Association of the MTHFR C677T polymorphism with primary brain tumor risk

Tumor Biology

Volumn 34, Issue 6, 2013, Pages 3457-3464

  Xu, Chen ^a   Yuan, Lutao ^a   Tian, Hengli ^a   Cao, Heli ^a   Chen, Shiwen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Gene polymorphism; Glioma; Meningioma; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ARTICLE; BRAIN TUMOR; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; ETHNICITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GLIOMA; HUMAN; MENINGIOMA; MTHFR GENE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW;

EID: 84891491359     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0922-9     Document Type: Article

References (42)

1. Kutzbach C, Stokstad EL. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine. Biochim Biophys Acta. 1971;250:459-77.
2. Jaffe JJ, Chrin LR. Folate metabolism in filariae: enzymes associated with 5,10-methylenetetrahydrofolate. J Parasitol. 1980;66:53-8.
3. Chen H, Zhu J. C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model. Med Hypotheses. 2013;80:679-83.
4. Khandanpour N, Willis G, Meyer FJ, Armon MP, Loke YK, Wright AJ, et al. Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: a case-control study and meta-analysis. J Vasc Surg. 2009;49:711-8.
5. Jin F, Qu LS, Shen XZ. Association between the methylenetetrahydrofolate reductase C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis. Diagn Pathol. 2009;4:39.
6. Zhang J, Qiu LX, Wang ZH, Wu XH, Liu XJ, Wang BY, et al. MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls. Breast Cancer Res Treat. 2010;123:549-55.
7. Kawamoto R, Kohara K, Oka Y, Tomita H, Tabara Y, Miki T. An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke. J Stroke Cerebrovasc Dis. 2005;14:67-74.
8. Zhang L, Liu W, Hao Q, Bao L, Wang K. Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk. Int J Mol Sci. 2012;13:4009-20.
9. Fattal-Valevski A, Bassan H, Korman SH, Lerman-Sagie T, Gutman A, Harel S. Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis. J Child Neurol. 2000;15:539-43.
10. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics. 2001;1:189-201.
11. Ostrom QT, Barnholtz-Sloan JS. Current state of our knowledge on brain tumor epidemiology. Curr Neurol Neurosci Rep. 2011;11:329-35.
12. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, et al. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008;113:1953-68.
13. Wrensch M, Minn Y, Chew T, Bondy M, Berger MS. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol. 2002;4:278-99.
14. Sima X, Xu J, Li Q, Luo L, Liu J, You C. Gene-gene interactions between interleukin-12A and interleukin-12B with the risk of brain tumor. DNA Cell Biol. 2012;31:219-23.
15. Ruan Z, Zhao Y, Yan L, Chen H, Fan W, Chen J, et al. Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma. Front Biosci (Elite Ed). 2011;3:33-45.
16. Montelli Tde C, Peracoli MT, Rogatto SR, Kaneno R, do Prado CH, Rocha Pde M. Genetic and modifying factors that determine the risk of brain tumors. Cent Nerv Syst Agents Med Chem. 2011;11:8-30.
17. Khatri RG, Navaratne K, Weil RJ. The role of a single nucleotide polymorphism of MDM2 in glioblastoma multiforme. J Neurosurg. 2008;109:842-8.
18. Cochran WG. The comparison of percentages in matched samples. Biometrika. 1950;37:256-66.
19. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60.
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.
21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-48.
22. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-34.
23. Stuck AE, Rubenstein LZ, Wieland D. Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ. 1998;316:469. author reply 70-1.
24. Sciacca FL, Ciusani E, Silvani A, Corsini E, Frigerio S, Pogliani S, et al. Genetic and plasma markers of venous thromboembolism in patients with high grade glioma. Clin Cancer Res. 2004;10:1312-7.
25. Semmler A, Simon M, Moskau S, Linnebank M. The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme. Cancer Epidemiol Biomark Prev. 2006;15:2314-6.
26. Kafadar AM, Yilmaz H, Kafadar D, Ergen A, Zeybek U, Bozkurt N, et al. C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas. Anticancer Res. 2006;26:2445-9.
27. Sirachainan N, Wongruangsri S, Kajanachumpol S, Pakakasama S, Visudtibhan A, Nuchprayoon I, et al. Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children. Cancer Detect Prev. 2008;32:72-8.
28. Bethke L, Webb E, Murray A, Schoemaker M, Feychting M, Lonn S, et al. Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma. Cancer Epidemiol Biomark Prev. 2008;17:1195-202.
29. Semmler A, Simon M, Moskau S, Linnebank M. Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation. J Neurosurg. 2008;108:999-1004.
30. da Costa DM, de Lima GP, Faria MH, Rabenhorst SH. Polymorphisms of folate pathway enzymes (methylenetetrahydrofolate reductase and thymidylate synthase) and their relationship with thymidylate synthase expression in human astrocytic tumors. DNA Cell Biol. 2012;31:57-66.
31. Li R, Wang R, Li Y, Li X, Feng Y, Jiang C. Association study on MTHFR polymorphisms and meningioma in northern China. Gene. 2013;516:291-3.
32. Kim TY, Zhong S, Fields CR, Kim JH, Robertson KD. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res. 2006;66:7490-501.
33. Nikbakht M, MalekZadeh K, Kumar Jha A, Askari M, Marwaha RK, Kaul D, et al. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India. Exp Oncol. 2012;34:43-8.
34. Koppen IJ, Hermans FJ, Kaspers GJ. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol. 2010;148:3-14.
35. Baylin SB. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol. 2005;2 Suppl 1:S4-S11.
36. Botezatu A, Socolov D, Iancu IV, Huica I, Plesa A, Ungureanu C, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer. J Cell Mol Med. 2013;17:543-9.
37. Fard-Esfahani P, Mohammadi Torbati P, Hashemi Z, Fayaz S, Golkar M. Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males. Acta Med Iran. 2012;50:657-63.
38. Diakite B, Tazzite A, Hamzi K, Jouhadi H, Nadifi S. Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women. Afr Health Sci. 2012;12:204-9.
39. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64:169-72.
40. Domagala TB, Adamek L, Nizankowska E, Sanak M, Szczeklik A. Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease. Blood Coagul Fibrinolysis. 2002;13:423-31.
41. Gava MM, Kayaki EA, Bianco B, Teles JS, Christofolini DM, Pompeo AC, et al. Polymorphisms in folate-related enzyme genes in idiopathic infertile Brazilian men. Reprod Sci. 2011;18:1267-72.
42. Jiang L, Fang X, Bao Y, Zhou JY, Shen XY, Ding MH, et al. Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies. PLoS One. 2013;8:e55597.