Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Tiburzy, Benjamin ^a   Szyska, Martin ^a   Iwata, Hiroaki ^a   Chrobok, Navina ^a   Kulkarni, Upasana ^a   Hirose, Misa ^a   Ludwig, Ralf J ^a   Kalies, Kathrin ^a   Westermann, Jurgen ^a   Wong, David ^a   Manz, Rudolf Armin ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; BYSTANDER EFFECT; CD4+ T LYMPHOCYTE; CELL COUNT; CELL POPULATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; EPIDERMOLYSIS BULLOSA ACQUISITA; LIFESPAN; LYMPHADENOPATHY; LYMPHATIC DRAINAGE; MOUSE; NONHUMAN; PLASMA CELL;

ANIMALS; AUTOANTIBODIES; BONE MARROW; COLLAGEN TYPE VII; DISEASE MODELS, ANIMAL; EPIDERMOLYSIS BULLOSA ACQUISITA; EPITOPES, B-LYMPHOCYTE; LYMPH NODES; MICE; PLASMA CELLS; SPLEEN; T-LYMPHOCYTE SUBSETS;

EID: 84891320005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083631     Document Type: Article

References (41)

1. Manz RA, Hauser AE, Hiepe F, Radbruch A (2005) Maintenance of Serum Antibody Levels. Annual Review of Immunology 23: 367-386. doi:10.1146/annurev. immunol.23.021704.115723 (Pubitemid 40563174)
2. Ho F, Lortan JE, MacLennan IC, Khan M (1986) Distinct short-lived and longlived antibody-producing cell populations. Eur J Immunol 16: 1297-1301. doi:10.1002/eji.1830161018 (Pubitemid 17171537)
3. Manz RA, Arce S, Cassese G, Hauser AE, Hiepe F, et al. (2002) Humoral immunity and long-lived plasma cells. Curr Opin Immunol 14: 517-521 (Pubitemid 34671256)
4. Hiepe F, Dörner T, Hauser AE, Hoyer BF, Mei H, et al. (2011) Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7: 170-178. doi:10.1038/nrrheum.2011.1
5. Mumtaz IM, Hoyer BF, Panne D, Moser K, Winter O, et al. (2012) Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity. J Autoimmun 39: 180-188. doi:10.1016/j.jaut.2012.05.010
6. Hoyer BF (2004) Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB/W Mice. Journal of Experimental Medicine 199: 1577-1584. doi:10.1084/jem.20040168 (Pubitemid 38780412)
7. Schmidt E, Obe K, Bröcker EB, Zillikens D (2000) Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid. Arch Dermatol 136: 174-178 (Pubitemid 30090755)
8. Nagel A, Hertl M, Eming R (2009) B-cell-directed therapy for inflammatory skin diseases. J Invest Dermatol 129: 289-301. doi:10.1038/jid.2008.192
9. Ferraro AJ, Drayson MT, Savage COS, MacLennan ICM (2008) Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab. Eur J Immunol 38: 292-298. doi:10.1002/eji.200737557
10. Ludwig RJ, Zillikens D (2011) Pathogenesis of epidermolysis bullosa acquisita. Dermatol Clin 29: 493-501, xi. doi:10.1016/j.det.2011.03.003
11. Gupta R, Woodley DT, Chen M (2012) Epidermolysis bullosa acquisita. Clin Dermatol 30: 60-69. doi:10.1016/j.clindermatol.2011.03.011
12. Sitaru C, Kromminga A, Hashimoto T, Bröcker EB, Zillikens D (2002) Autoantibodies to type VII collagen mediate Fcgamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin. Am J Pathol 161: 301-311 (Pubitemid 34760796)
13. Sitaru C, Mihai S, Otto C, Chiriac MT, Hausser I, et al. (2005) Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen. J Clin Invest 115: 870-878. doi:10.1172/JCI21386 (Pubitemid 40489391)
14. Sitaru C, Chiriac MT, Mihai S, Büning J, Gebert A, et al. (2006) Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. The Journal of Immunology 177: 3461
15. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, et al. (2006) Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol 126: 1323-1330. doi:10.1038/sj.jid.5700254 (Pubitemid 43997915)
16. Chen M, Doostan A, Bandyopadhyay P, Remington J, Wang X, et al. (2007) The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita. Am J Pathol 170: 2009-2018. doi:10.2353/ajpath.2007.061212 (Pubitemid 47339274)
17. Ludwig RJ (2012) Model systems duplicating epidermolysis bullosa acquisita: a methodological review. Autoimmunity 45: 102-110. doi:10.3109/08916934.2011.606451
18. Sitaru AG, Sesarman A, Mihai S, Chiriac MT, Zillikens D, et al. (2010) T cells are required for the production of blister-inducing autoantibodies in experimental epidermolysis bullosa acquisita. The Journal of Immunology 184: 1596
19. Tesch H, Smith FI, Müller-Hermes WJ, Rajewsky K (1984) Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) antibody populations in the primary adoptive response. I. Isotype distribution. Eur J Immunol 14: 188-194. doi:10.1002/eji.1830140215 (Pubitemid 14192935)
