Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly

Journal of Biological Chemistry

Volumn 288, Issue 52, 2013, Pages 36773-36786

  Pandey, Alok ^a   Gordon, Donna M ^a,d   Pain, Jayashree ^a   Stemmler, Timothy L ^b   Dancis, Andrew ^c   Pain, Debkumar ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CYSTEINE DESULFURASE; FRATAXIN; SCAFFOLD PROTEIN; SUBSTRATE-BINDING SITES;

MITOCHONDRIA; PROTEINS; SCAFFOLDS (BIOLOGY);

AMINO ACIDS;

CELL PROTEIN; CYSTATHIONINE GAMMA LYASE; FRATAXIN; IRON; IRON SULFUR PROTEIN; ISD11 PROTEIN; ISU1 PROTEIN; MITOCHONDRIAL ENZYME; MUTANT PROTEIN; NFS1 PROTEIN; PERSULFIDE; SCAFFOLD PROTEIN; SULFUR DERIVATIVE; UNCLASSIFIED DRUG; YFH1 PROTEIN;

ARTICLE; BINDING KINETICS; BINDING SITE; CELL ISOLATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME MODIFICATION; ENZYME SUBSTRATE COMPLEX; FRIEDREICH ATAXIA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY;

EID: 84891379841     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.525857     Document Type: Article

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