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Volumn 53, Issue 9, 2012, Pages 1666-1676

The role of natural killer cells in immunity against multiple myeloma

Author keywords

immunotherapy; multiple myeloma; Natural killer cells

Indexed keywords

BORTEZOMIB; CD2 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; DEXAMETHASONE; ELOTUZUMAB; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 21 RECEPTOR; L SELECTIN; LENALIDOMIDE; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; POMALIDOMIDE; RECOMBINANT ALPHA INTERFERON; RECOMBINANT INTERLEUKIN 2; THALIDOMIDE; UNINDEXED DRUG;

EID: 84865021329     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.676175     Document Type: Review
Times cited : (59)

References (142)
  • 1
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • K yle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111:2962-2972.
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 2
    • 79952713144 scopus 로고    scopus 로고
    • From myeloma precursor disease to multiple myeloma: New diagnostic concepts and opportunities for early intervention
    • L angren O, Kyle RA, Rajkumar SV. From myeloma precursor disease to multiple myeloma: New diagnostic concepts and opportunities for early intervention. Clin Cancer Res 2011;17:1243-1252.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1243-1252
    • Langren, O.1    Kyle, R.A.2    Rajkumar, S.V.3
  • 3
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • K umar SK, Rajkukmar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008;111:2516-2520.
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkukmar, S.V.2    Dispenzieri, A.3
  • 4
    • 34547677725 scopus 로고    scopus 로고
    • Immunodefi ciency and immunotherapy in multiple myeloma
    • P ratt G, Goodyear O, Moss P. Immunodefi ciency and immunotherapy in multiple myeloma. Br J Haematol 2007;138:563-569.
    • (2007) Br. J. Haematol , vol.138 , pp. 563-569
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 5
    • 50949124847 scopus 로고    scopus 로고
    • Human natural killer cells
    • C aligiuri MA. Human natural killer cells. Blood 2008;112:461-469.
    • (2008) Blood , vol.112 , pp. 461-469
    • Caligiuri, M.A.1
  • 6
    • 0016711166 scopus 로고
    • Natural cytotoxic reactiving of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specifi city
    • H erberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactiving of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specifi city. Int J Cancer 1985:16; 216-229.
    • (1985) Int. J. Cancer , vol.16 , pp. 216-229
    • Herberman, R.B.1    Nunn, M.E.2    Lavrin, D.H.3
  • 7
    • 0016762220 scopus 로고
    • Natural killer cells in the mouse. I. Cytotoxic cells wiThspecifi city for mouse Moloney leukemia cells. Specifi city and distribution according to genotype
    • K iessling R, Klien E, Wigzell G. Natural killer cells in the mouse. I. Cytotoxic cells wiThspecifi city for mouse Moloney leukemia cells. Specifi city and distribution according to genotype. Eur J Immunol 1975:5;112-117.
    • (1975) Eur. J. Immunol , vol.5 , pp. 112-117
    • Kiessling, R.1    Klien, E.2    Wigzell, G.3
  • 8
    • 78650970845 scopus 로고    scopus 로고
    • Innate or adaptive immunity? The example of natural killer cells
    • V ivier E, Raulet DH, Moretta A, et al. Innate or adaptive immunity? The example of natural killer cells. Science 2011;331:44-49.
    • (2011) Science , vol.331 , pp. 44-49
    • Vivier, E.1    Raulet, D.H.2    Moretta, A.3
  • 9
    • 33750694590 scopus 로고    scopus 로고
    • Activation, coactivation, and costimulation of resting human natural killer cells
    • B ryceson YT, March ME, Ljunggren HG, et a l. Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev 2006;214:73-91.
    • (2006) Immunol Rev. , vol.214 , pp. 73-91
    • Bryceson, Y.T.1    March, M.E.2    Ljunggren, H.G.3
  • 10
    • 0037105453 scopus 로고    scopus 로고
    • Natural killer cell receptors: New biology and insights into the graft-versus-leukemia eff ect
    • F arag SS, Fehniger TA, Ruggeri L, et a l. Natural killer cell receptors: New biology and insights into the graft-versus-leukemia eff ect. Blood 2002;100:1935-1947.
    • (2002) Blood , vol.100 , pp. 1935-1947
    • Farag, S.S.1    Fehniger, T.A.2    Ruggeri, L.3
  • 11
    • 0031406018 scopus 로고    scopus 로고
    • Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    • Valiante NM, Uhrberg M, Shilling HG, et al. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 1997;7:739-751.
    • (1997) Immunity , vol.7 , pp. 739-751
    • Valiante, N.M.1    Uhrberg, M.2    Shilling, H.G.3
  • 12
    • 14944355535 scopus 로고    scopus 로고
    • MHC class I molecules and KIRs in human history, healThand survival
    • P arham P. MHC class I molecules and KIRs in human history, healThand survival. Nat Rev Immunol 2005;5:201-214.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 201-214
    • Parham, P.1
  • 13
    • 33747101972 scopus 로고    scopus 로고
    • Human NK cell education by inhibitory receptors for MHC class I
    • A nfossi N, Andre P, Guia S, et a l. Human NK cell education by inhibitory receptors for MHC class I. Immunity 2006;25:331-342.
    • (2006) Immunity , vol.25 , pp. 331-342
    • Anfossi, N.1    Andre, P.2    Guia, S.3
  • 14
    • 9444249908 scopus 로고    scopus 로고
    • Natural killer cell signaling pathways
    • V ivier E, Nunes JA, Vely F. Natural killer cell signaling pathways. Science 2004;306:1517-1519.
    • (2004) Science , vol.306 , pp. 1517-1519
    • Vivier, E.1    Nunes, J.A.2    Vely, F.3
  • 15
    • 85044832411 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999;285:727-729.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3
  • 16
    • 0042922822 scopus 로고    scopus 로고
    • Identifi cation of PVR (CD155) and Nectin-2 (Cd112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    • Bottino C, Castriconi R, Pende D, et al. Identifi cation of PVR (CD155) and Nectin-2 (Cd112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003;198:557-567.
    • (2003) J. Exp. Med. , vol.198 , pp. 557-567
    • Bottino, C.1    Castriconi, R.2    Pende, D.3
  • 17
    • 79955031874 scopus 로고    scopus 로고
    • Crystal structure of human natural cytotoxicity receptor NKp30 and identifi cation of its ligand binding site
    • Joyce MG, Tran P, Zhuravleva MA, et a l. Crystal structure of human natural cytotoxicity receptor NKp30 and identifi cation of its ligand binding site. Proc Natl Acad Sci USA 2011;108:6223-6228.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 6223-6228
    • Joyce, M.G.1    Tran, P.2    Zhuravleva, M.A.3
  • 18
    • 0035931861 scopus 로고    scopus 로고
    • Recognition of hemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    • Mandelboim O, Lieberman N, Lev M, et al. Recognition of hemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 2001;409:1055-1059.
    • (2001) Nature , vol.409 , pp. 1055-1059
    • Mandelboim, O.1    Lieberman, N.2    Lev, M.3
  • 19
  • 20
    • 0036434914 scopus 로고    scopus 로고
    • Anti-myeloma activity of natural killer lymphocytes
    • Frohn C, Hoppner M, Schlenke P, et al. Anti-myeloma activity of natural killer lymphocytes. Br J Haematol 2002;119:660-664.
    • (2002) Br. J. Haematol , vol.119 , pp. 660-664
    • Frohn, C.1    Hoppner, M.2    Schlenke, P.3
  • 21
    • 0025086435 scopus 로고
    • Natural killer cell activity in monoclonal gammopathies: Relation to disease activity
    • O sterborg A, Nilsson B, Bjorkholm M, et a l. Natural killer cell activity in monoclonal gammopathies: Relation to disease activity. Eur J Haematol 1990;45:153-157.
    • (1990) Eur. J. Haematol , vol.45 , pp. 153-157
    • Osterborg, A.1    Nilsson, B.2    Bjorkholm, M.3
  • 22
    • 0026980280 scopus 로고
    • Natural killer cell frequency and function in patients wiThmonoclonal gammopathies
    • F amularo G, D'Ambrosio A, Quintieri F, et al. Natural killer cell frequency and function in patients wiThmonoclonal gammopathies. J Clin Lab Immunol 1992;37:99-109.
