ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6261-6265

  Hanessian, Stephen ^a   Auzzas, Luciana ^a,b   Giannini, Giuseppe ^c   Marzi, Mauro ^c   Cabri, Walter ^c   Barbarino, Marcella ^c   Vesci, Loredana ^c   Pisano, Claudio ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CNR   (Italy)

^c Sigma Tau SpA   (Italy)

Author keywords

Anticancer activity; HDAC; Hydroxamic acid

Indexed keywords

BENZYL DERIVATIVE; ETHER DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CHIRALITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; QUANTUM YIELD; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZENE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ETHERS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35248841005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.014     Document Type: Article

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