Generation of antibodies of distinct subclasses and specificity is linked to H2s in an active mouse model of epidermolysis bullosa acquisita

Journal of Investigative Dermatology

Volumn 131, Issue 1, 2011, Pages 167-176

  Ludwig, Ralf J ^a   Recke, Andreas ^a   Bieber, Katja ^a   Müller, Susen ^a   Marques, Andreia De Castro ^a   Banczyk, David ^a   Hirose, Misa ^a   Kasperkiewicz, Michael ^a   Ishii, Norito ^a,b   Schmidt, Enno ^a   Westermann, Jürgen ^a   Zillikens, Detlef ^a   Ibrahim, Saleh M ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIBODY; EPITOPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPIDERMOLYSIS BULLOSA ACQUISITA; FEMALE; GENETIC SUSCEPTIBILITY; HAPLOTYPE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 78650276702     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.248     Document Type: Article

References (57)

1. Azeredo da SS, Kikuchi S, Fossati-Jimack L et al. (2002) Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72
2. Baiu DC, Barger B, Sandor M et al. (2005) Autoantibodies to vascular smooth muscle are pathogenic for vasculitis. Am J Pathol 166:1851-60
3. Banfield CC, Wojnarowska F, Allen J et al. (1998) The association of HLA-DQ7 with bullous pemphigoid is restricted to men. Br J Dermatol 138:1085-90
4. Benacerraf B (1981) Role of MHC gene products in immune regulation. Science 212:1229-38
5. Bieber K, Sun S, Ishii N et al. (2009) Animal models for autoimmune bullous dermatoses. Exp Dermatol 19:2-11
6. Bradley PP, Priebat DA, Christensen RD et al. (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
7. Chan LS, Vanderlugt CJ, Hashimoto T et al. (1998) Epitope spreading: lessons from autoimmune skin diseases. J Invest Dermatol 110:103-9
8. Chen M, Doostan A, Bandyopadhyay P et al. (2007) The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita. Am J Pathol 170:2009-18
9. Chiriac MT, Roesler J, Sindrilaru A et al. (2007) NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage. J Pathol 212:56-65
10. Dausset J (1958) Iso-leuko-antibodies. Acta Haematol 20:156-66
11. Delgado JC, Turbay D, Yunis EJ et al. (1996) A common major histocompat-ibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid. Proc Natl Acad Sci USA 93:8569-71
12. Fairley JA, Woodley DT, Chen M et al. (2004) A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading. J Am Acad Dermatol 51:118-22
13. Fernando MM, Stevens CR, Walsh EC et al. (2008) Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 4:e1000024
14. Gammon WR, Heise ER, Burke WA et al. (1988) Increased frequency of HLA-DR2 in patients with autoantibodies to epidermolysis bullosa acquisita antigen: evidence that the expression of autoimmunity to type VII collagen is HLA class II allele associated. J Invest Dermatol 91: 228-32
15. Gunther E, Odenthal H, Wechsler W (1978) Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains. Clin Exp Immunol 32:429-34
16. Happ MP, Wettstein P, Dietzschold B et al. (1988) Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects. J Immunol 141:1489-94
17. Harbo HF, Lie BA, Sawcer S et al. (2004) Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens 63:237-47
18. Ichikawa M, Koh CS, Inaba Y et al. (1999) IgG subclass switching is associated with the severity of experimental autoimmune encephalo-myelitis induced with myelin oligodendrocyte glycoprotein peptide in NOD mice. Cell Immunol 191:97-104
19. Ishii N, Yoshida M, Hisamatsu Y et al. (2004) Epidermolysis bullosa acquisita sera react with distinct epitopes on the NC1 and NC2 domains of type VII collagen: study using immunoblotting of domain-specific recombi-nant proteins and postembedding immunoelectron microscopy. Br J Dermatol 150:843-51
20. Ishii N, Yoshida M, Ishida-Yamamoto A et al. (2009) Some epidermolysis bullosa acquisita sera react with epitopes within the triple-helical collagenous domain as indicated by immunoelectron microscopy. Br J Dermatol 160:1090-3
21. Kanno H, Nose M, Itoh J et al. (1992) Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism. Clin Exp Immunol 89:68-73
22. Karachunski PI, Ostlie NS, Monfardini C et al. (2000) Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice. J Immunol 164:5236-44
23. Kotzin BL, Palmer E (1987) The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice. J Exp Med 165:1237-51
24. Lapiere JC, Woodley DT, Parente MG et al. (1993) Epitope mapping of type VII collagen. Identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. J Clin Invest 92:1831-9
25. Li N, Aoki V, Hans-Filho G et al. (2003) The role of intramolecular epi-tope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem). J Exp Med 197:1501-10