    • (1992) J. Clin. Lab. Immunol , vol.37 , pp. 99-109
    • Famularo, G.1    D'Ambrosio, A.2    Quintieri, F.3
  • 23
    • 0030763435 scopus 로고    scopus 로고
    • Natural killer cell frequency and serum cytokine levels in monoclonal gammopathies: Correlation of bone marrow granular lymphocytes to prognosis
    • S awanobori M, Suzuki K, Nakagawa Y, et al. Natural killer cell frequency and serum cytokine levels in monoclonal gammopathies: Correlation of bone marrow granular lymphocytes to prognosis. Acta Haematol 1997;98:150-154.
    • (1997) Acta. Haematol , vol.98 , pp. 150-154
    • Sawanobori, M.1    Suzuki, K.2    Nakagawa, Y.3
  • 24
    • 36249011958 scopus 로고    scopus 로고
    • Clinical stage-depending decrease of NK cell activity in multiple myeloma patients
    • Jurisic V, Srdic T, Konjevic G, et al. Clinical stage-depending decrease of NK cell activity in multiple myeloma patients. Med Oncol 2007;24:312-317.
    • (2007) Med. Oncol. , vol.24 , pp. 312-317
    • Jurisic, V.1    Srdic, T.2    Konjevic, G.3
  • 25
    • 0026601798 scopus 로고
    • Increased expression of natural-killer-associated and activation antigens in multiple myeloma
    • G onzalez M, San Miguel JF, Gascon A, et a l. Increased expression of natural-killer-associated and activation antigens in multiple myeloma. Am J Hematol 1992;39:84-89.
    • (1992) Am. J. Hematol. , vol.39 , pp. 84-89
    • Gonzalez, M.1    San Miguel, J.F.2    Gascon, A.3
  • 26
    • 0023070158 scopus 로고
    • Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined signifi cance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/suppressor cell ratio are features common to boThdiseases
    • De Rossi G, De Sanctis G, Bottari V, et al. Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined signifi cance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/suppressor cell ratio are features common to boThdiseases. Cancer Immunol Immunother 1987;25:133-136.
    • (1987) Cancer Immunol Immunother , vol.25 , pp. 133-136
    • De Rossi, G.1    De Sanctis, G.2    Bottari, V.3
  • 27
    • 0021162354 scopus 로고
    • Strong natural killer (NK) cell activity in bone marrow of myeloma patients: Accelerated maturation of bone marrow NK cells and their interaction wiThother bone marrow cells
    • U chida A, Yagita M, Sugiyama H, et al. Strong natural killer (NK) cell activity in bone marrow of myeloma patients: Accelerated maturation of bone marrow NK cells and their interaction wiThother bone marrow cells. Int J Cancer 1984;35:375-381.
    • (1984) Int. J. Cancer , vol.35 , pp. 375-381
    • Uchida, A.1    Yagita, M.2    Sugiyama, H.3
  • 28
    • 0023674235 scopus 로고
    • Natural killer cell activity in patients wiThmultiple myeloma
    • O gmundsdottir HM. Natural killer cell activity in patients wiThmultiple myeloma. Cancer Detect Prev 1988;12:133-143.
    • (1988) Cancer Detect. Prev. , vol.12 , pp. 133-143
    • Ogmundsdottir, H.M.1
  • 29
    • 9244243598 scopus 로고    scopus 로고
    • Analysis of natural killer-associated antigens in peripheral blood and bone marrow of multiple myeloma patients and prognostic implications
    • G arcia-Sanz R, Gonzalez M, Orfao A, et al. Analysis of natural killer-associated antigens in peripheral blood and bone marrow of multiple myeloma patients and prognostic implications. Br J Haematol 1996;93:81-88.
    • (1996) Br. J. Haematol , vol.93 , pp. 81-88
    • Garcia-Sanz, R.1    Gonzalez, M.2    Orfao, A.3
  • 30
    • 0029949996 scopus 로고    scopus 로고
    • Natural killer cells and CD56- T cells in the blood of multiple myeloma patients: Ananlysis by 4-colour fl ow cytometry
    • K ing MA, Radicchi-Mastroianni MA. Natural killer cells and CD56- T cells in the blood of multiple myeloma patients: Ananlysis by 4-colour fl ow cytometry. Cytometry 1996;26:121-124.
    • (1996) Cytometry , vol.26 , pp. 121-124
    • King, M.A.1    Radicchi-Mastroianni, M.A.2
  • 31
    • 44249113093 scopus 로고    scopus 로고
    • Prediction of survival using absolute lymphocyte count for newly diagnosed patients wiThmultiple myeloma: A retrospective study
    • E ge H, Gertz MA, Markovic SN, et al. Prediction of survival using absolute lymphocyte count for newly diagnosed patients wiThmultiple myeloma: A retrospective study. Br J Haematol 2008;141:792-798.
    • (2008) Br. J. Haematol , vol.141 , pp. 792-798
    • Ege, H.1    Gertz, M.A.2    Markovic, S.N.3
  • 32
    • 0029149209 scopus 로고
    • An interleukin-1 receptor antagonist blocks the IL-1 induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma
    • L u ZY, Bataille R, Poubelle P, et a l. An interleukin-1 receptor antagonist blocks the IL-1 induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma. Stem Cells 1995;13(Suppl. 2):28-34.
    • (1995) Stem Cells , vol.13 , Issue.SUPPL. 2 , pp. 28-34
    • Lu, Z.Y.1    Bataille, R.2    Poubelle, P.3
  • 33
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by STAT-3 signaling in tumor cells
    • W ang T, Niu G, Kortylewski M, et al. Regulation of the innate and adaptive immune responses by STAT-3 signaling in tumor cells. Nat Med 2004;10:48-54.
    • (2004) Nat. Med. , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3
  • 34
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • K ortylewski M, Kujawski M, Wang T, et al. Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-1321.
    • (2005) Nat. Med. , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3
  • 35
    • 26844464792 scopus 로고    scopus 로고
    • CD4- CD25- regulatory T cells inhibit natural killer cell functions in a transforming growThfactor-b-dependent manner
    • G hiringhelli F, Menard C, Terme M, et al. CD4- CD25- regulatory T cells inhibit natural killer cell functions in a transforming growThfactor-b-dependent manner. J Exp Med 2005;202:1075-1085.
    • (2005) J. Exp. Med. , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Menard, C.2    Terme, M.3
  • 36
    • 33646575622 scopus 로고    scopus 로고
    • In vivo peripheral expansion of na ïve CD4- Cd25high FoxP-3- regulatory T cells in patients wiThmultiple myeloma
    • B eyer M, Kochanek M, Giese T, et al. In vivo peripheral expansion of na ïve CD4- Cd25high FoxP-3- regulatory T cells in patients wiThmultiple myeloma. Blood 2006;107:3940-3949.
    • (2006) Blood , vol.107 , pp. 3940-3949
    • Beyer, M.1    Kochanek, M.2    Giese, T.3
  • 37
    • 56149090590 scopus 로고    scopus 로고
    • TGF-beta utilizes SMAD3 to inhibit CD-16 mediated IFN-gamma production and antibodydependent cellular cytotoxicity in human NK cells
    • T rotta R, Col JD, Ciarlariello D, et al. TGF-beta utilizes SMAD3 to inhibit CD-16 mediated IFN-gamma production and antibodydependent cellular cytotoxicity in human NK cells. J Immunol 2008; 181:3784-3792.
    • (2008) J. Immunol , vol.181 , pp. 3784-3792
    • Trotta, R.1    Col, J.D.2    Ciarlariello, D.3
  • 38
    • 33646563695 scopus 로고    scopus 로고
    • Pro- and anti-infl amatory cytokine signaling: Reciprocal antagonism regulates interferon-gamma production by human natural killer cells
    • Y u J, Wei M, Becknell B, et al. Pro- and anti-infl amatory cytokine signaling: Reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity 2006;24:575-590.
