Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 61-64

  Taddei, Maurizio ^a   Cini, Elena ^a   Giannotti, Luca ^a   Giannini, Giuseppe ^b   Battistuzzi, Gianfranco ^b   Vignola, Davide ^b   Vesci, Loredana ^b   Cabri, Walter ^b,c  

^a UNIVERSITY OF SIENA   (Italy)

^b Sigma Tau SpA   (Italy)

^c INDENA S P A   (Italy)

Author keywords

Anticancer; HDAC; Heterocycles; Hydroxamic acid; Pan inhibitor

Indexed keywords

7 AMINO SUBEROYLAMIDE HYDROXAMIC ACID; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 10; HISTONE DEACETYLASE 11; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; LACTAM DERIVATIVE; ST 8078AA 1; UNCLASSIFIED DRUG; HYDROXAMIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DEACETYLATION; HORNER WADSWORTH EMMONS REACTION; IC 50; TUMOR CELL LINE; DRUG POTENCY; ENZYME INHIBITION; IC50; IN VITRO STUDY;

ANTICANCER; HDAC; HETEROCYCLES; HYDROXAMIC ACID; PAN-INHIBITOR;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LACTAMS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891496536     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.11.072     Document Type: Article

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