Survivors of childhood and adolescent cancer: Life-long risks and responsibilities

Nature Reviews Cancer

Volumn 14, Issue 1, 2014, Pages 61-70

  Robison, Leslie L ^a   Hudson, Melissa M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT CANCER; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURGERY; CANCER SURVIVOR; CHILDHOOD CANCER; DEVELOPED COUNTRY; HEALTH; HEALTH CARE; HUMAN; INSURANCE; MANAGEMENT; MEDICAL RESEARCH; MORBIDITY; NEOPLASM; OUTCOME ASSESSMENT; POLICY; PRIORITY JOURNAL; QUALITY OF LIFE; RESPONSIBILITY; REVIEW; SURVIVAL RATE;

EID: 84891018674     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3634     Document Type: Review

References (157)

1. Howlader, N. et al. (eds) SEER Cancer Statistics Review, 1975-2010. National Cancer Institute. Bethesda, MD [online] http://seer.cancer.gov/csr/ 1975-2010/ (2013).
2. Gajjar, A. et al. Children's Oncology Group's 2013 blueprint for research: central nervous system tumors. Pediatr. Blood Cancer 60, 1022-1026 (2013).
3. Norris, R. E. & Adamson, P. C. Challenges and opportunities in childhood cancer drug development. Nature Rev. Cancer 12, 776-782 (2012).
4. Pui, C. H., Carroll, W. L., Meshinchi, S. & Arceci, R. J. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J. Clin. Oncol. 29, 551-565 (2011).
5. Smith, M. A. et al. Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J. Clin. Oncol. 28, 2625-2634 (2010).
6. Mariotto, A. B. et al. Long-term survivors of childhood cancers in the United States. Cancer Epidemiol. Biomarkers Prev. 18, 1033-1040 (2009).
7. Hudson, M. M. et al. Health status of adult long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. JAMA 290, 1583-1592 (2003).
8. Hudson, M. M. et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA 309, 2371-2381 (2013).
9. Oeffinger, K. C. et al. Chronic health conditions in adult survivors of childhood cancer. N. Engl. J. Med. 355, 1572-1582 (2006).
10. Sun, C. L. et al. Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: A report from the Bone Marrow Transplant Survivor Study. Blood 116, 3129-3139, (2010).
11. Tai, E. et al. Health status of adolescent and young adult cancer survivors. Cancer 118, 4884-4891 (2012).
12. Armstrong, G. T., Pan, Z., Ness, K. K., Srivastava, D. & Robison, L. L. Temporal trends in cause-specific late mortality among 5year survivors of childhood cancer. J. Clin. Oncol. 28, 1224-1231 (2010).
13. Mertens, A. C. et al. Cause-specific late mortality among 5year survivors of childhood cancer: the Childhood Cancer Survivor Study. J. Natl Cancer Inst. 100, 1368-1379 (2008).
14. Diller, L. et al. Chronic disease in the Childhood Cancer Survivor Study cohort: A review of published findings. J. Clin. Oncol. 27, 2339-2355 (2009).
15. Green, D. M. et al. Fertility of female survivors of childhood cancer: A report from the childhood cancer survivor study. J. Clin. Oncol. 27, 2677-2685 (2009).
16. Gurney, J. G. et al. Social outcomes in the Childhood Cancer Survivor Study cohort. J. Clin. Oncol. 27, 2390-2395 (2009).
17. Meadows, A. T. et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J. Clin. Oncol. 27, 2356-2362 (2009).
18. Ness, K. K. et al. Physical performance limitations in the Childhood Cancer Survivor Study cohort. J. Clin. Oncol. 27, 2382-2389 (2009).
19. Zeltzer, L. K. et al. Psychological status in childhood cancer survivors: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 27, 2396-2404 (2009).
20. Hudson, M. M. et al. High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance. J. Clin. Oncol. 27, 2405-2414 (2009).