    • (2006) Immunity , vol.24 , pp. 575-590
    • Yu, J.1    Wei, M.2    Becknell, B.3
  • 39
    • 0025807149 scopus 로고
    • Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice
    • T anner J, Tosato G. Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice. J Clin Invest 1991;88:239-247.
    • (1991) J. Clin. Invest. , vol.88 , pp. 239-247
    • Tanner, J.1    Tosato, G.2
  • 40
    • 0027530129 scopus 로고
    • Interleukin 12 and tumor necrosis factor a are costimulators of interferon gamma production by natural killer cells in severe combined immune defi ciency mice wiThlisteriosis, and interleukin 10 is a physiologic antagonist
    • T ripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumor necrosis factor a are costimulators of interferon gamma production by natural killer cells in severe combined immune defi ciency mice wiThlisteriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 1993;90:3725-3729.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3725-3729
    • Tripp, C.S.1    Wolf, S.F.2    Unanue, E.R.3
  • 41
    • 0027240219 scopus 로고
    • Interleukin-10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A, Aste-Amezaga, Valiante N, et al. Interleukin-10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezag, A.2    Valiante, N.3
  • 42
    • 20444422917 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome
    • L adetto M, Vallet S, Trojan A, et al. Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome. Blood 2005;105:4784-4791.
    • (2005) Blood , vol.105 , pp. 4784-4791
    • Ladetto, M.1    Vallet, S.2    Trojan, A.3
  • 43
    • 27644525342 scopus 로고    scopus 로고
    • Overexpression of cyclooxygenase-2 in multiple myeloma: Association wiThreduced survival
    • C etin M, Buyukberber S, Demir M, et al. Overexpression of cyclooxygenase-2 in multiple myeloma: Association wiThreduced survival. Am J Hematol 2005;80:169-173.
    • (2005) Am. J. Hematol. , vol.80 , pp. 169-173
    • Cetin, M.1    Buyukberber, S.2    Demir, M.3
  • 44
    • 33744488766 scopus 로고    scopus 로고
    • Oncogenic RAS mutations in myeloma cells selectively induce COX-2 expression, which participates in enhanced adhesion to fi bronectin and chemoresistance
    • H oang B, Zhu L, Shi Y, et al. Oncogenic RAS mutations in myeloma cells selectively induce COX-2 expression, which participates in enhanced adhesion to fi bronectin and chemoresistance. Blood 2006;107:4484-4490.
    • (2006) Blood , vol.107 , pp. 4484-4490
    • Hoang, B.1    Zhu, L.2    Shi, Y.3
  • 45
    • 82355182118 scopus 로고    scopus 로고
    • Prostaglandin E2 (PGE 2 ) suppresses natural killer cell function primarily through the PGE 2 receptor EP4
    • H olt D, Ma X, Kundu N, et al. Prostaglandin E2 (PGE 2 ) suppresses natural killer cell function primarily through the PGE 2 receptor EP4. Cancer Immunol Immunother 2001;60:1577-1586.
    • (2001) Cancer Immunol Immunother , vol.60 , pp. 1577-1586
    • Holt, D.1    Ma, X.2    Kundu, N.3
  • 46
    • 33748189347 scopus 로고    scopus 로고
    • Cell-surface association between matrix metalloproteinases and integrins: Role of the complexes in leukocyte migration and cancer progression
    • S tefanidakis M, Koivunen E. Cell-surface association between matrix metalloproteinases and integrins: Role of the complexes in leukocyte migration and cancer progression. Blood 2006;108:1441-1450.
    • (2006) Blood , vol.108 , pp. 1441-1450
    • Stefanidakis, M.1    Koivunen, E.2
  • 47
    • 77955862810 scopus 로고    scopus 로고
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growThand inhibits immune function in multiple myeloma
    • P rabhala RH, Pelluru D, Fulciniti M, et a l. Elevated IL-17 produced by TH17 cells promotes myeloma cell growThand inhibits immune function in multiple myeloma. Blood 2010;115:5385-5392.
    • (2010) Blood , vol.115 , pp. 5385-5392
    • Prabhala, R.H.1    Pelluru, D.2    Fulciniti, M.3
  • 48
    • 58849093606 scopus 로고    scopus 로고
    • CD4- CD25- FoxP3- regulatory T cells are increased whilst CD3-CD4- CD8-alphabetaTCR- double negative T cells are decreased in the peripheral blood of patients wiThmultiple myeloma which correlates wiThdisease burden
    • F eyler S, von Lilienfeld-Toal M, Jarmin S, et al. CD4- CD25- FoxP3- regulatory T cells are increased whilst CD3-CD4- CD8-alphabetaTCR- double negative T cells are decreased in the peripheral blood of patients wiThmultiple myeloma which correlates wiThdisease burden. Br J Haematol 2009;144:686-695.
    • (2009) Br. J. Haematol , vol.144 , pp. 686-695
    • Feyler, S.1    Von Lilienfeld-Toal, M.2    Jarmin, S.3
  • 49
    • 84856099993 scopus 로고    scopus 로고
    • A small molecule, LLL12, inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growThsuppressive activity in human multiple myeloma cells
    • Li L, Benson DM Jr, DeAngelis S, et al. A small molecule, LLL12, inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growThsuppressive activity in human multiple myeloma cells. Int J Cancer 2012;130:1459-1469.
    • Int. J. Cancer , vol.2012 , Issue.130 , pp. 1459-1469
    • Li, L.1    Benson Jr., D.M.2    DeAngelis, S.3
  • 50
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Londowski TH, Oshiro MM, et al. Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Londowski, T.H.2    Oshiro, M.M.3
  • 51
    • 79952207466 scopus 로고    scopus 로고
    • Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells
    • Bedel R, Thiery-Vuillemin A, Grandclement C, et al. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells. Cancer Res 2011;71:1615-1626.
    • (2011) Cancer Res. , vol.71 , pp. 1615-1626
    • Bedel, R.1    Thiery-Vuillemin, A.2    Grandclement, C.3
  • 52
    • 0022289718 scopus 로고
    • Natural killer activity and antibody-dependent cell-mediated cytotoxicity in multiple myeloma
    • Matsuzaki H, Kagimoto T, Oda T, et a l. Natural killer activity and antibody-dependent cell-mediated cytotoxicity in multiple myeloma. Jpn J Clin Oncol 1985;15:611-617.
    • (1985) Jpn. J. Clin. Oncol. , vol.15 , pp. 611-617
    • Matsuzaki, H.1    Kagimoto, T.2    Oda, T.3
  • 53
    • 0022543054 scopus 로고
    • Inhibition of natural killer cell activity by IgA
    • Komiyama K, Crago SS, Itoh K, et al. Inhibition of natural killer cell activity by IgA. Cell Immunol 1986;101:143-155.
    • (1986) Cell Immunol , vol.101 , pp. 143-155
    • Komiyama, K.1    Crago, S.S.2    Itoh, K.3
  • 54
    • 0023264546 scopus 로고
    • Regulation of human natural cytotoxicity by IgG-I.Characterization of the structural site on monomeric IgG responsible for inhibiting natural killer cell activity
    • Gherman M, Manciulea M, Bancu AC, et al. Regulation of human natural cytotoxicity by IgG-I. Characterization of the structural site on monomeric IgG responsible for inhibiting natural killer cell activity. Int Immunol 1987;24:743-750.
    • (1987) Int. Immunol. , vol.24 , pp. 743-750
    • Gherman, M.1    Manciulea, M.2    Bancu, A.C.3
  • 55
    • 0030612553 scopus 로고    scopus 로고
    • IgG M-components in active myeloma patients induce a down-regulation of natural killer cell activity
    • Frassinito MA, Silvestris F, Caff orio P, et al. IgG M-components in active myeloma patients induce a down-regulation of natural killer cell activity. Int J Clin Lab Res 1997;27:48-54.
