Endocrine complications in long-term survivors of childhood cancers

Endocrine-Related Cancer

Volumn 17, Issue 3, 2010, Pages

  Chemaitilly, Wassim ^a   Sklar, Charles A ^b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; BUSULFAN; CHLORMETHINE; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; GLUCOCORTICOID; IFOSFAMIDE; MELPHALAN; METHOTREXATE; PREDNISONE; PROCARBAZINE; THIOTEPA; VINBLASTINE; VINCRISTINE;

BONE DENSITY; BONE DYSPLASIA; CANCER RADIOTHERAPY; CANCER SURVIVOR; CANCER THERAPY; CHILDHOOD CANCER; CORTICOTROPIN DEFICIENCY; ENDOCRINE DISEASE; FRACTURE; GLUCOSE METABOLISM; GONAD DYSFUNCTION; GROWTH HORMONE DEFICIENCY; HODGKIN DISEASE; HUMAN; HYPERPROLACTINEMIA; HYPERTHYROIDISM; HYPOGONADOTROPIC HYPOGONADISM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHYROIDISM; MALE INFERTILITY; OBESITY; OSTEOPENIA; OSTEOPOROSIS; OVARY INSUFFICIENCY; PRECOCIOUS PUBERTY; REVIEW; SIDE EFFECT; SKULL IRRADIATION; SPERMATOGENESIS; TESTIS INJURY; THYROID DISEASE; ADULT; CHILD; ENDOCRINE SYSTEM; NEOPLASM; PATHOPHYSIOLOGY; SURVIVOR;

ADULT; CHILD; ENDOCRINE SYSTEM; ENDOCRINE SYSTEM DISEASES; HUMANS; NEOPLASMS; SURVIVORS;

EID: 77956209784     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-10-0002     Document Type: Review

References (158)

1. Acharya S, Sarafoglou K, LaQuaglia M, Lindsley S, Gerald W, Wollner N, Tan C & Sklar C 2003 Thyroid neoplasms after therapeutic radiation of malignancies during childhood or adolescence. Cancer 97 2397-2403. (Pubitemid 36542477)
2. Adan L, Sainte-Rose C, Souberbielle JC, Zucker JM, Kalifa C & Brauner R 2000 Adult height after growth hormone (GH) treatment for GH deficiency due to cranial irradiation. Medical and Pediatric Oncology 34 14-19. (Pubitemid 30022703)
3. Afify A, Shaw PJ, Clavano-Harding A & Cowell CT 2000 Growth and endocrine function in children with acute myeloid leukemia after bone marrow transplantation using busulfan/cyclophosphamide. Bone Marrow Transplantation 25 1087-1092. (Pubitemid 30303599)
4. Aisenberg J, Hsieh K, Kalaitzoglou G, Whittam E, Heller G, Schneider R & Sklar C 1998 Bone mineral density (BMD) in long-term survivors of childhood cancer. Journal of Pediatric Hematology/Oncology 20 241-245. (Pubitemid 28280901)
5. Andreu JAL, Fernandez PJ, i Tortajada JF, Navarro I, Rodriguez-Ineba A, Antonio P, Muro MD & Romeu A 2000 Persistent altered spermatogenesis in long-term childhood cancer survivors. Pediatric Hematology and Oncology 17 21-30. (Pubitemid 30053452)
6. Anserini P, Chiodi S, Spinelli S, Costa M, Conte N, Copello F & Bacigalupo A 2002 Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling. Bone Marrow Transplantation 30 447-451.
7. Armenian SH & Bhatia S 2009 Chronic health conditions in childhood cancer survivors: is it all treatment-related - or do genetics play a role? Journal of General Internal Medicine 24 S395-S400.
8. Armstrong GT, Whitton JA, Gajjar A, Kun LE, Chow EJ, Stovall M, Leisenring W, Robison LL & Sklar CA 2009 Abnormal timing of menarche in survivors of central nervous system tumors. A report from the Childhood Cancer Survivor Study. Cancer 115 2562-2570.
9. Au WY, Lie AK, Kung AW, Liang R, Hawkins BR & Kwong YL 2005 Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation. Bone Marrow Transplantation 35 383-388. (Pubitemid 40309484)
10. Baker KS, Ness KK, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG et al. 2007 Diabetes, hypertension and cardiovascular events in survivors of hematopoietic stem cell transplantation: a report from the bone marrow transplant survivor study. Blood 109 1765-1772. (Pubitemid 46239613)
11. Bakker B, Oostdijk W, Bresters D, Walenkamp MJ, Vossen JM & Wit JM 2004 Disturbances of growth and endocrine function after busulfan-based conditioning for haematopoeitic stem cell transplantation during infancy and childhood. Bone Marrow Transplantation 33 1049-1056. (Pubitemid 38744793)
12. Bath LE, Critchley HOD, Chambers SE, Anderson RA, Kelnar CJ & Wallace WH 1999 Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement. British Journal of Obstetrics and Gynaecology 106 1265-1272.
