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Volumn 8, Issue 11, 2013, Pages

Roscovitine-induced apoptosis in neutrophils and neutrophil progenitors is regulated by the Bcl-2-family members Bim, Puma, noxa and Mcl-1

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN NOXA; PUMA PROTEIN; ROSCOVITINE;

EID: 84891465803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079352     Document Type: Article
Times cited : (17)

References (34)
  • 1
    • 78649375771 scopus 로고    scopus 로고
    • Neutrophils, from marrow to microbes
    • doi:10.1016/j.immuni.2010.11.011. PubMed: 21094463
    • Borregaard N (2010) Neutrophils, from marrow to microbes. Immunity 33: 657-670. doi:10.1016/j.immuni.2010.11.011. PubMed: 21094463.
    • (2010) Immunity , vol.33 , pp. 657-670
    • Borregaard, N.1
  • 2
    • 77956025424 scopus 로고    scopus 로고
    • In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
    • doi:10.1182/blood-2010-01-259028. PubMed: 20410504
    • Pillay J, den Braber I, Vrisekoop N, Kwast LM, de Boer RJ et al. (2010) In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood 116: 625-627. doi:10.1182/blood-2010-01-259028. PubMed: 20410504.
    • (2010) Blood , vol.116 , pp. 625-627
    • Pillay, J.1    Den Braber, I.2    Vrisekoop, N.3    Kwast, L.M.4    De Boer, R.J.5
  • 4
    • 79958002788 scopus 로고    scopus 로고
    • Doubts concerning the recently reported human neutrophil lifespan of 5.4 days
    • author reply: 21636720
    • Tofts PS, Chevassut T, Cutajar M, Dowell NG, Peters AM (2011) Doubts concerning the recently reported human neutrophil lifespan of 5.4 days. Blood 117: 6050-6054; author reply: 21636720.
    • (2011) Blood , vol.117 , pp. 6050-6054
    • Tofts, P.S.1    Chevassut, T.2    Cutajar, M.3    Dowell, N.G.4    Peters, A.M.5
  • 5
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • doi:10.1038/nri957. PubMed: 12461569
    • Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2: 965-975. doi:10.1038/nri957. PubMed: 12461569.
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 6
    • 67249093699 scopus 로고    scopus 로고
    • Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis
    • PubMed: 19478887
    • Koedel U, Frankenberg T, Kirschnek S, Obermaier B, Häcker H et al. (2009) Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLOS Pathog 5: e1000461. PubMed: 19478887.
    • (2009) PLOS Pathog , vol.5
    • Koedel, U.1    Frankenberg, T.2    Kirschnek, S.3    Obermaier, B.4    Häcker, H.5
  • 7
    • 44449102749 scopus 로고    scopus 로고
    • Apoptotic cells protect mice against lipopolysaccharide-induced shock
    • PubMed: 18354223
    • Ren Y, Xie Y, Jiang G, Fan J, Yeung J et al. (2008) Apoptotic cells protect mice against lipopolysaccharide-induced shock. J Immunol 180: 4978-4985. PubMed: 18354223.
    • (2008) J Immunol , vol.180 , pp. 4978-4985
    • Ren, Y.1    Xie, Y.2    Jiang, G.3    Fan, J.4    Yeung, J.5
  • 8
    • 80052230860 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
    • doi:10.1189/jlb.0211062. PubMed: 21562052
    • McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I et al. (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol 90: 855-865. doi:10.1189/jlb.0211062. PubMed: 21562052.
    • (2011) J Leukoc Biol , vol.90 , pp. 855-865
    • McGrath, E.E.1    Marriott, H.M.2    Lawrie, A.3    Francis, S.E.4    Sabroe, I.5
  • 9
    • 57149112608 scopus 로고    scopus 로고
    • Double-edged swords as cancer therapeutics: Simultaneously targeting p53 and NF-kappaB pathways
    • doi:10.1038/nrd2759. PubMed: 19043452
    • Dey A, Tergaonkar V, Lane DP (2008) Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways. Nat Rev Drug Discov 7: 1031-1040. doi:10.1038/nrd2759. PubMed: 19043452.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 1031-1040
    • Dey, A.1    Tergaonkar, V.2    Lane, D.P.3
  • 10
    • 33748462267 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
    • doi:10.1038/nm1468. PubMed: 16951685
    • Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA et al. (2006) Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 12: 1056-1064. doi:10.1038/nm1468. PubMed: 16951685.
