The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita

American Journal of Pathology

Volumn 170, Issue 6, 2007, Pages 2009-2018

  Chen, Mei ^a   Doostan, Arvin ^a   Bandyopadhyay, Pubali ^a   Remington, Jennifer ^a   Wang, Xinyi ^a   Hou, Yingping ^a   Liu, Ziu ^b   Woodley, David T ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; COLLAGEN TYPE 7; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; MATRIX PROTEIN; AUTOANTIBODY; CARTILAGE MATRIX PROTEIN; COLLAGEN TYPE 8; EPITOPE; GLYCOPROTEIN; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLISTER; BULLOUS PEMPHIGOID; CARTILAGE MATRIX; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMOLYSIS BULLOSA ACQUISITA; HISTOPATHOLOGY; HUMAN; IMMUNOBLOTTING; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; CHEMISTRY; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; NUDE MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SKIN;

ANIMALS; AUTOANTIBODIES; COLLAGEN TYPE VIII; EPIDERMOLYSIS BULLOSA ACQUISITA; EPITOPES; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; HUMANS; MICE; MICE, NUDE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SKIN;

EID: 34447309358     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.061212     Document Type: Article

References (30)

1. Roenigk HH, Ryan JG, Bergfeld MA: Epidermolysis bullosa acquisita: report of three cases and review of all published cases. Arch Dermatol 1971, 103:1-10
2. Woodley DT, Briggaman RA, O'Keefe EJ, Inman AQ, Queen LL, Gammon WR: Identification of the skin basement membrane autoantigen in epidermolysis bullosa acquisita. New Engl J Med 1984, 310:1007-1013
3. Woodley DT, Burgeson RE, Lunstrum G, Bruckner-Tuderman L, Reese MJ, Briggaman RA: The epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen. J Clin Invest 1988, 81:683-687
4. Woodley DT, Briggaman RA, Falk RJ, Reese MJ, Tomsick RS, Gammon WR, O'Keefe EJ: Epidermolysis bullosa acquisita antigen, a major cutaneous basement membrane component, is synthesized by human dermal fibroblasts and other cutaneous tissues. J Invest Dermatol 1986, 87:227-231
5. Briggaman RA, Wheeler Jr CE: The epidermal-dermal junction. J Invest Dermatol 1975, 65:71-84
6. Burgeson RE: Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J Invest Dermatol 1993, 101:252-255
7. Sakai LY, Keene DR, Morris NP, Burgeson RE: Type VII collagen is a major structural component of anchoring fibrils. J Cell Biol 1986, 103:1577-1586
8. Keene DR, Sakai LY, Lundstru GP, Morris NP, Burgeson RE: Type VII collagen forms an extended network of anchoring fibrils. J Cell Biol 1987, 104:611-621
9. Uitto J, Christiano AM: Molecular basis for the dystrophic forms of epidermolysis bullosa: mutations in the type VII collagen gene. Arch Dermatol Res 1994, 287:16-22
10. Uitto J, Christiano AM: Molecular genetics of the cutaneous basement membrane zone: perspectives on epidermolysis bullosa and other blistering skin diseases. J Clin Invest 1992, 90:687-692
11. Lunstrum GP, Kuo HJ, Rosenbaum LM, Keene DR, Glanville RW, Sakai LY, Burgeson RE: Anchoring fibrils contain the carboxyl-terminal globular domain of type VII procollagen, but lack the amino-terminal globular domain. J Biol Chem 1987, 262:13706-13712
12. Lunstrum GP, Sakai LY, Keene DR, Morris NP, Burgeson RE: Large complex globular domains of type VII procollagen contribute to the structure of the anchoring fibrils. J Biol Chem 1986, 261:9042-9048
13. Christiano AM, Greenspan DS, Lee S, Uitto J: Cloning of human type VII collagen: complete primary sequence of the alpha 1(VII) chain and identification of intragenic polymorphisms. J Biol Chem 1994, 269:20256-20262
14. Chen M, Marinkovich MP, Veis A, O'Toole EA, Rao CN, Cai XY, Woodley DT: Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components: a potential role in epidermal-dermal adherence in human skin. J Biol Chem 1997, 272:14516-14522
15. Chen M, Marinkovich MP, Jones JC, O'Toole EA, Li YY, Woodley DT: NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats. J Invest Dermatol 1999, 112:177-183
16. Lapiere JC, Chen JD, Iwasaki T, Hu L, Uitto J, Woodley DT: Type VII collagen specifically binds fibronectin via a unique subdomain within the collagenous triple helix. J Invest Dermatol 1994, 103:637-641
17. Rousselle P, Keene DR, Ruggiero F, Champliaud MF, Rest M, Burgeson RE: Laminin 5 binds the NC-1 domain of type VII collagen. J Cell Biol 1997, 11:719-728
18. Lapiere JC, Woodley DT, Parente MG, Iwasaki T, Wynn KC, Christiano AM, Uitto J: Epitope mapping of type VII collagen: identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. J Clin Invest 1993, 92:1831-1839
19. Jones DA, Hunt III SW, Prisayanh PS, Briggaman RA, Gammon WR: Immunodominant autoepitopes of type VII collagen are short, paired peptide sequences within the fibronectin type III homology region of the noncollagenous (NC1) domain. J Invest Dermatol 1995, 104:231-235
20. Gammon WR, Murrell DF, Jenison MW, Padilla KM, Prisayanh PS, Jones DA, Briggaman RA, Hunt III SW: Autoantibodies to type VII collagen recognize epitopes in a fibronectin-like region of the non-collagenous (NC1) domain. J Invest Dermatol 1993, 100:618-622
21. Woodley DT, Chang C, Saadat P, Ram R, Liu Z, Chen M: Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita. J Invest Dermatol 2005, 124:958-964
22. Sitaru C, Mihai S, Otto C, Chiriac MT, Hausser I, Dotterweich B, Saito H, Rose C, Ishiko A, Zillikens D: Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen. J Clin Invest 2005, 115:870-878
23. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Remington J, Hou YP, Keene DR, Liu Z, Chen M: Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol 2006, 126:1324-1330
24. Gammon WR, Kowalewski C, Chorzelski TP, Kumar V, Briggaman RA, Beutner EH: Direct immunofluorescence studies of sodium chloride-separated skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. J Am Acad Dermatol 1990, 22:664-679
25. Woodley DT, Sauder D, Talley MJ, Silver M, Grotendorst G, Qwarnstrom E: Localization of basement membrane components after dermal-epidermal junction separation. J Invest Dermatol 1983, 81:149-153
26. Chen M, Chan LS, Cai X, O'Toole EA, Samples JC, Woodley DT: Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita. J Invest Dermatol 1997, 108:68-72
27. Yaoita H, Briggaman RA, Lawley TJ, Provost TT, Katz SI: Epidermolysis bullosa acquisita: ultrastructural and immunological studies. J Invest Dermatol 1981, 76:288-292
28. Gammon WR, Woodley DT, Dole K, Briggaman RA: Evidence that antibasement membrane zone antibodies in bullosa eruption of systemic lupus erythematosus recognize epidermolysis bullosa acquisita autoantigen. J Invest Dermatol 1985, 84:472-476
29. Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli of fusions with glutathione S-transferase. Gene 1988, 67:31-40
30. Nieboer C, Boorsma DM, Woerdeman MJ, Kalsbeek GL: Epidermolysis bullosa acquisita: immunofluorescence, electron microscopic and immunoelectron microscopic studies in four patients. Br J Dermatol 1980, 102:383-292