13. Bath LE, Anderson RA, Critchley HOD, Kelnar CJ & Wallace WH 2001 Hypothalamic-pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia. Human Reproduction 16 1838-1844.
14. van den Berg H, Furstner F, van den Bos C & Begrendt H 2004 Decreasing the number of MOPP courses reduces gonadal damage in childhood Hodgkin's disease. Pediatric Blood & Cancer 42 210-215. (Pubitemid 38235069)
15. Björk J, Link K & Erfurth EM 2005 The utility of the growth hormone (GH) releasing hormone-arginine test for diagnosing GH deficiency in adults with childhood acute lymphoblastic leukemia treated with cranial irradiation. Journal of Clinical Endocrinology and Metabolism 90 6048-6054. (Pubitemid 41606524)
16. Blatt J, Poplack DG & Sherins RJ 1981 Testicular function in boys after chemotherapy for acute lymphoblastic leukemia. New England Journal of Medicine 304 1121-1124. (Pubitemid 11099206)
17. Blethen SL & Rundle AC 1996 Slipped capital femoral epiphyses in children treated with growth hormone. A summary of the natural cooperative growth experience. Hormone Research 46 113-116.
18. Bounacer A, Wicker R, Caillou B, Cailleux AF, Sarasin A, Schlumberger M & Suarez HG 1997 High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene 15 1263-1276.
19. Bramswig JH, Heimes U, Heiermann E, Schlegel W, Nieschlag E & Schellong G 1990 The effect of different cumulative doses of chemotherapy on testicular function. Cancer 65 1298-1302.
20. Brauner R, Czernichow P & Rappaport R 1984 Precocious puberty after hypothalamic and pituitary irradiation in young children. New England Journal of Medicine 311 920. (Pubitemid 14041556)
21. Brauner R, Fontoura M, Zucker JM, Devergie A, Souberbielle JC, Prevot-Saucet C, Michon J, Gluckman E, Griscelli C, Fischer A et al. 1993 Growth and growth hormone secretion after bone marrow transplantation. Archives of Disease in Childhood 64 458-463. (Pubitemid 23136646)
22. Brennan BM, Rahim A, Mackie EM, Eden OB & Shalet SM 1998 Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clinical Endocrinology 48 777-783. (Pubitemid 28289248)
23. Brennan BMD, Rahim A, Adams JA, Eden OB & Shalet SM 1999 Reduced bone mineral density in young adults following cure of acute lymphoblastic leukaemia in childhood. British Journal of Cancer 79 1859-1863. (Pubitemid 29132316)
24. Brignardello E, Corrias A, Isolato G, Palestini N, Cordero di Montezemolo L, Fagioli F & Boccuzzi G 2008 Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series. Journal of Clinical Endocrinology and Metabolism 93 4840-4843.
25. Brownstein CM, Mertens AC, Mitby PA, Stovall M, Qin J, Heller G, Robison LL & Sklar CA 2004 Factors that affect final height and change in height standard deviation scores in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study. Journal of Clinical Endocrinology and Metabolism 89 4422-4427.
26. Byrne J, Fears TR, Gail MH, Pee D, Connelli RR, Austin DF, Holmes GF, Holmes FF, Latourette HB, Meigs JW et al. 1992 Early menopause in longterm survivors of cancer during adolescence. American Journal of Obstetrics and Gynecology 166 788-793.
27. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Meadows AT, Reaman GH & Robison LL 2004 Fertility of longterm male survivors of acute lymphoblastic leukemia diagnosed during childhood. Pediatric Blood & Cancer 42 364-372. (Pubitemid 38327632)
28. Carr BR 1992 Disorders of the ovary and the reproductive tract. In WIlliams Textbook of Endocrinology, vol 8, pp 733-798. Eds JD Wilson & DW Foster. Philadelphia: W.B. Saunders.
29. Chemaitilly W, Trivin C, Souberbielle JC & Brauner R 2003 Assessing short statured children for growth hormone deficiency. Hormone Research 60 34-42. (Pubitemid 36693884)
30. Chemaitilly W, Mertens AC, Mitby P, Whitton J, Stovall M, Yasui Y, Robison LL & Sklar CA 2006 Acute ovarian failure in the childhood cancer survivor study. Journal of Clinical Endocrinology and Metabolism 91 1723-1728.
31. Chemaitilly W, Boulad F, Oeffinger KC & Sklar CA 2009 Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study. Bone Marrow Transplantation 44 339-343.
32. Chin D, Sklar C, Donahue B, Uli N, Geneiser N, Allen J, Nirenberg A, David R, Kohn B & Oberfield SE 1997 Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neurectodermal tumors: a comparison of hyperfractionated versus conventional radiotherapy. Cancer 80 798-804.
33. Chow EJ, Friedman DL, Yasui Y, Whitton JA, Stovall M, Robison LL & Sklar CA 2008 Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Pediatric Blood & Cancer 50 854-858. (Pubitemid 351356099)
34. Chow EJ, Friedman DL, Stovall M, Yasui Y, Whitton JA, Robison LL & Sklar CA 2009 Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the childhood cancer survivors study. Pediatric Blood & Cancer 53 432-437.
