Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 286, Issue 5 55-5, 2004, Pages

  Hua, Fang ^a   Ricketts, Brian A ^a   Reifsteck, Angela ^a   Ardell, Jeffrey L ^a   Williams, Carole A ^a  

^a East Tennessee State University   (United States)

Author keywords

Algogenic substances; Angina; Antibody coated microprobes; Cardiac nervous system; Coronary artery occlusion

Indexed keywords

ADENOSINE; BRADYKININ; PROSTAGLANDIN E2; SEROTONIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NERVE CELL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SENSORY NERVE; THORACIC SPINAL CORD;

ANIMALS; CORONARY DISEASE; EXUDATES AND TRANSUDATES; FEMALE; HEART; MALE; MYOCARDIAL ISCHEMIA; NEURONS, AFFERENT; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANCE P; THORACIC VERTEBRAE;

EID: 1942469385     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00906.2003     Document Type: Article

References (39)

1. Armour JA, Linderoth B, Arora RC, DeJongste MJL, Ardell JL, Kingma JG, Hill M, and Foreman RD. Long term modulation of the intrinsic cardiac nervous system by spinal cord neurons in normal and ischemic hearts. Auton Neurosci 95: 71-79, 2002.
2. Baker DG, Coleridge HM, Coleridge JCG, and Nersdrum T. Search for a cardiac nociceptor: stimulation by bradykinin of sympathetic afferent nerve endings in the heart of cat. J Physiol 306: 519-536, 1980.
3. Besson JM and Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol Rev 67: 67-186, 1987.
4. Blair RW, Weber RN, and Foreman RD. Responses of thoracic spinoreticular and spinothalamic cells to intracardiac bradykinin. Am J Physiol Heart Circ Physiol 246: H500-H507, 1984.
5. Brodin E, Linderoth B, Gazelius B, and Ungerstedt U. In vivo release of substance P in cat dorsal horn studied with microdialysis. Neurosci Lett 76: 357-362, 1988.
6. Chandler MJ, Zhang J, and Foreman RD. Vagal, sympathetic and somatic sensory inputs to upper cervical (C1-C3) spinothalamic tract neurons in monkeys. J Neurophysiol 76: 2555-2567, 1996.
7. Chandler MJ, Zhang J, Qin C, Yuan Y, and Foreman RD. Intrapericardiac injections of algogenic chemicals excite primate C1-C2 spinothalamic tract neurons. Am J Physiol Regul Integr Comp Physiol 279: R560-R568, 2000.
8. DeBiasi S and Rustioni A. Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord. Neurosci Lett 85: 7820-7824, 1988.
9. Duggan AW. Release of neuropeptide in the spinal cord. In: Neuropeptides in the Spinal Cord Progress in Brain Research, edited by Nyberg F, Sharma HS, and Wiesenfeld-Hallin Z. New York: Elsevier, 197-223, 1995.
10. Duggan AW and Hendry IA. Laminar localization of the sites of release of immunoreactive substance P in the dorsal horn with antibody coated microelectrodes. Neurosci Lett 68: 134-140, 1986.
11. Duggan AW, Hendry LA, Green JC, Morton CR, and Hutchison WD. The preparation and use of antibody microprobes. J Neurosci Methods 23: 241-247, 1988.
12. Duggan AW, Hendry IA, Green LJ, Morton CR, and Zhao ZQ. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res 451: 261-273, 1988.
13. Euchner-Wamser I, Meller ST, and Gebhart GF. A model of cardiac nociception in chronically instrumented rats: behavioral and electrophysiological effects of pericardial adminstration of algogenic substances. Pain 58: 117-128, 1994.
14. Foreman RD. Mechanisms of cardiac pain. Annu Rev Physiol 61: 143-167, 1999.
15. Foreman RD, DeJongste MJL, and Linderoth B. Integrative control of cardiac function by cervical and thoracic spinal neurons. In: Basic and Clinical Neurocardiology, edited by JA Armour and JL Ardell. New York: Oxford Univ. Press, 2004, p. 153-186.
16. Hendry IA, Morton CR, and Duggan AW. Analysis of antibody microprobe autoradiographs by computerized image processing. J Neurosci Methods 23: 249-256, 1988.
17. Hokfelt T, Ljungdahl A, Terenius L, Elde R, and Nilsson G. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci USA 74: 3081-3085, 1977.
