메뉴 건너뛰기




Volumn 169, Issue 3, 2013, Pages 171-179

Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release

Author keywords

Anticancer drugs; Biodegradable micelles; Controlled release; Dual responsive; Stimuli sensitive

Indexed keywords

CYTOLOGY; CYTOTOXICITY; DRUG PRODUCTS; MICELLES; POLYETHYLENE OXIDES;

EID: 84884291917     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.001     Document Type: Article
Times cited : (356)

References (46)
  • 1
    • 67650741406 scopus 로고    scopus 로고
    • Self-assembled polymer nanostructures for delivery of anticancer therapeutics
    • N. Wiradharma, Y. Zhang, S. Venkataraman, J.L. Hedrick, Y.Y. Yang, Self-assembled polymer nanostructures for delivery of anticancer therapeutics, Nano Today 4 (2009) 302-317.
    • (2009) Nano Today , vol.4 , pp. 302-317
    • Wiradharma, N.1    Zhang, Y.2    Venkataraman, S.3    Hedrick, J.L.4    Yang, Y.Y.5
  • 2
    • 67649229657 scopus 로고    scopus 로고
    • Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers
    • Y. Bae, K. Kataoka, Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers, Adv. Drug Deliv. Rev. 61 (2009) 768-784.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 768-784
    • Bae, Y.1    Kataoka, K.2
  • 3
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • M.E. Davis, Z. Chen, D.M. Shin, Nanoparticle therapeutics: an emerging treatment modality for cancer, Nat. Rev. Drug Discov. 7 (2008) 771-782.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 4
    • 36849067019 scopus 로고    scopus 로고
    • Nanocarriers as an emerging platform for cancer therapy
    • DOI 10.1038/nnano.2007.387, PII NNANO2007387
    • D. Peer, J.M. Karp, S. Hong, O.C. Farokhzad, R. Margalit, R. Langer, Nanocarriers as an emerging platform for cancer therapy, Nat. Nanotechnol. 2 (2007) 751-760. (Pubitemid 350223348)
    • (2007) Nature Nanotechnology , vol.2 , Issue.12 , pp. 751-760
    • Peer, D.1    Karp, J.M.2    Hong, S.3    Farokhzad, O.C.4    Margalit, R.5    Langer, R.6
  • 5
    • 84867689207 scopus 로고    scopus 로고
    • Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects
    • C. Deng, Y. Jiang, R. Cheng, F. Meng, Z. Zhong, Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: promises, progress and prospects, Nano Today 7 (2012) 467-480.
    • (2012) Nano Today , vol.7 , pp. 467-480
    • Deng, C.1    Jiang, Y.2    Cheng, R.3    Meng, F.4    Zhong, Z.5
  • 6
    • 58149284060 scopus 로고    scopus 로고
    • Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature
    • M.R. Kano, Y. Komuta, C. Iwata, M. Oka, Y.-t. Shirai, Y. Morishita, Y. Ouchi, K. Kataoka, K. Miyazono, Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature, Cancer Sci. 100 (2009) 173-180.
    • (2009) Cancer Sci. , vol.100 , pp. 173-180
    • Kano, M.R.1    Komuta, Y.2    Iwata, C.3    Oka, M.4    Shirai, Y.-T.5    Morishita, Y.6    Ouchi, Y.7    Kataoka, K.8    Miyazono, K.9
  • 7
    • 79953048071 scopus 로고    scopus 로고
    • Tumor delivery of macromolecular drugs based on the EPR effect
    • V. Torchilin, Tumor delivery of macromolecular drugs based on the EPR effect, Adv. Drug Deliv. Rev. 63 (2011) 131-135.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 8
    • 64149094873 scopus 로고    scopus 로고
    • Stimuli-responsive polymersomes for programmed drug delivery
    • F.H. Meng, Z.Y. Zhong, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery, Biomacromolecules 10 (2009) 197-209.
