Substance P in heart failure: The good and the bad

International Journal of Cardiology

Volumn 170, Issue 3, 2014, Pages 270-277

  Dehlin, Heather M ^a   Levick, Scott P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Heart failure; Myocardial remodeling; Neuropeptide; Sensory nerve; Substance P; Tachykinin

Indexed keywords

SUBSTANCE P; TACHYKININ RECEPTOR;

CARDIAC FIBROBLAST; CAT; CORONARY ARTERY ENDOTHELIAL CELL; DOG; ENDOTHELIUM CELL; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; FIBROBLAST; GUINEA PIG; HEART FAILURE; HEART MUSCLE CELL; HEART NERVE; HEART VENTRICLE OVERLOAD; HUMAN; HYPERTENSION; INFLAMMATORY CELL; MAGNESIUM DEFICIENCY; MYOCARDITIS; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REPERFUSION INJURY; REVIEW;

HEART FAILURE; MYOCARDIAL REMODELING; NEUROPEPTIDE; SENSORY NERVE; SUBSTANCE P; TACHYKININ;

ANIMALS; HEART; HEART FAILURE; HUMANS; SENSORY RECEPTOR CELLS; SUBSTANCE P; VENTRICULAR REMODELING;

EID: 84891042283     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.11.010     Document Type: Review

References (84)

