3D QSAR analysis of quinolone based s- triazines as antimicrobial agent

International Journal of PharmTech Research

Volumn 4, Issue 3, 2012, Pages 1096-1100

  Sawant, Ramesh L ^a   Ramdin, Supriya S ^a   Rathi, Sumidha R ^a  

^a Padmashri Dr Vithalrao Vikhe Patil Foundation's College of Pharmacy   (India)

Author keywords

1, 3, 5 triazine; 3D descriptors; 3D QSAR; Antimicrobial activity

Indexed keywords

ANTIINFECTIVE AGENT; QUINOLONE; TRIAZINE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; COMPUTER PROGRAM; CORRELATION COEFFICIENT; DRUG STRUCTURE; MATHEMATICAL MODEL; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS; SUBSTITUTION REACTION;

EID: 84870220308     PISSN: 09744304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Saleh M., Abbott S., Perron V. and Lauzon C., Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines, Bioorg. Med. Chem. Lett., 2010, 20, 945-949.
2. Saczewski F. and Bułakowska A., Synthesis, structure and anticancer activity of novel alkenyl-1,3,5-triazine derivatives, Eur. J. Med. Chem., 2006, 41, 611-615.
3. Golankiewicz B., Januszczyk P., Ikeda S., Balzarini J. and De Clercq E., Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9- dideazapurine) derivatives, J. Med. Chem., 1995, 38, 3558-3565.
4. Nathan C., Antibiotics at the crosswords, Nature, 2004, 431, 899-902.
5. Srinivas K., Srinivas U., Bhanuprakash K., Harakishor K., Murthy U.S.N. and Jayatirtha R.V., synthesis and antibacterial activity of various substituted s-triazines, Eur. J. Med. Chem., 2006, 41, 1240-1246.
6. Patel D., Patel R., Kumari P. and Patel N., Heter Comm., 2011, 17, 33-41.
7. QSAR Plus of Molecular Design Suit [MDS] VLife Sciences Technology Pvt. Ltd. Pune.
8. Halgren T.A., Merck molecular force field III, Molecular geometries and vibrational frequencies, J. Comp. Chem., 1996, 17, 553-586.
9. Ajmani S., Jadhav K. and Kulkarni S.A., Three- dimensional QSAR using the k-nearest neighbor method and its interpretation, J. Chem. Inf. Model., 2006, 46, 24-31.