21. Hudson, M. M. A model for care across the cancer continuum. Cancer 104, 2638-2642 (2005).
22. Green, D. M. et al. Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors. Pediatr. Blood Cancer 60, 1083-1094 (2013).
23. Hudson, M. M. et al. Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies. Pediatr. Blood Cancer 58, 334-343 (2012).
24. Armstrong, G. T., Stovall, M. & Robison, L. L. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Radiat. Res. 174, 840-850 (2010).
25. van Dijk, I. W. et al. Dose-effect relationships for adverse events after cranial radiation therapy in long-term childhood cancer survivors. Int. J. Radiat. Oncol. Biol. Phys. 85, 768-775 (2013).
26. Galper, S. L. et al. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood 117, 412-418 (2011).
27. Schellong, G. et al. Late valvular and other cardiac diseases after different doses of mediastinal radiotherapy for Hodgkin disease in children and adolescents: report from the longitudinal GPOH followup project of the German-Austrian DALHD studies. Pediatr. Blood Cancer 55, 1145-1152 (2010).
28. Tukenova, M. et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J. Clin. Oncol. 28, 1308-1315 (2010).
29. van der Pal, H. J. et al. High risk of symptomatic cardiac events in childhood cancer survivors. J. Clin. Oncol. 30, 1429-1437 (2012).
30. Bowers, D. C. et al. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 24, 5277-5282 (2006).
31. Bowers, D. C. et al. Stroke as a late treatment effect of Hodgkin's Disease: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 23, 6508-6515 (2005).
32. Morris, B. et al. Cerebrovascular disease in childhood cancer survivors: A Children's Oncology Group Report. Neurology 73, 1906-1913 (2009).
33. Chemaitilly, W. & Sklar, C. A. Endocrine complications in long-term survivors of childhood cancers. Endocr. Relat. Cancer 17, R141-R159 (2010).
34. de Vathaire, F. et al. Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: A retrospective cohort study. Lancet Oncol. 13, 1002-1010 (2012).
35. Laughton, S. J. et al. Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB96 trial. J. Clin. Oncol. 26, 1112-1118 (2008).
36. Meacham, L. R. et al. Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: A report for the childhood cancer survivor study. Arch. Intern. Med. 169, 1381-1388 (2009).
37. Merchant, T. E. et al. Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors. J. Clin. Oncol. 29, 4776-4780 (2011).
38. Patterson, B. C., Truxillo, L., Wasilewski-Masker, K., Mertens, A. C. & Meacham, L. R. Adrenal function testing in pediatric cancer survivors. Pediatr. Blood Cancer 53, 1302-1307 (2009).
39. Goldsby, R. et al. Survivors of childhood cancer have increased risk of gastrointestinal complications later in life. Gastroenterology 140, 1464-1471, e1 (2011).
40. Green, D. M. et al. Fertility of male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 28, 332-339 (2010).
41. Kenney, L. B. et al. Male reproductive health after childhood, adolescent, and young adult cancers: A report from the Children's Oncology Group. J. Clin. Oncol. 30, 3408-3416 (2012).
42. Metzger, M. L. et al. Female reproductive health after childhood, adolescent, and young adult cancers: guidelines for the assessment and management of female reproductive complications. J. Clin. Oncol. 31, 1239-1247 (2013).
43. Signorello, L. B. et al. Female survivors of childhood cancer: preterm birth and low birth weight among their children. J. Natl Cancer Inst. 98, 1453-1461 (2006).
44. Signorello, L. B. et al. Stillbirth and neonatal death in relation to radiation exposure before conception: A retrospective cohort study. Lancet 376, 624-630 (2010).
45. Castellino, S. et al. Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group. Pediatr. Blood Cancer 54, 663-669 (2010).
46. Huang, T. T. et al. Pulmonary outcomes in survivors of childhood cancer: A systematic review. Chest 140, 881-901 (2011).