1. J.N. Pennefather, A. Lecci, and M.L. Candenas et al. Tachykinins and tachykinin receptors: a growing family Life Sci 74 2004 1445 1463
2. N.M. Page Hemokinins and endokinins Cell Mol Life Sci 61 2004 1652 1663
3. S.D. Brain, and H.M. Cox Neuropeptides and their receptors: innovative science providing novel therapeutic targets Br J Pharmacol 147 Suppl. 1 2006 S202 S211
4. C.A. Massaad, B. Safieh-Garabedian, and S. Poole et al. Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats J Neuroimmunol 153 2004 171 182
5. N. Vergnolle, N.W. Bunnett, and K.A. Sharkey et al. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway Nat Med 7 2001 821 826
6. A. Kavelaars, F. Jeurissen, and C.J. Heijnen Substance P receptors and signal transduction in leukocytes Immunomethods 5 1994 41 48
7. P. Rameshwar, P. Gascon, and D. Ganea Stimulation of IL-2 production in murine lymphocytes by substance P and related tachykinins J Immunol 151 1993 2484 2496
8. A. Azzolina, A. Bongiovanni, and N. Lampiasi Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cells Biochim Biophys Acta (BBA) - Mol Cell Res 1643 2003 75 83
9. D.B. Hoover Effects of substance P on rate and perfusion pressure in the isolated guinea pig heart J Pharmacol Exp Ther 252 1990 179 184
10. D.B. Hoover, Y. Chang, J.C. Hancock, and L. Zhang Actions of tachykinins within the heart and their relevance to cardiovascular disease Jpn J Pharmacol 84 2000 367 373
11. M. Reinecke, E. Weihe, and W.G. Forssmann Substance P-immunoreactive nerve fibers in the heart Neurosci Lett 20 1980 265 269
12. M.W. Hougland, and D.B. Hoover Detection of substance P-like immunoreactivity in nerve fibers in the heart of guinea-pigs but not rats J Auton Nerv Syst 8 1983 295 301
13. J. Wharton, J.M. Polak, G.P. McGregor, A.E. Bishop, and S.R. Bloom The distribution of substrate P-like immunoreactive nerves in the guinea-pig heart Neuroscience 6 1981 2193 2204
14. R.E. Papka, and L. Urban Distribution, origin and sensitivity to capsaicin of primary afferent substance P-immunoreactive nerves in the heart Acta Physiol Hung 69 1987 459 468
15. C.J. Dalsgaard, A. Franco-Cereceda, and A. Saria et al. Distribution and origin of substance P- and neuropeptide Y-immunoreactive nerves in the guinea-pig heart Cell Tissue Res 243 1986 477 485
16. P. Holzer, A. Bucsics, and F. Lembeck Distribution of capsaicin-sensitive nerve fibres containing immunoreactive substance P in cutaneous and visceral tissues of the rat Neurosci Lett 31 1982 253 257
17. K. Rysevaite, I. Saburkina, and N. Pauziene et al. Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations Heart Rhythm 8 2011 731 738
18. M. D'Souza, M.A. Garza, and M. Xie et al. Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection J Parasitol 93 2007 1121 1127
19. P. Robinson, A. Garza, and J. Moore et al. Substance P is required for the pathogenesis of EMCV infection in mice Int J Clin Exp Med 2 2009 76 86
20. W. Zhu, and R.D. Dey Distribution of the neuropeptide galanin in the cat heart and coexistence with vasoactive intestinal peptide, substance P and neuropeptide Y J Mol Cell Cardiol 24 1992 35 41
21. J.M. Brum, V.L. Go, and Q. Sufan et al. Substance P distribution and effects in the canine epicardial coronary arteries Regul Pept 14 1986 41 55
22. S.S. Tay, and W.C. Wong Immunocytochemical localisation of substance P-like nerves in the cardiac ganglia of the monkey (Macaca fascicularis) J Anat 180 1992 239 245
23. J. Wharton, J.M. Polak, and L. Gordon et al. Immunohistochemical demonstration of human cardiac innervation before and after transplantation Circ Res 66 1990 900 912
24. D.B. Hoover, E.R. Isaacs, and F. Jacques et al. Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia Neuroscience 164 2009 1170 1179
25. E. Weihe, M. Reinecke, D. Opherk, and W.G. Forssmann Peptidergic innervation (substance P) in the human heart J Mol Cell Cardiol 13 1981 331 333
26. P. Laine, A. Naukkarinen, L. Heikkila, A. Penttila, and P.T. Kovanen Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries Circulation 101 2000 1665 1669
27. L. Rechardt, K. Aalto-Setala, M. Purjeranta, M. Pelto-Huikko, and K. Kyosola Peptidergic innervation of human atrial myocardium: an electron microscopical and immunocytochemical study J Auton Nerv Syst 17 1986 21 32
28. F. Hua, B.A. Ricketts, A. Reifsteck, J.L. Ardell, and C.A. Williams Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord Am J Physiol Heart Circ Physiol 286 2004 H1654 H1664