35. Clayton PE & Shalet SM 1991a Dose dependency of time of onset of radiation-induced growth hormone deficiency. Journal of Pediatrics 118 226-228.
36. Clayton PE & Shalet SM 1991b The evolution of spinal growth after irradiation. Clinical Oncology 3 220-222.
37. Clayton PE, Shalet SM, Price DA & Jones PH 1989 Ovarian function following chemotherapy for childhood brain tumours. Medical and Pediatric Oncology 17 92-96. (Pubitemid 19120908)
38. Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF & Rubin P 1993 Hypothalamic-pituitary dysfunction after radiation for brain tumors. New England Journal of Medicine 328 87-94.
39. Costin G 1988 Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function. American Journal of Diseases of Children 142 847-852.
40. Couto-Silva AC, Trivin C, Esperou H, Michon J, Fischer A & Brauner R 2000 Changes in height, weight and plasma leptin after bone marrow transplantation. Bone Marrow Transplantation 26 1205-1210.
41. Crofton PM, Ahmed SF, Wade JC, Stephen R, Elmlinger MW, Ranke MB, Kelnar CJ & Wallace WH 1998 Effects of intensive chemotherapy on bone and collagen turnover and the growth hormone axis in children with acute lymphoblastic leukemia. Journal of Clinical Endocrinology and Metabolism 83 3121-3129. (Pubitemid 28500945)
42. Damewood MD & Grochow LB 1986 Prospects for fertility after chemotherapy or radiation for neoplastic disease. Fertility and Sterility 45 443-459.
43. d'Annunzio G, Bonetti F, Locatelli F, Pistorio A & Lorini R 2005 Insulin resistance in children and adolescents after bone marrow transplant for haematological malignancies. Bone Marrow Transplantation 35 209-210.
44. Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E & Shalet SM 2003 The usefulness of combined growth hormone (GH) releasing hormone and arginine stimulation test in the diagnosis of radiation induced GH deficiency is dependent on the time interval. Journal of Clinical Endocrinology and Metabolism 88 95-102. (Pubitemid 36115149)
45. De Boer H, Blok GJ, Van Lingen A, Teule GJ, Lips P & van der Veen EA 1994 Consequences of childhood onset growth hormone deficiency for adult bone mass. Journal of Bone and Mineral Research 9 1319-1326. (Pubitemid 24238363)
46. Diller L, Chow EJ, Gurney GJ, Hudson MM, Kadin-Lottick NS, Kawashima TI, Leisenring WM, Meacham LR, Mertens AC, Mulrooney DA et al. 2009 Chronic disase in the Childhood Cancer Survivor Study Cohort: a review of published findings. Journal of Clinical Oncology 27 2339-2355.
47. Elisei R, Romei C, Vorontsova T, Cosci B, Veremeychik V, Kushinskaya E, Basolo F, Demidchik EP, Miccoli P, Pinchera A et al. 2001 RET/PTC rearrangements in thyroid nodules: studies in irradiated and non irradiated malignant and benign thyroid lesions in children and adults. Journal of Clinical Endocrinology and Metabolism 86 3211-3216. (Pubitemid 32673490)
48. Ergun-Longmire B, Mertens AC, Mitby P, Qin J, Heller G, Shi W, Yasui Y, Robison LL & Sklar CA 2006 Growth hormone treatment and risk of second neoplasm in the childhood cancer survivor. Journal of Clinical Endocrinology and Metabolism 91 3494-3498. (Pubitemid 44402126)
49. Follin C, Thilén U, Ahrén B & Erfurth EM 2006 Improvement in cardiac systolic function and reduced prevalence of metabolic syndrome after two years of growth hormone (GH) treatment in GH-deficien adult survivors of childhood-onset acute lymphoblastic leukemia. Journal of Clinical Endocrinology and Metabolism 91 1872-1875.
50. Gafni RI & Baron J 2004 Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy X-ray absorptiometry (DEXA). Journal of Pediatrics 144 53-57.
51. Garmey EG, Liu Q, Sklar CA, Meacham LR, Mertens AC, Stovall MA, Yasui Y, Robison LL & Oeffinger KC 2008 Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology 26 4639-4645.
52. Gleeson HK, Stoeter R, Ogilvy-Stuart AL, Gattamaneni HR, Brennan BM & Shalet SM 2003 Improvements in final height over 25 years in growth hormone (GH)-deficient childhood survivors of brain tumours receiving GH replacement. Journal of Clinical Endocrinology and Metabolism 88 3682-3689.
53. Gleeson HK, Gattamaneni HR, Smethurst C, Brennan BM & Shalet SM 2004 Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy. Journal of Clinical Endocrinology and Metabolism 89 662-666.