47. Mertens, A. C. et al. Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer 95, 2431-2441 (2002).
48. Motosue, M. S. et al. Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies. Cancer 118, 1450-1456 (2012).
49. Mulder, R. L. et al. Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer. Thorax 66, 1065-1071 (2011).
50. Dawson, L. A. et al. Radiation-associated kidney injury. Int. J. Radiat. Oncol. Biol. Phys. 76, S108-S115 (2010).
51. Jones, D. P., Spunt, S. L., Green, D. & Springate, J. E. Renal late effects in patients treated for cancer in childhood: A report from the Children's Oncology Group. Pediatr. Blood Cancer 51, 724-731 (2008).
52. Ritchey, M., Ferrer, F., Shearer, P. & Spunt, S. L. Late effects on the urinary bladder in patients treated for cancer in childhood: A report from the Children's Oncology Group. Pediatr. Blood Cancer 52, 439-446 (2009).
53. Estilo, C. L. et al. Effects of therapy on dentofacial development in long-term survivors of head and neck rhabdomyosarcoma: the memorial sloan-kettering cancer center experience. J. Pediatr. Hematol. Oncol. 25, 215-222 (2003).
54. Merchant, T. E. et al. Differential attenuation of clavicle growth after asymmetric mantle radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 59, 556-561 (2004).
55. Paulino, A. C. Late effects of radiotherapy for pediatric extremity sarcomas. Int. J. Radiat. Oncol. Biol. Phys. 60, 265-274 (2004).
56. Goldsby, R. E. et al. Late-occurring neurologic sequelae in adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 28, 324-331 (2010).
57. Grewal, S. et al. Auditory late effects of childhood cancer therapy: A report from the Children's Oncology Group. Pediatrics 125, e938-e950 (2010).
58. Packer, R. J. et al. Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study. J. Clin. Oncol. 21, 3255-3261 (2003).
59. Whelan, K. et al. Auditory complications in childhood cancer survivors: A report from the childhood cancer survivor study. Pediatr. Blood Cancer 57, 126-134 (2011).
60. Whelan, K. F. et al. Ocular late effects in childhood and adolescent cancer survivors: A report from the childhood cancer survivor study. Pediatr. Blood Cancer 54, 103-109 (2010).
61. Winick, N. Neurocognitive outcome in survivors of pediatric cancer. Curr. Opin. Pediatr. 23, 27-33 (2011).
62. Armstrong, G. T. et al. Occurrence of multiple subsequent neoplasms in long-term survivors of childhood cancer: A report from the childhood cancer survivor study. J. Clin. Oncol. 29, 3056-3064 (2011).
63. Bassal, M. et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 24, 476-483 (2006).
64. Bhatti, P. et al. Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study. Radiat. Res. 174, 741-752 (2010).
65. Boukheris, H. et al. Risk of salivary gland cancer after childhood cancer: A report from the Childhood Cancer Survivor Study. Int. J. Radiat. Oncol. Biol. Phys. 85, 776-783 (2013).
66. Friedman, D. L. et al. Subsequent neoplasms in 5year survivors of childhood cancer: the Childhood Cancer Survivor Study. J. Natl Cancer Inst. 102, 1083-1095 (2010).
67. Henderson, T. O. et al. Secondary gastrointestinal cancer in childhood cancer survivors: A cohort study. Ann. Intern. Med. 156, 757-766 (2012).
68. Henderson, T. O. et al. Risk factors associated with secondary sarcomas in childhood cancer survivors: A report from the childhood cancer survivor study. Int. J. Radiat. Oncol. Biol. Phys. 84, 224-230 (2012).
69. Inskip, P. D. et al. Radiation dose and breast cancer risk in the childhood cancer survivor study. J. Clin. Oncol. 27, 3901-3907 (2009).