29. P. Aline Boer, M. Ueno, J.S.M. Sant'Ana, M.J.A. Saad, and J.A.R. Gontijo Expression and localization of NK1R, substance P and CGRP are altered in dorsal root ganglia neurons of spontaneously hypertensive rats (SHR) Mol Brain Res 138 2005 35 44
30. D.B. Hoover, A.V. Shepherd, E.M. Southerland, J.A. Armour, and J.L. Ardell Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium Auton Neurosci 141 2008 38 45
31. E.K. Corbett, J.K. Sinfield, P.N. McWilliam, J. Deuchars, and T.F. Batten Differential expression of vesicular glutamate transporters by vagal afferent terminals in rat nucleus of the solitary tract: projections from the heart preferentially express vesicular glutamate transporter 1 Neuroscience 135 2005 133 145
32. P. Milner, V. Ralevic, and A.M. Hopwood et al. Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia Experientia 45 1989 121 125
33. G.W. Thompson, D.B. Hoover, J.L. Ardell, and J.A. Armour Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors Am J Physiol Regul Integr Comp Physiol 275 1998 R1683 R1689
34. D.B. Hoover, and J.C. Hancock Distribution of substance P binding sites in guinea-pig heart and pharmacological effects of substance P J Auton Nerv Syst 23 1988 189 197
35. R.J. Walsh, W.B. Weglicki, and R. Correa-de-Araujo Distribution of specific substance P binding sites in the heart and adjacent great vessels of the Wistar white rat Cell Tissue Res 284 1996 495 500
36. D.J. Church, S.J. Arkinstall, and M.B. Vallotton et al. Stimulation of atrial natriuretic peptide release by neurokinins in neonatal rat ventricular cardiomyocytes Am J Physiol 270 1996 H935 H944
37. E.E. Ustinova, D. Bergren, and H.D. Schultz Neuropeptide depletion impairs postischemic recovery of the isolated rat heart: role of substance P Cardiovasc Res 30 1995 55 63
38. H. Chiao, and R.W. Caldwell The role of substance P in myocardial dysfunction during ischemia and reperfusion Naunyn Schmiedebergs Arch Pharmacol 353 1996 400 407
39. L. Wang, and D.H. Wang TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice Circulation 112 2005 3617 3623
40. B. Zhong, and D.H. Wang TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice Am J Physiol Heart Circ Physiol 293 2007 H1791 H1798
41. J.Y. Ren, J.X. Song, M.Y. Lu, and H. Chen Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P Regul Pept 169 2011 49 57
42. L.L. Wang, Z. Guo, and Y. Han et al. Implication of substance P in myocardial contractile function during ischemia in rats Regul Pept 167 2011 185 191
43. R.L. Zhang, Z. Guo, L.L. Wang, and J. Wu Degeneration of capsaicin sensitive sensory nerves enhances myocardial injury in acute myocardial infarction in rats Int J Cardiol 160 2012 41 47
44. S. Amadesi, C. Reni, and R. Katare et al. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects Circulation 125 2012 1774 1786
45. G.C. Melendez, J. Li, and B.A. Law et al. Substance P induces adverse myocardial remodeling via a mechanism involving cardiac mast cells Cardiovasc Res 92 2011 420 429
46. S.P. Levick, J.D. Gardner, and M. Holland et al. Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats J Mol Cell Cardiol 45 2008 56 61
47. G.L. Brower, A.L. Chancey, S. Thanigaraj, B.B. Matsubara, and J.S. Janicki Cause and effect relationship between myocardial mast cell number and matrix metalloproteinase activity Am J Physiol 283 2002 H518 H525
48. W.B. Weglicki, and T.M. Phillips Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis Am J Physiol 263 1992 R734 R737
49. W.B. Weglicki, I.T. Mak, and T.M. Phillips Blockade of cardiac inflammation in Mg2 + deficiency by substance P receptor inhibition Circ Res 74 1994 1009 1013
50. I.T. Mak, J.J. Chmielinska, J.H. Kramer, C.F. Spurney, and W.B. Weglicki Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: protection by substance P receptor blockade Exp Clin Cardiol 16 2011 121 124
51. J.H. Kramer, T.M. Phillips, and W.B. Weglicki Magnesium-deficiency- enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade J Mol Cell Cardiol 29 1997 97 110
52. Z. Liu, H. Liu, and Z. Li Formation of neuromuscular junctions and synthesis of sensory neuropeptides in the co-cultures of dorsal root ganglion and cardiac myocytes Cell Mol Neurobiol 28 2008 939 947
53. S. Sapna, and K. Shivakumar Substance P enhances soluble ICAM-1 release from adult rat cardiac fibroblasts by a p42/44 Cell Biol Int 31 2007 856 859
54. N.L. Tsakadze, U. Sen, and Z. Zhao et al. Signals mediating cleavage of intercellular adhesion molecule-1 Am J Physiol Cell Physiol 287 2004 C55 C63
55. V.I. Otto, S.M. Gloor, and S. Frentzel et al. The production of macrophage inflammatory protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase J Neurochem 80 2002 824 834