54. Green DM, Whitton JA, Stovall M, Mertens AC, Donaldson SS, Ruymann FB, Pendergrass TW & Robison LL 2002 Pregnancy outcome of female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. American Journal of Obstetrics and Gynecology 187 1070-1080. (Pubitemid 35178413)
55. Green DM, Kawashima T, Stovall M, Leisenring W, Sklar CA, Mertens AC, Donaldson SA, Byrne J & Robison LL 2009 Fertility of female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology 27 2677-2685.
56. Greulich W & Pyle S 1959 Radiographic atlas of skeletal development of the hand and wrist. edn 2. Stanford, CA, USA: Stanford University Press.
57. Griffin JE & Wilson JD 1992 Disorders of the testes and the male reproductive tract. In Williams Textbook of Endocrinology, vol 8, pp 799-852. Eds JD Wilson & DW Foster. Philadelphia: W.B. Saunders.
58. Grigg AP, McLachlan R, Zajac J & Szer J 2000 Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120 mg/kg). Bone Marrow Transplantation 26 1089-1095.
59. Growth Hormone Research Society 2000 Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. Journal of Clinical Endocrinology and Metabolism 85 3990-3993.
60. Gurney JG, Kadan-Lottick NS, Packer RJ, Neglia JP, Sklar CA, Punyko JA, Stovall M, Yasui Y, Nicholson HS, Wolden S et al. 2003a Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer 97 663-673. (Pubitemid 36125844)
61. Gurney JG, Ness KK, Stovall M, Wolden S, Punyko JA, Neglia JP, Mertens AC, Packer RJ, Robison LL & Sklar CA 2003b Final height and body mass index among adult survivors of childhood brain cancer: Childhood Cancer Survivor Study. Journal of Clinical Endocrinology and Metabolism 88 4731-4739. (Pubitemid 37357519)
62. Halton JM, Atkinson SA, Fraher L, Webber C, Gill GJ, Dawson S & Barr RD 1996 Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia. Journal of Bone and Mineral Research 11 1774-1783.
63. Hamre MR, Robison LL, Nesbit ME, Sather HN, Meadows AT, Ortega JA, D'Angio GJ & Hammond GD 1987 Effects of radiation on ovarian function in long term survivors of childhood acute lymphoblastic leukemia: a report from the Children Cancer Study Group. Journal of Clinical Oncology 5 1759-1765.
64. Heikens J, Behrendt H, Adriaanse R & Berghout A 1996 Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease. Cancer 78 2020-2024.
65. Himelstein-Braw R, Peters H & Faber M 1978 Morphological studies of the ovaries of leukaemic children. British Journal of Cancer 38 82-87.
66. Hoffmeister PA, Storer BE & Sanders JE 2004 Diabetes mellitus in long-term survivors of peiatric hematopietic cell transplantation. Journal of Pediatric Hematology/Oncology 26 81-90.
67. Holm K, Nysom K, Rasmussen MH, Hertz H, Jacobsen N, Skakkebaek NE, Krabbe S & Muller J 1996 Growth, growth hormone and final height after bone marrow transplantation: possible recovery of irradiation-induced growth hormone insufficiency. Bone Marrow Transplantation 18 163-170.
68. Holm K, Nysom K, Brocks V, Hertz H, Jacobsen N & Muller J 1999 Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. Bone Marrow Transplantation 23 259-263.
69. Horning SJ, Hoppe RT, Kaplan HS & Rosenberg SA 1981 Female reproductive potential after treatment for Hodgkin's disease. New England Journal of Medicine 304 1377-1382.
70. Hows JM, Passweg JR, Tichelli A, Locasciulli A, Szydlo R, Bacigalupo A, Jacobson N, Ljungman P, Cornish J, Nunn A et al. 2006 Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donors. Bone Marrow Transplantation 38 799-805.
71. Hudson MM, Greenwald C, Thompson E, Wilimas J, Marina N, Fairclough D, Kauffman W, Bozeman P, Mackert PW, Abromowitch M et al. 1993 Efficacy and toxicity of multiagent chemotherapy and low-dose involved field radiotherapy in children and adolescents with Hodgkin's disease. Journal of Clinical Oncology 11 100-108.
72. Izard MA 1995 Leydig cell function and radiation: a review of the literature. Radiotherapy and Oncology 34 1-8.
73. Jones TS, Kaste SC, Liu W, Cheng C, Yang W, Tantisira KG, Pui CH & Relling MV 2008 CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia. Journal of Clinical Oncology 26 3031-3037.
74. Kenney LB, Laufer MR, Grant FD, Grier H & Diller L 2001 High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer 91 613-621.
75. Lam KSL, Tse VKC, Wang C, Yeung RT & Ho JH 1991 Effects of irradiation on hypothalamic-pituitary function: a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Quarterly Journal of Medicine 78 165-176.