70. Neglia, J. P. et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J. Natl Cancer Inst. 98, 1528-1537 (2006).
71. Nottage, K. et al. Secondary colorectal carcinoma after childhood cancer. J. Clin. Oncol. 30, 2552-2558 (2012).
72. Pappo, A. S. et al. Melanoma as a subsequent neoplasm in adult survivors of childhood cancer: A report from the childhood cancer survivor study. Pediatr. Blood Cancer 60, 461-466 (2013).
73. Perkins, J. L. et al. Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: A report from the childhood cancer survivor study. J. Clin. Oncol. 23, 3733-3741 (2005).
74. Reulen, R. C. et al. Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA 305, 2311-2319 (2011).
75. Ronckers, C. M. et al. Thyroid cancer in childhood cancer survivors: A detailed evaluation of radiation dose response and its modifiers. Radiat. Res. 166, 618-628 (2006).
76. Tukenova, M. et al. Second malignant neoplasms in digestive organs after childhood cancer: A cohort-nested case-control study. Int. J. Radiat. Oncol. Biol. Phys. 82, e383-e390 (2012).
77. De Bruin, M. L. et al. Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumes. J. Clin. Oncol. 27, 4239-4246 (2009).
78. Swerdlow, A. J. et al. Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: A National Cohort Study. J. Clin. Oncol. 30, 2745-2752 (2012).
79. Sigurdson, A. J. et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): A nested case-control study. Lancet 365, 2014-2023 (2005).
80. Bowers, D. C. et al. Subsequent neoplasms of the CNS among survivors of childhood cancer: A systematic review. Lancet Oncol. 14, e321-e328 (2013).
81. Taylor, A. J. et al. Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study. J. Clin. Oncol. 28, 5287-5293 (2010).
82. Wilson, C. L. et al. Renal carcinoma after childhood cancer: A report from the childhood cancer survivor study. J. Natl Cancer Inst. 105, 504-508 (2013).
83. Ibrahim, E. M. et al. Increased risk of second lung cancer in Hodgkin's lymphoma survivors: A meta-analysis. Lung 191, 117-134 (2013).
84. Brock, P. R. et al. Platinum-induced ototoxicity in children: A consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J. Clin. Oncol. 30, 2408-2417 (2012).
85. Feldman, D. R., Schaffer, W. L. & Steingart, R. M. Late cardiovascular toxicity following chemotherapy for germ cell tumors. J. Natl Compr. Canc. Netw. 10, 537-544 (2012).
86. Hijiya, N., Ness, K. K., Ribeiro, R. C. & Hudson, M. M. Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues. Cancer 115, 23-35 (2009).
87. Skinner, R. Nephrotoxicity - what do we know and what don't we know? J. Pediatr. Hematol. Oncol. 33, 128-134 (2011).
88. Lipshultz, S. E. et al. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J. Clin. Oncol. 23, 2629-2636 (2005).
89. Mulrooney, D. A. et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 339, b4606 (2009).
90. Wasilewski-Masker, K. et al. Bone mineral density deficits in survivors of childhood cancer: long-term followup guidelines and review of the literature. Pediatrics 121, e705-e713 (2008).
91. Kadan-Lottick, N. S. et al. Osteonecrosis in adult survivors of childhood cancer: A report from the childhood cancer survivor study. J. Clin. Oncol. 26, 3038-3045 (2008).
92. Jain, P. et al. Vincristine-induced neuropathy in childhood ALL (acute lymphoblastic leukemia) survivors: prevalence and electrophysiological characteristics. J. Child Neurol. http://dx.doi. org/10.1177/0883073813491829 (2013).
93. Ness, K. K. et al. Chemotherapy-related neuropathic symptoms and functional impairment in adult survivors of extracranial solid tumors of childhood: results from the st. Jude lifetime cohort study. Arch. Phys. Med. Rehabil. 94, 1451-1457 (2013).
94. Bhatia, S. Role of genetic susceptibility in development of treatment-related adverse outcomes in cancer survivors. Cancer Epidemiol. Biomarkers Prev. 20, 2048-2067 (2011).
