Combining fiber dissection, plastination, and tractography for neuroanatomical education: Revealing the cerebellar nuclei and their white matter connections

Anatomical Sciences Education

Volumn 7, Issue 1, 2014, Pages 47-55

  Arnts, Hisse ^a   Kleinnijenhuis, Michiel ^a,b   Kooloos, Jan G M ^a   Schepens Franke, Annelieke N ^a   Van Cappellen van Walsum, Anne Marie ^a,b,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY   (Netherlands)

^c UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Brain dissection; Cerebellum; Diffusion tensor imaging (DTI) tractography; Fiber dissection; Medical education; Neuroanatomy; Neuroscience education; Plastination; White matter

Indexed keywords

ARTICLE; AUDIOVISUAL EQUIPMENT; BRAIN DISSECTION; CEREBELLUM; CEREBELLUM NUCLEUS; COMPUTER ASSISTED DIAGNOSIS; COMPUTER GRAPHICS; DIFFUSION TENSOR IMAGING; DIFFUSION TENSOR IMAGING (DTI) TRACTOGRAPHY; DISSECTION; EDUCATION; FEMALE; FIBER DISSECTION; FREEZING; HISTOLOGY; HUMAN; MALE; MEDICAL EDUCATION; METHODOLOGY; MIDDLE AGED; NERVE TRACT; NEUROANATOMY; NEUROSCIENCE EDUCATION; PLASTINATION; TEACHING; THREE DIMENSIONAL IMAGING; TISSUE FIXATION; WHITE MATTER;

BRAIN DISSECTION; CEREBELLUM; DIFFUSION TENSOR IMAGING (DTI) TRACTOGRAPHY; FIBER DISSECTION; MEDICAL EDUCATION; NEUROANATOMY; NEUROSCIENCE EDUCATION; PLASTINATION; WHITE MATTER;

CEREBELLAR NUCLEI; COMPUTER GRAPHICS; DIFFUSION TENSOR IMAGING; DISSECTION; FEMALE; FREEZING; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MALE; MIDDLE AGED; MODELS, ANATOMIC; NEURAL PATHWAYS; NEUROANATOMY; REPLICA TECHNIQUES; TEACHING; TISSUE FIXATION;

EID: 84891372381     PISSN: 19359772     EISSN: 19359780     Source Type: Journal    
DOI: 10.1002/ase.1385     Document Type: Article

References (75)