56. H. Schmal, B.J. Czermak, and A.B. Lentsch et al. Soluble ICAM-1 activates lung macrophages and enhances lung injury J Immunol 161 1998 3685 3693
57. M.C. LaPointe, M. Mendez, A. Leung, Z. Tao, and X.P. Yang Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse Am J Physiol Heart Circ Physiol 286 2004 H1416 H1424
58. P. Harding, and M.C. LaPointe Prostaglandin E2 increases cardiac fibroblast proliferation and increases cyclin D expression via EP1 receptor Prostaglandins Leukot Essent Fatty Acids 84 2011 147 152
59. C. Kumaran, and K. Shivakumar Calcium- and superoxide anion-mediated mitogenic action of substance P on cardiac fibroblasts Am J Physiol Heart Circ Physiol 282 2002 H1855 H1862
60. C. Ramos, M. Montano, and J. Cisneros et al. Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast Exp Lung Res 33 2007 151 167
61. P.R. Cury, F. Canavez, V.C. de Araújo, C. Furuse, and N.S. de Araújo Substance P regulates the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in cultured human gingival fibroblasts J Periodontal Res 43 2008 255 260
62. C. Morrey, J. Brazin, and N. Seyedi et al. Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction J Pharmacol Exp Ther 335 2010 76 84
63. I. Bot, S.C. de Jager, and M. Bot et al. The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis Circ Res 106 2010 89 92
64. J. Li, H. Lu, and E. Plante et al. Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart J Mol Cell Cardiol 53 2012 469 474
65. S.P. Levick, D.B. Murray, J.S. Janicki, and G.L. Brower Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart Hypertension 55 2010 270 276
66. I. Marriott, and K.L. Bost IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages J Immunol 165 2000 182 191
67. S.P. Levick, J.L. McLarty, and D.B. Murray et al. Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart Hypertension 53 2009 1041 1047
68. W.W. Li, T.Z. Guo, and D.Y. Liang et al. Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome Anesthesiology 116 2012 882 895
69. D. Lorenz, B. Wiesner, and J. Zipper et al. Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies J Gen Physiol 112 1998 577 591
70. J. Sun, R.D. Ramnath, L. Zhi, R. Tamizhselvi, and M. Bhatia Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways Am J Physiol Cell Physiol 294 2008 C1586 C1596
71. J. Sun, R.D. Ramnath, R. Tamizhselvi, and M. Bhatia Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages FASEB J 23 2009 997 1010
72. K. Lieb, B.L. Fiebich, M. Berger, J. Bauer, and K. Schulze-Osthoff The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells J Immunol 159 1997 4952 4958
73. J.D. Boot, S. de Haas, and S. Tarasevych et al. Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma Am J Respir Crit Care Med 175 2007 450 457
74. T.U. Shah, R. Liddle, and M.S. Branch et al. Pilot study of aprepitant for prevention of post-ERCP pancreatitis in high risk patients: a phase II randomized, double-blind placebo controlled trial JOP 13 2012 514 518
75. S. Valdemarsson, L. Edvinsson, R. Ekman, P. Hedner, and A. Sjoholm Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors J Intern Med 230 1991 325 331
76. J.R. Kambam, W. Merrill, and W. Parris et al. Substance P, acetylcholinesterase, and beta-endorphin levels in the plasma and pericardial fluid of patients with and without angina pectoris J Lab Clin Med 116 1990 707 710
77. C. Heymes, M. Vanderheyden, J.G. Bronzwaer, A.M. Shah, and W.J. Paulus Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy Circulation 99 1999 3009 3016
78. D. Santini, B. Vincenzi, and F.M. Guida et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study Lancet Oncol 13 2012 1020 1024
79. M.C. Vallejo, A.L. Phelps, and J.W. Ibinson et al. Aprepitant plus ondansetron compared with ondansetron alone in reducing postoperative nausea and vomiting in ambulatory patients undergoing plastic surgery Plast Reconstr Surg 129 2012 519 526
80. N. Kakuta, Y.M. Tsutsumi, and Y.T. Horikawa et al. Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures J Med Invest 58 2011 246 251
81. E. Ratti, K. Bellew, and P. Bettica et al. Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder J Clin Psychopharmacol 31 2011 727 733
82. D.J. Goldstein, W.W. Offen, and E.G. Klein et al. Lanepitant, an NK-1 antagonist, in migraine prevention Cephalalgia 21 2001 102 106
83. D.J. Goldstein, O. Wang, and J.R. Saper et al. Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study Cephalalgia 17 1997 785 790
84. S.H. Sindrup, A. Graf, and N. Sfikas The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial Eur J Pain 10 2006 567 571