Prefrontal Cortex Function in Nonpsychotic Siblings of Individuals with Schizophrenia

Biological Psychiatry

Volumn 63, Issue 5, 2008, Pages 490-497

  Delawalla, Zainab ^a   Csernansky, John G ^a,b   Barch, Deanna M ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Context processing; DLPFC; executive function; fMRI; genetic high risk; schizophrenia

Indexed keywords

ADULT; ARTICLE; ATTENTION; BRAIN REGION; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; HIGH RISK PATIENT; HUMAN; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROCESSING; RELIABILITY; SCHIZOPHRENIA; SIBLING; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ADULT; AGNOSIA; ATTENTION; BRAIN; BRAIN MAPPING; COGNITION DISORDERS; DOMINANCE, CEREBRAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MALE; MEMORY, SHORT-TERM; OXYGEN; PATTERN RECOGNITION, VISUAL; PREFRONTAL CORTEX; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER;

EID: 38949183056     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.05.007     Document Type: Article

References (54)

1. Heinrichs R.W., and Zakzanis K.K. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology 12 (1998) 426-445
2. Servan-Schreiber D., Cohen J.D., and Steingard S. Schizophrenic deficits in the processing of context: A test of a theoretical model. Arch Gen Psychiatry 53 (1996) 1105-1113
3. Cohen J.D., Barch D.M., Carter C., and Servan-Schreiber D. Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. J Abnorm Psychol 108 (1999) 120-133
4. Barch D.M., Braver T.S., Nystom L.E., Forman S.D., Noll D.C., and Cohen J.D. Dissociating working memory from task difficulty in human prefrontal cortex. Neuropsychologia 35 (1997) 1373-1380
5. MacDonald III A.W., and Carter C.S. Event-related FMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia. J Abnorm Psychol 112 (2003) 689-697
6. Perlstein W.M., Dixit N.K., Carter C.S., Noll D.C., and Cohen J.D. Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biol Psychiatry 53 (2003) 25-38
7. Holmes A.J., MacDonald A., Carter C.S., Barch D.M., Stenger V.A., and Cohen J.D. Prefrontal functioning during context processing in schizophrenia and major-depression: An event related fMRI study. Schizophr Res 76 (2005) 199-206
8. Barch D.M., Mitropoulou V., Harvey P.D., New A.S., Silverman J.M., and Siever L.J. Context-processing deficits in schizotypal personality disorder. J Abnorm Psychol 113 (2004) 556-568
9. Goldman-Rakic P.S. The prefrontal landscape: Implications of functional architecture for understanding human mentation and the central executive. In: Roberts A.C., Robbins T.W., and Weiskrantz L. (Eds). The prefrontal cortex: Executive and cognitive functions (1996), Oxford University Press, Oxford 87-103
10. Jonides J., and Smith E.E. The architecture of working memory. In: Rugg M.D. (Ed). Cognitive neuroscience (1997), The MIT Press, Cambridge, MA
11. Braver T.S., Cohen J.D., and Servan-Schreiber D. Neural network simulations of schizophrenic performance in a variant of the CPT-AX: A predicted double dissociation. Schizophr Res 15 (1995) 110
12. Cohen J.D., Forman S.D., Braver T.S., Casey B.J., Servan-Schreiber D., and Noll D.C. Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI. Hum Brain Mapp 1 (1994) 293-304
13. Sylvester C.Y., Wager T.D., Lacey S.C., Hernandez L., Nichols T.E., Smith E.E., et al. Switching atttention and resolving interference: fMRI measures of executive functions. Neuropsychologia 41 (2003) 357-370
14. MacDonald A.W., Goghari V.M., Hicks B.M., Flory J.D., Carter C.S., and Manuck S.B. A convergent-divergent approach to context processing, general intellectual functioning, and the genetic liability to schizophrenia. Neuropsychology 19 (2005) 814-821
15. Braver T.S., Satpute A.B., Rush B.K., Racine C.A., and Barch D.M. Context processing and context maintenance in healthy aging and early stage dementia of the Alzheimer's type. Psychol Aging 20 (2005) 33-46
16. Barch D.M., Carter C.S., MacDonald A., Braver T.S., and Cohen J.D. Context processing deficit in schizophrenia: Diagnostic specificity, 4-week course, and relationships to clinical symptoms. J Abnorm Psychol 112 (2003) 132-143
17. Javitt D.C., Shelley A., Silipo G., and Lieberman J.A. Deficits in auditory and visual context-dependent processing in schizophrenia. Arch Gen Psychiatry 57 (2000) 1131-1137
18. Stratta P., Daneluzzo E., Bustini M., Prosperini P., and Rossi A. Schizophrenic patients use context-independent reasoning more often than context-dependent reasoning as measured by the Cognitive Bias Task (CBT): A controlled study. Schizophr Res 37 (1999) 45-51
19. Condray R., Steinhauer S.R., Cohen J.D., van Kammen D.P., and Kasparek A. Modulation of language processing in schizophrenia: effects of context and haloperidol on the event-relate potential. Biol Psychiatry 45 (1999) 1336-1355
20. Titone D., Levy D.L., and Holzman P.S. Contextual insensitivity in schizophrenic language processing: evidence from lexical ambiguity. J Abnorm Psychol 109 (2000) 761-767
21. Niznikiewicz M.A., O'Donnell B.F., Nestor P.G., Smith L., Law S., Karapelou M., et al. ERP assessment of visual and auditory language processing in schizophrenia. J Abnorm Psychol 106 (1997) 85-94
22. Barch D.M., Carter C.S., Braver T.S., McDonald A., Sabb F.W., Noll D.C., et al. Selective deficits in prefrontal cortex regions in medication naive schizophrenia patients. Arch Gen Psychiatry 50 (2001) 280-288
