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Volumn 22, Issue 3, 2009, Pages 241-246

Calcitonin gene-related peptide: An update on the biology

Author keywords

Calcitonin gene related peptide (CGRP); CGRP receptor; Migraine; Therapy

Indexed keywords

BMS 694153; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; MK 0974; OLCEGEPANT; TELCAGEPANT; UNCLASSIFIED DRUG; ZOLMITRIPTAN;

EID: 67049108842     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/WCO.0b013e32832b2427     Document Type: Review
Times cited : (60)

References (62)
  • 1
    • 4644298462 scopus 로고    scopus 로고
    • Caloitonin gene-related peptide and its role in migraine pathophysiology
    • Arulmani U, Maassenvandenbrink A, Villalon CM, et al. Caloitonin gene-related peptide and its role in migraine pathophysiology. Eur J Pharmacol 2004; 500:315-330.
    • (2004) Eur J Pharmacol , vol.500 , pp. 315-330
    • Arulmani, U.1    Maassenvandenbrink, A.2    Villalon, C.M.3
  • 2
    • 1542346238 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    • Olesen J, Diener HC, Husstedt IW, et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med 2004; 350:1104-1110.
    • (2004) N Engl J Med , vol.350 , pp. 1104-1110
    • Olesen, J.1    Diener, H.C.2    Husstedt, I.W.3
  • 3
    • 30344453954 scopus 로고    scopus 로고
    • Recent advances in the diagnosis and management of migraine
    • Goadsby PJ. Recent advances in the diagnosis and management of migraine. BMJ 2006; 332:25-29.
    • (2006) BMJ , vol.332 , pp. 25-29
    • Goadsby, P.J.1
  • 4
    • 4043057222 scopus 로고    scopus 로고
    • Edvinsson L Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache. Cephalalgia 2004; 24:611-622.
    • Edvinsson L Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache. Cephalalgia 2004; 24:611-622.
  • 5
    • 33846145074 scopus 로고    scopus 로고
    • CGRP receptor antagonists: A new frontier of antimigraine medications
    • de Prado BM, Russo AF. CGRP receptor antagonists: a new frontier of antimigraine medications. Drug Discov Today 2006; 3:593-597.
    • (2006) Drug Discov Today , vol.3 , pp. 593-597
    • de Prado, B.M.1    Russo, A.F.2
  • 6
    • 33646922284 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) and migraine
    • Durham PL. Calcitonin gene-related peptide (CGRP) and migraine. Headache 2006; 46 (Suppl 1):S3-S8.
    • (2006) Headache , vol.46 , Issue.SUPPL. 1
    • Durham, P.L.1
  • 7
    • 0025143541 scopus 로고
    • Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
    • Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neural 1990; 28:183-187.
    • (1990) Ann Neural , vol.28 , pp. 183-187
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 8
    • 0344737766 scopus 로고    scopus 로고
    • NO-induced migraine attack: Strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release
    • Juhasz G, Zsombok T, Modos EA, et al. NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. Pain 2003; 106: 461-470.
    • (2003) Pain , vol.106 , pp. 461-470
    • Juhasz, G.1    Zsombok, T.2    Modos, E.A.3
  • 9
    • 0027509161 scopus 로고
    • The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
    • Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neural 1993; 33:48-56.
    • (1993) Ann Neural , vol.33 , pp. 48-56
    • Goadsby, P.J.1    Edvinsson, L.2
  • 10
    • 25444458847 scopus 로고    scopus 로고
    • No increase of calcitonin gene-related peptide in jugular blood during migraine
    • Tvedskov JF, Lipka K, Ashina M, et al. No increase of calcitonin gene-related peptide in jugular blood during migraine. Ann Neural 2005; 58:561-568.
    • (2005) Ann Neural , vol.58 , pp. 561-568
    • Tvedskov, J.F.1    Lipka, K.2    Ashina, M.3
  • 11
    • 0034192812 scopus 로고    scopus 로고
    • Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
    • Ashina M, Bendtsen L, Jensen R, et al. Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks. Pain 2000; 86:133-138.
    • (2000) Pain , vol.86 , pp. 133-138
    • Ashina, M.1    Bendtsen, L.2    Jensen, R.3
  • 12
    • 33847689071 scopus 로고    scopus 로고
    • Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods
    • Fusayasu E, Kowa H, Takeshima T, et al. Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. Pain 2007; 128:209-214.