1. Adams CM, Wilson TD. 2011. Virtual cerebral ventricular system: An MR-based three-dimensional computer model. Anat Sci Educ 4:340-347.
2. Agrawal A, Kapfhammer JP, Kress A, Wichers H, Deep A, Feindel W, Sonntag VK, Spetzler RF, Preul MC. 2011. Josef Klingler's models of white matter tracts: Influences on neuroanatomy, neurosurgery, and neuroimaging. Neurosurgery 69:238-252.
3. Baeres FM, Møller M. 2001. Plastination of dissected brain specimens and Mulligan-stained sections of the human brain. Eur J Morphol 39:307-311.
4. Catani M, Howard RJ, Pajevic S, Jones DK. 2002. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 17:77-94.
5. Catani M, Thiebaut de Schotten M. 2008. A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44:1105-1132.
6. Ciccarelli O, Catani M, Johansen-Berg H, Clark C, Thompson A. 2008. Diffusion-based tractography in neurological disorders: Concepts, applications, and future developments. Lancet Neurol 7:715-727.
7. Clatworthy PL, Williams GB, Acosta-Cabronero J, Jones SP, Harding SG, Johansen-Berg H, Baron JC. 2010. Probabilistic tractography of the optic radiations-An automated method and anatomical validation. Neuroimage 49:2001-2012.
8. Codd AM, Choudhury B. 2011. Virtual reality anatomy: Is it comparable with traditional methods in the teaching of human forearm musculoskeletal anatomy? Anat Sci Educ 4:119-125.
9. Collins JP. 2008. Modern approaches to teaching and learning anatomy. BMJ 337:665-667.
10. Cornwall J. 2011. The diverse utility of wet prosections and plastinated specimens in teaching gross anatomy in New Zealand. Anat Sci Educ 4:269-274.
11. De Castro I, Christoph Dde H, dos Santos DP, Landeiro JA. 2005. Internal structure of the cerebral hemispheres: An introduction of fiber dissection technique. Arq Neuropsiquiatr 63:252-258.
12. DeHoff ME, Clark KL, Meganathan K. 2011. Learning outcomes and student-perceived value of clay modeling and cat dissection in undergraduate human anatomy and physiology. Adv Physiol Educ 35:68-65.
13. DeJong K, Henry RW. 2007. Silicone plastination of biological tissue: Cold-temperature technique Biodur S10/S15 technique and products. J Int Soc Plast 22:2-14.
14. Dimou S, Battisti RA, Hermens DF, Lagopoulos J. 2013. A systematic review of functional magnetic resonance imaging and diffusion tensor imaging modalities used in presurgical planning of brain tumour resection. Neurosurg Rev 36:205-214.
15. Drake RL, McBride JM, Lachman N, Pawlina W. 2009. Medical education in the anatomical sciences: The winds of change continue to blow. Anat Sci Educ 2:253-259.
16. Estevez ME, Lindgren KA, Bergethon PR. 2010. A novel three-dimensional tool for teaching human neuroanatomy. Anat Sci Educ 3:309-317.
17. Familiari G, Relucenti M, Heyn R, Baldini R, D'Andrea G, Familiari P, Bozzao A, Raco A. 2013. The value of neurosurgical and intraoperative magnetic resonance imaging and diffusion tensor imaging tractography in clinically integrated neuroanatomy modules: A cross-sectional study. Anat Sci Educ 6:294-306.
18. Fernandez-Miranda JC, Rhoton AL Jr, Kakizawa Y, Choi C, Alvarez-Linera J. 2008. The claustrum and its projection system in the human brain: A microsurgical and tractographic anatomical study. J Neurosurg 108:764-774.
19. Filley CM. 1998. The behavioral neurology of cerebral white matter. Neurology 50:1535-1540.
20. Filley CM. 2005. White matter and behavioral neurology. Ann N Y Acad Sci 1064:162-183.
21. Fruhstorfer BH, Palmer J, Brydges S, Abrahams PH. 2011. The use of plastinated prosections for teaching anatomy-The view of medical students on the value of this learning resource. Clin Anat 24:246-252.
22. Gluhbegovic N, Williams TH. 1980. The Human Brain: A Photographic Guide. 1st Ed. Hagerstown, MD: Harper & Row, Inc. 176 p.
23. Hammer N, Löffler S, Feja C, Sandrock M, Schmidt W, Bechmann I, Steinke H. 2012. Ethanol-glycerin fixation with thymol conservation: A potential alternative to formaldehyde and phenol embalming. Anat Sci Educ 5:225-233.
