Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat

Molecular Nutrition and Food Research

Volumn 58, Issue 1, 2014, Pages 211-215

  Magielse, Joanna ^a   Verlaet, Annelies ^a   Breynaert, Annelies ^a   Keenoy, Begoña Manuel Y ^a   Apers, Sandra ^a   Pieters, Luc ^a   Hermans, Nina ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

8 Hydroxydeoxyguanosine (8 OHdG); Artichoke; Cynara scolymus; Glutathione (GSH); Malondialdehyde (MDA)

Indexed keywords

8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE; DRUG DERIVATIVE; GLUTATHIONE; MALONALDEHYDE; PLANT EXTRACT; STREPTOZOCIN;

8-HYDROXYDEOXYGUANOSINE (8-OHDG); ANIMAL; ARTICHOKE; ARTICLE; BODY WEIGHT; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUTATHIONE (GSH); MALONDIALDEHYDE (MDA); METABOLISM; OXIDATIVE STRESS; PLANT LEAF; RAT; WISTAR RAT;

8-HYDROXYDEOXYGUANOSINE (8-OHDG); ARTICHOKE; CYNARA SCOLYMUS; GLUTATHIONE (GSH); MALONDIALDEHYDE (MDA);

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CYNARA SCOLYMUS; DEOXYGUANOSINE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; GLUTATHIONE; MALONDIALDEHYDE; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 84891453084     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300282     Document Type: Article

References (27)

1. Zapolska-Downar, D., Zapolski-Downar, A., Naruszewicz, M., Siennicka, A. et al., Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci. 2002, 71, 2897-2908.
2. Betancor-Fernandez, A., Pérez-Gálvez, A., Sies, H., Stahl, W., Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J. Pharm. Pharmacol. 2003, 55, 981-986.
3. Menghini, L., Genovese, S., Epifano, F., Tirillini, B. et al., Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation. Int. J. Immunopathol. Pharmacol. 2010, 23, 601-610.
4. Jimenez-Escrig, A., Dragsted, L.-O., Daneshvar, B., Pulido, R. et al., In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. J. Agric. Food Chem. 2003, 51, 5540-5545.
5. Manach, C., Donovan, J.-L., Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic. Res. 2004, 38, 771-785.
6. Hermans, N., Cos, P., Maes, L., Vanden Berghe, D. et al., Challenges and pitfalls in antioxidant research. Curr. Med. Chem. 2007, 14, 417-430.
7. Mulinacci, N., Prucher, D., Peruzzi, M., Romani, A. et al., Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content. J. Pharm. Biomed. 2004, 34, 349-357.
8. Bebrevska, L., Foubert, K., Hermans, N., Chatterjee, S. et al., In vivo antioxidative activity of a quantified Pueraria lobata root extract. J. Ethnopharmacol. 2010, 127, 112-117.
9. Hermans, N., Cos, P., De Meyer, G.-R., Maes, L. et al., Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidants. J. Pharm. Pharmacol. 2007, 59, 131-136.
10. Englisch, W., Beckers, C., Unkauf, M., Ruepp, M. et al., Efficacy of artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittel-Forschung 2000, 50, E260-E265.
11. Barnes, J., Anderson, L.-A., Phillipson, J.-D. (Eds.), Herbal Medicines, Pharmaceutical Press, London 2007.
12. Holtmann, G., Adam, B., Haag, S., Collet, W. et al., Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial. Aliment. Pharmacol. Ther. 2003, 18, 1099-1105.
13. Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659-661.
14. Kusku-Kiraz, Z., Mehmetcik, G., Dogru-Abbasoglu, S., Uysal, M., Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet. Phytother. Res. 2010, 24, 565-570.
15. Kanazawa, K., Uehara, M., Yanagitani, H., Hashimoto, T., Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. Arch. Biochem. Biophys. 2006, 455, 197-203.
16. Turunen, M., Olsson, J., Dallner, G., Metabolism and function of coenzyme Q. Biochim. Biophys. Acta 2004, 1660, 171-199.
17. Bundy, R., Walker, A.-F., Middleton, R.-W., Marakis, G. et al., Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial. Phytomedicine 2008, 15, 668-675.
18. Gebhardt, R., Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol. Appl. Pharm. 1997, 144, 279-286.
19. Miccadei, S., Di Venere, D., Cardinali, A., Romano, F. et al., Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr. Cancer 2008, 60, 276-283.
20. Mehmetcik, G., Ozdemirler, G., Kocak-Toker, N., Cevikbas, U. et al., Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Exp. Toxicol. Pathol. 2008, 60, 475-480.
21. Aquilano, K., Baldelli, S., Rotilio, G., Ciriolo, M.-R., Role of nitric oxide synthases in Parkinson's Disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem. Res. 2008, 33, 2416-2426.
22. Tognoni, G., Avanzini, F., Pangrazzi, J., Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001, 357, 89-95.
23. Lonn, E., Bosch, J., Yusuf, S., Sheridan, P. et al., Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005, 293, 1338-1347.
24. Mursu, J., Voutilainen, S., Nurmi, T., Alfthan, G. et al., The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial. Free Radic. Biol. Med. 2005, 38, 527-534.
25. Noordzij, M., Uiterwaal, C.-S., Arends, L.-R., Kok, F.-J. et al., Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J. Hypertens. 2005, 23, 921-928.
26. Yordi, E.-G., Pérez, E.-M., Matos, M.-J., Villares, E.-U., in: Bouayed, J., Bohn, T. (Eds.), Nutrition, Well-Being and Health, InTech, Rijeka 2012, pp. 23-47.
27. Jacociunas, L.-V., Rodrigues de Andrade, H.-H., Lehmann, M., Pedersini, L.-W. et al., Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alteration in CHO cells. Phytomedicine 2013, 20, 1131-1134.