    • (2007) Pain , vol.128 , pp. 209-214
    • Fusayasu, E.1    Kowa, H.2    Takeshima, T.3
  • 14
    • 13944253331 scopus 로고    scopus 로고
    • BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation
    • Petersen KA, Lassen LH, Birk S, et al. BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation. Clin Pharmacol Ther 2005; 77:202-213.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 202-213
    • Petersen, K.A.1    Lassen, L.H.2    Birk, S.3
  • 15
    • 53049110894 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype
    • This study shows that CGRP does not cause an aura or delayed headache in individuals with familial hemiplegic migraine
    • Hansen JM, Thomsen LL, Olesen J, et al. Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype. Neurology 2008; 71:841-847. This study shows that CGRP does not cause an aura or delayed headache in individuals with familial hemiplegic migraine.
    • (2008) Neurology , vol.71 , pp. 841-847
    • Hansen, J.M.1    Thomsen, L.L.2    Olesen, J.3
  • 16
    • 41849140522 scopus 로고    scopus 로고
    • Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide
    • Hansen JM, Thomsen LL, Olesen J, et al. Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide. Cephalalgia 2008; 28:496-505.
    • (2008) Cephalalgia , vol.28 , pp. 496-505
    • Hansen, J.M.1    Thomsen, L.L.2    Olesen, J.3
  • 17
    • 40349085497 scopus 로고    scopus 로고
    • Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine
    • Hansen JM, Thomsen LL, Marconi R, et al. Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine. Cephalalgia 2008; 28:367-375.
    • (2008) Cephalalgia , vol.28 , pp. 367-375
    • Hansen, J.M.1    Thomsen, L.L.2    Marconi, R.3
  • 18
    • 55149086558 scopus 로고    scopus 로고
    • The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
    • Comprehensive review of the role of nitric oxide in primary headaches with references to interactions of the CGRP and nitric oxide pathways in headache pathophysiology
    • Olesen J. The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther 2008; 120:157-171. Comprehensive review of the role of nitric oxide in primary headaches with references to interactions of the CGRP and nitric oxide pathways in headache pathophysiology.
    • (2008) Pharmacol Ther , vol.120 , pp. 157-171
    • Olesen, J.1
  • 19
    • 41849112045 scopus 로고    scopus 로고
    • Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects
    • This study shows that peripheral microcirculation in migraineurs is not hypersensitive to CGRP and nitric oxide, suggesting that central effects of CGRP may be more relevant in migraine
    • Edvinsson ML, Edvinsson L Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects. Cephalalgia 2008; 28:563-566. This study shows that peripheral microcirculation in migraineurs is not hypersensitive to CGRP and nitric oxide, suggesting that central effects of CGRP may be more relevant in migraine.
    • (2008) Cephalalgia , vol.28 , pp. 563-566
    • Edvinsson, M.L.1    Edvinsson, L.2
  • 20
    • 42249087655 scopus 로고    scopus 로고
    • Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine
    • Phase II clinical trial of the oral CGRP antagonist telcagepant showing effectiveness and tolerability in comparison with a triptan
    • Ho TW, Mannix LK, Fan X, et al. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology 2008; 70:1304-1312. Phase II clinical trial of the oral CGRP antagonist telcagepant showing effectiveness and tolerability in comparison with a triptan.
    • (2008) Neurology , vol.70 , pp. 1304-1312
    • Ho, T.W.1    Mannix, L.K.2    Fan, X.3
  • 21
    • 57649233374 scopus 로고    scopus 로고
    • Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: A randomised, placebo-controlled, parallel-treatment trial
    • Phase III clinical trial of the oral CGRP antagonist telcagepant showing effectiveness and tolerability in comparison with a triptan
    • Ho TW, Ferrari MD, Dodick DW, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008; 372:2115-2123. Phase III clinical trial of the oral CGRP antagonist telcagepant showing effectiveness and tolerability in comparison with a triptan.
    • (2008) Lancet , vol.372 , pp. 2115-2123
    • Ho, T.W.1    Ferrari, M.D.2    Dodick, D.W.3
  • 22
    • 50349094014 scopus 로고    scopus 로고
    • Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF
    • Review of P2X3 receptors in chronic pain and possible role in migraine
    • Giniatullin R, Nistri A, Fabbretti E. Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF. Mol Neurobiol 2008; 37:83-90. Review of P2X3 receptors in chronic pain and possible role in migraine.