    • (1997) Int. J. Clin. Lab. Res. , vol.27 , pp. 48-54
    • Frassinito, M.A.1    Silvestris, F.2    Cafforio, P.3
  • 56
    • 0032601040 scopus 로고    scopus 로고
    • IgA monoclonal and polyclonal proteins as regulatory factors of the NK cytotoxic activity
    • Mota G, Galatiuc C, Popescu I, et a l. IgA monoclonal and polyclonal proteins as regulatory factors of the NK cytotoxic activity. Rom J Virol 1999;50:17-31.
    • (1999) Rom. J. Virol. , vol.50 , pp. 17-31
    • Mota, G.1    Galatiuc, C.2    Popescu, I.3
  • 57
    • 63849224072 scopus 로고    scopus 로고
    • Stem cell factor and IL-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells
    • B enson DM Jr, Yu J, Becknell B, et a l. Stem cell factor and IL-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells. Blood 2009;113:2706-2714.
    • (2009) Blood , vol.113 , pp. 2706-2714
    • Benson Jr., D.M.1    Yu, J.2    Becknell, B.3
  • 58
    • 13444257757 scopus 로고    scopus 로고
    • Interleukin-2, interleukin-15, and their roles in human natural killer cells
    • Becknell B, Caligiuri MA. Interleukin-2, interleukin-15, and their roles in human natural killer cells. Adv Immunol 2005;86:209-239.
    • (2005) Adv. Immunol , vol.86 , pp. 209-239
    • Becknell, B.1    Caligiuri, M.A.2
  • 59
    • 0025726153 scopus 로고
    • Immune dysfunction in multiple myeloma Reduced natural killer cell activity and increased levels of soluble interleukin-2 receptors
    • Neilsen H, Neilsen HJ, Tyede N, et a l. Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin-2 receptors. APMIS 1991;99:340-346.
    • (1991) Apmis. , vol.99 , pp. 340-346
    • Neilsen, H.1    Neilsen, H.J.2    Tyede, N.3
  • 60
    • 0030906448 scopus 로고    scopus 로고
    • A potential role for interleukin-15 in the regulation of human natural killer cell survival
    • C arson WE, Fehniger TA, Haldar S, et a l. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest 1997;99:937-943.
    • (1997) J. Clin. Invest. , vol.99 , pp. 937-943
    • Carson, W.E.1    Fehniger, T.A.2    Haldar, S.3
  • 61
    • 0037460058 scopus 로고    scopus 로고
    • Interleukin (IL)-15Ra defi cient natural killer cells survive in normal but not IL-15Ra-defi cient mice
    • K oka R, Burkett PR, Chien M, et al. Interleukin (IL)-15Ra defi cient natural killer cells survive in normal but not IL-15Ra-defi cient mice. J Exp Med 2003;197:977-984.
    • (2003) J. Exp. Med. , vol.197 , pp. 977-984
    • Koka, R.1    Burkett, P.R.2    Chien, M.3
  • 62
    • 0034651023 scopus 로고    scopus 로고
    • Expression of a functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
    • T inofer I, Marschitz I, Henn T, et a l. Expression of a functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma. Blood 2000;95:610-618.
    • (2000) Blood , vol.95 , pp. 610-618
    • Tinofer, I.1    Marschitz, I.2    Henn, T.3
  • 63
    • 0029812490 scopus 로고    scopus 로고
    • Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death
    • Dimartis A, Bernassola F, Savino R, et al. Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death. Cancer Res 1996;56:4213-4218.
    • (1996) Cancer Res. , vol.56 , pp. 4213-4218
    • Dimartis, A.1    Bernassola, F.2    Savino, R.3
  • 64
    • 0029124138 scopus 로고
    • Introduction of an activated N-ras oncogene alters the growThcharacteristics of the interleukin-6 depenednt myeloma cell line ANBL6
    • Billadeau D, Jelinek DF, Shah N, et al. Introduction of an activated N-ras oncogene alters the growThcharacteristics of the interleukin-6 depenednt myeloma cell line ANBL6. Cancer Res 1995;55:3640-3646.
    • (1995) Cancer Res. , vol.55 , pp. 3640-3646
    • Billadeau, D.1    Jelinek, D.F.2    Shah, N.3
  • 65
    • 34548765601 scopus 로고    scopus 로고
    • The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer-cell mediating killing of myeloma cells
    • E l-Sherbiny YM, Meade JL, Holmes TD, et a l. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer-cell mediating killing of myeloma cells. Cancer Res 2007;67:8444-8449.
    • (2007) Cancer Res. , vol.67 , pp. 8444-8449
    • El-Sherbiny, Y.M.1    Meade, J.L.2    Holmes, T.D.3
  • 66
    • 39549084084 scopus 로고    scopus 로고
    • MHC class-Rfis1 chain-related protein A antibodies and shedding are associated wiThthe progression of multiple myeloma
    • J inushi M, Vanneman M, Munshi NC, et al. MHC class-Rfis1 chain-related protein A antibodies and shedding are associated wiThthe progression of multiple myeloma. Proc Natl Acad Sci USA 2008;105:1285-1290.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 1285-1290
    • Jinushi, M.1    Vanneman, M.2    Munshi, N.C.3
  • 67
    • 19944428928 scopus 로고    scopus 로고
    • HLA class I NKG2D and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells
    • Carbone E, Neri P, Mesuraca M, et a l. HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 2005;105:251-258.
    • (2005) Blood , vol.105 , pp. 251-258
    • Carbone, E.1    Neri, P.2    Mesuraca, M.3
  • 68
    • 20144376830 scopus 로고    scopus 로고
    • Clonal plasma cells from monoclonal gammopathy of undetermined signifi cance, multiple myeloma, and plasma cell leukemia show diff erent expression profi les of molecules involved in the interaction wiThthe immunological bone marrow microenvironment
    • Perez-Andres M, Almeida J, Martin-Ayuso M, et al. Clonal plasma cells from monoclonal gammopathy of undetermined signifi cance, multiple myeloma, and plasma cell leukemia show diff erent expression profi les of molecules involved in the interaction wiThthe immunological bone marrow microenvironment. Leukemia 2005;19:449-455.
    • (2005) Leukemia , vol.19 , pp. 449-455
    • Perez-Andres, M.1    Almeida, J.2    Martin-Ayuso, M.3
  • 69
    • 58249084333 scopus 로고    scopus 로고
    • Soluble and membrane levels of molecules involved in the interaction between clonal lasma cells and the immunological microenvironment in multiple myeloma and their association wiThthe characteristics of the disease
    • Perez-Andres M, Almeida J, Martin-Ayuso M, et al. Soluble and membrane levels of molecules involved in the interaction between clonal lasma cells and the immunological microenvironment in multiple myeloma and their association wiThthe characteristics of the disease. Int J Cancer 2009;124:367-375.
    • (2009) Int. J. Cancer , vol.124 , pp. 367-375
    • Perez-Andres, M.1    Almeida, J.2    Martin-Ayuso, M.3
  • 70
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, et a l. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 2002;99:12293-12297.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 71
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 signaling axis modulates the natural killer cell versus multiple myeloma eff ect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson DM Jr, Bakan CE, Mishra A, et a l. The PD-1/PD-L1 signaling axis modulates the natural killer cell versus multiple myeloma eff ect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 2010;116:2286-2294.
    • (2010) Blood , vol.116 , pp. 2286-2294
    • Benson Jr., D.M.1    Bakan, C.E.2    Mishra, A.3
  • 72
    • 65349131915 scopus 로고    scopus 로고
    • ATM-ATR-dependent upregulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated wiTha senescent phenotype
    • Soriani A, Zingoni A, Cerboni C, et al. ATM-ATR-dependent upregulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated wiTha senescent phenotype. Blood 2009;113:3503-3511.
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1    Zingoni, A.2    Cerboni, C.3
  • 73
    • 70349336692 scopus 로고    scopus 로고
    • Changes in the activatory and inhibitory natural killer (NK) receptors may induce progression to multiple myeloma: Implications for tumor evasion of T and NK cells
    • B ernal M, Garrido P, Jimenez P, et al. Changes in the activatory and inhibitory natural killer (NK) receptors may induce progression to multiple myeloma: Implications for tumor evasion of T and NK cells. Hum Immunol 2009;70:854-857.
