Which drugs cause cancer?* Cancer bioassays

BMJ

Volumn 331, Issue 7521, 2005, Pages E389-E391

  Knight, Andrew ^a   Bailey, Jarrod ^b   Balcombe, Jonathan ^c   Farland, William H ^d   Rodan, Bruce ^d   Preuss, Peter ^d  

^a Animal Consultants International 91 Vanbrugh Court Wincott ^*  (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c PHYSICIANS COMMITTEE FOR RESPONSIBLE MEDICINE   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN;

ANIMAL EXPERIMENT; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; FACTUAL DATABASE; HUMAN; HUMAN EXPERIMENT; NEOPLASM; REVIEW; BIOASSAY; ENVIRONMENTAL EXPOSURE; METHODOLOGY; NOTE; RISK FACTOR; STANDARD;

ANIMAL EXPERIMENTATION; CARCINOGENICITY TESTS; CARCINOGENS; DATABASES, FACTUAL; HUMAN EXPERIMENTATION; HUMANS; NEOPLASMS; BIOLOGICAL ASSAY; ENVIRONMENTAL EXPOSURE; RISK FACTORS;

EID: 26944448621     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.331.7521.E389     Document Type: Article

References (9)

1. US Environmental Protection Agency. Guidelines for carcinogen risk assessment. EPA/630/P-03/001F, March 2005.
2. Versar Inc, 2000. Characterization of data uncertainty and variability in IRIS assessments, pre-pilot vs pilot/post-pilot.
3. Huff J. Long-term chemical carcinogenesis bioassays predict human cancer hazards. Issues, controversies, and uncertainties. Ann NY Acad Sci 1999; 895: 56 79.
4. Maronpot RR, Flake G, Huff J. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol 2004; 32(Suppl 1): 40 48.
5. Rall DP. Laboratory animal tests and human cancer. Drug Metab Rev 2000; 32 (2): 119 128.
6. NRC. Guide for the care and use of laboratory animals. Institute for Laboratory Animal Research. National Academies Press. 1996.
7. NIH. NIH Office of Animal Care and Use.
8. Stephens ML, Mendoza P, Weaver A, Hamilton T. Unrelieved pain and distress in animals: an analysis of USDA data on experimental procedures. J App Animal Welfare Science 1998; 1 (1): 15 26.
9. ICCVAM/NICEATM. The Interagency Coordinating Committee on the Validation of Alternative Methods/The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods. National Institute of Environmental Health Sciences.