메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

Identification of CHIP as a novel causative gene for autosomal recessive cerebellar ataxia

(28)  Shi, Yuting a   Wang, Junling a,b,e   Li, Jia Da b   Ren, Haigang d   Guan, Wenjuan a   He, Miao a   Yan, Weiqian a   Zhou, Ying a   Hu, Zhengmao b   Zhang, Jianguo c,f   Xiao, Jingjing c   Su, Zheng c   Dai, Meizhi c   Wang, Jun c,g,h,i,j   Jiang, Hong a,b,e   Guo, Jifeng a,b,e   Zhou, Yafang a   Zhang, Fufeng a   Li, Nan a   Du, Juan a   more..


Author keywords

[No Author keywords available]

Indexed keywords

DNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; UBIQUITIN PROTEIN LIGASE E3;

EID: 84891602619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081884     Document Type: Article
Times cited : (90)

References (45)
  • 1
    • 34248181247 scopus 로고    scopus 로고
    • Autosomal recessive cerebellar ataxias
    • doi:10.1186/1750-1172-1-47. PubMed: 17112370
    • Palau F, Espinós C (2006) Autosomal recessive cerebellar ataxias. Orphanet J Rare Dis 1: 47. doi:10.1186/1750-1172-1-47. PubMed: 17112370.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 47
    • Palau, F.1    Espinós, C.2
  • 2
    • 33846882183 scopus 로고    scopus 로고
    • Clinical features and molecular genetics of autosomal recessive cerebellar ataxias
    • doi:10.1016/S1474-4422(07)70054-6. PubMed: 17303531
    • Fogel BL, Perlman S (2007) Clinical features and molecular genetics of autosomal recessive cerebellar ataxias. Lancet Neurol 6: 245-257. doi:10.1016/S1474-4422(07)70054-6. PubMed: 17303531.
    • (2007) Lancet Neurol , vol.6 , pp. 245-257
    • Fogel, B.L.1    Perlman, S.2
  • 3
    • 76149138082 scopus 로고    scopus 로고
    • Autosomal recessive ataxias: 20 Types, and counting
    • doi:10.1590/S0004-282X2009000600036. PubMed: 20069237
    • Embiruçu EK, Martyn ML, Schlesinger D, Kok F (2009) Autosomal recessive ataxias: 20 types, and counting. Arq Neuropsiquiatr 67: 1143-1156. doi:10.1590/S0004-282X2009000600036. PubMed: 20069237.
    • (2009) Arq Neuropsiquiatr , vol.67 , pp. 1143-1156
    • Embiruçu, E.K.1    Martyn, M.L.2    Schlesinger, D.3    Kok, F.4
  • 4
    • 80955142813 scopus 로고    scopus 로고
    • Autosomal recessive cerebellar ataxias: The current state of affairs
    • doi:10.1136/jmedgenet-2011-100210. PubMed: 21856962
    • Vermeer S, van de Warrenburg BP, Willemsen MA, Cluitmans M, Scheffer H et al. (2011) Autosomal recessive cerebellar ataxias: the current state of affairs. J Med Genet 48: 651-659. doi:10.1136/jmedgenet-2011-100210. PubMed: 21856962.
    • (2011) J Med Genet , vol.48 , pp. 651-659
    • Vermeer, S.1    Van De Warrenburg, B.P.2    Willemsen, M.A.3    Cluitmans, M.4    Scheffer, H.5
  • 5
    • 84857132924 scopus 로고    scopus 로고
    • The autosomal recessive cerebellar ataxias
    • doi:10.1056/NEJMra1006610. PubMed: 22335741
    • Anheim M, Tranchant C, Koenig M (2012) The autosomal recessive cerebellar ataxias. N Engl J Med 366: 636-646. doi:10.1056/NEJMra1006610. PubMed: 22335741.