95. Oeffinger, K. C. & Hudson, M. M. Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors. CA Cancer J. Clin. 54, 208-236 (2004).
96. Barr, R. D. & Wunder, J. S. Bone and soft tissue sarcomas are often curable - but at what cost?: A call to arms (and legs). Cancer 115, 4046-4054 (2009).
97. Lin, H. Y. & Liao, S. L. Orbital development in survivors of retinoblastoma treated by enucleation with hydroxyapatite implant. Br. J. Ophthalmol. 95, 630-633 (2011).
98. Turner, C. D. et al. Medical, psychological, cognitive and educational late-effects in pediatric low-grade glioma survivors treated with surgery only. Pediatr. Blood Cancer 53, 417-423 (2009).
99. Kinahan, K. E. et al. Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor study. J. Clin. Oncol. 30, 2466-2474 (2012).
100. Henderson, T. O. et al. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann. Intern. Med. 152, 444-455 (2010).
101. Pui, C. H. Prophylactic cranial irradiation: going, going, gone. Lancet Oncol. 10, 932-933 (2009).
102. Hodgson, D. C., Hudson, M. M. & Constine, L. S. Pediatric hodgkin lymphoma: maximizing efficacy and minimizing toxicity. Semin. Radiat. Oncol. 17, 230-242 (2007).
103. Lund, L. W., Schmiegelow, K., Rechnitzer, C. & Johansen, C. A systematic review of studies on psychosocial late effects of childhood cancer: structures of society and methodological pitfalls may challenge the conclusions. Pediatr. Blood Cancer 56, 532-543 (2011).
104. Nathan, P. C. et al. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: A report from the Children's Oncology Group. Arch. Pediatr. Adolesc. Med. 161, 798-806 (2007).
105. Wakefield, C. E. et al. The psychosocial impact of completing childhood cancer treatment: A systematic review of the literature. J. Pediatr. Psychol. 35, 262-274 (2010).
106. Kirchhoff, A. C. et al. Occupational outcomes of adult childhood cancer survivors: A report from the childhood cancer survivor study. Cancer 117, 3033-3044 (2011).
107. Kuehni, C. E. et al. Educational achievement in Swiss childhood cancer survivors compared with the general population. Cancer 118, 1439-1449 (2012).
108. Lancashire, E. R. et al. Educational attainment among adult survivors of childhood cancer in Great Britain: A population-based cohort study. J. Natl Cancer Inst. 102, 254-270 (2010).
109. Mitby, P. A. et al. Utilization of special education services and educational attainment among long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 97, 1115-1126 (2003).
110. Kirchhoff, A. C. et al. Employer-sponsored health insurance coverage limitations: results from the Childhood Cancer Survivor Study. Support Care Cancer 21, 377-383 (2013).
111. Park, E. R. et al. Health insurance coverage in survivors of childhood cancer: the Childhood Cancer Survivor Study. J. Clin. Oncol. 23, 9187-9197 (2005).
112. Frobisher, C., Lancashire, E. R., Winter, D. L., Jenkinson, H. C. & Hawkins, M. M. Long-term population-based marriage rates among adult survivors of childhood cancer in Britain. Int. J. Cancer 121, 846-855 (2007).
113. Frobisher, C. et al. Long-term population-based divorce rates among adult survivors of childhood cancer in Britain. Pediatr. Blood Cancer 54, 116-122 (2010).
114. Janson, C. et al. Predictors of marriage and divorce in adult survivors of childhood cancers: A report from the Childhood Cancer Survivor Study. Cancer Epidemiol. Biomarkers Prev. 18, 2626-2635 (2009).
115. Brinkman, T. M. et al. Longitudinal patterns of psychological distress in adult survivors of childhood cancer. Br. J. Cancer 109, 1373-1381 (2013).
116. Zebrack, B. J. et al. Psychological outcomes in long-term survivors of childhood brain cancer: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 22, 999-1006 (2004).