24. Heiervang E, Behrens TEJ, Mackay CE, Robson MD, Johansen-Berg H. 2006. Between session reproducibility and between subject variability of diffusion MR and tractography measures. Neuroimage 33:867-877.
25. Henry RW. 2007. Silicone plastination of biological tissue: Cold-temperature technique North Carolina technique and products. J Int Soc Plast 22:15-19.
26. Henry RW, Reed RB, Henry CL. 2001. "Classic" silicone processed specimens vs "new formula" silicone plastinated specimens: A two year study. J Int Soc Plast 16:33.
27. Jastrow H, Vollrath L. 2003. Teaching and learning gross anatomy using modern electronic media based on the visible human project. Clin Anat 16:44-54.
28. Johansen-Berg H, Rushworth MF. 2009. Using diffusion imaging to study human connectional anatomy. Annu Rev Neurosci 32:75-94.
29. Jones DG. 2002. Re-inventing anatomy: The impact of plastination on how we see the human body. Clin Anat 15:436-440.
30. Khot Z, Quinlan K, Norman GR, Wainman B. 2013. The relative effectiveness of computer-based and traditional resources for education in anatomy. Anat Sci Educ 6:211-215.
31. Klingler J. 1935. Erleichterung der makroskopischen Praeparation des Gehirns durch den Gefrierprozess. Schweiz Arch Neurol Psychiatr 36:247-256.
32. Klingler J, Gloor P. 1960. The connections of the amygdala and of the anterior temporal cortex in the human brain. J Comp Neurol 115:333-369.
33. Latorre RM, García-Sanz MP, Moreno M, Hernández F, Gil F, López O, Ayala MD, Ramírez G, Vázquez JM, Arencibia A, Henry RW. 2007. How useful is plastination in learning anatomy? J Vet Med Educ 34:172-176.
34. Le Bihan D. 2003. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 4:469-480.
35. Le Bihan D, Johansen-Berg H. 2012. Diffusion MRI at 25: Exploring brain tissue structure and function. Neuroimage 61:324-341.
36. Ludwig E, Klingler J. 1956. Atlas Cerebri Humani: Der innere Bau des Gehirns dargestellt auf Grund mackroskopischer Praeparate. Basel, Switzerland: S. Karger. 136 p.
37. Marks SC Jr. 2000. The role of three-dimensional information in health care and medical education: The implications for anatomy and dissection. Clin Anat 13:448-452.
38. Moon K, Filis AK, Cohen AR. 2010. The birth and evolution of neuroscience through cadaveric dissection. Neurosurgery 67:799-809.
39. Mori S, Wakana S, Nagae-Poetscher LM, van Zijl PCM. 2005. MRI Atlas of Human White Matter. 1st Ed. Amsterdam, The Netherlands: Elsevier, B.V. 239 p.
40. Mori S, Oishi K, Faria AV. 2009. White matter atlases based on diffusion tensor imaging. Curr Opin Neurol 22:362-269.
41. Motoike HK, O'Kane RL, Lenchner E, Haspel C. 2009. Clay modeling as a method to learn human muscles: A community college study. Anat Sci Educ 2:19-23.
42. Murillo OR, López-Soler M, Roda-Murillo A, Ramírez-Ortiz I. 2006. Plastination in the teaching of neuroanatomy. Eur J Anat 10:85-89.
43. Nguyen N, Nelson AJ, Wilson TD. 2012. Computer visualizations: Factors that influence spatial anatomy comprehension. Anat Sci Educ 5:98-108.
44. Nicholson DT, Chalk C, Funnell WR, Daniel SJ. 2006. Can virtual reality improve anatomy education? A randomised controlled study of a computer-generated three-dimensional anatomical ear model. Med Educ 40:1081-1087.
45. Nnodim JO. 1990. Learning human anatomy: By dissection or from prosections? Med Educ 24:389-395.
46. Nnodim JO, Ohanaka EC, Osuji CU. 1996. A follow-up comparative study of two modes of learning human anatomy: By dissection and from prosections. Clin Anat 9:258-262.
47. Nolte J, Angevine JBJr. 2007. The Human Brain in Photographs and Diagrams. 3rd Ed. St Louis. MO: C.V. Mosby Inc. 272 p.
48. NTP. 2010. National Toxicology Program. Final Report on Carcinogens Background Document for Formaldehyde. January 22, 2010. Research triangle Park, NC: U.S. Department of Health and Human Services, National Toxicology Program. 552 p. URL: http://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf [accessed 13 March 2013].
49. Oh CS, Kim JY, Choe YH. 2009. Learning of cross-sectional anatomy using clay models. Anat Sci Educ 2:156-159.