76. Larsen E, Muller J, Schmiegelow K, Rechnitzer C & Andersen AN 2003 Reduced ovarian function in long-term survivors of radiation and chemotherapy-treated childhood cancer. Journal of Clinical Endocrinology and Metabolism 88 5307-5314. (Pubitemid 37452732)
77. Larsen EC, Schmiegelow K, Rechnitzer C, Loft A, Muller J& Andersen AN 2004 Radiotherapy at a young age reduces uterine volume of childhood cancer survivors. Acta Obstetricia et Gynecologica Scandinavica 83 96-102. (Pubitemid 38121736)
78. Laughton SJ, Merchant TE, Sklar CA, Kun LE, Fouladi M, Broniscer A, Morris EB, Sanders RP, Krasin MJ, Shelso J et al. 2008 Endocrine outcomes for children with embryonal brain tumors after risk adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem cell rescue on the SJMB-96 trial. Journal of Clinical Oncology 26 1112-1118.
79. Laverdiére C, Cheung N-KV, Kushner BH, Kramer K, Modak S, La Quaglia MP, Wolden S, Ness KK, Gurney JG & Sklar CA 2005 Long-term complications in survivors of advanced stage neuroblastoma. Pediatric Blood & Cancer 45 324-332. (Pubitemid 41077167)
80. Leiper AD, Grant DB & Chessels JM 1986 Gonadal function after testicular radiation for acute lymphoblastic leukemia. Archives of Disease in Childhood 61 53-56. (Pubitemid 16124850)
81. Lewis K & Lee PA 2009 Endocrinology of male puberty. Current Opinion in Endocrinology, Diabetes and Obesity 16 5-9.
82. Link K, Moëll C, Garwicz S, Cavallin-Ståhl E, Björk J, Thilén U, Ahrén B & Erfurth EM 2004 Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. Journal of Clinical Endocrinology and Metabolism 89 5003-5012. (Pubitemid 39391441)
83. Lissett CA, Saleem S, Rahim A, Brennan BM & Shalet SM 2001 The impact of irradiation on GH responsiveness to provocative agents is stimulus dependent: results in 161 individuals with radiation damage to the somatotropic axis. Journal of Clinical Endocrinology and Metabolism 86 663-668. (Pubitemid 32207478)
84. Lorini R, Cortona L, Scaramuzza A, De Stefano P, Locatelli F, Bonetti F & Severi F 1995 Hyperinsulinemia in children and adolescents after bone marrow transplantation. Bone Marrow Transplantation 15 873-877.
85. Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S & Merchant TE 2003a Risk factors for the development of obesity in children surviving brain tumors. Journal of Clinical Endocrinology and Metabolism 88 611-616. (Pubitemid 36207799)
86. Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S & Xiong X 2003b Octreotide therapy of pediatric hypothalamic obesity: a doubleblind, placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism 88 2586-2592. (Pubitemid 36724428)
87. Mackie EJ, Radford M & Shalet SM 1996 Gonadal function following chemotherapy for childhood Hodgkin's disease. Medical and Pediatric Oncology 27 74-78. (Pubitemid 26198772)
88. Mariotto AB, Rowland JH, Yabroff KR, Scoppa S, Hachey M, Ries L & Feuer EJ 2009 Long-term survivors of childhood cancers in the United States. Cancer Epidemiology, Biomarkers & Prevention 18 1033-1040.
89. Mason PW, Krawiecki N & Meacham LR 2002 The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Archives of Pediatrics & Adolescent Medicine 156 887-892. (Pubitemid 36343499)
90. Matsumoto M, Shinohara O, Ishiguro H, Shimizu T, Hattori K, Ichikawa M, Yabe H, Kubota C, Yabe M & Kato S 1999 Ovarian function after bone marrow transplantation performed before menarche. Archives of Disease in Childhood 80 452-454. (Pubitemid 29220182)
91. Meacham LR, Sklar CA, Li S, Liu Q, Gimpel N, Yasui Y, Whitton JA, Stovall M, Robison LL & Oeffinger KC 2009 Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report from the Childhood Cancer Survivor Study. Archives of Internal Medicine 169 1381-1388.
92. Meistrich ML, Vassillopoulou-Sellin R & Lipshultz LI 1997 Gonadal dysfunction. In Cancer: Principles and Practice of Oncology, vol 5, pp 2758-2773. Eds VT DeVita Jr, S Hellman & SA Rosenberg. Philadelphia: Lippincott-Raven.
93. Metzger ML, Hudson MM, Somes GW, Shorr RI, Li CS, Krasin MJ, Shelso J, Pui CH & Howard SC 2006a White race as a risk factor for hypothyroidism after treatment for pediatric Hodgkin's lymphoma. Journal of Clinical Oncology 24 1516-1521. (Pubitemid 46638772)
94. Metzger ML, Howard SC, Hudson MM, Gow KW, Li CS, Krasin MJ, Merchant T, Kun L, Shelso J, Pui CH et al. 2006b Natural history of thyroid nodules in survivors of pediatric Hodgkin lymphoma. Pediatric Blood & Cancer 46 314-319. (Pubitemid 43201846)
95. Michel G, Socie G, Gebhard F, Bernaudin F, Thuret I, Vannier JP, Demeocq F, Leverger G, Pico JL, Rubie H et al. 1997 Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: the impact of conditioning regimen without total-body irradiation - a report from the Société Française de Greffe de Moelle. Journal of Clinical Oncology 15 2238-2246.