    • (2008) Mol Neurobiol , vol.37 , pp. 83-90
    • Giniatullin, R.1    Nistri, A.2    Fabbretti, E.3
  • 23
    • 49649113201 scopus 로고    scopus 로고
    • Mechanisms mediating the en-hanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons
    • This study describes the effect of CGRP on two target genes relevant to migraine, which may help explain the mechanism underlying the delayed onset of headache following CGRP injection
    • Simonetti M, Giniatullin R, Fabbretti E. Mechanisms mediating the en-hanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons. J Biol Chem 2008; 283:18743-18752. This study describes the effect of CGRP on two target genes relevant to migraine, which may help explain the mechanism underlying the delayed onset of headache following CGRP injection.
    • (2008) J Biol Chem , vol.283 , pp. 18743-18752
    • Simonetti, M.1    Giniatullin, R.2    Fabbretti, E.3
  • 24
    • 58149200161 scopus 로고    scopus 로고
    • The tortuous road to an ideal CGRP function blocker for the treatment of migraine
    • Davis CD, Xu C. The tortuous road to an ideal CGRP function blocker for the treatment of migraine. CurrTop Med Chem 2008; 8:1468-1479.
    • (2008) CurrTop Med Chem , vol.8 , pp. 1468-1479
    • Davis, C.D.1    Xu, C.2
  • 25
    • 0033970471 scopus 로고    scopus 로고
    • Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
    • Doods H, Hallermayer G, Wu D, et al. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br J Pharmacol 2000; 129:420-423.
    • (2000) Br J Pharmacol , vol.129 , pp. 420-423
    • Doods, H.1    Hallermayer, G.2    Wu, D.3
  • 26
    • 34547503547 scopus 로고    scopus 로고
    • Recober A, Russo AF. Olcegepant, a nonpeptide CGRP1 antagonist for migraine treatment. IDrugs 2007; 10:566-574.
    • Recober A, Russo AF. Olcegepant, a nonpeptide CGRP1 antagonist for migraine treatment. IDrugs 2007; 10:566-574.
  • 28
    • 57649176601 scopus 로고    scopus 로고
    • CGRP-receptor antagonism in migraine treatment
    • Comment discussing CGRP antagonists in migraine therapy
    • Edvinsson L. CGRP-receptor antagonism in migraine treatment. Lancet 2008; 372:2089-2090. Comment discussing CGRP antagonists in migraine therapy.
    • (2008) Lancet , vol.372 , pp. 2089-2090
    • Edvinsson, L.1
  • 29
    • 38749114993 scopus 로고    scopus 로고
    • Salvatore CA, Hershey JC, Corcoran HA, et al. Pharmacological character-ization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2- trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl) -piperidine-1-carbox amide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. J Pharmacol Exp Ther 2008; 324:416-421. This is a detailed description of the pharmacological characteristics of telcagepant.
    • Salvatore CA, Hershey JC, Corcoran HA, et al. Pharmacological character-ization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2- trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl) -piperidine-1-carbox amide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. J Pharmacol Exp Ther 2008; 324:416-421. This is a detailed description of the pharmacological characteristics of telcagepant.
  • 30
    • 0037134498 scopus 로고    scopus 로고
    • Receptor activity-modifying protein 1 determines the species selectivity of nonpeptide CGRP receptor antagonists
    • Mallee JJ, Salvatore CA, LeBourdelles B, et al. Receptor activity-modifying protein 1 determines the species selectivity of nonpeptide CGRP receptor antagonists. J Biol Chem 2002; 277:14294-14298.
    • (2002) J Biol Chem , vol.277 , pp. 14294-14298
    • Mallee, J.J.1    Salvatore, C.A.2    LeBourdelles, B.3
  • 31
    • 33847790338 scopus 로고    scopus 로고
    • Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
    • Zhang Z, Winborn CS, Marquez de Prado B, et al. Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion. J Neurosci 2007; 27:2693-2703.
    • (2007) J Neurosci , vol.27 , pp. 2693-2703
    • Zhang, Z.1    Winborn, C.S.2    Marquez de Prado, B.3
  • 32
    • 61849148972 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor inhibition reduces neuronal activity induced by prolonged increase in nitric oxide in the rat spinal trigeminal nucleus
    • This study demonstrates how a CGRP receptor antagonist can prevent nitric oxide-induced activation of the spinal trigeminal nucleus and suggests possible shared mechanisms between nitric oxide and CGRP
    • Koulchitsky S, Fischer M, Messlinger K. Calcitonin gene-related peptide receptor inhibition reduces neuronal activity induced by prolonged increase in nitric oxide in the rat spinal trigeminal nucleus. Cephalalgia 2009; 29:408-417. This study demonstrates how a CGRP receptor antagonist can prevent nitric oxide-induced activation of the spinal trigeminal nucleus and suggests possible shared mechanisms between nitric oxide and CGRP.