    • (2012) N Engl J Med , vol.366 , pp. 636-646
    • Anheim, M.1    Tranchant, C.2    Koenig, M.3
  • 6
    • 13344270899 scopus 로고    scopus 로고
    • Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion
    • doi:10.1126/science.271.5254.1423. PubMed: 8596916
    • Campuzano V, Montermini L, Moltò MD, Pianese L, Cossée M et al. (1996) Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science 271: 1423-1427. doi:10.1126/science.271.5254.1423. PubMed: 8596916.
    • (1996) Science , vol.271 , pp. 1423-1427
    • Campuzano, V.1    Montermini, L.2    Moltò, M.D.3    Pianese, L.4    Cossée, M.5
  • 7
    • 0028876572 scopus 로고
    • Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein
    • doi:10.1038/ng0295-141. PubMed: 7719340
    • Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M et al. (1995) Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 9: 141-145. doi:10.1038/ng0295-141. PubMed: 7719340.
    • (1995) Nat Genet , vol.9 , pp. 141-145
    • Ouahchi, K.1    Arita, M.2    Kayden, H.3    Hentati, F.4    Ben Hamida, M.5
  • 8
    • 0034785531 scopus 로고    scopus 로고
    • The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin
    • doi:10.1038/ng1001-189. PubMed: 11586300
    • Moreira MC, Barbot C, Tachi N, Kozuka N, Uchida E et al. (2001) The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet 29: 189-193. doi:10.1038/ng1001-189. PubMed: 11586300.
    • (2001) Nat Genet , vol.29 , pp. 189-193
    • Moreira, M.C.1    Barbot, C.2    Tachi, N.3    Kozuka, N.4    Uchida, E.5
  • 9
    • 10744230604 scopus 로고    scopus 로고
    • Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2
    • doi:10.1038/ng1303. PubMed: 14770181
    • Moreira MC, Klur S, Watanabe M, Németh AH, Le Ber I et al. (2004) Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet 36: 225-227. doi:10.1038/ng1303. PubMed: 14770181.
    • (2004) Nat Genet , vol.36 , pp. 225-227
    • Moreira, M.C.1    Klur, S.2    Watanabe, M.3    Németh, A.H.4    Le Ber, I.5
  • 10
    • 33845891591 scopus 로고    scopus 로고
    • Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia
    • doi:10.1038/ng1927. PubMed: 17159980
    • Gros-Louis F, Dupré N, Dion P, Fox MA, Laurent S et al. (2007) Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia. Nat Genet 39: 80-85. doi:10.1038/ng1927. PubMed: 17159980.
    • (2007) Nat Genet , vol.39 , pp. 80-85
    • Gros-Louis, F.1    Dupré, N.2    Dion, P.3    Fox, M.A.4    Laurent, S.5
  • 11
    • 78649774853 scopus 로고    scopus 로고
    • Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia
    • doi:10.1016/j.ajhg.2010.10.015. PubMed: 21092923
    • Vermeer S, Hoischen A, Meijer RP, Gilissen C, Neveling K et al. (2010) Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia. Am J Hum Genet 87: 813-819. doi:10.1016/j.ajhg.2010.10.015. PubMed: 21092923.
    • (2010) Am J Hum Genet , vol.87 , pp. 813-819
    • Vermeer, S.1    Hoischen, A.2    Meijer, R.P.3    Gilissen, C.4    Neveling, K.5
  • 12
    • 84861235522 scopus 로고    scopus 로고
    • Recent advances in the genetics of cerebellar ataxias
    • doi:10.1007/s11910-012-0267-6. PubMed: 22527681
    • Sailer A, Houlden H (2012) Recent advances in the genetics of cerebellar ataxias. Curr Neurol Neurosci Rep 12: 227-236. doi:10.1007/s11910-012-0267-6. PubMed: 22527681.
    • (2012) Curr Neurol Neurosci Rep , vol.12 , pp. 227-236
    • Sailer, A.1    Houlden, H.2
  • 13
    • 78649890408 scopus 로고    scopus 로고
    • TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing
    • doi:10.1093/brain/awq323. PubMed: 21106500
    • Wang JL, Yang X, Xia K, Hu ZM, Weng L et al. (2010) TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain 133: 3510-3518. doi:10.1093/brain/awq323. PubMed: 21106500.
