.S., Juelich R.J., Molokotos E., Whitfield-Gabrieli S., Brent B.K., Makris N., Seidman L.J. Neuroimaging of young relatives of persons with schizophrenia: a developmental perspective from schizotaxia to schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013, (accepted for publication).
131. Torrey E.F. Schizophrenia and the inferior parietal lobule. Schizophr. Res. 2007, 97(1-3):215-225.
132. van der Meer L., Costafreda S., Aleman A., David A.S. Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci. Biobehav. Rev. 2010, 34(6):935-946.
133. Van Dijk K.R.A., Sabuncu M.R., Buckner R.L. The influence of head motion on intrinsic functional connectivity MRI. NeuroImage 2012, 59:431-438.
134. Venkatasubramanian G., Puthumana D.T., Jayakumar P.N., Gangadhar B.N. A functional magnetic resonance imaging study of neurohemodynamic abnormalities during emotion processing in subjects at high risk for schizophrenia. Indian J. Psychiatry 2010, 52(4):308-315.
135. Vinogradov S., Luks T.L., Schulman B.J., Simpson G.V. Deficit in a neural correlate of reality monitoring in schizophrenia patients. Cereb. Cortex 2008, 18(11):2532-2539.
136. Vogeley K. Schizophrenia as a disturbance of the self-construct. The Self in Neuroscience and Psychiatry 2007, Cambridge University Press, Cambridge, United Kingdom. 2nd ed. T. Kircher, A.S. David (Eds.).
137. Vogeley K., Schneider-Axmann T., Pfeiffer U., Tepest R., Bayer T.A., Bogerts B., Honer W.G., Falkai P. Disturbed gyrification of the prefrontal region in male schizophrenic patients: a morphometric postmortem study. Am. J. Psychiatry 2000, 157(1):34-39.
138. Wang L., Metzak P.D., Woodward T.S. Aberrant connectivity during self-other source monitoring in schizophrenia. Schizophr. Res. 2011, 125(2-3):136-142.
139. Whalley H.C., Simonotto E., Flett S., Marshall I., Ebmeier K.P., Owens D.G., Goddard N.H., Johnstone E.C., Lawrie S.M. fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia. Brain 2004, 127(Pt 3):478-490.
140. White T., Andreasen N.C., Nopoulos P., Magnotta V. Gyrification abnormalities in childhood- and adolescent-onset schizophrenia. Biol. Psychiatry 2003, 54(4):418-426.
141. Whitfield-Gabrieli S., Ford J.M. Default mode network activity and connectivity in psychopathology. Annu. Rev. Clin. Psychol. 2012, 8:49-76.
142. Whitfield-Gabrieli S., Thermenos H.W., Milanovic S., Tsuang M.T., Faraone S.V., McCarley R.W., Shenton M.E., Green A.I., Nieto-Castanon A., LaViolette P., Wojcik J., Gabrieli J.D., Seidman L.J. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(4):1279-1284.