    • (2009) Cephalalgia , vol.29 , pp. 408-417
    • Koulchitsky, S.1    Fischer, M.2    Messlinger, K.3
  • 33
    • 50249096199 scopus 로고    scopus 로고
    • Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1 H-in dazol-5-yl)-1 -oxo-1 -(4-(piperidin-1 -yljpiperidin-1 -yl)propan-2-yl) piperidine-1 -carboxamide (BMS-694153): A potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure
    • Degnan AP, Chaturvedula PV, Conway CM, ef al. Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1 H-in dazol-5-yl)-1 -oxo-1 -(4-(piperidin-1 -yljpiperidin-1 -yl)propan-2-yl) piperidine-1 -carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem 2008; 51:4858-4861.
    • (2008) J Med Chem , vol.51 , pp. 4858-4861
    • Degnan, A.P.1    Chaturvedula, P.V.2    Conway, C.M.3    ef al4
  • 34
    • 38149000824 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template
    • Nguyen DN, Paone DV, Shaw AW, et al. Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template. Bioorg Med Chem Lett 2008; 18:755-758.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 755-758
    • Nguyen, D.N.1    Paone, D.V.2    Shaw, A.W.3
  • 35
    • 39549094684 scopus 로고    scopus 로고
    • Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system
    • Link AS, Kuris A, Edvinsson L. Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system. J Headache Pain 2008; 9:5-12.
    • (2008) J Headache Pain , vol.9 , pp. 5-12
    • Link, A.S.1    Kuris, A.2    Edvinsson, L.3
  • 36
    • 51549089370 scopus 로고    scopus 로고
    • Clinical and preclinical rationale for CGRP-receptor antagonists in the treatment of migraine
    • Tepper SJ, Stillman MJ. Clinical and preclinical rationale for CGRP-receptor antagonists in the treatment of migraine. Headache 2008; 48:1259-1268.
    • (2008) Headache , vol.48 , pp. 1259-1268
    • Tepper, S.J.1    Stillman, M.J.2
  • 37
    • 51149090168 scopus 로고    scopus 로고
    • Proinflammatory mediators and migraine pathogenesis: Moving towards CGRP as a target for a novel therapeutic class
    • Farinelli I, Missori S, Martelletti P. Proinflammatory mediators and migraine pathogenesis: moving towards CGRP as a target for a novel therapeutic class. Expert Rev Neurother 2008; 8:1347-1354.
    • (2008) Expert Rev Neurother , vol.8 , pp. 1347-1354
    • Farinelli, I.1    Missori, S.2    Martelletti, P.3
  • 38
    • 59349095975 scopus 로고    scopus 로고
    • CGRP receptors in the control of pain and inflammation
    • Benemei S, Nicoletti P, Capone JG, et al. CGRP receptors in the control of pain and inflammation. Curr Opin Pharmacol 2009; 9:9-14.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 9-14
    • Benemei, S.1    Nicoletti, P.2    Capone, J.G.3
  • 39
    • 34548834456 scopus 로고    scopus 로고
    • Novel migraine therapy with calcitonin gene-regulated peptide receptor antagonists
    • Comprehensive review of CGRP antagonists in migraine therapy
    • Edvinsson L. Novel migraine therapy with calcitonin gene-regulated peptide receptor antagonists. Expert Opin Ther Targets 2007; 11:1179-1188. Comprehensive review of CGRP antagonists in migraine therapy.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 1179-1188
    • Edvinsson, L.1
  • 40
    • 56749157338 scopus 로고    scopus 로고
    • CGRP blockers in migraine therapy: Where do they act?
    • This review discusses the controversy regarding the site of action of CGRP receptor antagonists
    • Edvinsson L. CGRP blockers in migraine therapy: where do they act? Br J Pharmacol 2008; 155:967-969. This review discusses the controversy regarding the site of action of CGRP receptor antagonists.
    • (2008) Br J Pharmacol , vol.155 , pp. 967-969
    • Edvinsson, L.1
  • 41
    • 40949083906 scopus 로고    scopus 로고
    • Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
    • This study is the first detailed analysis of the distribution of CGRP receptor components throughout the rat trigeminovascular system
    • Lennerz JK, Ruhle V, Ceppa EP, et al. Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution. J Comp Neural 2008; 507:1277-1299. This study is the first detailed analysis of the distribution of CGRP receptor components throughout the rat trigeminovascular system.