    • (2009) Biomacromolecules , vol.10 , pp. 197-209
    • Meng, F.H.1    Zhong, Z.Y.2    Feijen, J.3
  • 9
    • 84863636578 scopus 로고    scopus 로고
    • Recent advances in stimuli-responsive degradable block copolymer micelles: Synthesis and controlled drug delivery applications
    • Q. Zhang, N. Re Ko, J. Kwon Oh, Recent advances in stimuli-responsive degradable block copolymer micelles: synthesis and controlled drug delivery applications, Chem. Commun. 48 (2012) 7542-7552.
    • (2012) Chem. Commun. , vol.48 , pp. 7542-7552
    • Zhang, Q.1    Re Ko, N.2    Kwon Oh, J.3
  • 10
    • 84861233382 scopus 로고    scopus 로고
    • Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications
    • E. Fleige, M.A. Quadir, R. Haag, Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications, Adv. Drug Deliv. Rev. 64 (2012) 866-884.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 866-884
    • Fleige, E.1    Quadir, M.A.2    Haag, R.3
  • 11
    • 84869038084 scopus 로고    scopus 로고
    • Intracellular drug release nanosystems
    • F. Meng, R. Cheng, C. Deng, Z. Zhong, Intracellular drug release nanosystems, Mater. Today 15 (2012) 436-442.
    • (2012) Mater. Today , vol.15 , pp. 436-442
    • Meng, F.1    Cheng, R.2    Deng, C.3    Zhong, Z.4
  • 12
    • 79955465276 scopus 로고    scopus 로고
    • Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells
    • R. Tang, W. Ji, D. Panus, R.N. Palumbo, C. Wang, Block copolymer micelles with acid-labile ortho ester side-chains: synthesis, characterization, and enhanced drug delivery to human glioma cells, J. Control. Release 151 (2010) 18-27.
    • (2010) J. Control. Release , vol.151 , pp. 18-27
    • Tang, R.1    Ji, W.2    Panus, D.3    Palumbo, R.N.4    Wang, C.5
  • 13
    • 79958101789 scopus 로고    scopus 로고
    • Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs
    • Z.-Y. Qiao, R. Zhang, F.-S. Du, D.-H. Liang, Z.-C. Li, Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs, J. Control. Release 152 (2011) 57-66.
    • (2011) J. Control. Release , vol.152 , pp. 57-66
    • Qiao, Z.-Y.1    Zhang, R.2    Du, F.-S.3    Liang, D.-H.4    Li, Z.-C.5
  • 14
    • 0142119372 scopus 로고    scopus 로고
    • Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change
    • DOI 10.1002/anie.200250653
    • Y. Bae, S. Fukushima, A. Harada, K. Kataoka, Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change, Angew. Chem. Int. Ed. 42 (2003) 4640-4643. (Pubitemid 37271305)
    • (2003) Angewandte Chemie - International Edition , vol.42 , Issue.38 , pp. 4640-4643
    • Bae, Y.1    Fukushima, S.2    Harada, A.3    Kataoka, K.4
  • 15
    • 79955859899 scopus 로고    scopus 로고
    • Endosomal pH-activatable poly(ethylene oxide)-graft-doxorubicin prodrugs: Synthesis, drug release, and biodistribution in tumor-bearing mice
    • L. Zhou, R. Cheng, H. Tao, S. Ma, W. Guo, F. Meng, H. Liu, Z. Liu, Z. Zhong, Endosomal pH-activatable poly(ethylene oxide)-graft-doxorubicin prodrugs: synthesis, drug release, and biodistribution in tumor-bearing mice, Biomacromolecules 12 (2011) 1460-1467.