    • (2009) Hum Immunol , vol.70 , pp. 854-857
    • Bernal, M.1    Garrido, P.2    Jimenez, P.3
  • 74
    • 0030715354 scopus 로고    scopus 로고
    • Mutations in the Fas antigen in patients wiThmultiple myeloma
    • L andowski TH, Qu N, Buyuksal I, et a l. Mutations in the Fas antigen in patients wiThmultiple myeloma. Blood 1997;90:4266-4270.
    • (1997) Blood , vol.90 , pp. 4266-4270
    • Landowski, T.H.1    Qu, N.2    Buyuksal, I.3
  • 75
    • 77953111633 scopus 로고    scopus 로고
    • Reduced immune eff ector cell NKG2D expression and increase levels of soluble NKG2D ligands in multiple myeloma may not be causally linked
    • v on Lilienfeld-Toal M, Frank S, Leyendecker C, et al. Reduced immune eff ector cell NKG2D expression and increase levels of soluble NKG2D ligands in multiple myeloma may not be causally linked. Cancer Immunol Immunother 2010;59:829-839.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 829-839
    • Von Lilienfeld-Toal, M.1    Frank, S.2    Leyendecker, C.3
  • 76
    • 33646477295 scopus 로고    scopus 로고
    • Impaired activating receptor expression pattern in natural killer cells from patients wiThmultiple myeloma
    • F auriat C, Mallet F, Olive D, et al. Impaired activating receptor expression pattern in natural killer cells from patients wiThmultiple myeloma. Leukemia 2006;20:732-733.
    • (2006) Leukemia , vol.20 , pp. 732-733
    • Fauriat, C.1    Mallet, F.2    Olive, D.3
  • 77
    • 0021246077 scopus 로고
    • Interferons in the treatment of human cancer
    • K irkwood JM, Ernstoff MS. Interferons in the treatment of human cancer. J Clin Oncol 1984;2:336-352.
    • (1984) J. Clin. Oncol. , vol.2 , pp. 336-352
    • Kirkwood, J.M.1    Ernstoff, M.S.2
  • 78
    • 0019973051 scopus 로고
    • Interferon and natural killer activity in multiple myeloma Lack of correlation between interferoninduced enhancement of natural killer activity and clinical response to human interferon-alpha
    • E inhorn S, Ahre A, Blomgren H, et al. Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferoninduced enhancement of natural killer activity and clinical response to human interferon-alpha. Int J Cancer 1982;30:167-172.
    • (1982) Int. J. Cancer , vol.30 , pp. 167-172
    • Einhorn, S.1    Ahre, A.2    Blomgren, H.3
  • 79
    • 0030033381 scopus 로고    scopus 로고
    • Lymphocyte recovery and clinical response in multiple myeloma patients receiving interferon alpha 2 beta after intensive therapy
    • M illar BC, Bell JB, Powles RL. Lymphocyte recovery and clinical response in multiple myeloma patients receiving interferon alpha 2 beta after intensive therapy. Br J Cancer 1996;73:236-240.
    • (1996) Br. J. Cancer , vol.73 , pp. 236-240
    • Millar, B.C.1    Bell, J.B.2    Powles, R.L.3
  • 80
    • 0031000637 scopus 로고    scopus 로고
    • The interaction of maintenance interferon wiThcytolytic cells in patients wiThmultiple myeloma who responded to cytotoxic chemotherapy
    • H all PD, Self SE, Hall RK. The interaction of maintenance interferon wiThcytolytic cells in patients wiThmultiple myeloma who responded to cytotoxic chemotherapy. Pharmacotherapy 1997;17: 248-255.
    • (1997) Pharmacotherapy , vol.17 , pp. 248-255
    • Hall, P.D.1    Self, S.E.2    Hall, R.K.3
  • 81
    • 0031472311 scopus 로고    scopus 로고
    • Interferon alpha in the therapy of multiple myeloma
    • G isslinger H. Interferon alpha in the therapy of multiple myeloma. Leukemia 1997;11(Suppl. 5):S52-S56.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 5
    • Gisslinger, H.1
  • 82
    • 0033637036 scopus 로고    scopus 로고
    • Interferon-alpha treatment in multiple myeloma: Meta-analysis of 30 randomized trials among 3948 patients
    • F ritz E, Ludwig H. Interferon-alpha treatment in multiple myeloma: Meta-analysis of 30 randomized trials among 3948 patients. Ann Oncol 2000;11:1427-1436.
    • (2000) Ann. Oncol. , vol.11 , pp. 1427-1436
    • Fritz, E.1    Ludwig, H.2
  • 83
    • 0029099343 scopus 로고
    • Randomized trial of interferon maintenance in multiple myeloma: A study of the National Cancer Institute of Canada Clinical Trials Group
    • B rowman GP, Bergsagel D, Sicheri D, et al. Randomized trial of interferon maintenance in multiple myeloma: A study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1995;13:2354-2360.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2354-2360
    • Browman, G.P.1    Bergsagel, D.2    Sicheri, D.3
  • 85
    • 0025746219 scopus 로고
    • Phenotypic and functional analysis of peripheral blood lymphocytes during interferon-alpha 2b therapy in multiple myeloma patients wiThlow tumor mass
    • B ianchi A, Omede P, Attisano C, et al. Phenotypic and functional analysis of peripheral blood lymphocytes during interferon-alpha 2b therapy in multiple myeloma patients wiThlow tumor mass. Haematologica 1991;76:383-388.
    • (1991) Haematologica , vol.76 , pp. 383-388
    • Bianchi, A.1    Omede, P.2    Attisano, C.3
  • 86
    • 0024202663 scopus 로고
    • Cell-mediated toxicity of interleukin-2-activated lymphocytes against autologous and allogeneic human myeloma cells
    • S himazaki C, Atzpodien J, Wisniewski D, et al. Cell-mediated toxicity of interleukin-2-activated lymphocytes against autologous and allogeneic human myeloma cells. Acta Haematol 1988;80:203-209.
    • (1988) Acta. Haematol , vol.80 , pp. 203-209
    • Shimazaki, C.1    Atzpodien, J.2    Wisniewski, D.3
  • 87
    • 0024414585 scopus 로고
    • Eff ects of recombinant interleukin-2 administration on cytotoxic function following highdose chemo-radiotherapy for hematological malignancy
    • G ottlieb DJ, Prentice HG, Heslop HE, et al. Eff ects of recombinant interleukin-2 administration on cytotoxic function following highdose chemo-radiotherapy for hematological malignancy. Blood 1989;74:2335-2342.
    • (1989) Blood , vol.74 , pp. 2335-2342
    • Gottlieb, D.J.1    Prentice, H.G.2    Heslop, H.E.3
  • 88
    • 0025045269 scopus 로고
    • Malignant plasma cells are sensitive to LAK cell lysis: Pre-clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma
    • G ottlieb DJ, Prentice HG, Mehta AB, et al. Malignant plasma cells are sensitive to LAK cell lysis: Pre-clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma. Br J Haematol 1990;75:499-505.
    • (1990) Br. J. Haematol , vol.75 , pp. 499-505
    • Gottlieb, D.J.1    Prentice, H.G.2    Mehta, A.B.3
  • 89
    • 0034750613 scopus 로고    scopus 로고
    • Immunomodulation of early engrafted natural killer cells wiThinterleukin-2 and interferonalpha in autologous stem cell transplantation
    • P orrata LF, Inwards DJ, Lacy MQ, et al. Immunomodulation of early engrafted natural killer cells wiThinterleukin-2 and interferonalpha in autologous stem cell transplantation. Bone Marrow Transplant 2001;28:673-680.
    • (2001) Bone. Marrow. Transplant , vol.28 , pp. 673-680
    • Porrata, L.F.1    Inwards, D.J.2    Lacy, M.Q.3
  • 90
    • 0029165189 scopus 로고
    • Tumor-directed cytotoxicity in multiple myeloma - The basis for an experimental treatment wiThinterleukin-2
    • P eest D, Leo R, Deicher H. Tumor-directed cytotoxicity in multiple myeloma - the basis for an experimental treatment wiThinterleukin-2. Stem Cells 1995;13(Suppl. 2):72-76.