    • (2010) Brain , vol.133 , pp. 3510-3518
    • Wang, J.L.1    Yang, X.2    Xia, K.3    Hu, Z.M.4    Weng, L.5
  • 14
    • 83755205987 scopus 로고    scopus 로고
    • Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias
    • doi:10.1093/brain/awr289. PubMed: 22120146
    • Wang JL, Cao L, Li XH, Hu ZM, Li JD et al. (2011) Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain 134: 3493-3501. doi:10.1093/brain/awr289. PubMed: 22120146.
    • (2011) Brain , vol.134 , pp. 3493-3501
    • Wang, J.L.1    Cao, L.2    Li, X.H.3    Hu, Z.M.4    Li, J.D.5
  • 15
    • 40049104732 scopus 로고    scopus 로고
    • SOAP: Short oligonucleotide alignment program
    • doi:10.1093/bioinformatics/btn025. PubMed: 18227114
    • Li R, Li Y, Kristiansen K, Wang J (2008) SOAP: short oligonucleotide alignment program. Bioinformatics 24: 713-714. doi:10.1093/bioinformatics/ btn025. PubMed: 18227114.
    • (2008) Bioinformatics , vol.24 , pp. 713-714
    • Li, R.1    Li, Y.2    Kristiansen, K.3    Wang, J.4
  • 16
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate long-read alignment with Burrows-Wheeler transform
    • doi:10.1093/bioinformatics/btp698. PubMed: 20080505
    • Li H, Durbin R (2010) Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26: 589-595. doi:10.1093/ bioinformatics/btp698. PubMed: 20080505.
    • (2010) Bioinformatics , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 17
    • 0036338150 scopus 로고    scopus 로고
    • Merlin - Rapid analysis of dense genetic maps using sparse gene flow trees
    • doi:10.1038/ng786. PubMed: 11731797
    • Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30: 97-101. doi:10.1038/ng786. PubMed: 11731797.
    • (2002) Nat Genet , vol.30 , pp. 97-101
    • Abecasis, G.R.1    Cherny, S.S.2    Cookson, W.O.3    Cardon, L.R.4
  • 18
    • 0020641096 scopus 로고
    • Classification of the hereditary ataxias and paraplegias
    • PubMed: 6133167
    • Harding AE (1983) Classification of the hereditary ataxias and paraplegias. Lancet 1: 1151-1155. PubMed: 6133167.
    • (1983) Lancet , vol.1 , pp. 1151-1155
    • Harding, A.E.1
  • 19
    • 0033013126 scopus 로고    scopus 로고
    • Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
    • PubMed: 10330192
    • Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ et al. (1999) Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 19: 4535-4545. PubMed: 10330192.
    • (1999) Mol Cell Biol , vol.19 , pp. 4535-4545
    • Ballinger, C.A.1    Connell, P.2    Wu, Y.3    Hu, Z.4    Thompson, L.J.5
  • 20
    • 33645293437 scopus 로고    scopus 로고
    • CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
    • doi:10.1038/nature04600. PubMed: 16554822
    • Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C (2006) CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 440: 551-555. doi:10.1038/nature04600. PubMed: 16554822.
    • (2006) Nature , vol.440 , pp. 551-555
    • Qian, S.B.1    McDonough, H.2    Boellmann, F.3    Cyr, D.M.4    Patterson, C.5
  • 21
    • 0035900793 scopus 로고    scopus 로고
    • CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
    • doi:10.1074/jbc.M101968200. PubMed: 11557750
    • Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM et al. (2001) CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem 276: 42938-42944. doi:10.1074/jbc.M101968200. PubMed: 11557750.