50. Pashaei S. 2010. A brief review on the history, methods and applications of plastination. Int J Morphol 28:1075-1079.
51. Peuskens D, van Loon J, Van Calenbergh F, van den Bergh R, Goffin J, Plets C. 2004. Anatomy of the anterior temporal lobe and the frontotemporal region demonstrated by fiber dissection. Neurosurgery 55:1174-1184.
52. Raoof A, Henry RW, Reed RB. 2007. Silicone plastination of biological tissue: Room-temperature technique Dow/Corcoran technique and products. J Int Soc Plast 22:21-25.
53. Reidenberg JS, Laitman JT. 2002. The new face of gross anatomy. Anat Rec 269:81-88.
54. Riederer BM. 2013. Plastination and its importance in teaching anatomy. Critical points for long-term preservation of human tissue. J Anat (in press; doi: 10.1111/joa.12056).
55. Schmahmann JD, Smith EE, Eichler FS, Filley CM. 2008. Cerebral white matter: Neuroanatomy, clinical neurology, and neurobehavioral correlates. Ann N Y Acad Sci 1142:266-309.
56. Sergovich A, Johnson M, Wilson TD. 2010. Explorable three-dimensional digital model of the female pelvis, pelvic contents, and perineum for anatomical education. Anat Sci Educ 3:127-133.
57. Skadorwa T, Kunicki J, Nauman P, Ciszek B. 2009. Image-guided dissection of human white matter tracts as a new method of modern neuroanatomical training. Folia Morphol (Warsz) 68:135-139.
58. Sora M-C, Brugger P, Traxler H. 1999. P40 plastination of human brain slices: Comparison between different immersion and impregnation conditions. J Int Soc Plast 14:22-24.
59. Steinke H, Pfeiffer S, Spanel-Borowski K. 2002. A new plastination technique for head slices containing brain. Ann Anat 184:353-358.
60. Sugand K, Abrahams P, Khurana A. 2010. The anatomy of anatomy: a review for its modernization. Anat Sci Educ 3:83-93.
61. Suriyaprapadilok L, Withyachumnarnkul B. 1997. Plastination of stained sections of the human brain: Comparison between different staining methods. J Int Soc Plast 12:27-32.
62. Tournier JD, Calamante F, Connelly A. 2012. MRtrix: Diffusion tractography in crossing fiber regions. Int J Imaging Syst Technol 22:53-66.
63. Ture U, Yasargil MG, Friedman AH, Al-Mefty O. 2000. Fiber dissection technique: Lateral aspect of the brain. Neurosurgery 47:417-426.
64. Ulfig N, Wuttke M. 1990. Plastination of stained sections of the human brain. Anat Anz 170:309-312.
65. van Baarsen K, Kleinnijenhuis M, Konert T, van Cappellen van Walsum AM, Grotenhuis A. 2013. Tractography demonstrates dentate-rubrothalamic tract disruption in an adult with cerebellar mutism. Cerebellum 12:617-622.
66. Venail F, Deveze A, Lallemant B, Guevara N, Mondain M. 2010. Enhancement of temporal bone anatomy learning with computer 3D rendered imaging software. Med Teach 32:e282-e288.
67. Visser E, Poser BA, Barth M, Zwiers MP. 2012. Reference-free unwarping of EPI data using dynamic off-resonance correction with multiecho acquisition (DOCMA). Magn Reson Med 68:1247-1254.
68. von Hagens G. 1979. Impregnation of soft biological specimens with thermosetting resins and elastomers. Anat Rec 194:247-255.
69. von Hagens G, Tiedemann K, Kriz W. 1987. The current potential of plastination. Anat Embryol (Berl) 175:411-421.
70. Wadood AA, Jabbar A, Das N. 2001. Plastination of whole brain specimen and brain slices. J Ayub Med Coll Abbottabad 13:11-13.
71. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. 2004. Fiber tract-based atlas of human white matter anatomy. Radiology 230:77-87.
72. Waters JR, Van Meter P, Perrotti W, Drogo S, Cyr RJ. 2005. Cat dissection vs. sculpting human structures in clay: An analysis of two approaches to undergraduate human anatomy laboratory education. Adv Physiol Educ 29:27-34.
73. Weiglein AH. 1997. Plastination in the neurosciences. Keynote lecture. Acta Anat (Basel) 158:6-9.
74. Winkelmann A. 2007. Anatomical dissection as a teaching method in medical school: A review of the evidence. Med Educ 41:15-22.
75. Zwiers MP. 2010. Patching cardiac and head motion artefacts in diffusion-weighted images. Neuroimage 53:565-575.