26. Ludwig RJ, Ishii N, Kasperkiewicz M et al. (2008) Intravenous immuno-globulin (IVIG) is effective in experimental epidermolysis bullosa acquisita. J Invest Derm 128:S24
27. Ludwig RJ, Zollner TM, Santoso S et al. (2005) Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. J Invest Dermatol 125:969-76
28. Marietta E, Black K, Camilleri M et al. (2004) A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J Clin Invest 114:1090-7
29. Mihai S, Chiriac MT, Takahashi K et al. (2007) The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. J Immunol 178:6514-21
30. Miller JF, Vadas MA, Whitelaw A et al. (1976) Role of major histocompat-ibility complex gene products in delayed-type hypersensitivity. Proc Natl Acad Sci USA 73:2486-90
31. Okazaki A, Miyagawa S, Yamashina Y et al. (2000) Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid. J Dermatol 27:149-56
32. Park MS, Terasaki PI, Ahmed AR et al. (1979) HLA-DRW4 in 91% of Jewish pemphigus vulgaris patients. Lancet 2:441-2
33. Recke A, Rose C, Schmidt E et al. (2009a) Transition from pemphigus foliaceus to bullous pemphigoid: intermolecular B-cell epitope spreading without IgG subclass shifting. J Am Acad Dermatol 61:333-6
34. Recke A, Sitaru C, Vidarsson G et al. (2009b) Pathogenicity of IgG subclass autoantibodies to type VII collagen: Induction of dermal-epidermal separation. J Autoimmun 34:435-44
35. Remington J, Chen M, Burnett J et al. (2008) Autoimmunity to type VII collagen: epidermolysis bullosa acquisita. Curr Dir Autoimmun 10:195-205
36. Saenz-Cantele AM, Fernandez-Mestre M, Montagnani S et al. (2007) HLA-DRB1*0402 haplotypes without DQB1*0302 in Venezuelan patients with pemphigus vulgaris. Tissue Antigens 69:318-25
37. Sardy M, Karpati S, Merkl B et al. (2002) Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med 195:747-57
38. Satsangi J, Welsh KI, Bunce M et al. (1996) Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 347:1212-7
39. Sesarman A, Mihai S, Chiriac MT et al. (2008a) Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in mice. Br J Dermatol 158:463-71
40. Sesarman A, Sitaru AG, Olaru F et al. (2008b) The neonatal Fc-receptor promotes tissue injury in experimental epidermolysis bullosa acquisita. J Mol Med 86:951-9
41. Shams S, Amirzargar AA, Yousefi M et al. (2009) HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris. J Clin Immunol 29:175-9
42. Sitaru AG, Sesarman A, Mihai S et al. (2010) T cells are required for the production of blister-inducing autoantibodies in experimental epider-molysis bullosa acquisita. J Immunol 184:1596-603
43. Sitaru C, Chiriac MT, Mihai S et al. (2006) Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177:3461-8
44. Sitaru C, Mihai S, Otto C et al. (2005) Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen. J Clin Invest 115:870-8
45. Sitaru C, Zillikens D (2005) Mechanisms of blister induction by autoanti-bodies. Exp Dermatol 14:861-75
46. Snell GD (1964) Methods for study of histocompatibility genes and isoantigens. Methods Med Res 10:1-7
47. Spurkland A, Ingvarsson G, Falk ES et al. (1997) Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers. Tissue Antigens 49:29-34
48. Staines NA, Ekong TA, Thompson HS et al. (1990) Low affinity antibodies against collagen type II are associated with pathology in collagen-induced arthritis in mice. J Autoimmun 3:643-57
49. Szafer F, Brautbar C, Tzfoni E et al. (1987) Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the HLA-D region. Proc Natl Acad Sci USA 84:6542-5
50. Wicker LS, Miller BJ, Coker LZ et al. (1987) Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med 165:1639-54
51. Woodley DT, Briggaman RA, O'Keefe EJ et al. (1984) Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita. N Engl J Med 310:1007-13
52. Woodley DT, Burgeson RE, Lunstrum G et al. (1988) Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen. J Clin Invest 81:683-7
53. Woodley DT, Chang C, Saadat P et al. (2005) Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita. J Invest Dermatol 124:958-64
54. Woodley DT, Ram R, Doostan A et al. (2006) Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol 126:1323-30
55. Woodley PH, Luthra HS, Stuart JM et al. (1981) Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med 154:688-700
56. Zillikens D (2009) Autoimmune bullous skin diseases. In: Braun-Falco's Dermatology. (Burgdorf WHC, Plewig G, Wolff HH, Landthaler M eds). 3rd edn, Heidelberg: Springer, 641-70
57. Zillikens D, Kawahara Y, Ishiko A et al. (1996) A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone. J Invest Dermatol 106:1333-8