    • (2001) J Biol Chem , vol.276 , pp. 42938-42944
    • Jiang, J.1    Ballinger, C.A.2    Wu, Y.3    Dai, Q.4    Cyr, D.M.5
  • 22
    • 0038333642 scopus 로고    scopus 로고
    • Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination
    • PubMed: 12716955
    • Barski JJ, Hartmann J, Rose CR, Hoebeek F, Mörl K et al. (2003) Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neurosci 23: 3469-3477. PubMed: 12716955.
    • (2003) J Neurosci , vol.23 , pp. 3469-3477
    • Barski, J.J.1    Hartmann, J.2    Rose, C.R.3    Hoebeek, F.4    Mörl, K.5
  • 24
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • doi:10.1016/S0959-4388(00)00215-4. PubMed: 11399431
    • Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11: 327-335. doi:10.1016/S0959-4388(00)00215-4. PubMed: 11399431.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 25
    • 25144473954 scopus 로고    scopus 로고
    • Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function
    • doi:10.1080/14734220510008003. PubMed: 16147948
    • Sanchez-Perez A, Llansola M, Cauli O, Felipo V (2005) Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function. Cerebellum 4: 162-170. doi:10.1080/ 14734220510008003. PubMed: 16147948.
    • (2005) Cerebellum , vol.4 , pp. 162-170
    • Sanchez-Perez, A.1    Llansola, M.2    Cauli, O.3    Felipo, V.4
  • 26
    • 33746009937 scopus 로고    scopus 로고
    • A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control
    • doi:10.1074/jbc.M602423200. PubMed: 16682404
    • Nelson RF, Glenn KA, Miller VM, Wen H, Paulson HL (2006) A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. J Biol Chem 281: 20242-20251. doi:10.1074/jbc.M602423200. PubMed: 16682404.
    • (2006) J Biol Chem , vol.281 , pp. 20242-20251
    • Nelson, R.F.1    Glenn, K.A.2    Miller, V.M.3    Wen, H.4    Paulson, H.L.5
  • 27
    • 56749154434 scopus 로고    scopus 로고
    • Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome
    • doi:10.1016/j.nbd.2008.07.024. PubMed: 18773961
    • Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J et al. (2008) Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiol Dis 32: 377-384. doi:10.1016/j.nbd.2008.07.024. PubMed: 18773961.
    • (2008) Neurobiol Dis , vol.32 , pp. 377-384
    • Altafaj, X.1    Ortiz-Abalia, J.2    Fernández, M.3    Potier, M.C.4    Laffaire, J.5
  • 28
    • 77649202326 scopus 로고    scopus 로고
    • Protein aggregation diseases: Pathogenicity and therapeutic perspectives
    • doi:10.1038/nrd3050. PubMed: 20190788
    • Aguzzi A, O'Connor T (2010) Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat Rev Drug Discov 9: 237-248. doi:10.1038/nrd3050. PubMed: 20190788.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 237-248
    • Aguzzi, A.1    O'Connor, T.2
  • 29
    • 80052580969 scopus 로고    scopus 로고
    • Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    • doi:10.1038/nature10353. PubMed: 21857683
    • Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH et al. (2011) Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 477: 211-215. doi:10.1038/nature10353. PubMed: 21857683.
    • (2011) Nature , vol.477 , pp. 211-215
    • Deng, H.X.1    Chen, W.2    Hong, S.T.3    Boycott, K.M.4    Gorrie, G.H.5
  • 30
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • doi:10.1038/33416. PubMed: 9560156
    • Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y et al. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608. doi:10.1038/33416. PubMed: 9560156.
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, T.1    Asakawa, S.2    Hattori, N.3    Matsumine, H.4    Yamamura, Y.5
  • 31
    • 33646140347 scopus 로고    scopus 로고
    • Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport
    • doi:10.1093/hmg/ddl069. PubMed: 16565160
    • Ding J, Allen E, Wang W, Valle A, Wu C et al. (2006) Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet 15: 1451-1463. doi:10.1093/hmg/ddl069. PubMed: 16565160.