    • (2006) Nat Med , vol.12 , pp. 1056-1064
    • Rossi, A.G.1    Sawatzky, D.A.2    Walker, A.3    Ward, C.4    Sheldrake, T.A.5
  • 11
    • 84866764681 scopus 로고    scopus 로고
    • R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae
    • PubMed: 22692577
    • Hoogendijk AJ, Roelofs JJ, Duitman J, van Lieshout MH, Blok DC et al. (2012) R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. Mol Med 18: 1086-1095. PubMed: 22692577.
    • (2012) Mol Med , vol.18 , pp. 1086-1095
    • Hoogendijk, A.J.1    Roelofs, J.J.2    Duitman, J.3    Van Lieshout, M.H.4    Blok, D.C.5
  • 12
    • 84869082844 scopus 로고    scopus 로고
    • Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
    • doi:10.1038/cdd.2012.80. PubMed: 22743999
    • Leitch AE, Lucas CD, Marwick JA, Duffin R, Haslett C et al. (2012) Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation. Cell Death Differ 19: 1950-1961. doi:10.1038/cdd.2012.80. PubMed: 22743999.
    • (2012) Cell Death Differ , vol.19 , pp. 1950-1961
    • Leitch, A.E.1    Lucas, C.D.2    Marwick, J.A.3    Duffin, R.4    Haslett, C.5
  • 13
    • 20444477948 scopus 로고    scopus 로고
    • Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
    • doi:10.1158/0008-5472.CAN-05-0233. PubMed: 15958589
    • MacCallum DE, Melville J, Frame S, Watt K, Anderson S et al. (2005) Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res 65: 5399-5407. doi:10.1158/0008-5472.CAN-05-0233. PubMed: 15958589.
    • (2005) Cancer Res , vol.65 , pp. 5399-5407
    • MacCallum, D.E.1    Melville, J.2    Frame, S.3    Watt, K.4    Anderson, S.5
  • 14
    • 23044439051 scopus 로고    scopus 로고
    • Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
    • doi:10.1182/blood-2005-01-0320. PubMed: 15827128
    • Raje N, Kumar S, Hideshima T, Roccaro A, Ishitsuka K et al. (2005) Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood 106: 1042-1047. doi:10.1182/blood-2005-01-0320. PubMed: 15827128.
    • (2005) Blood , vol.106 , pp. 1042-1047
    • Raje, N.1    Kumar, S.2    Hideshima, T.3    Roccaro, A.4    Ishitsuka, K.5
  • 15
    • 77951050556 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis
    • doi:10.1002/eji.200939664. PubMed: 20127676
    • Leitch AE, Riley NA, Sheldrake TA, Festa M, Fox S et al. (2010) The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis. Eur J Immunol 40: 1127-1138. doi:10.1002/eji.200939664. PubMed: 20127676.
    • (2010) Eur J Immunol , vol.40 , pp. 1127-1138
    • Leitch, A.E.1    Riley, N.A.2    Sheldrake, T.A.3    Festa, M.4    Fox, S.5
  • 16
    • 64049114316 scopus 로고    scopus 로고
    • Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
    • doi:10.1182/blood-2008-05-159145. PubMed: 19064728
    • Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP et al. (2009) Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113: 2805-2815. doi:10.1182/blood-2008-05- 159145. PubMed: 19064728.
    • (2009) Blood , vol.113 , pp. 2805-2815
    • Steimer, D.A.1    Boyd, K.2    Takeuchi, O.3    Fisher, J.K.4    Zambetti, G.P.5
  • 17
    • 77953378973 scopus 로고    scopus 로고
    • Ubiquitin-independent degradation of antiapoptotic MCL-1
    • doi:10.1128/MCB.01266-09. PubMed: 20385764
    • Stewart DP, Koss B, Bathina M, Perciavalle RM, Bisanz K et al. (2010) Ubiquitin-independent degradation of antiapoptotic MCL-1. Mol Cell Biol 30: 3099-3110. doi:10.1128/MCB.01266-09. PubMed: 20385764.