    • (2011) Biomacromolecules , vol.12 , pp. 1460-1467
    • Zhou, L.1    Cheng, R.2    Tao, H.3    Ma, S.4    Guo, W.5    Meng, F.6    Liu, H.7    Liu, Z.8    Zhong, Z.9
  • 16
    • 0037130252 scopus 로고    scopus 로고
    • Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
    • DOI 10.1016/S0168-3659(02)00088-3, PII S0168365902000883
    • H.S. Yoo, E.A. Lee, T.G. Park, Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages, J. Control. Release 82 (2002) 17-27. (Pubitemid 34775044)
    • (2002) Journal of Controlled Release , vol.82 , Issue.1 , pp. 17-27
    • Yoo, H.S.1    Lee, E.A.2    Park, T.G.3
  • 17
    • 70350211845 scopus 로고    scopus 로고
    • Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles
    • F.-Q. Hu, L.-N. Liu, Y.-Z. Du, H. Yuan, Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles, Biomaterials 30 (2009) 6955-6963.
    • (2009) Biomaterials , vol.30 , pp. 6955-6963
    • Hu, F.-Q.1    Liu, L.-N.2    Du, Y.-Z.3    Yuan, H.4
  • 18
    • 0037625476 scopus 로고    scopus 로고
    • A new approach towards acid sensitive copolymer micelles for drug delivery
    • E.R. Gillies, J.M.J. Fréchet, A new approach towards acid sensitive copolymer micelles for drug delivery, Chem. Commun. (2003) 1640-1641. (Pubitemid 36829574)
    • (2003) Chemical Communications , Issue.14 , pp. 1640-1641
    • Gillies, E.R.1    Frechet, J.M.J.2
  • 19
    • 49449098661 scopus 로고    scopus 로고
    • Acetal-derivatized dextran: An acid-responsive biodegradable material for therapeutic applications
    • E.M. Bachelder, T.T. Beaudette, K.E. Broaders, J. Dashe, J.M.J. Fréchet, Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications, J. Am. Chem. Soc. 130 (2008) 10494-10495.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 10494-10495
    • Bachelder, E.M.1    Beaudette, T.T.2    Broaders, K.E.3    Dashe, J.4    Fréchet, J.M.J.5
  • 20
    • 4644264045 scopus 로고    scopus 로고
    • Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers
    • DOI 10.1021/ja0463738
    • E.R. Gillies, T.B. Jonsson, J.M.J. Fréchet, Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers, J. Am. Chem. Soc. 126 (2004) 11936-11943. (Pubitemid 39298343)
    • (2004) Journal of the American Chemical Society , vol.126 , Issue.38 , pp. 11936-11943
    • Gillies, E.R.1    Jonsson, T.B.2    Frechet, J.M.J.3
  • 21
    • 15244345124 scopus 로고    scopus 로고
    • PH-responsive copolymer assemblies for controlled release of doxorubicin
    • DOI 10.1021/bc049851c
    • E.R. Gillies, J.M.J. Fréchet, pH-Responsive copolymer assemblies for controlled release of doxorubicin, Bioconjug. Chem. 16 (2005) 361-368. (Pubitemid 40388212)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.2 , pp. 361-368
    • Gillies, E.R.1    Frechet, J.M.J.2
  • 22
    • 76749128372 scopus 로고    scopus 로고
    • PH-sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles
    • W. Chen, F. Meng, R. Cheng, Z. Zhong, pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles, J. Control. Release 142 (2010) 40-46.
    • (2010) J. Control. Release , vol.142 , pp. 40-46
    • Chen, W.1    Meng, F.2    Cheng, R.3    Zhong, Z.4
  • 23
    • 67650459919 scopus 로고    scopus 로고
    • PH-responsive biodegradable micelles based on acid-labile polycarbonate hydrophobe: Synthesis and triggered drug release
    • W. Chen, F.H. Meng, F. Li, S.J. Ji, Z.Y. Zhong, pH-Responsive biodegradable micelles based on acid-labile polycarbonate hydrophobe: synthesis and triggered drug release, Biomacromolecules 10 (2009) 1727-1735.
    • (2009) Biomacromolecules , vol.10 , pp. 1727-1735
    • Chen, W.1    Meng, F.H.2    Li, F.3    Ji, S.J.4    Zhong, Z.Y.5
  • 24
    • 84864307789 scopus 로고    scopus 로고
    • PH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride
    • Y. Du, W. Chen, M. Zheng, F. Meng, Z. Zhong, pH-Sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride, Biomaterials 33 (2012) 7291-7299.
