An improved process for the synthesis of DMTMM-based coupling reagents

Tetrahedron Letters

Volumn 50, Issue 8, 2009, Pages 946-948

  Raw, Steven A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4,6 DIMETHOXY 1,3,5 TRIAZIN 2 YL) 4 METHYLMORPHOLINIUM HEXAFLUOROPHOSPHATE; 4 (4,6 DIMETHOXY 1,3,5 TRIAZIN 2 YL) 4 METHYLMORPHOLINIUM TETRAFLUOROBORATE; MORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DEGRADATION; REACTION TIME; STOICHIOMETRY; SYNTHESIS;

EID: 58149356958     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.12.047     Document Type: Article

References (20)

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15. 4.
16. 4 1b in both acetonitrile and water. When the unmodified process is used, the isolated yield of 1d is 47%, product loss to the mother liquors accounting for this significantly lower yield. Conducting the reaction at higher concentration significantly improves recovery.
17. 7a
18. 6, using 1,2,4,5-tetrachloro-3-nitrobenzene as an internal standard.
19. 3 241.1295. Found 241.1297 (0.6 ppm error)].
20. 7a