Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: Key roles of alanine-5 and threonine-6 in receptor activation

British Journal of Pharmacology

Volumn 171, Issue 2, 2014, Pages 415-426

  Hay, Debbie L ^a   Harris, Paul W R ^b   Kowalczyk, Renata ^b   Brimble, Margaret A ^b   Rathbone, Dan L ^c   Barwell, James ^c   Conner, Alex C ^d   Poyner, David R ^c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c ASTON UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

arrestin; amylin; calcitonin gene related peptide; cAMP; efficacy; GPCR; ligand binding; structure activity relationship

Indexed keywords

ALANINE; BETA ARRESTIN 2; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP; RADIOLIGAND; THREONINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RECEPTOR BINDING; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMYLIN; CALCITONIN GENE-RELATED PEPTIDE; CAMP; EFFICACY; GPCR; LIGAND BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; Β-ARRESTIN;

ALANINE; ANIMALS; ARRESTINS; CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; ISOTOPE LABELING; PEPTIDES; PROTEIN TRANSPORT; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SALIVARY ALPHA-AMYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; TRANSFECTION;

EID: 84891274041     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12464     Document Type: Article

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