    • (2006) Hum Mol Genet , vol.15 , pp. 1451-1463
    • Ding, J.1    Allen, E.2    Wang, W.3    Valle, A.4    Wu, C.5
  • 32
    • 74049116574 scopus 로고    scopus 로고
    • Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease
    • doi:10.1074/jbc.M109.006312. PubMed: 19892702
    • Rao SN, Sharma J, Maity R, Jana NR (2010) Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease. J Biol Chem 285: 1404-1413. doi:10.1074/jbc.M109.006312. PubMed: 19892702.
    • (2010) J Biol Chem , vol.285 , pp. 1404-1413
    • Rao, S.N.1    Sharma, J.2    Maity, R.3    Jana, N.R.4
  • 33
    • 0343384355 scopus 로고    scopus 로고
    • ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF
    • doi:10.1038/72769. PubMed: 10655055
    • Engert JC, Bérubé P, Mercier J, Doré C, Lepage P et al. (2000) ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet 24: 120-125. doi:10.1038/72769. PubMed: 10655055.
    • (2000) Nat Genet , vol.24 , pp. 120-125
    • Engert, J.C.1    Bérubé, P.2    Mercier, J.3    Doré, C.4    Lepage, P.5
  • 34
    • 84877935385 scopus 로고    scopus 로고
    • Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination
    • doi:10.1056/NEJMoa1215993. PubMed: 23656588
    • Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD et al. (2013) Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. N Engl J Med 368: 1992-2003. doi:10.1056/NEJMoa1215993. PubMed: 23656588.
    • (2013) N Engl J Med , vol.368 , pp. 1992-2003
    • Margolin, D.H.1    Kousi, M.2    Chan, Y.M.3    Lim, E.T.4    Schmahmann, J.D.5
  • 35
    • 33748741301 scopus 로고    scopus 로고
    • CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation
    • doi:10.1074/jbc.M601603200. PubMed: 16831871
    • Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M et al. (2006) CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J Biol Chem 281: 26714-26724. doi:10.1074/jbc.M601603200. PubMed: 16831871.
    • (2006) J Biol Chem , vol.281 , pp. 26714-26724
    • Al-Ramahi, I.1    Lam, Y.C.2    Chen, H.K.3    De Gouyon, B.4    Zhang, M.5
  • 36
    • 24144440041 scopus 로고    scopus 로고
    • In vivo evidence of CHIP up-regulation attenuating tau aggregation
    • doi:10.1111/j.1471-4159.2005.03272.x. PubMed: 16111477
    • Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y et al. (2005) In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem 94: 1254-1263. doi:10.1111/j.1471-4159.2005.03272.x. PubMed: 16111477.
    • (2005) J Neurochem , vol.94 , pp. 1254-1263
    • Sahara, N.1    Murayama, M.2    Mizoroki, T.3    Urushitani, M.4    Imai, Y.5
  • 37
    • 33845874433 scopus 로고    scopus 로고
    • Brain CHIP: Removing the culprits in neurodegenerative disease
    • doi:10.1016/j.molmed.2006.11.003. PubMed: 17127096
    • Dickey CA, Patterson C, Dickson D, Petrucelli L (2007) Brain CHIP: removing the culprits in neurodegenerative disease. Trends Mol Med 13: 32-38. doi:10.1016/j.molmed.2006.11.003. PubMed: 17127096.
    • (2007) Trends Mol Med , vol.13 , pp. 32-38
    • Dickey, C.A.1    Patterson, C.2    Dickson, D.3    Petrucelli, L.4
  • 38
    • 15744387323 scopus 로고    scopus 로고
    • Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes
    • doi:10.1074/jbc.M412042200. PubMed: 15664989
    • Jana NR, Dikshit P, Goswami A, Kotliarova S, Murata S et al. (2005) Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. J Biol Chem 280: 11635-11640. doi:10.1074/jbc.M412042200. PubMed: 15664989.