    • (2008) J Comp Neural , vol.507 , pp. 1277-1299
    • Lennerz, J.K.1    Ruhle, V.2    Ceppa, E.P.3
  • 42
    • 34547787129 scopus 로고    scopus 로고
    • Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: Localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors
    • This study shows the distribution of the CGRP receptor in the rat dorsal horn
    • Marvizon JC, Perez OA, Song B, et al. Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors. Neuroscience 2007; 148:250-265. This study shows the distribution of the CGRP receptor in the rat dorsal horn.
    • (2007) Neuroscience , vol.148 , pp. 250-265
    • Marvizon, J.C.1    Perez, O.A.2    Song, B.3
  • 43
    • 23744494704 scopus 로고    scopus 로고
    • Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat
    • Cottrell GS, Roosterman D, Marvizon JC, et al. Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. J Comp Neural 2005; 490:239-255.
    • (2005) J Comp Neural , vol.490 , pp. 239-255
    • Cottrell, G.S.1    Roosterman, D.2    Marvizon, J.C.3
  • 44
    • 10644231738 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons
    • Anderson LE, Seybold VS. Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons. J Neurochem 2004; 91:1417-1429.
    • (2004) J Neurochem , vol.91 , pp. 1417-1429
    • Anderson, L.E.1    Seybold, V.S.2
  • 45
    • 49649110601 scopus 로고    scopus 로고
    • Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues
    • This study addresses the distribution of serotonin type 1D receptors as a potential explanation for the specificity of triptans for headache versus other pain syndromes
    • Harriott AM, Gold MS. Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues. Cephalalgia 2008; 28:933-944. This study addresses the distribution of serotonin type 1D receptors as a potential explanation for the specificity of triptans for headache versus other pain syndromes.
    • (2008) Cephalalgia , vol.28 , pp. 933-944
    • Harriott, A.M.1    Gold, M.S.2
  • 46
    • 56749176453 scopus 로고    scopus 로고
    • CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat
    • This study describes a complementary, but alternative strategy to CGRP receptor antagonists
    • Zeller J, Poulsen KT, Sutton JE, et al. CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat. Br J Pharmacol 2008; 155:1093-1103. This study describes a complementary, but alternative strategy to CGRP receptor antagonists.
    • (2008) Br J Pharmacol , vol.155 , pp. 1093-1103
    • Zeller, J.1    Poulsen, K.T.2    Sutton, J.E.3
  • 47
    • 33745107264 scopus 로고    scopus 로고
    • Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonu-cleotide
    • Denekas T, Troltzsch M, Vater A, et al. Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonu-cleotide. Br J Pharmacol 2006; 148:536-543.
    • (2006) Br J Pharmacol , vol.148 , pp. 536-543
    • Denekas, T.1    Troltzsch, M.2    Vater, A.3
  • 48
    • 33847671313 scopus 로고    scopus 로고
    • Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and nonperfused rat middle cerebral artery
    • This study looks at the site of action of CGRP receptor antagonists, CGRP antibody and RNA-Spiegelmer on the vasculature
    • Edvinsson L, Nilsson E, Jansen-Olesen I. Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and nonperfused rat middle cerebral artery. Br J Pharmacol 2007; 150:633-640. This study looks at the site of action of CGRP receptor antagonists, CGRP antibody and RNA-Spiegelmer on the vasculature.
    • (2007) Br J Pharmacol , vol.150 , pp. 633-640
    • Edvinsson, L.1    Nilsson, E.2    Jansen-Olesen, I.3
  • 49
    • 60349086313 scopus 로고    scopus 로고
    • Are migraineurs at increased risk of adverse drug responses? A meta-analytic comparison of topiramate-related adverse drug reactions in epilepsy and migraine
    • Luykx J, Mason M, Ferrari MD, ef al. Are migraineurs at increased risk of adverse drug responses? A meta-analytic comparison of topiramate-related adverse drug reactions in epilepsy and migraine. Clin Pharmacol Ther 2009; 85:283-288.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 283-288
    • Luykx, J.1    Mason, M.2    Ferrari, M.D.3    ef al4
  • 50
    • 67049158151 scopus 로고    scopus 로고
    • Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine
    • Epub ahead of print, This study found elevated levels of CGRP in migraineurs in a pediatric population
    • Fan PC, Kuo PH, Chang SH, ef al. Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine. Cephalalgia 2009 [Epub ahead of print]. This study found elevated levels of CGRP in migraineurs in a pediatric population.