96. Mukherjee A, Tolhurst-Cleaver S, Ryder WD, Smethurst L & Shalet SM 2005 The characteristics of quality of life impairment in adult growth hormone (GH)-deficient survivors of cancer and their response to GH replacement therapy. Journal of Clinical Endocrinology and Metabolism 90 1542-1549. (Pubitemid 40464016)
97. Murray RD, Darzy KH, Gleeson HK & Shalet SM 2002 GH deficient survivors of childhood cancer: GH replacement during adult life. Journal of Clinical Endocrinology and Metabolism 87 129-135. (Pubitemid 34084681)
98. Nasir J, Walton C, Lindow SW & Masson EA 1997 Spontaneous recovery of chemotherapy-induced primary ovarian failure: implication for management. Clinical Endocrinology 46 217-219. (Pubitemid 27122169)
99. Neville KA, Cohn RJ, Steinbeck KS, Johnston K & Walker JL 2006 Hyperinsulinemia, impaired glucose tolerance and diabetes mellitus in survivors of childhood cancer: prevalence and risk factors. Journal of Clinical Endocrinology and Metabolism 91 4401-4407. (Pubitemid 44833416)
100. Nysom K, Holm K, Michaelsen KF, Hertz H, Jacobsen N, Müller J & Mølgaard C 2000 Bone mass after allogeneic bone marrow transplantation for childhood leukaemia or lymphoma. Bone Marrow Transplantation 25 191-196.
101. Oberfield SE, Soranno D, Nirenberg A, Heller G, Allen JC, David R, Levine LS & Sklar CA 1996 Age at the onset of puberty following high-dose central nervous system radiation therapy. Archives of Pediatrics & Adolescent Medicine 150 589-592. (Pubitemid 26196768)
102. Oeffinger KC, Mertens AC, Sklar CA, Yasui Y, Fears T, Stovall M, Vik TA, Inskip PD & Robison LL 2003 Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology 21 1359-1365. (Pubitemid 46606416)
103. Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS et al. 2006 Chronic health conditions in adult survivors of childhood cancer. New England Journal of Medicine 355 1572-1582. (Pubitemid 44547808)
104. Ogilvy-Stuart AL & Shalet SM 1995 Growth and puberty after growth hormone treatment after irradiation for brain tumours. Archives of Disease in Childhood 73 141-146.
105. Oglivy-Stuart AL, Wallace WH & Shalet SM 1994 Radiation and neuroregulatory control of growth hormone secretion. Clinical Endocrinology 41 163-168. (Pubitemid 24239919)
106. Packer RJ, Boyett JM, Janns AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M et al. 2001 Growth hormone replacement therapy in children with medulloblastoma: use and effect on tumor control. Journal of Clinical Oncology 19 480-487.
107. Papadakis V, Vlachopapadopoulou E, Van Syckle K, Ganshaw L, Kalmanti M, Tan C & Sklar C 1999 Gonadal function in young patients successfully treated for Hodgkin's disease. Medical and Pediatric Oncology 32 366-372. (Pubitemid 29196286)
108. Patterson BC, Truxillo L, Wasilewski-Masker K, Mertens AC & Meacham LR 2009 Adrenal function testing in pediatric cancer survivors. Pediatric Blood & Cancer 53 1302-1307.
109. Picco P, Garaventa A, Claudiani F, Gattorno M, De Bernardi B & Borrone C 1995 Primary hypothyroidism as a consequence of 131-I- metaiodobenzylguanidine treatment for children with neuroblastoma. Cancer 76 1662-1664.
110. Reilly JJ, Vetham JC, Ralston JM, Donaldson M & Gibson B 1998 Reduced energy expenditure in pre-obese children treated for acute lymphoblastic leukemia. Pediatric Research 44 557-562. (Pubitemid 28447343)
111. Reilly JJ, Kelly A, Ness P, Dorosty AR, Wallace WH, Gibson BE, Emmett PM & ALSPAC Study Team 2001 Premature adiposity rebound in children treated for acute lymphoblastic leukaemia. Journal of Clinical Endocrinology and Metabolism 86 3742-3745. (Pubitemid 32755970)
112. Reiter EO & Rosenfeld RG 2003 Normal and abnormal growth. In Williams Textbook of Endocrinology, pp 1003-1014. Eds PR Larsen, HM Kronenberg & S Melmed. Philadelphia: WB Saunders.
113. Relander T, Gavallin-Stahl E, Garwicz S, Olsson AM & Willen M 2000 Gonadal and sexual function in men treated for childhood cancer. Medical and Pediatric Oncology 35 52-63. (Pubitemid 30447825)
114. Rivkees SA & Crawford JD 1988 The relationship of gonadal activity and chemotherapy-induced gonadal damage. Journal of the American Medical Association 259 2123-2125.
115. Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS, Green DM, Hammond S, Meadows AT, Mertens AC et al. 2009 The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. Journal of Clinical Oncology 27 2308-2318.
116. Romerius P, Ståhl O, Moëll C, Relander T, Cavallin-Ståhl E, Wiebe T, Giwercman YL & Giwercman A 2009 Hypogonadism risk in men treated for childhood cancer. Journal of Clinical Endocrinology and Metabolism 94 4180-4186.
117. Rose SR, Lustig RH, Pitukcheewanont P, Broome DC, Burghen GA, Li H, Hudson MM, Kun LE & Heideman RL 1999 Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. Journal of Clinical Endocrinology and Metabolism 84 4472-4479.
118. Rose SR, Schreiber RE, Kearney NS, Lustig RH, Danish RK, Burghen GA & Hudson MM 2004 Hypothalamic dysfunction after chemotherapy. Journal of Pediatric Endocrinology and Metabolism 17 55-66.
119. Rose SR, Danish RK, Kearney NS, Schreiber RE, Lustig RH, Burghen GA & Hudson MM 2005 ACTH deficiency in childhood cancer survivors. Pediatric Blood & Cancer 45 808-813. (Pubitemid 41416491)
120. Ross JA, Oeffinger KC, Davies SM, Mertens AC, Langer EK, Kiffmeyer WR, Sklar CA, Stovall M, Yasui Y & Robison LL 2004 Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology 22 3558-3562. (Pubitemid 41103662)
121. Sala A & Barr RD 2007 Osteopenia and cancer in children and adolescents: the fragility of success. Cancer 109 1420-1431. (Pubitemid 46466571)
122. Sanders JE 2004 Endocrine complications of high-dose therapy with stem cell transplantation. Pediatric Transplantation 8 39-50. (Pubitemid 38787575)
123. Sanders JE, Pritchard S, Mahoney P, Amos D, Buckner CD, Witherspoon RP, Deeg HJ, Doney KC, Sullivan KM, Appelbaum FR et al. 1986 Growth and development following marrow transplantation for leukemia. Blood 68 1129-1135. (Pubitemid 17186392)
124. Sanders JE, Buckner CD, Amos D, Levy W, Appelbaum FR, Doney K, Storb R, Sullivan KM, Witherspoon RP & Thomas ED 1988 Ovarian function following marrow transplantation for aplastic anemia or leukemia. Journal of Clinical Oncology 6 813-818.
125. Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeg HJ, Doney K, Storb R, Sullivan K, Witherspoon R et al. 1996 Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood 87 3045-3052. (Pubitemid 26102258)
126. Sarafoglou K, Boulad F, Gillio A & Sklar C 1997 Gonadal function after bone marrow transplantation for acute leukemia during childhood. Journal of Pediatrics 130 210-216. (Pubitemid 27495155)
127. Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Poulsen HS & Muller J 2003 A population-based study of thyroid function after radiotherapy and chemotherapy for a childhood brain tumor. Journal of Clinical Endocrinology and Metabolism 88 136-140. (Pubitemid 36115155)
128. Shalet SM, Horner A, Ahmed SR & Morris-Jones PH 1985 Leydig cell damage after testicular irradiation for lymphoblastic leukemia. Medical and Pediatric Oncology 13 65-68. (Pubitemid 15113157)
129. Shalet SM, Gibson B, Swindell R & Pearson D 1987 Effects of spinal irradiation on growth. Archives of Disease in Childhood 62 461-464.
130. Shalet SM, Tsatsoulis A, Whitehead E & Read G 1989 Vulnerability of the human Leydig cell to radiation damage is dependent upon age. Journal of Endocrinology 120 161-165. (Pubitemid 19022053)
131. Sigurdson AJ, Ronckers CM, Mertens AC, Stovall M, Smith SA, Liu Y, Berkow RL, Hammond S, Neglia JP, Meadows AT et al. 2005 Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case - control study. Lancet 365 2014-2023.
132. Sigurjonssdottir T & Hayes A 1968 Precocious puberty: a report of 96 cases. American Journal of Diseases of Children 1115 309-321.
133. Siimes MA, Rautonen J, Makipernaa A & Sipila I 1995 Testicular function in adult males surviving childhood malignancy. Pediatric Hematology and Oncology 12 231-241.
134. Sklar CA 1997 Growth and neuroendocrine dysfunction following therapy for childhood cancer. Pediatric Clinics of North America 44 489-503.
135. Sklar C 1999 Reproductive physiology and treatment-related loss of sex-hormone production. Medical and Pediatric Oncology 33 2-8. (Pubitemid 29318657)
136. Sklar CA & Constine LS 1995 Chronic neuro-endocrinological sequelae of radiation therapy. International Journal of Radiation Oncology, Biology, Physics 31 1113-1120.