    • (2010) Mol Cell Biol , vol.30 , pp. 3099-3110
    • Stewart, D.P.1    Koss, B.2    Bathina, M.3    Perciavalle, R.M.4    Bisanz, K.5
  • 18
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • doi:10.1038/nrm2308. PubMed: 18097445
    • Youle RJ, Strasser A (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59. doi:10.1038/nrm2308. PubMed: 18097445.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 19
    • 84873307384 scopus 로고    scopus 로고
    • Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
    • doi:10.1016/j.cell.2012.12.031. PubMed: 23374347
    • Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C et al. (2013) Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis. Cell 152: 519-531. doi:10.1016/j.cell.2012. 12.031. PubMed: 23374347.
    • (2013) Cell , vol.152 , pp. 519-531
    • Czabotar, P.E.1    Westphal, D.2    Dewson, G.3    Ma, S.4    Hockings, C.5
  • 20
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • doi:10.1016/S1535-6108(02)00127-7. PubMed: 12242151
    • Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S et al. (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192. doi:10.1016/S1535-6108(02)00127-7. PubMed: 12242151.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5
  • 21
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • doi:10.1101/gad.1304105. PubMed: 15901672
    • Willis SN, Chen L, Dewson G, Wei A, Naik E et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19: 1294-1305. doi:10.1101/gad.1304105. PubMed: 15901672.
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5
  • 22
    • 81355146366 scopus 로고    scopus 로고
    • A unified model of mammalian BCL-2 protein family interactions at the mitochondria
    • doi:10.1016/j.molcel.2011.10.001. PubMed: 22036586
    • Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J et al. (2011) A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 44: 517-531. doi:10.1016/j.molcel.2011.10.001. PubMed: 22036586.
    • (2011) Mol Cell , vol.44 , pp. 517-531
    • Llambi, F.1    Moldoveanu, T.2    Tait, S.W.3    Bouchier-Hayes, L.4    Temirov, J.5
  • 23
    • 33645318751 scopus 로고    scopus 로고
    • Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
    • doi:10.1038/nmeth865. PubMed: 16554834
    • Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H et al. (2006) Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods 3: 287-293. doi:10.1038/nmeth865. PubMed: 16554834.
    • (2006) Nat Methods , vol.3 , pp. 287-293
    • Wang, G.G.1    Calvo, K.R.2    Pasillas, M.P.3    Sykes, D.B.4    Häcker, H.5
  • 24
    • 80053958679 scopus 로고    scopus 로고
    • Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa
    • doi:10.1038/cdd.2011.69. PubMed: 21660046
    • Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S et al. (2011) Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa. Cell Death Differ 18: 1805-1814. doi:10.1038/cdd.2011.69. PubMed: 21660046.
    • (2011) Cell Death Differ , vol.18 , pp. 1805-1814
    • Kirschnek, S.1    Vier, J.2    Gautam, S.3    Frankenberg, T.4    Rangelova, S.5
  • 25
    • 79957913018 scopus 로고    scopus 로고
    • In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils
    • 10.1096/fj.10-178517. PubMed: 21368104
    • McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS et al. (2011) In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB J 25: 1972-1982. 10.1096/fj.10-178517. PubMed: 21368104.
    • (2011) FASEB J , vol.25 , pp. 1972-1982
    • McDonald, J.U.1    Cortini, A.2    Rosas, M.3    Fossati-Jimack, L.4    Ling, G.S.5
  • 26
    • 33745841375 scopus 로고    scopus 로고
    • FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
    • doi:10.1084/jem.20060353. PubMed: 16801400
    • You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G et al. (2006) FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203: 1657-1663. doi:10.1084/jem.20060353. PubMed: 16801400.