    • (1995) Stem. Cells , vol.13 , Issue.SUPPL. 2 , pp. 72-76
    • Peest, D.1    Leo, R.2    Deicher, H.3
  • 91
    • 0025784832 scopus 로고
    • Toxicity andimmunomodulatory eff ects of interleukin-2 after autologous bone marrow transplantation for hematologic malignancies
    • Higuchi CM, Thompson JA, Petersen FB, et a l. Toxicity andimmunomodulatory eff ects of interleukin-2 after autologous bone marrow transplantation for hematologic malignancies. Blood 1991;77:2561-2568.
    • (1991) Blood , vol.77 , pp. 2561-2568
    • Higuchi, C.M.1    Thompson, J.A.2    Petersen, F.B.3
  • 92
    • 0035437134 scopus 로고    scopus 로고
    • Early lymphocyte recoverypredicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma
    • P orrata LF, Gertz MA, Inwards DJ, et a l. Early lymphocyte recoverypredicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma. Blood 2001;98:579-585.
    • (2001) Blood , vol.98 , pp. 579-585
    • Porrata, L.F.1    Gertz, M.A.2    Inwards, D.J.3
  • 93
    • 2942638133 scopus 로고    scopus 로고
    • The dose of infused lymphocytes in the autograft directly correlates wiThclinicaloutcomes after autologous peripheral blood hematopoietic stem celltransplantation in multiple myeloma
    • P orrata LF, Gertz Ma, Geyer SM, et al. The dose of infused lymphocytes in the autograft directly correlates wiThclinicaloutcomes after autologous peripheral blood hematopoietic stem celltransplantation in multiple myeloma. Leukemia 2004;18:1085-1092.
    • (2004) Leukemia , vol.18 , pp. 1085-1092
    • Porrata, L.F.1    Gertz, M.A.2    Geyer, S.M.3
  • 94
    • 33646812248 scopus 로고    scopus 로고
    • Early lymphocyte recoverypredicts longer survival after autologous peripheral blood stem cell transplantation in multiple myeloma
    • K im H, Sohn HJ, Kim S, et al. Early lymphocyte recoverypredicts longer survival after autologous peripheral blood stem cell transplantation in multiple myeloma. Bone Marrow Transplant 2006;37:1037-1042.
    • (2006) Bone Marrow Transplant , vol.37 , pp. 1037-1042
    • Kim, H.1    Sohn, H.J.2    Kim, S.3
  • 95
    • 37349079921 scopus 로고    scopus 로고
    • Higher infused lymphocytedose predicts higher lymphocyte recovery, which in turn, predicts superior overall survival following autologous stem cell transplantation for multiple myeloma
    • H iwase DK, Hiwase S, Bailey M, et al. Higher infused lymphocytedose predicts higher lymphocyte recovery, which in turn, predicts superior overall survival following autologous stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 2008;14:116-124.
    • (2008) Biol. Blood Marrow Transplant , vol.14 , pp. 116-124
    • Hiwase, D.K.1    Hiwase, S.2    Bailey, M.3
  • 96
    • 0037409663 scopus 로고    scopus 로고
    • Re-infused autologousgraft natural killer cells correlates wiThabsolute lymphocyte countrecovery after autologous stem cell transplantation
    • P oratta LF, Gastineau DA, Padley D, et a l. Re-infused autologousgraft natural killer cells correlates wiThabsolute lymphocyte countrecovery after autologous stem cell transplantation. Leuk Lymphoma 2003;44:997-1000.
    • (2003) Leuk Lymphoma , vol.44 , pp. 997-1000
    • Poratta, L.F.1    Gastineau, D.A.2    Padley, D.3
  • 97
    • 37349061396 scopus 로고    scopus 로고
    • Day 15 naturalkiller cell recovery predicts progression free survival after autologousstem cell transplantation in non-Hodgkin lymphoma
    • Abstract 2914
    • S iddiqui MA, Markovic SN, Nevala WK, et a l. Day 15 naturalkiller cell recovery predicts progression free survival after autologousstem cell transplantation in non-Hodgkin lymphoma. Blood 2006;108(Suppl. 1): Abstract 2914.
    • (2006) Blood , vol.108 , Issue.SUPPL. 1
    • Siddiqui, M.A.1    Markovic, S.N.2    Nevala, W.K.3
  • 98
    • 33847389891 scopus 로고    scopus 로고
    • Eff ect of frequentlyused chemotherapeutic drugs on the cytotoxic activity of human natural killer cells
    • M arkasz L, Stuber G, Vanherberghen B, et al. Eff ect of frequentlyused chemotherapeutic drugs on the cytotoxic activity of human natural killer cells. Mol Cancer Ther 2007;6:644-654.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 644-654
    • Markasz, L.1    Stuber, G.2    Vanherberghen, B.3
  • 99
    • 77957193432 scopus 로고    scopus 로고
    • Interaction betweenKIR3DS1 and HLABw4 predicts for progression-free survival afterautologous stem cell transplantation in patients wiThmultiple myeloma
    • Gabriel IH, Sergeant R, Szydlo R, et a l. Interaction betweenKIR3DS1 and HLABw4 predicts for progression-free survival afterautologous stem cell transplantation in patients wiThmultiple myeloma. Blood 2010;116:2033-2039.
    • (2010) Blood , vol.116 , pp. 2033-2039
    • Gabriel, I.H.1    Sergeant, R.2    Szydlo, R.3
  • 100
    • 78650623731 scopus 로고    scopus 로고
    • International myelomaworking group consensus statement regarding the current status of allogeneic stem cell transplantation for multiple myeloma
    • Lokhorst H, Einsele H, Vesole D, et a l. International myelomaworking group consensus statement regarding the current status of allogeneic stem cell transplantation for multiple myeloma. J Clin Oncol 2010;28:4521-4530.
    • (2010) J. Clin. Oncol , vol.28 , pp. 4521-4530
    • Lokhorst, H.1    Einsele, H.2    Vesole, D.3
  • 101
    • 77956954589 scopus 로고    scopus 로고
    • Progress in allogeneic stem cell transplantation for multiple myeloma
    • Gharton G. Progress in allogeneic stem cell transplantation for multiple myeloma. Eur J Haematol 2010;85:279-289.
    • (2010) Eur. J. Haematol , vol.85 , pp. 279-289
    • Gharton, G.1
  • 102
    • 0030043438 scopus 로고    scopus 로고
    • Graft versus myeloma eff ect: Proof of principle
    • Tricot G, Vesole DH, Jagannath S, et al. Graft versus myeloma eff ect: Proof of principle. Blood 1996;87:73-91.
    • (1996) Blood , vol.87 , pp. 73-91
    • Tricot, G.1    Vesole, D.H.2    Jagannath, S.3
  • 103
    • 36148984928 scopus 로고    scopus 로고
    • Anti-myeloma activityof endogenous and adoptively transferred activated natural killercells in experimental multiple myeloma model
    • Alici E, Konstantinidis KV, Sutlu T, et al. Anti-myeloma activityof endogenous and adoptively transferred activated natural killercells in experimental multiple myeloma model. Exp Hematol 2007;35: 1839-1846.
    • (2007) Exp. Hematol , vol.35 , pp. 1839-1846
    • Alici, E.1    Konstantinidis, K.V.2    Sutlu, T.3
  • 104
    • 0037086131 scopus 로고    scopus 로고
    • Eff ectiveness of donornatural killer cell alloreactivity in mismatched hematopoietictransplants
    • Ruggeri L, Capanni M, Urbani E, et al. Eff ectiveness of donornatural killer cell alloreactivity in mismatched hematopoietictransplants. Science 2002;295:2097-2100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3
  • 105
    • 20444463165 scopus 로고    scopus 로고
    • Comparison betweenantithymocyte globulin and alemtuzumab and the possible impact ofKIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients wiThmultiple myeloma
    • Kroger N, Shaw B, Iacobelli S, et a l. Comparison betweenantithymocyte globulin and alemtuzumab and the possible impact ofKIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients wiThmultiple myeloma. Br J Haematol 2005;129:631-643.