    • (2009) Cephalalgia
    • Fan, P.C.1    Kuo, P.H.2    Chang, S.H.3    ef al4
  • 51
    • 0036266044 scopus 로고    scopus 로고
    • Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002; 54:233-246.
    • Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002; 54:233-246.
  • 53
    • 0032574982 scopus 로고    scopus 로고
    • RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    • McLatchie LM, Fraser NJ, Main MJ, ef al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998; 393:333-339.
    • (1998) Nature , vol.393 , pp. 333-339
    • McLatchie, L.M.1    Fraser, N.J.2    Main, M.J.3    ef al4
  • 54
    • 33751073196 scopus 로고    scopus 로고
    • Determinants of 1 -piper-idinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl] carbonyl]-pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl] -4-(1,4-dihydro-2-oxo-3(2 H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors-the role of receptor activity modifying protein 1
    • Hay DL, Christopoulos G, Christopoulos A, et al. Determinants of 1 -piper-idinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl] carbonyl]-pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl] -4-(1,4-dihydro-2-oxo-3(2 H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors-the role of receptor activity modifying protein 1. Mol Pharmacol 2006; 70:1984-1991.
    • (2006) Mol Pharmacol , vol.70 , pp. 1984-1991
    • Hay, D.L.1    Christopoulos, G.2    Christopoulos, A.3
  • 55
    • 62849124664 scopus 로고    scopus 로고
    • Modulating receptor function through RAMPs: Can they represent drug targets in themselves?
    • This review discusses the role of RAMPs as potential drug targets
    • Sexton PM, Poyner DR, Simms J, et al. Modulating receptor function through RAMPs: can they represent drug targets in themselves? Drug Discov Today 2009; 14:413-419. This review discusses the role of RAMPs as potential drug targets.
    • (2009) Drug Discov Today , vol.14 , pp. 413-419
    • Sexton, P.M.1    Poyner, D.R.2    Simms, J.3
  • 56
    • 55549092099 scopus 로고    scopus 로고
    • Crystal structure of the human receptor activity-modifying protein 1 extracellular domain
    • Kusano S, Kukimoto-Niino M, Akasaka R, et al. Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. Protein Sci 2008; 17:1907-1914.
    • (2008) Protein Sci , vol.17 , pp. 1907-1914
    • Kusano, S.1    Kukimoto-Niino, M.2    Akasaka, R.3
  • 57
    • 3042597423 scopus 로고    scopus 로고
    • Vascular actions of calcitonin gene-related peptide and adrenomedullin
    • Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 2004; 84:903-934.
    • (2004) Physiol Rev , vol.84 , pp. 903-934
    • Brain, S.D.1    Grant, A.D.2
  • 58
    • 52949141814 scopus 로고    scopus 로고
    • Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function
    • This study identifies important residues of the RAMPs that may affect the CGRP receptor function
    • Qi T, Christopoulos G, Bailey RJ, et al. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. Mol Pharmacol 2008; 74:1059-1071. This study identifies important residues of the RAMPs that may affect the CGRP receptor function.
    • (2008) Mol Pharmacol , vol.74 , pp. 1059-1071
    • Qi, T.1    Christopoulos, G.2    Bailey, R.J.3
  • 59
    • 34548099668 scopus 로고    scopus 로고
    • Ramping it up: RAMP1 and the implications for migraine
    • This editorial discusses the potential roles of RAMP1 in migraine
    • Russo AF. Ramping it up: RAMP1 and the implications for migraine. Pharmacogenomics 2007; 8:687-690. This editorial discusses the potential roles of RAMP1 in migraine.
    • (2007) Pharmacogenomics , vol.8 , pp. 687-690
    • Russo, A.F.1
  • 60
    • 51649126753 scopus 로고    scopus 로고
    • Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide
    • Toda M, Suzuki T, Hosono K, et al. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A 2008; 105:13550-13555.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13550-13555
    • Toda, M.1    Suzuki, T.2    Hosono, K.3
  • 61
    • 41549108389 scopus 로고    scopus 로고
    • Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury
    • Huang R, Karve A, Shah I, et al. Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2008; 294:H1291-H1297.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Huang, R.1    Karve, A.2    Shah, I.3


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