Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet

Phytotherapy Research

Volumn 24, Issue 4, 2010, Pages 565-570

  Kusku Kiraz Z ^a   Mehmetcik G ^b   Dogru Abbasoglu S ^a   Uysal, Müjdat ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b NEAR EAST UNIVERSITY   (Turkey)

Author keywords

Apo B containing lipoproteins; Artichoke leaf extract; Hypercholesterolemia; Lipid peroxidation; Serum

Indexed keywords

ALKADIENE; ARTICHOKE LEAF EXTRACT; CHOLESTEROL; CHOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICHOKE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HOMEOSTASIS; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; APOLIPOPROTEINS B; CHOLESTEROL, DIETARY; CYNARA SCOLYMUS; DRUG EVALUATION, PRECLINICAL; FEMALE; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDS; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

CYNARA SCOLYMUS; RATTUS;

EID: 77951592404     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2985     Document Type: Article

References (41)

1. Ahotupa M, Ruutu M, Mantyla E. 1996. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem 29: 139-144. (Pubitemid 26115431)
2. Aktay G, Deliorman D, Ergun E, Ergun, F, Yeşilada E, Çevik C. 2000. Hepatoprotective effects of Turkish folk remedies on experimental liver injury. J Ethnopharmacol 73: 121-129.
3. Balkan J, Doǧru-Abbasoǧlu S, Aykaç-Toker G, Uysal M. 2004a. Serum prooxidant-antioxidant balance and LDL oxidation in healthy subjects with different cholesterol levels. Clin Exp Med 3: 237-242. (Pubitemid 38570006)
4. Balkan J, Doǧru-Abbasoǧlu S, Aykaç-Toker G, Uysal M. 2004b. The effects of high cholesterol diets on lipids and oxidative stress in plasma, liver and aorta of rabbits and rats. Nutr Res 24: 229-234. (Pubitemid 38328542)
5. Balkan J, Hatipoǧlu A, Aykaç-Toker G, Uysal M. 2003. Influence of hazelnut oil administration on peroxidation status of erythrocytes and apolipoprotein B-100 containing lipoproteins in rabbits fed on a high cholesterol diet. J Agric Food Chem 51: 3905-3909.
6. Benzie IFF, Strain JJ. 1996. The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 239: 70-76.
7. Brown JE, Rice-Evans CA. 1998. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res 29: 247-255. (Pubitemid 28499598)
8. Buege JA, Aust JD. 1978. Microsomal lipid peroxidation. Methods Enzymol 52: 302-310.
9. Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HCR. 2008. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: A randomized, double blind placebo controlled trial. Phytomedicine 15: 668-675.
10. Deepa PR, Varalakshmi P. 2005. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 355: 119-130.
11. Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V. 2000. Efficacy of artichoke dry extract in patients with hyperlipoproteinemia. Arznheim Forsch Drug Res 50: 260-265. (Pubitemid 30167593)
12. Esterbauer H, Gebicki J, Puhl H, Jürgens G. 1992. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 13: 341-390.
13. Gebhardt R. 1997. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultered rat hepatocytes. Toxicol Appl Pharmacol 144: 279-286. (Pubitemid 27268349)
14. Gebhardt R. 1998. Inhibition of cholesterol biosynthesis in primary cultered rat hepatocytes by artichoke (cynara scolymus L.) extracts. J Pharmacol Exp Ther 286: 1122-1128. (Pubitemid 29135519)
15. Grundy SM. 1990. Cholesterol and coronary heart disease. JAMA 264: 3053-3059.
16. Itabe H. 2003. Oxidized low-density lipoproteins: What is understood and what remains to be clarified. Biol Pharm Bull 26: 1-9. (Pubitemid 39663633)
17. Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. 2008. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact 176: 88-98.
18. Jimenez-Escrig A, Dragsted LO, Daneshvar B, Pulido R, Saura-Calixto F. 2003. In Vitro antioxidant activities of edible artichoke (Cynara Scolymus L.) and effect on biomarkers of antioxidants in rats. J Argric Food Chem 51: 5540-5545.
19. Joy JF, Haber SL. 2007. Clinical uses of artichoke leaf extract. Am J Health- Syst Ph 64: 1906-1909.