    • (2005) Br. J. Haematol , vol.129 , pp. 631-643
    • Kroger, N.1    Shaw, B.2    Iacobelli, S.3
  • 106
    • 55949134663 scopus 로고    scopus 로고
    • Infusion of halpo-identical killerimmunoglobulin-like receptor ligand mismatched NK cells for relapsedmyeloma in the setting of autologous stem cell transplantation
    • Shi J, Tricot G, Szmania S, et al. Infusion of halpo-identical killerimmunoglobulin-like receptor ligand mismatched NK cells for relapsedmyeloma in the setting of autologous stem cell transplantation. Br JHaematol 2008;143:641-653.
    • (2008) Br. J. Haematol , vol.143 , pp. 641-653
    • Shi, J.1    Tricot, G.2    Szmania, S.3
  • 107
    • 80054016181 scopus 로고    scopus 로고
    • Donor KIR haplotypeB improves progression-free and overall survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma
    • Kroger N, Zabelina T, Berger J, et a l. Donor KIR haplotypeB improves progression-free and overall survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. Leukemia 2011;25:1657-1661.
    • (2011) Leukemia , vol.25 , pp. 1657-1661
    • Kroger, N.1    Zabelina, T.2    Berger, J.3
  • 108
    • 76749162262 scopus 로고    scopus 로고
    • Lenalidomide assalvage therapy after allo-SCT for multiple myeloma is eff ective andleads to an increase in activated NK (NKp44-) and T (HLA-DR-) cells
    • Lioznov M, El-Cheikh J, Hoff mann F, et al. Lenalidomide assalvage therapy after allo-SCT for multiple myeloma is eff ective andleads to an increase in activated NK (NKp44-) and T (HLA-DR-) cells. Bone Marrow Transplant 2010;45:349-353.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 349-353
    • Lioznov, M.1    El-Cheikh, J.2    Hoffmann, F.3
  • 109
    • 74249089972 scopus 로고    scopus 로고
    • Mechanism of action ofimmunomodulatory drugs (IMiDS) in multiple myeloma
    • Quach H, Ritchie D, Stewart AK, et a l. Mechanism of action ofimmunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia2001;24:22-32.
    • (2001) Leukemia , vol.24 , pp. 22-32
    • Quach, H.1    Ritchie, D.2    Stewart, A.K.3
  • 110
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 111
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinicalapplication
    • H ayashi T, Hideshima T, Akiyama M, et a l. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinicalapplication. Br J Haematol 2005;128:192-203.
    • (2005) Br. J. Haematol , vol.128 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 112
    • 0038476461 scopus 로고    scopus 로고
    • Enhancementof cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
    • Schafer PH, Gandhi AK, Loveland MA, et a l. Enhancementof cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther 2003;305:1222-1232.
    • (2003) J. Pharmacol Exp. Ther. , vol.305 , pp. 1222-1232
    • Schafer, P.H.1    Gandhi, A.K.2    Loveland, M.A.3
  • 113
    • 29244488561 scopus 로고    scopus 로고
    • Immunomodulatory druglenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications
    • Tai YT, Li XF, Catley L, et a l. Immunomodulatory druglenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications. CancerRes 2005;65:11712-11720.
    • (2005) Cancer Res. , vol.65 , pp. 11712-11720
    • Tai, Y.T.1    Li, X.F.2    Catley, L.3
  • 114
    • 78049386125 scopus 로고    scopus 로고
    • Immunomodulatoryeff ects of lenalidomide and pomalidomide on interaction of tumorand bone marrow accessory cells in multiple myeloma
    • G orgun G, Calabrese E, Soydan E, et al. Immunomodulatoryeff ects of lenalidomide and pomalidomide on interaction of tumorand bone marrow accessory cells in multiple myeloma. Blood2010;116:3227-3237.
    • (2010) Blood , vol.116 , pp. 3227-3237
    • Gorgun, G.1    Calabrese, E.2    Soydan, E.3
  • 115
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel antiinhibitorKIR antibody, and lenalidomide combine to enhance thenatural killer cell versus multiple myeloma eff ect
    • Benson DM Jr, Bakan CE, Zhang S, et al. IPH2101, a novel antiinhibitorKIR antibody, and lenalidomide combine to enhance thenatural killer cell versus multiple myeloma eff ect. Blood 2011;118:6387-6391.
    • (2011) Blood , vol.118 , pp. 6387-6391
    • Benson Jr., D.M.1    Bakan, C.E.2    Zhang, S.3
  • 116
    • 79551641781 scopus 로고    scopus 로고
    • How immunomodulatory are IMIDs
    • Mitsiades CS. How immunomodulatory are IMIDs? Blood 2011;117:1440-1441.
    • (2011) Blood , vol.117 , pp. 1440-1441
    • Mitsiades, C.S.1
  • 117
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizeswiThlenalidomide to inhibit multiple myeloma tumor growth, butreduced lenalidomide-induced immunomodulation of T and NK cellfunction
    • G handhi AK, Kang J, Capone L, et al. Dexamethasone synergizeswiThlenalidomide to inhibit multiple myeloma tumor growth, butreduced lenalidomide-induced immunomodulation of T and NK cellfunction. Curr Cancer Drug Targets 2010;10:155-167.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 155-167
    • Ghandhi, A.K.1    Kang, J.2    Capone, L.3
  • 118
    • 79551615800 scopus 로고    scopus 로고
    • The immuno-stimulatory eff ect oflenalidomide on NK cell function is profoundly inhibited by concurrentdexamethasone therapy
    • H su AK, Quach H, Tai T, et a l. The immuno-stimulatory eff ect oflenalidomide on NK cell function is profoundly inhibited by concurrentdexamethasone therapy. Blood 2011;117:1605-1613.
    • (2011) Blood , vol.117 , pp. 1605-1613
    • Hsu, A.K.1    Quach, H.2    Tai, T.3
  • 119
    • 38949113714 scopus 로고    scopus 로고
    • Bortezomib down-regulates thecell surface expression of HLA-class I and enhances natural killer cellmediated lysis of myeloma
    • S hi J, Tricot G, Garg TK, et a l. Bortezomib down-regulates thecell surface expression of HLA-class I and enhances natural killer cellmediated lysis of myeloma. Blood 2008;111:1309-1317.
    • (2008) Blood , vol.111 , pp. 1309-1317
    • Shi, J.1    Tricot, G.2    Garg, T.K.3
  • 120
    • 80755175740 scopus 로고    scopus 로고
    • Proteasome inhibitor lacta cystinaugments natural killer cell cytotoxicity of myeloma via downregulationof HLA class I
    • W u X, Shao Y, Tao Y, et al. Proteasome inhibitor lacta cystinaugments natural killer cell cytotoxicity of myeloma via downregulationof HLA class I. Biochem Biophys Res Commun 2001;415:187-192.
    • (2001) Biochem Biophys Res. Commun , vol.415 , pp. 187-192
    • Wu, X.1    Shao, Y.2    Tao, Y.3
  • 121
    • 40449100492 scopus 로고    scopus 로고
    • Sensitization of tumorcells to NK cell-mediated killing by proteasome inhibition
    • H allett WH, Ames E, Motarjemi M, et a l. Sensitization of tumorcells to NK cell-mediated killing by proteasome inhibition. J Immunol 2008;180:163-170.
    • (2008) J. Immunol , vol.180 , pp. 163-170
    • Hallett, W.H.1    Ames, E.2    Motarjemi, M.3
  • 122
    • 0025980998 scopus 로고
    • Preliminary studies foran immunotherapeutic approach to the treatment of human myelomausing chimeric anti-CD38 antibody
    • S tevenson FK, Bell AJ, Crusack R, et al. Preliminary studies foran immunotherapeutic approach to the treatment of human myelomausing chimeric anti-CD38 antibody. Blood 1991;77:1071-1079.