    • (2012) Biomaterials , vol.33 , pp. 7291-7299
    • Du, Y.1    Chen, W.2    Zheng, M.3    Meng, F.4    Zhong, Z.5
  • 25
    • 80053128144 scopus 로고    scopus 로고
    • Non-viral gene transfection in vitro using endosomal pH-sensitive reversibly hydrophobilized polyethylenimine
    • Z. Liu, M. Zheng, F. Meng, Z. Zhong, Non-viral gene transfection in vitro using endosomal pH-sensitive reversibly hydrophobilized polyethylenimine, Biomaterials 32 (2011) 9109-9119.
    • (2011) Biomaterials , vol.32 , pp. 9109-9119
    • Liu, Z.1    Zheng, M.2    Meng, F.3    Zhong, Z.4
  • 26
    • 60849122214 scopus 로고    scopus 로고
    • Reduction-sensitive polymers and bioconjugates for biomedical applications
    • F. Meng, W.E. Hennink, Z. Zhong, Reduction-sensitive polymers and bioconjugates for biomedical applications, Biomaterials 30 (2009) 2180-2198.
    • (2009) Biomaterials , vol.30 , pp. 2180-2198
    • Meng, F.1    Hennink, W.E.2    Zhong, Z.3
  • 27
    • 79958176375 scopus 로고    scopus 로고
    • Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
    • R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, Z. Zhong, Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery, J. Control. Release 152 (2011) 2-12.
    • (2011) J. Control. Release , vol.152 , pp. 2-12
    • Cheng, R.1    Feng, F.2    Meng, F.3    Deng, C.4    Feijen, J.5    Zhong, Z.6
  • 28
    • 69849089755 scopus 로고    scopus 로고
    • Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxo-rubicin
    • H. Sun, B. Guo, R. Cheng, F. Meng, H. Liu, Z. Zhong, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxo-rubicin, Biomaterials 30 (2009) 6358-6366.
    • (2009) Biomaterials , vol.30 , pp. 6358-6366
    • Sun, H.1    Guo, B.2    Cheng, R.3    Meng, F.4    Liu, H.5    Zhong, Z.6
  • 29
    • 77950826451 scopus 로고    scopus 로고
    • Shell-sheddable micelles based on dextran-SS-poly(ε-caprolactone) diblock copolymer for efficient intra-cellular release of doxorubicin
    • H. Sun, B. Guo, X. Li, R. Cheng, F. Meng, H. Liu, Z. Zhong, Shell-sheddable micelles based on dextran-SS-poly(ε-caprolactone) diblock copolymer for efficient intra-cellular release of doxorubicin, Biomacromolecules 11 (2010) 848-854.
    • (2010) Biomacromolecules , vol.11 , pp. 848-854
    • Sun, H.1    Guo, B.2    Li, X.3    Cheng, R.4    Meng, F.5    Liu, H.6    Zhong, Z.7
  • 30
    • 67649215077 scopus 로고    scopus 로고
    • Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery
    • L.-Y. Tang, Y.-C. Wang, Y. Li, J.-Z. Du, J. Wang, Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery, Bioconjug. Chem. 20 (2009) 1095-1099.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 1095-1099
    • Tang, L.-Y.1    Wang, Y.-C.2    Li, Y.3    Du, J.-Z.4    Wang, J.5
  • 31
    • 80054813265 scopus 로고    scopus 로고
    • Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells
    • Y.-C. Wang, F. Wang, T.-M. Sun, J. Wang, Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells, Bioconjug. Chem. 22 (2011) 1939-1945.
    • (2011) Bioconjug. Chem. , vol.22 , pp. 1939-1945
    • Wang, Y.-C.1    Wang, F.2    Sun, T.-M.3    Wang, J.4
  • 32
    • 79955805690 scopus 로고    scopus 로고
    • Bioreducible micelles self-assembled from amphiphilic hyperbranched multiarm copolymer for glutathione-mediated intracellular drug delivery
    • J. Liu, Y. Pang, W. Huang, X. Huang, L. Meng, X. Zhu, Y. Zhou, D. Yan, Bioreducible micelles self-assembled from amphiphilic hyperbranched multiarm copolymer for glutathione-mediated intracellular drug delivery, Biomacromolecules 12 (2011) 1567-1577.