    • (2006) J Exp Med , vol.203 , pp. 1657-1663
    • You, H.1    Pellegrini, M.2    Tsuchihara, K.3    Yamamoto, K.4    Hacker, G.5
  • 27
    • 34547127636 scopus 로고    scopus 로고
    • Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    • doi:10.1038/ni1487. PubMed: 17618288
    • Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM et al. (2007) Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol 8: 856-863. doi:10.1038/ni1487. PubMed: 17618288.
    • (2007) Nat Immunol , vol.8 , pp. 856-863
    • Huntington, N.D.1    Puthalakath, H.2    Gunn, P.3    Naik, E.4    Michalak, E.M.5
  • 28
    • 13544263218 scopus 로고    scopus 로고
    • The transcriptional program of terminal granulocytic differentiation
    • doi:10.1182/blood-2004-08-3346. PubMed: 15514007
    • Theilgaard-Mönch K, Jacobsen LC, Borup R, Rasmussen T, Bjerregaard MD et al. (2005) The transcriptional program of terminal granulocytic differentiation. Blood 105: 1785-1796. doi:10.1182/blood-2004-08-3346. PubMed: 15514007.
    • (2005) Blood , vol.105 , pp. 1785-1796
    • Theilgaard-Mönch, K.1    Jacobsen, L.C.2    Borup, R.3    Rasmussen, T.4    Bjerregaard, M.D.5
  • 29
    • 79952271269 scopus 로고    scopus 로고
    • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    • doi:10.1038/nature09779. PubMed: 21368834
    • Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W et al. (2011) Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471: 110-114. doi:10.1038/nature09779. PubMed: 21368834.
    • (2011) Nature , vol.471 , pp. 110-114
    • Wertz, I.E.1    Kusam, S.2    Lam, C.3    Okamoto, T.4    Sandoval, W.5
  • 30
    • 84863726664 scopus 로고    scopus 로고
    • BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
    • doi:10.1038/cdd.2012.9. PubMed: 22343714
    • Wilfling F, Weber A, Potthoff S, Vögtle FN, Meisinger C et al. (2012) BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell Death Differ 19: 1328-1336. doi:10.1038/cdd.2012.9. PubMed: 22343714.
    • (2012) Cell Death Differ , vol.19 , pp. 1328-1336
    • Wilfling, F.1    Weber, A.2    Potthoff, S.3    Vögtle, F.N.4    Meisinger, C.5
  • 31
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • doi:10.1016/j.molcel.2004.12.030. PubMed: 15694340
    • Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI et al. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393-403. doi:10.1016/j.molcel.2004.12.030. PubMed: 15694340.
    • (2005) Mol Cell , vol.17 , pp. 393-403
    • Chen, L.1    Willis, S.N.2    Wei, A.3    Smith, B.J.4    Fletcher, J.I.5
  • 32
    • 68149153007 scopus 로고    scopus 로고
    • Noxa: At the tip of the balance between life and death
    • doi:10.1038/onc.2009.46. PubMed: 19641509
    • Ploner C, Kofler R, Villunger A (2008) Noxa: at the tip of the balance between life and death. Oncogene 27 Suppl 1: S84-S92. doi:10.1038/onc.2009.46. PubMed: 19641509.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Ploner, C.1    Kofler, R.2    Villunger, A.3
  • 33
    • 13844319184 scopus 로고    scopus 로고
    • Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells
    • doi:10.1126/science.1106114. PubMed: 15718471
    • Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S et al. (2005) Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307: 1101-1104. doi:10.1126/science.1106114. PubMed: 15718471.
    • (2005) Science , vol.307 , pp. 1101-1104
    • Opferman, J.T.1    Iwasaki, H.2    Ong, C.C.3    Suh, H.4    Mizuno, S.5
  • 34
    • 84865200787 scopus 로고    scopus 로고
    • NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1
    • doi:10.1038/cdd.2012.16. PubMed: 22361683
    • Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J et al. (2012) NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Differ 19: 1424-1434. doi:10.1038/cdd.2012.16. PubMed: 22361683.
    • (2012) Cell Death Differ , vol.19 , pp. 1424-1434
    • Craxton, A.1    Butterworth, M.2    Harper, N.3    Fairall, L.4    Schwabe, J.5


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