18. Huang MH, Horackova M, Negoescu RM, Wolf S, and Armour JA. Polysensoy response characteristics of dorsal root ganglion neurons that may serve sensory functions during myocardial ischemia. Cardiovasc Res 32: 503-515, 1996.
19. Huang MH, Sylven C, Horackova M, and Armour JA. Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P. Am J Physiol Regul Integr Comp Physiol 269: R318-R324, 1995.
20. Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, and Sumagawa K. Effects of brief ischemia on myocardial acetylcholine and noradrenaline levels in anesthetized cats. Auton Neurosci 95: 37-42, 2002.
21. Kimura E, Hashimoto K, Furukawa S, and Hayakawa H. Changes in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary artery. Am Heart J 85: 635-647, 1973.
22. Kostreva DR and Pontus SP. Pericardial mechanoreceptors with phrenic afferents. Am J Physiol Heart Circ Physiol 264: H1836-H1846, 1993.
23. Kuo DC, Oravitz JJ, and deGroat WE. Tracing of afferent and efferent pathways in the left inferior cardiac nerve of the cat using retrograde and transport of horseradish peroxidase. Brain Res 321: 111-118, 1984.
24. Linderoth B and Brodin E. Tachykinin release from rat spinal cord in vitro and in vivo in response to various stimuli. Regul Pept 21: 129-140, 1988.
25. Meller ST and Gebhart GF. A critical review on the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience 48: 501-521, 1992.
26. Nerdrum T, Baker DG, Coleridge HM, and Coleridge JCG. Interaction of bradykinin and prostaglandin E1 on cardiac pressor reflex and sympathetic afferents. Am J Physiol Regul Integr Comp Physiol 250: R815-R822, 1986.
27. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (4th ed.). San Diego, CA: Academic, 1998.
28. Qin C, Chandler MJ, Miller KE, and Foreman RD. Chemical activation of cardiac receptors affects activity of superficial and deeper T3-T4 spinal neurons in rats. Brain Res 959: 77-85, 2003.
29. Salt TE and Hill RG. Neurotransmitter candidates of somatosensory primary afferent fibers. Neuroscience 10: 1083-1103, 1983.
30. Schaible HG, Jarrot B, Hope PJ, and Duggan AW. Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes. Brain Res 529: 214-223, 1990.
31. Schaible HG, Hope PJ, Lang CW, and Duggan AW. Calcitonin gene-related peptide causes intraspinal spreading of substance P released by peripheral stimulation. Eur J Neurosci 4: 750-757, 1992.
32. Shults CW, Quirion R, Chronwall B, Chase TN, and O'Donohue TL. A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system. Peptides 5: 1097-1128, 1984.
33. Thompson GW, Horackova M, and Armour JA. Chemotransduction properties of nodose ganglion cardiac afferent neurons in guinea pigs. Am J Physiol Regul Integr Comp Physiol 279: R433-R439, 2000.
34. Williams CA, Ecay T, Reifsteck A, Fry B, and Ricketts B. Direct injection of substance P-antisense oligonucleotide into the feline NTS modifies the cardiovascular responses to ergoreceptor but not baroreceptor afferent input. Brain Res 963: 26-42, 2003.
35. Williams CA, Reifsteck A, Hampton TA, and Fry B. Substance P release in the feline nucleus tractus solitarius during ergoreceptor but not baroreceptor afferent signaling. Brain Res 944: 19-31, 2002.
36. Wilson LB, Fuchs IE, Matsukawa K, Mitchell JH, and Wall PT. Substance P release in the spinal cord during the exercise pressor reflex in the anesthetized cat. J Physiol 460: 79-90, 1993.
37. Woolf CJ and Wiesenfeld-Hallin Z. Substance P and calcitonin-gene-related peptide synergistically modulate the gain of the nociceptive flexor-withdrawal reflex in the rat. Neurosci Lett 66: 226-230, 1986.
38. Xu XJ, Dlasgaard CJ, and Wiesenfeld-Hallin Z. Spinal substance P and N-methyl-D-aspartate receptors are co-activated in the induction of central sensitization of the nociceptive flexor reflex. Neuroscience 51: 641-648, 1992.
39. Zimmerman M. Encoding in the dorsal horn interneurons receiving noxious and non-noxious afferents. J Physiol 73: 221-232, 1977.