Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 406-418

  Lv, Wei ^a   Banerjee, Biplab ^a   Molland, Katrina L ^b   Seleem, Mohamed N ^c   Ghafoor, Adil ^c   Hamed, Maha I ^c   Wan, Baojie ^d   Franzblau, Scott G ^d   Mesecar, Andrew D ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

3 (3 Aryl pyrrolidin 1 yl) 5 aryl 1,2,4 triazine; Antibacterial agents; Inhibitors; Inorganic pyrophosphatase

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 2 METHOXY 5 [1 [5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZIN 3 YL]PYRROLIDIN 3 YL]PHENOL; 3 (3 ARYL PYRROLIDIN 1 YL) 5 ARYL 1,2,4 TRIAZINE DERIVATIVE; 3 [1 [5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZIN 3 YL]PYRROLIDIN 3 YL]ANILINE; 3 [1 [5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZIN 3 YL]PYRROLIDIN 3 YL]BENZONITRILE; 3 [1 [5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZIN 3 YL]PYRROLIDIN 3 YL]PHENOL; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 (3 NITROPHENYL) 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 (3' NITROBIPHENYL 4 YL) 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 (3,4 DIMETHOXYPHENYL) 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 (4 NITROPHENYL) 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 [5 (3 NITROPHENYL)FURAN 2 YL] 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 [5 [2 (TRIFLUOROMETHYL)PHENYL]FURAN 2 YL] 1,2,4 TRIAZINE; 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 5 PHENYL 1,2,4 TRIAZINE; 3 [3 (3 FLUOROPHENYL)PYRROLIDIN 1 YL] 5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZINE; 3 [3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZIN 5 YL]ANILINE; 3 [3 [3 (BENZYLOXY)PHENYL]PYRROLIDIN 1 YL] 5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZINE; 4 [1 [5 (5 METHYLFURAN 2 YL) 1,2,4 TRIAZIN 3 YL]PYRROLIDIN 3 YL]BENZENE 1,2 DIOL; 4 [3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZIN 5 YL]ANILINE; 5 (3,4 METHYLENEDIOXYPHENYL) 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZINE; 5 (4 BROMOPHENYL) 3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZINE; 5 (5 METHYLFURAN 2 YL) 3 (3 PHENYLPYRROLIDIN 1 YL) 1,2,4 TRIAZINE; 5 (5 METHYLFURAN 2 YL) 3 [3 (3 NITROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZINE; 5 (5 METHYLFURAN 2 YL) 3 [3 [3 (TRIFLUOROMETHYL)PHENYL]PYRROLIDIN 1 YL] 1,2,4 TRIAZINE; INORGANIC PYROPHOSPHATASE; ISONIAZID; METHYL 3 [5 [3 [3 (3 CHLOROPHENYL)PYRROLIDIN 1 YL] 1,2,4 TRIAZIN 5 YL]FURAN 2 YL]BENZOATE; RIFAMPICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; VANCOMYCIN INTERMEDIATE STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS;

BACILLUS ANTHRACIS; MAMMALIA; MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS;

3-(3-ARYL-PYRROLIDIN-1-YL)-5-ARYL-1,2,4-TRIAZINE; ANTIBACTERIAL AGENTS; INHIBITORS; INORGANIC PYROPHOSPHATASE;

ANTI-BACTERIAL AGENTS; HIGH-THROUGHPUT SCREENING ASSAYS; INORGANIC PYROPHOSPHATASE; MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84891496839     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.011     Document Type: Article

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