A synthetic approach and antimicrobial evaluation of annulated pyrimidine and triazine derivatives

Current Organic Chemistry

Volumn 13, Issue 17, 2009, Pages 1758-1764

  Aly, A A ^a  

^a BENHA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; SUGAR SUBSTITUTES; SYNTHESIS (CHEMICAL);

ANTI-MICROBIAL ACTIVITY; BENZIMIDAZOLES; BIOLOGICAL STUDIES; CHEMICAL EVIDENCES; ONE STEP SYNTHESIS; PYRIMIDINE DERIVATIVES; SPECTROSCOPIC EVIDENCE; SYNTHESISED; SYNTHETIC APPROACH; TRIAZINE DERIVATIVES;

MICROORGANISMS;

EID: 73049115660     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/138527209789578090     Document Type: Article

References (19)

1. Leal, B.; Afonso, I.F.; Rodrigues, C.R.; Abreu, P.A.; Garett, R.; Pinheiro, L.C.S.; Azevedo, A.R.; Borges, J.C.; Vegi, P.F.; Santos, C.C.C.; Dasilveira, F.C.A.; Cabral, L.M.; Frugulhetti, I.C.P.P.; Bernardino, A.M.R.; Santos, D.O.; Castro, H.C. Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives. Bioorg. Med. Chem., 2008, 16, 8196.
2. Hamblin, J.N.; Angell, T.D.R.; Ballantine, S.P.; Cook, C.M.; Cooper, A.W.J.; Dawson, J.; Delves, C.J.; Jones, P.S.; Lindvall, M.; Lucas, F.S.; Mitchell, C.J.; Neu, M.Y.; Ranshaw, L.E.; Solanke, Y.E.; Somers, D.O.; Wiseman, J.O. Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. Bioorg. Med. Chem. Lett., 2008, 18, 4237.
3. Bharate, S.B.; Mahajan, T.R.; Gole, Y.R.; Nambiar, M.; Mattan, T.T.; Kulkarni-Almeida, A.; Balachandran, S.; Junjappa, H.; Balakrishnan, A.; Vishwakarma, R.A. Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-?? and IL-6 inhibitors. Bioorg. Med. Chem., 2008, 16, 7167.
4. Lin, R.; Connolly, P.J.; Lu, Y.; Chiu, G.; Li, S.; Yu, Y.; Huang, S.; Li, X.; Emanuel, S.L.; Middleton, S.A.; Gruninger, R.H.; Adams, M.; Fuentes-Pesquerea, A.R.; Greenberger, L.M. Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as antitumor agents. Bioorg. Med. Chem. Lett., 2007, 17, 4297.
5. Bernardino, A.M.R.; Azevedo, A.R.; Pinheiro, L.C.S.; Borges, J.C.; Carvalho, V.L.; Miranda, M.D.; Meneses, M.D.F.; Nascimento, M.; Ferreira, D.; Rebello, M.A.; Silva, V.A.G.G.; Frugulhetti, I.C. P.P. Synthesis and antiviral activity of new 4- (phenylamino)/4-[(methylpyridin-2-yl)amino]-1-phenyl-1Hpyrazolo[3,4-b]pyridine-4-carboxylic acids derivatives. Med. Chem. Res., 2007, 16, 352.
6. - substituents. Bioorg. Med. Chem. Lett., 2008, 18, 1958.
7. Chioua, M.; Samadi, A.; Soriano, E.; Lozach, O.; Meijer, L.; Marco-Contelles, J. Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. Bioorg. Med. Chem. Lett., 2009, 19, 4566.
8. Dias, L. R. S.; Santos, M. B.; Albuquerque, S.; Castro, H. C.; Souza, A. M. T.; Freitas, A. C. C.; DiVaio, M. A. V.; Cabral, L. M.; Rodrigues, C. R. Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series. Bioorg. Med. Chem., 2007, 15, 211.
9. Zhang, G.; Ren, P.; Grary, N.S.; Sim, T.; Liu, Y.; Wang, X.; Che, J.; Tian, S.; Sandberg, M.L.; Spalding, T.A.; Romeo, R.; Iskandar, M.; Chow, D.; Seidel, H.M.; Karanewsky, D.S.; He, Y. Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I. Bioorg. Med. Chem. Lett., 2008, 18, 5618.
10. Kinzel, O.D.; Ball, R.G.; Donghi, M.; Courtney, K.M.; Muraglia, E.; Pesci, S.; Rowley, M.; Vincenzo, S. 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors. Tetrahedron Lett., 2008, 49, 6556.
11. Venu, T.D.; Khanum, S.A.; Firdouse, A.; Manuprasad, B.K.; Shashikanth, S.; Mohamed, R.; Vishwanth, B.S. Synthesis and antiinflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxypyrimidines. Bioorg. Med. Chem. Lett., 2008, 18, 4409.
12. Aly, A.A. A facile synthesis and heteroannulation of thiazolopyrimidine and related heterocyclic systems. J. Heterocycl. Chem., 2008, 45, 993.
13. Aly, A.A. Synthesis of polyfunctionally substituted pyrazolonaphthyridine, pentaazanaphthalene, and heptaazaphenanthrene derivatives. Phosphorus, Sulfur Silicon Relat. Elem., 2006, 181, 2395.
14. --yl}benzimidazole derivatives. Bioorg. Med. Chem. Lett., 2008, 18, 5010.
15. Zhu, G.; Gandhi, V.B.; Gong, J.; Thomas, S.; Luo, Y.; Liu, X.; Shi, Y.; Klinghofer, V.; Johnson, E.F.; Frost, D.; Donawho, C.; Jarvis, K.; Bouska, J.; Marsh, K.C.; Rosenberg, S.H.; Giranda, V.L.; Penning, T.D. Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADPribose) polymerase (PARP) with a quaternary methylene-amino substituent. Bioorg. Med. Chem. Lett., 2008, 18, 3955.
16. Fahey, K.; Aldabbagh, F. Synthesis of seven- and eight-membered [1,2-a]alicyclic ring-fused benzimidazoles and 3- aziridinylazepino[1,2-a]benzimidazolequinone as a potential antitumour agent. Tetrahedron Lett., 2008, 49, 5235.
17. Aslanina, R.; Zhu, X.; Vaccaro, H.A.; Shih, N.; Piwinski, J.J.; Williams, S.M.; West, R.E. Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands. Bioorg. Med. Chem. Lett., 2008, 18, 5032.
18. Aly, A. A. A Convenient synthesis of novel functionalized pyrimido[5',4':4,5]thieno[3,2-c]pyridazines and related fused systems. Phosphorus, Sulfur Silicon Relat. Elem., 2008, 183, 3079.
19. Leiferet, C.; Chidbouree, S.; Hampson, S.; Workman, S.; Sigee, D.; Epton, H.A.; Harbour, A. Antibiotic production and biocontrol activity by Bacillus subtilis CL27 and Bacillus pumilus CL45. J. Appl. Bacteriol., 1995, 78, 97.