23. MacDonald A., Carter C.S., Kerns J.G., Ursu S., Barch D.M., Holmes A.J., et al. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am J Psychiatry 162 (2005) 475-484
24. Cadenhead K.S. Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome. Psychiatr Clin North Am 25 (2002) 837-853
25. Baron M., Gruen R., Rainer J., Kane J., Asnis L., and Lord S. A family study of schizophrenic and normal control probands: Implications for the spectrum concept of schizophrenia. Am J Psychiatry 142 (1985) 447-455
26. Kety S.S., Wender P.H., Jacobsen B., Ingraham L.J., Jansson L., Faber B., et al. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Archives of General Psychiatry 51 (1994) 442-455
27. MacDonald A.W., Pogue-Geile M.F., Johnson M.K., and Carter C.S. A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Arch Gen Psychiatry 60 (2003) 57-65
28. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinski B., et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry 160 (2003) 709-719
29. Thermenos H.W., Seidman L.J., Breiter H., Goldstein J.M., Goodman J.M., Poldrack R., et al. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: A pilot study. Biol Psychiatry 55 (2004) 490-500
30. Brahmbhatt S., Haut K., Csernansky J.G., and Barch D.M. Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings. Schizophr Res 87 (2006) 191-204
31. MacDonald A., Becker T.M., and Carter C.S. Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients. Biol Psychiatry 60 (2006) 1241-1249
32. Seidman L.J., Thermenos H.W., Poldrack R., Peace N.K., Koch J.K., Faraone S.V., et al. Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: An fMRI study of working memory. Schizophr Res 85 (2006) 58-72
33. Spitzer R.L., Williams J.B., Gibbon M., and First M.B. User's guide for the structured clinical interview for DSM-III-R: SCID (1990), American Psychiatric Press, Washington D. C
34. Oldfield R.C. The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9 (1971) 97-113
35. Wechsler D. Wechsler Adult Intelligence Scale - Third Edition (1997), The Psychological Corporation, San Antonio
36. Braver T.S., Barch D.M., Keys B.A., Carter C.S., Cohen J.D., Kaye J.A., et al. Context processing in older adults: Evidence for a theory relating cognitive control to neurobiology in healthy aging. J Exp Psychol Gen 130 (2001) 746-763
37. Braver T.S., and Cohen J.D. Working memory, cognitive control, and the prefrontal cortex: Computational and empirical studies. Cognit Process 2 (2001) 25-55
38. Ojemann J., Akbudak E., Snyder A., McKinstry R., Raichle M., and Conturo T. Anatomic localization and quantitative analysis of gradient refocused echo-planar fMRI susceptibility artifacts. Neuroimage 6 (1997) 156-167
39. Talairach J., and Tournoux P. Co-planar stereotaxic atlas of the human brain (1988), Thieme, New York
40. Woods R.P., Grafton S.T., Watson J.D.G., Sicotte N.L., and Mazziotta J.C. Automated image registration: II. intersubject validation of linear and nonlinear models. J Comput Assist Tomogr 22 (1998) 153-165
41. Rajkowski G., and Goldman-Rakic P.S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the talairach coordinate system. Cereb Cortex 5 (1995) 323-337
42. Braver T., Reynolds J., and Donaldson D. Neural mechanisms of transient and sustained cognitive control during task switching. Neuron 39 (2003) 713-726
43. Nichols T., Brett M., Andersson J., Wager T., and Poline J.B. Valid conjunction inference with the minimum statistic. Neuroimage 25 (2005) 653-660
44. Forman S.D., Cohen J.D., Fitzgerald M., Eddy W.F., Mintun M.A., and Noll D.C. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magn Reson Med 33 (1995) 636-647
45. McAvoy M.P., Ollinger J.M., and Buckner R.L. Cluster size thresholds for assessment of significant activation in fMRI. Neuroimage 13 (2001) S198
46. Schneider F., Habel U., Reske M., Kellermann T., Stocker T., Shah N.J., et al. Neural correlates of working memory dysfunction in first-episode schziophrenia patients: An fMRI multi-center study. Schizophr Res 89 (2006) 198-210
47. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., Coppola R., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 10 (2000) 1078-1092
48. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., Halpern E., Saper C.B., and Warach S. Schizophrenia subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry 45 (1999) 1128-1137
49. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., Halpern E., et al. Schizophrenic subjects show aberrant fMRI activation of dorsolatral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry 48 (2000) 99-109
50. Thermenos H.W., Goldstein J.M., Buka S.L., Poldrack R.A., Koch J.K., Tsuang M.T., et al. The effect of working memory performance on functional MRI in schizophrenia. Schizophr Res 74 (2005) 179-194
51. Callicott J.H., Mattay V.S., Verchinski B.A., Marenco S., Egan M.F., and Weinberger D.R. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry 160 (2003) 2209-2215
52. Manoach D. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr Res 60 (2003) 285-298
53. Braver T.S., Gray J.R., and Burgess G.C. Explaining the many varieties of working memory variation: Dual mechanisms of cognitive control. In: Conway A.R., Jarrold C., Kane M., Miyake A., and Towse J. (Eds). Variation in working memory (2007), Oxford University Press, Oxford
54. Paxton J.L., Barch D.M., Storandt M., and Braver T.S. Effects of environmental support and strategy training on older adults' use of context. Psychol Aging 21 (2006) 499-509