117. Zebrack, B. J. et al. Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin's disease, and non-Hodgkin's lymphoma: A report from the Childhood Cancer Survivor Study. Pediatrics 110, 42-52 (2002).
118. Kwak, M. et al. Trajectories of psychological distress in adolescent and young adult patients with cancer: A 1year longitudinal study. J. Clin. Oncol. 31, 2160-2166 (2013).
119. Stuber, M. L. et al. Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer. Pediatrics 125, e1124-e1134 (2010).
120. Zebrack, B. J. et al. Perceived positive impact of cancer among long-term survivors of childhood cancer: A report from the childhood cancer survivor study. Psychooncology 21, 630-639 (2012).
121. Clanton, N. R. et al. Fatigue, vitality, sleep, and neurocognitive functioning in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 117, 2559-2568 (2011).
122. Meeske, K. A., Siegel, S. E., Globe, D. R., Mack, W. J. & Bernstein, L. Prevalence and correlates of fatigue in long-term survivors of childhood leukemia. J. Clin. Oncol. 23, 5501-5510 (2005).
123. Mulrooney, D. A. et al. Fatigue and sleep disturbance in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS). Sleep 31, 271-281 (2008).
124. Lu, Q. et al. Pain in long-term adult survivors of childhood cancers and their siblings: A report from the Childhood Cancer Survivor Study. Pain 152, 2616-2624 (2011).
125. Schultz, K. A. et al. Behavioral and social outcomes in adolescent survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 25, 3649-3656 (2007).
126. Robison, L. L. et al. The Childhood Cancer Survivor Study: A National Cancer Institute-supported resource for outcome and intervention research. J. Clin. Oncol. 27, 2308-2318 (2009).
127. Hawkins, M. M. et al. The British Childhood Cancer Survivor Study: objectives, methods, population structure, response rates and initial descriptive information. Pediatr. Blood Cancer 50, 1018-1025 (2008).
128. Menu-Branthomme, A. et al. Radiation dose, chemotherapy and risk of soft tissue sarcoma after solid tumours during childhood. Int. J. Cancer 110, 87-93 (2004).
129. Hawkins, M. M. & Robison, L. L. Importance of clinical and epidemiological research in defining the long-term clinical care of pediatric cancer survivors. Pediatr. Blood Cancer 46, 174-178 (2006).
130. Leisenring, W. M. et al. Pediatric cancer survivorship research: experience of the Childhood Cancer Survivor Study. J. Clin. Oncol. 27, 2319-2327 (2009).
131. Hudson, M. M. et al. Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort study. Pediatr. Blood Cancer 56, 825-836 (2011).
132. Sieswerda, E. et al. The EKZ/AMC childhood cancer survivor cohort: methodology, clinical characteristics, and data availability. J. Cancer Surviv 7, 439-454 (2013).
133. Geenen, M. M. et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA 297, 2705-2715 (2007).
134. Landier, W. et al. Yield of screening for long-term complications using the children's oncology group long-term followup guidelines. J. Clin. Oncol. 30, 4401-4408 (2012).
135. In Dutch Childhood Oncology Group, Richtlijn followup na kinderkanker meer dan 5 jaar na diagnose. SKION, Den Haag/Amsterdam [online], http://www.skion.nl/ (2010).
136. In Scottish Intercollegiate Guidelines Network, Long term follow up care of survivors of childhood cancer. A national clinical guideline [online], http://www.sign.ac.uk/ (2004).
137. In United Kingdom Children's Cancer Study Group, Late Effects Group, Therapy based long term follow up practice statement [online], http://www.cclg.org.uk/ (2011).
138. In Children's Oncology Group, Long-term followup guidelines for survivors of childhood, adolescent, and young adult cancers. Version 3.0 [online], http://www.survivorshipguidelines.org/ (2008).