    • (2005) J Biol Chem , vol.280 , pp. 11635-11640
    • Jana, N.R.1    Dikshit, P.2    Goswami, A.3    Kotliarova, S.4    Murata, S.5
  • 39
    • 34248327285 scopus 로고    scopus 로고
    • CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model
    • doi:10.1523/JNEUROSCI.1242-07.2007. PubMed: 17494697
    • Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M et al. (2007) CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. J Neurosci 27: 5115-5126. doi:10.1523/JNEUROSCI.1242-07.2007. PubMed: 17494697.
    • (2007) J Neurosci , vol.27 , pp. 5115-5126
    • Adachi, H.1    Waza, M.2    Tokui, K.3    Katsuno, M.4    Minamiyama, M.5
  • 40
    • 0036345454 scopus 로고    scopus 로고
    • CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
    • doi:10.1016/S1097-2765(02)00583-X. PubMed: 12150907
    • Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T et al. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 10: 55-67. doi:10.1016/S1097-2765(02)00583-X. PubMed: 12150907.
    • (2002) Mol Cell , vol.10 , pp. 55-67
    • Imai, Y.1    Soda, M.2    Hatakeyama, S.3    Akagi, T.4    Hashikawa, T.5
  • 41
    • 7444256611 scopus 로고    scopus 로고
    • A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity
    • doi:10.1016/j.bbrc.2004.10.037. PubMed: 15522241
    • Klucken J, Shin Y, Hyman BT, McLean PJ (2004) A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity. Biochem Biophys Res Commun 325: 367-373. doi:10.1016/j.bbrc.2004.10.037. PubMed: 15522241.
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 367-373
    • Klucken, J.1    Shin, Y.2    Hyman, B.T.3    McLean, P.J.4
  • 42
    • 67650164931 scopus 로고    scopus 로고
    • Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP
    • doi:10.1371/journal.pone.0005949. PubMed: 19536328
    • Ding X, Goldberg MS (2009) Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLOS ONE 4: e5949. doi:10.1371/journal.pone.0005949. PubMed: 19536328.
    • (2009) PLOS ONE , vol.4
    • Ding, X.1    Goldberg, M.S.2
  • 43
    • 44949127204 scopus 로고    scopus 로고
    • CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control
    • doi:10.1128/MCB.00296-08. PubMed: 18411298
    • Min JN, Whaley RA, Sharpless NE, Lockyer P, Portbury AL et al. (2008) CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol 28: 4018-4025. doi:10.1128/MCB.00296-08. PubMed: 18411298.
    • (2008) Mol Cell Biol , vol.28 , pp. 4018-4025
    • Min, J.N.1    Whaley, R.A.2    Sharpless, N.E.3    Lockyer, P.4    Portbury, A.L.5
  • 44
    • 10744223839 scopus 로고    scopus 로고
    • CHIP activates HSF1 and confers protection against apoptosis and cellular stress
    • doi:10.1093/emboj/cdg529. PubMed: 14532117
    • Dai Q, Zhang C, Wu Y, McDonough H, Whaley RA et al. (2003) CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J 22: 5446-5458. doi:10.1093/emboj/cdg529. PubMed: 14532117.
    • (2003) EMBO J , vol.22 , pp. 5446-5458
    • Dai, Q.1    Zhang, C.2    Wu, Y.3    McDonough, H.4    Whaley, R.A.5
  • 45
    • 84864706637 scopus 로고    scopus 로고
    • Suppression of calbindin-D28k expression exacerbates SCA1 phenotype in a disease mouse model
    • doi:10.1007/s12311-011-0323-9. PubMed: 22076800
    • Vig PJ, Wei J, Shao Q, Lopez ME, Halperin R et al. (2012) Suppression of calbindin-D28k expression exacerbates SCA1 phenotype in a disease mouse model. Cerebellum 11: 718-732. doi:10.1007/s12311-011-0323-9. PubMed: 22076800.
    • (2012) Cerebellum , vol.11 , pp. 718-732
    • Vig, P.J.1    Wei, J.2    Shao, Q.3    Lopez, M.E.4    Halperin, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.