20. Kumar SA, Sudhahar V, Varalakshmi P. 2006. Protective role of eicosapentaenoate-lipoate (EPA-LA) derivative in combating in hypercholesterolemic atherogenesis. Atherosclerosis 189: 115-122. (Pubitemid 44080526)
21. Lavy A, Brook GJ, Dankner G, Amotz AB, Aviram M. 1991. Enhanced in vitro oxidation of plasma lipoproteins derived from hypercholesterolemic patients. Metabolism 40: 794-799.
22. Llorach R, Espin JC, Tomas-Barberan FA, Ferreres F. 2002. Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics. J Agr Food Chem 50: 3458-3464. (Pubitemid 34579274)
23. Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F, Vaudo G, Mannarino E. 2004. Artichoke juice improves endothelial function in hyperlipemia. Life Sci 76: 775-782. (Pubitemid 39576151)
24. Mahfouz MM, Kummerow FA. 2000. Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits. J Nutr Biochem 11: 293-302.
25. Mehmetçik G, Özdemirler G, Koçak-Toker N, Cevikbaş U, Uysal M. 2008. Effect of pretreatment with artichoke extract on carbon tetrachlopride-induced liver injury and oxidative stress. Exp Toxicol Pathol 60: 475-480.
26. Moghadasian MH. 2002. Experimental atherosclerosis. A historical overview. Life Sci 70: 855-865.
27. Nakajima K, Nakano T, Tanaka A. 2006. The oxidative modification hypothesis of atherosclerosis: The comparison of atherogenic effects on oxidized LDL and remnant lipoproteins in plasma. Clin Chim Acta 367: 36-47.
28. Nazni P, Vijayakumar TP, Alagianambi P, Amirthaveni M. 2006. Hypoglycemic and hypolipidemic effect of Cynara Scolymus among selected type 2 diabetic individuals. Pakistan J Nutr 5: 147-151. (Pubitemid 44083849)
29. Nomikos T, Detopoulou P, Fragopoulou E, Pliakis E, Antonopoulou S. 2007. Boiled wild artichoke reduces postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. Nutr Res 27: 741-749. (Pubitemid 350153651)
30. O'Brien KD, Chait A. 1994. The biology of the artery wall in atherogenesis. Med Clin North Am 78: 41-67.
31. Özdemirler G, Küçük S, Orhan Y, Aykaç-Toker G, Uysal M. 2001. Increased lipid and protein oxidation in erythrocyte membranes of hypercholesterolemic subjects. Clin Biochem 34: 335-339. (Pubitemid 32607578)
32. Perez-Garcia F, Adzet T, Canigueral S. 2000. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radic Res 33: 661-665. (Pubitemid 32103705)
33. Pittler MH, Thompson CJ, Ernst E. 2002. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst Rev 3: CD003335.
34. Sener G, Balkan J, Çevikbaş U, Keyer-Uysal M, Uysal M. 2004. Melatonin reduces cholesterol accumulation and prooxidant state induced by high cholesterol diet in the plasma, the liver and probably in the aorta of C57BL/6J mice. J Pineal Res 36: 212-216. (Pubitemid 38429288)
35. Shih C-K, Chang J-H, Yang S-H, Chou T-W, Cheng H-H. 2008. ß -Carotene and canthaxanthine alter the pro-oxidation and antioxidation balance in rats fed a high-cholesterol and high-fat diet. Br J Nutr 99: 59-66.
36. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. 1985. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85.
37. Sudhahar V, Kumar SA, Varalakshmi P, Sundarapandiyan R. 2007. Mitigating role of lupeol and lupeol linoleate on hepatic lipemic-oxidative injury and lipoprotein peroxidation in experimental hypercholesterolemia. Mol Cell Biochem 295: 189-198. (Pubitemid 46158001)
38. Wang M, Simon JE, Aviles IF, He K, Zheng QY, Tadmor Y. 2003. Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J Agr Food Chem 51: 601-608.
39. Zapolska-Downar D, Zapolski-Downar A, Naruszewicz M, Siennicka A, Krasnodebska B, Kolodziej B. 2002. Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultered endothelial cells and monocytes. Life Sci 71: 2897-2908.
40. Zhang A, Vertommen J, Van Gaal L, De Leeuw I. 1994. A rapid and simple method for measuring the susceptibility of low-density-lipoprotein and very-low-density-lipoprotein to copper-catalysed oxidation. Clin Chim Acta 227: 159-173. (Pubitemid 24227308)
41. Zhu X, Zhang H, Lo R. 2004 Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L. ) and their antimicrobial activities. J Agric Food Chem 52: 7272-7278.