    • (1991) Blood , vol.77 , pp. 1071-1079
    • Stevenson, F.K.1    Bell, A.J.2    Crusack, R.3
  • 123
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeuticantibody target for the treatment of multiple myeloma
    • H si ED, Steinle R, Balasa B, et a l. CS1, a potential new therapeuticantibody target for the treatment of multiple myeloma. Clin Cancer Res 2008;14:2775-2784.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2775-2784
    • Hsi, E.D.1    Steinle, R.2    Balasa, B.3
  • 124
    • 70349481310 scopus 로고    scopus 로고
    • Combinatorial effi cacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63)and bortezomib against multiple myeloma
    • V an Rhee F, Szmania SM, Dillon M, et al. Combinatorial effi cacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63)and bortezomib against multiple myeloma. Mol Cancer Ther 2009;8:2616-2624.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2616-2624
    • Van Rhee, F.1    Szmania, S.M.2    Dillon, M.3
  • 125
    • 60749124123 scopus 로고    scopus 로고
    • Infl uence of CRACC, aSLAM family receptor coupled to the adaptor EAT-2, on natural killercell function
    • C ruz-Munoz ME, Dong Z, Shi X, et a l. Infl uence of CRACC, aSLAM family receptor coupled to the adaptor EAT-2, on natural killercell function. Nat Immunol 2009;10:297-305.
    • (2009) Nat. Immunol , vol.10 , pp. 297-305
    • Cruz-Munoz, M.E.1    Dong, Z.2    Shi, X.3
  • 126
    • 85171940266 scopus 로고    scopus 로고
    • The eff ect of elotuzumabon NK cell function against myeloma
    • Abstract 2572
    • C ollins SM, Bakan CE, Alghothani Y, et a l. The eff ect of elotuzumabon NK cell function against myeloma. J Clin Oncol 2011;29(15 Suppl.):Abstract 2572.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 SUPPL.
    • Collins, S.M.1    Bakan, C.E.2    Alghothani, Y.3
  • 128
    • 84863971439 scopus 로고    scopus 로고
    • Elotuzumab in combinationwiThlenalidomide and low-dose dexamethasone in relapsed orrefractory multiple myeloma
    • Abstract8076
    • L onial S, Vij R, Harousseau J-L, et al. Elotuzumab in combinationwiThlenalidomide and low-dose dexamethasone in relapsed orrefractory multiple myeloma. J Clin Oncol 2011;29(15 Suppl.): Abstract8076.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 SUPPL.
    • Lonial, S.1    Vij, R.2    Harousseau, J.-L.3
  • 129
    • 84862672400 scopus 로고    scopus 로고
    • A phase I trialof anti-CS1 monoclonal antibody elotuzumab in combination withbortezomib in the treatment of relapsed/refractory multiple myeloma
    • Jan 30. [Epub ahead of print]
    • J akubowiak AJ, Benson DM, Bensinger W, et a l. A phase I trialof anti-CS1 monoclonal antibody elotuzumab in combination withbortezomib in the treatment of relapsed/refractory multiple myeloma.J Clin Oncol 2012 Jan 30. [Epub ahead of print]
    • (2012) J. Clin. Oncol.
    • Jakubowiak, A.J.1    Benson, D.M.2    Bensinger, W.3
  • 130
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plusdexamethasone for relapsed multiple myeloma in NorThAmerica
    • Weber DM, Chen C, Niesvizky R, et al. Lenalidomide plusdexamethasone for relapsed multiple myeloma in NorThAmerica.N Engl J Med 2007;357:2133-2142.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 131
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plusdexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plusdexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357:2123-2132.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 132
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory multiple myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory multiple myeloma. N Engl J Med 2003;348:2609-2617.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 133
    • 50549099901 scopus 로고    scopus 로고
    • Role of KIRs and KIR ligands in hematopoietic transplantation
    • Velardi A. Role of KIRs and KIR ligands in hematopoietic transplantation. Curr Opin Immunol 2008;20:581-587.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 581-587
    • Velardi, A.1
  • 134
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1 - 7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romange F, Andre P, Spee P, et al. Preclinical characterization of 1 - 7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 2009;114:2667-2677.
    • (2009) Blood , vol.114 , pp. 2667-2677
    • Romange, F.1    Andre, P.2    Spee, P.3
  • 135
    • 85171902757 scopus 로고    scopus 로고
    • Phase I trial of IPH2101 in patients wiThmyeloma
    • Suppl.): Abstract P-194
    • B enson DM, Bakan C, Hofmeister CC, et al. Phase I trial of IPH2101 in patients wiThmyeloma. Haematologica 2011;96(Suppl.): Abstract P-194.
    • (2011) Haematologica , vol.96
    • Benson, D.M.1    Bakan, C.2    Hofmeister, C.C.3
  • 136
    • 80052269192 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of multiple myeloma
    • R ichardson PG, Lonial S, Jakubowiak AJ, et al. Monoclonal antibodies in the treatment of multiple myeloma. Br J Haematol 2011;154:745-754.
    • (2011) Br. J. Haematol. , vol.154 , pp. 745-754
    • Richardson, P.G.1    Lonial, S.2    Jakubowiak, A.J.3
  • 137
    • 80053646308 scopus 로고    scopus 로고
    • Surface molecule CD229 as a novel target for the diagnosis and treatment of multiplemyeloma
    • Atanackovic D, Panse J, Hildebrandt Y, et al. Surface molecule CD229 as a novel target for the diagnosis and treatment of multiplemyeloma. Haematologica 2011;96:1512-1520.
    • (2011) Haematologica , vol.96 , pp. 1512-1520
    • Atanackovic, D.1    Panse, J.2    Hildebrandt, Y.3
  • 138
    • 52549088421 scopus 로고    scopus 로고
    • Immunomodulatorydrugs Revlimid (lenalidomide) and CC-4047 induce apoptosis ofboThhematological and solid tumor cells through NK cell activation
    • Zhu D, Corral LG, Fleming YW, et al. Immunomodulatorydrugs Revlimid (lenalidomide) and CC-4047 induce apoptosis ofboThhematological and solid tumor cells through NK cell activation. Canacer Immunol Immunother 2008;57:1849-1859.
    • (2008) Canacer Immunol Immunother , vol.57 , pp. 1849-1859
    • Zhu, D.1    Corral, L.G.2    Fleming, Y.W.3
  • 139
    • 53949108746 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitive tumor cells for cytotoxic eff ects of natural killer cells
    • Schmudde M, Braun A, Pende D, et al. Histone deacetylase inhibitors sensitive tumor cells for cytotoxic eff ects of natural killer cells. Cancer Lett 2008;272:110-121.
    • (2008) Cancer Lett. , vol.272 , pp. 110-121
    • Schmudde, M.1    Braun, A.2    Pende, D.3
  • 140
    • 70449717531 scopus 로고    scopus 로고
    • Heat shock protein- 90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation
    • Fionda C, Soriani A, Malgarini G, et al. Heat shock protein- 90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation. J Immunol 2009;183:4385-4394.
    • (2009) J. Immunol , vol.183 , pp. 4385-4394
    • Fionda, C.1    Soriani, A.2    Malgarini, G.3
  • 141
    • 42449160619 scopus 로고    scopus 로고
    • Autologous antitumoractivity by NK cells expanded from myeloma patients using GMPcompliantcomponents
    • Alici E, Sutlu T, Bjorkstrand B, et a l. Autologous antitumoractivity by NK cells expanded from myeloma patients using GMPcompliantcomponents. Blood 2008;111:3155-3162.
    • (2008) Blood , vol.111 , pp. 3155-3162
    • Alici, E.1    Sutlu, T.2    Bjorkstrand, B.3
  • 142
    • 77953404092 scopus 로고    scopus 로고
    • Safety analysis of ex vivo expanded NK and NK-like T cells administered to cancer patients: A phase I clinical study
    • Barkholt L, Alici E, Conrad R, et al. Safety analysis of ex vivo expanded NK and NK-like T cells administered to cancer patients: phase I clinical study. Immunotherapy 2009;1:753-764.
    • (2009) Immunotherapy , vol.1 , pp. 753-764
    • Barkholt, L.1    Alici, E.2    Conrad, R.3


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