    • (2011) Biomacromolecules , vol.12 , pp. 1567-1577
    • Liu, J.1    Pang, Y.2    Huang, W.3    Huang, X.4    Meng, L.5    Zhu, X.6    Zhou, Y.7    Yan, D.8
  • 33
    • 79952379757 scopus 로고    scopus 로고
    • Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)- SS-poly(ethyl glycol) copolymer for intracellu-lar drug release
    • T.-B. Ren, Y. Feng, Z.-H. Zhang, L. Li, Y.-Y. Li, Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellu-lar drug release, Soft Matter 7 (2011) 2329-2331.
    • (2011) Soft Matter , vol.7 , pp. 2329-2331
    • Ren, T.-B.1    Feng, Y.2    Zhang, Z.-H.3    Li, L.4    Li, Y.-Y.5
  • 34
    • 80054808953 scopus 로고    scopus 로고
    • Bioreducible block copolymers based on poly(ethylene glycol) and poly(gamma-benzyl L-glutamate) for intracellular delivery of camptothecin
    • T. Thambi, H.Y. Yoon, K. Kim, I.C. Kwon, C.K. Yoo, J.H. Park, Bioreducible block copolymers based on poly(ethylene glycol) and poly(gamma-benzyl L-glutamate) for intracellular delivery of camptothecin, Bioconjug. Chem. 22 (2011) 1924-1931.
    • (2011) Bioconjug. Chem. , vol.22 , pp. 1924-1931
    • Thambi, T.1    Yoon, H.Y.2    Kim, K.3    Kwon, I.C.4    Yoo, C.K.5    Park, J.H.6
  • 35
    • 79952424817 scopus 로고    scopus 로고
    • Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery
    • H.-Y. Wen, H.-Q. Dong, W.-j. Xie, Y.-Y. Li, K. Wang, G.M. Pauletti, D.-L. Shi, Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery, Chem. Commun. 47 (2011) 3550-3552.
    • (2011) Chem. Commun. , vol.47 , pp. 3550-3552
    • Wen, H.-Y.1    Dong, H.-Q.2    Xie, W.-J.3    Li, Y.-Y.4    Wang, K.5    Pauletti, G.M.6    Shi, D.-L.7
  • 36
    • 80053969259 scopus 로고    scopus 로고
    • Biodegradable block copolymer micelles with thiol-responsive sheddable coronas
    • B. Khorsand Sourkohi, A. Cunningham, Q. Zhang, J.K. Oh, Biodegradable block copolymer micelles with thiol-responsive sheddable coronas, Biomacromolecules 12 (2011) 3819-3825.
    • (2011) Biomacromolecules , vol.12 , pp. 3819-3825
    • Khorsand Sourkohi, B.1    Cunningham, A.2    Zhang, Q.3    Oh, J.K.4
  • 37
    • 80053165533 scopus 로고    scopus 로고
    • Interlayer-crosslinked micelle with partially hydrated core showing reduction and pHdual sensitivity for pinpointed intracellular drug release
    • J. Dai, S. Lin, D. Cheng, S. Zou, X. Shuai, Interlayer-crosslinked micelle with partially hydrated core showing reduction and pHdual sensitivity for pinpointed intracellular drug release, Angew. Chem. Int. Ed. 50 (2011) 9404-9408.
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 9404-9408
    • Dai, J.1    Lin, S.2    Cheng, D.3    Zou, S.4    Shuai, X.5
  • 38
    • 80053997746 scopus 로고    scopus 로고
    • PH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery
    • J. Chen, X. Qiu, J. Ouyang, J. Kong, W. Zhong, M.M.Q. Xing, pH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery, Biomacromolecules 12 (2011) 3601-3611.