139. Nathan, P. C. et al. Family physician preferences and knowledge gaps regarding the care of adolescent and young adult survivors of childhood cancer. J. Cancer Surviv 7, 275-282 (2013).
140. Staba Hogan, M. J., Ma, X. & Kadan-Lottick, N. S. New health conditions identified at a regional childhood cancer survivor clinic visit. Pediatr. Blood Cancer 60, 682-687 (2013).
141. Wasilewski-Masker, K., Mertens, A. C., Patterson, B. & Meacham, L. R. Severity of health conditions identified in a pediatric cancer survivor program. Pediatr. Blood Cancer 54, 976-982 (2010).
142. Kremer, L. C. et al. A worldwide collaboration to harmonize guidelines for the long-term followup of childhood and young adult cancer survivors: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Pediatr. Blood Cancer 60, 543-549 (2013).
143. Hudson, M. M. et al. Multi-component behavioral intervention to promote health protective behaviors in childhood cancer survivors: the protect study. Med. Pediatr. Oncol. 39, 2-11 (discussion 2) (2002).
144. Kadan-Lottick, N. S. et al. Childhood cancer survivors' knowledge about their past diagnosis and treatment: Childhood Cancer Survivor Study. JAMA 287, 1832-1839 (2002).
145. Wilkins, K. L. & Woodgate, R. L. Preventing second cancers in cancer survivors. Oncol. Nurs. Forum 35, E12-E22 (2008).
146. Oeffinger, K. C. et al. Increasing rates of breast cancer and cardiac surveillance among high-risk survivors of childhood Hodgkin lymphoma following a mailed, one-page survivorship care plan. Pediatr. Blood Cancer 56, 818-824 (2011).
147. Hinkle, A. S. et al. A clinic-based, comprehensive care model for studying late effects in long-term survivors of pediatric illnesses. Pediatrics 113, 1141-1145 (2004).
148. Kenney, L. B. et al. The current status of followup services for childhood cancer survivors, are we meeting goals and expectations: A report from the Consortium for New England Childhood Cancer Survivors. Pediatr. Blood Cancer 57, 1062-1066 (2011).
149. Ford, J. S., Chou, J. F. & Sklar, C. A. Attendance at a survivorship clinic: impact on knowledge and psychosocial adjustment. J. Cancer Surviv http://dx.doi.org/10.1007/s11764-013-0291-9 (2013).
150. Klosky, J. L. et al. Factors influencing long-term followup clinic attendance among survivors of childhood cancer. J. Cancer Surviv 2, 225-232 (2008).
151. Hewitt, M., Greenfield, S. & Stovall, E. (eds) From Cancer Patient to Cancer Survivor: Lost in Transition (National Academies Press, 2006).
152. Henderson, T. O., Hlubocky, F. J., Wroblewski, K. E., Diller, L. & Daugherty, C. K. Physician preferences and knowledge gaps regarding the care of childhood cancer survivors: A mailed survey of pediatric oncologists. J. Clin. Oncol. 28, 878-883 (2010).
153. Blaauwbroek, R., Tuinier, W., Meyboomde Jong, B., Kamps, W. A. & Postma, A. Shared care by paediatric oncologists and family doctors for long-term followup of adult childhood cancer survivors: A pilot study. Lancet Oncol. 9, 232-238 (2008).
154. In Advisory Board Company, Survivorship [online], http://www.advisory. com/Research/Oncology- Roundtable/Studies/2008/Elevating-the-Patient- Experience (2008).
155. Eshelman-Kent, D. et al. Cancer survivorship practices, services, and delivery: A report from the Children's Oncology Group (COG) nursing discipline, adolescent/ young adult, and late effects committees. J. Cancer Surviv 5, 345-357 (2011).
156. Oeffinger, K. C. & McCabe, M. S. Models for delivering survivorship care. J. Clin. Oncol. 24, 5117-5124 (2006).
157. The Patient Protection and Affordable Care Act. Public Law 111-148, (2010).