137. Sklar CA, Kim TH & Ramsay NKC 1984 Testicular function following bone marrow transplantation performed during or after puberty. Cancer 53 1498-1501. (Pubitemid 14166561)
138. Sklar C, Sarafoglou K & Whittam E 1993 Efficacy of insulin-like growth factor binding protein-3 (IGFBP-3) in predicting the growth hormone response to provocative testing in children treated with cranial irradiation. Acta Endocrinologica 129 511-515.
139. Sklar C, Whitton J, Mertens A, Stovall M, Green D, Marina N, Greffe B, Wolden S & Robison L 2000a Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. Journal of Clinical Endocrinology and Metabolism 85 3227-3232.
140. Sklar CA, Mertens AC, Walter A, Mitchell D, Nesbit ME, O'Leary M, Hutchinson R, Meadows AT & Robison LL 2000b Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation. Medical and Pediatric Oncology 35 91-95.
141. Sklar C, Boulad F, Small T & Kernan N 2001 Endocrine complications of pediatric stem cell transplantation. Frontiers in Bioscience 1 G12-G22.
142. Sklar CA, Mertens AC, Mitby P, Occhiogrosso G, Qin J, Heller G, Yasui Y & Robison LL 2002 Risk of disease recurrence and second neoplasm in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study. Journal of Clinical Endocrinology and Metabolism 87 3136-3141. (Pubitemid 34816355)
143. Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C, Mulder J, Green D, Nicholson HS, Yasui Y et al. 2006 Premature menopause in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute 98 890-896. (Pubitemid 44018918)
144. van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, Krenning EP & de Muinck Keizer-Schrama SM 2002 Altered bone mineral density and body composition, and increased fracture risk in childhood acute lymphoblastic leukemia. Journal of Pediatrics 141 204-210.
145. Stanislavejic S & Babcock AL 1997 Fractures in children treated with methotrexate for leukemia. Clinical Orthopaedics and Related Research 125 139-144.
146. Swerdlow AJ, Reddingius RE, Higgins CD, Spoudeas HA, Phipps K, Qiao Z, Ryder WD, Brada M, Hayward RD, Brook CG et al. 2000 Growth hormone treatment of children with brain tumours and risk of tumour recurrence. Journal of Clinical Endocrinology and Metabolism 85 4444-4449.
147. Talvensaari KK, Lanning M, Tapanainen P & Knip M 1996 Long term survivors of childhood cancer survivors have an increased risk of manifesting the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 81 3051-3055. (Pubitemid 26323907)
148. Taskinen M, Saarinen Pihkala UM, Hovi L & Lipsanen-Nyman M 2000 Impaired glucose tolerance and dyslipidaemia as late effects after bone marrow transplantation in childhood. Lancet 356 993-997.
149. Taylor AJ, Croft AP, Palace AM, Winter DL, Reulen RC, Stiller CA, Stevens MC & Hawkins MM 2009 Risk of thyroid cancer in survivors of childhood cancer: results from the British Childhood Cancer Survivor Study. International Journal of Cancer 125 2400-2405.
150. Thibaud E, Ramirez M, Brauner R, Flamant F, Zucker JM, Fekete C & Rappaport R 1992 Preservation of ovarian function by ovarian transposition performed before pelvic irradiation in childhood. Journal of Pediatrics 12 880-884.
151. Thibaud E, Rodriguez-Macias K, Trivin C, Esperou H, Michon J & Brauner R 1998 Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplantation 21 287-290. (Pubitemid 28052232)
152. Thomas BC, Stanhope R, Plowman PN & Leiper AD 1993 Growth following single fraction and fractionated total body irradiation for bone marrow transplantation. European Journal of Pediatrics 152 888-892. (Pubitemid 23323005)
153. Thomas IH, Donohue JE, Ness KK, Dengel DR, Baker KS & Gurney JG 2008 Bone mineral density in young adult survivors of acute lymphoblastic leukemia. Cancer 113 3248-3256.
154. Van Santen HM, Vulsma T, Dijkgraaf MG, Blumer RM, Heinen R, Jaspers MW, Geenen MM, Offringa MO, de Vijlder JJ & van den Bos C 2003 No damaging effect of chemotherapy in addition to radiotherapy on the thyroid axis in young adult survivors of childhood cancer. Journal of Clinical Endocrinology and Metabolism 88 3657-3663. (Pubitemid 37034510)
155. Wallace WH, Shalet SM, Crowne EC, Morris-Jones PH, Gattamaneni HR & Price DA 1989a Gonadal dysfunction due to cis-platinum. Medical and Pediatric Oncology 17 409-413.
156. Wallace WHB, Shalet SM, Crown EC, Morris-Jones PH & Gattamaneni HR 1989b Ovarian failure following abdominal irradiation in childhood: natural history and prognosis. Clinical Oncology 1 75-79.
157. Wasilewski-Masker K, Kaste SC, Hudson MM, Esiashvili N, Mattano LA & Meacham LR 2008 Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Pediatrics 121 e705-e713.
158. Weinzimer SA, Homan SA, Ferry RJ & Moshang T 1999 Serum IGF-1 and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumors. Clinical Endocrinology 51 339-345. (Pubitemid 29439054)