    • (2011) Biomacromolecules , vol.12 , pp. 3601-3611
    • Chen, J.1    Qiu, X.2    Ouyang, J.3    Kong, J.4    Zhong, W.5    Xing, M.M.Q.6
  • 39
    • 84863075939 scopus 로고    scopus 로고
    • PH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery
    • J. Zhang, L. Wu, F. Meng, Z. Wang, C. Deng, H. Liu, Z. Zhong, pH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery, Langmuir 28 (2012) 2056-2065.
    • (2012) Langmuir , vol.28 , pp. 2056-2065
    • Zhang, J.1    Wu, L.2    Meng, F.3    Wang, Z.4    Deng, C.5    Liu, H.6    Zhong, Z.7
  • 40
    • 84863229405 scopus 로고    scopus 로고
    • Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection
    • C. Zhu, M. Zheng, F. Meng, F.M. Mickler, N. Ruthardt, X. Zhu, Z. Zhong, Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS- PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection, Biomacromolecules 13 (2012) 769-778.
    • (2012) Biomacromolecules , vol.13 , pp. 769-778
    • Zhu, C.1    Zheng, M.2    Meng, F.3    Mickler, F.M.4    Ruthardt, N.5    Zhu, X.6    Zhong, Z.7
  • 41
    • 0032664298 scopus 로고    scopus 로고
    • A new, crystalline high melting bis(hydroxymethyl) polycarbonate and its acetone ketal for biomaterial applications
    • E.J. Vandenberg, D. Tian, A new, crystalline high melting bis(hydroxymethyl) polycarbonate and its acetone ketal for biomaterial applications, Macromolecules 32 (1999) 3613-3619.
    • (1999) Macromolecules , vol.32 , pp. 3613-3619
    • Vandenberg, E.J.1    Tian, D.2
  • 43
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • DOI 10.1016/S0006-2952(98)00307-4, PII S0006295298003074
    • D.A. Gewirtz, A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin, Biochem. Pharmacol. 57 (1999) 727-741. (Pubitemid 29094544)
    • (1999) Biochemical Pharmacology , vol.57 , Issue.7 , pp. 727-741
    • Gewirtz, D.A.1
  • 44
    • 1842638560 scopus 로고    scopus 로고
    • Folate receptor targeted biodegradable polymeric doxorubicin micelles
    • DOI 10.1016/j.jconrel.2004.02.003, PII S0168365904000811
    • H.S. Yoo, T.G. Park, Folate receptor targeted biodegradable polymeric doxorubicin micelles, J. Control. Release 96 (2004) 273-283. (Pubitemid 38481509)
    • (2004) Journal of Controlled Release , vol.96 , Issue.2 , pp. 273-283
    • Yoo, H.S.1    Park, T.G.2
  • 45
    • 77952151111 scopus 로고    scopus 로고
    • Amphiphilic toothbrushlike copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as drug carriers with enhanced properties
    • W. Zhang, Y. Li, L. Liu, Q. Sun, X. Shuai, W. Zhu, Y. Chen, Amphiphilic toothbrushlike copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as drug carriers with enhanced properties, Biomacromolecules 11 (2010) 1331-1338.
    • (2010) Biomacromolecules , vol.11 , pp. 1331-1338
    • Zhang, W.1    Li, Y.2    Liu, L.3    Sun, Q.4    Shuai, X.5    Zhu, W.6    Chen, Y.7
  • 46
    • 84865046495 scopus 로고    scopus 로고
    • Reduction-responsivedisassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release
    • R. Wei, L. Cheng, M. Zheng, R. Cheng, F. Meng, C. Deng, Z. Zhong, Reduction-responsivedisassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release, Biomacromolecules 13 (2012) 2429-2438.
    • (2012) Biomacromolecules , vol.13 , pp. 2429-2438
    • Wei, R.1    Cheng, L.2    Zheng, M.3    Cheng, R.4    Meng, F.5    Deng, C.6    Zhong, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.