20. Toellner K-M, Jenkinson WE, Taylor DR, Khan M, Sze DM-Y, et al. (2002) Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J Exp Med 195: 383-389 (Pubitemid 34461497)
21. Ludwig RJ, Recke A, Bieber K, Mü ller S, Marques A de C, et al. (2011) Generation of antibodies of distinct subclasses and specificity is linked to H2s in an active mouse model of epidermolysis bullosa acquisita. J Invest Dermatol 131: 167-176. doi:10.1038/jid.2010.248
22. Blink EJ, Light A, Kallies A, Nutt SL, Hodgkin PD, et al. (2005) Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med 201: 545-554. doi:10.1084/jem.20042060 (Pubitemid 40289545)
23. Winter O, Moser K, Mohr E, Zotos D, Kaminski H, et al. (2010) Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. Blood 116: 1867-1875. doi:10.1182/blood-2009-12-259457
24. Cassese G, Lindenau S, de Boer B, Arce S, Hauser A, et al. (2001) Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. European journal of immunology 31: 2726-2732 (Pubitemid 32898740)
25. Orsini Parent, Mundell Marchese, Benovic (2000) Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the Cterminal tail that mediate receptor internalization. J Biol Chem 275: 25876
26. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, et al. (2001) A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med 194: 45-56 (Pubitemid 32660436)
27. Cassese G, Arce S, Hauser AE, Lehnert K, Moewes B, et al. (2003) Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 171: 1684-1690 (Pubitemid 36966450)
28. Moser K, Kalies K, Szyska M, Humrich JY, Amann K, et al. (2012) CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice. Arthritis Rheum 64: 1237-1246. doi:10.1002/art.33424
29. Manz RA, Thiel A, Radbruch A (1997) Lifetime of plasma cells in the bone marrow. Nature 388: 133-134. doi:10.1038/40540 (Pubitemid 27297440)
30. Slifka MK, Antia R, Whitmire JK, Ahmed R (1998) Humoral immunity due to long-lived plasma cells. Immunity 8: 363-372 (Pubitemid 28188896)
31. Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, et al. (2005) Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nature Medicine 11: 1118-1124. doi:10.1038/nm1292 (Pubitemid 41486836)
32. Kirchhoff D, Frentsch M, Leclerk P, Bumann D, Rausch S, et al. (2007) Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur J Immunol 37: 2370-2377. doi:10.1002/eji.200737322 (Pubitemid 47423607)
33. Frey O, Mitera T, Kelchtermans H, Schurgers E, Kamradt T, et al. (2011) Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-c receptor knockout mice exposes an arthritis-promoting role of IFN-c. J Autoimmun 36: 161-169. doi:10.1016/j.jaut.2010.12.006
34. Hauser AE, Debes GF, Arce S, Cassese G, Hamann A, et al. (2002) Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol 169: 1277-1282 (Pubitemid 34809169)
35. Muehlinghaus G, Cigliano L, Huehn S, Peddinghaus A, Leyendeckers H, et al. (2005) Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 105: 3965-3971. doi:10.1182/blood-2004-08-2992 (Pubitemid 40656144)
36. Moser K, Tokoyoda K, Radbruch A, MacLennan I, Manz RA (2006) Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol 18: 265-270. doi:10.1016/j.coi.2006.03.004
37. Ryan KR, Patel SD, Stephens LA, Anderton SM (2007) Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry. J Autoimmun 29: 262-271. doi:10.1016/j.jaut.2007.07.014 (Pubitemid 350011035)
38. Starke C, Frey S, Wellmann U, Urbonaviciute V, Herrmann M, et al. (2011) High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice. Eur J Immunol 41: 2107-2112. doi:10.1002/eji.201041315
39. Schmidt E, Benoit S, Bröcker E-B, Zillikens D, Goebeler M (2006) Successful adjuvant treatment of recalcitrant epidermolysis bullosa acquisita with anti- CD20 antibody rituximab. Arch Dermatol 142: 147-150. doi:10.1001/archderm.142.2.147 (Pubitemid 43276525)
40. Kasperkiewicz M, Shimanovich I, Ludwig RJ, Rose C, Zillikens D, et al. (2011) Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients. J Am Acad Dermatol 65: 552-558. doi:10.1016/j.jaad.2010. 07.032
41. Le Roux-Villet C, Prost-Squarcioni C, Alexandre M, Caux F, Pascal F, et al. (2011) Rituximab for patients with refractory mucous membrane pemphigoid. Arch Dermatol 147: 843-849. doi:10.1001/archdermatol.2011.54