The role of 5-hydroxytryptamine receptor subtypes in the regulation of brain-derived neurotrophic factor gene expression

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 1, 2014, Pages 53-61

  Zetterström, Tyra S C ^a   Coppell, Alexander A ^a   Khundakar, Ahmad A ^b  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

5 HT receptors; antidepressant drugs; brain derived neurotrophic factor; fluoxetine; hippocampus

Indexed keywords

8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; BRAIN DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; GLUCOCORTICOID; GRANISETRON; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NORADRENALIN; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CONTROLLED STUDY; DENTATE GYRUS; DOWN REGULATION; GENE EXPRESSION REGULATION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NONHUMAN; NORADRENERGIC SYSTEM; RAT; SEROTONINERGIC SYSTEM;

5-HT RECEPTORS; ANTIDEPRESSANT DRUGS; BRAIN-DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; HIPPOCAMPUS;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; GENE EXPRESSION; GLUCOCORTICOIDS; HIPPOCAMPUS; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 84890970709     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12153     Document Type: Article

References (47)

1. Duman RS, et al. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54: 597-606.
2. Neto FL, et al. Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol 2011; 9: 530-552.
3. Chen B, et al. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 2001; 50: 260-265.
4. Gorgulu Y, Caliyurt O,. Rapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depression. Brain Res Bull 2009; 80: 158-162.
5. Wolkowitz OM, et al. Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 1623-1630.
6. Groves JO,. Is it time to reassess the BDNF hypothesis of depression. Mol Psychiatry 2007; 12: 1079-1088.
7. Martinowich K, et al. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007; 10: 1089-1093.
8. Coppell AL, et al. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology 2003; 44: 903-910.
9. de Foubert G, et al. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 2004; 128: 597-604.
10. Khundakar AA, Zetterström TS,. Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain Res 2006; 1106: 12-20.
11. Donnici L, et al. Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells. BMC Neurosci 2008; 9: 61.
12. Khundakar AA, Zetterström TS,. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. Eur J Pharmacol 2011; 671: 33-38.
13. Barnes NM, Sharp T,. A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38: 1083-1152.
14. Dumuis A, et al. The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn Schmiedebergs Arch Pharmacol 1989; 340: 403-410.
15. Fletcher A, et al. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behav Brain Res 1996; 73: 337-353.
16. Kennett GA, et al. Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats. Neuropharmacology 1997; 36: 707-712.
17. Nakayama K,. Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex. Naunyn Schmiedebergs Arch Pharmacol 2002; 365: 102-105.
18. Zetterström T, et al. In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine. J Neurochem 1983; 41: 1769-1773.
19. Pei Q, et al. Differential effects of acute and chronic electroconvulsive shock on the abundance of messenger RNAs for voltage-dependent potassium channel subunits in the rat brain. Neuroscience 1997; 78: 343-350.
20. Aid T, et al. Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 2007; 85: 525-535.
21. Zetterström TS, et al. Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration. Brain Res Mol Brain Res 1998; 57: 106-110.
22. Nibuya M, et al. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995; 15: 7539-7547.
23. Russo-Neustadt AA, et al. Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Neuropsychopharmacology 2004; 29: 2189-2199.
24. Dias BG, et al. Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 2003; 45: 553-563.
25. Miro X, et al. Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study. Neuropharmacology 2002; 43: 1148-1157.
26. Zetterström TS, et al. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology 1999; 38: 1063-1073.
27. Gartside SE, et al. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br J Pharmacol 1995; 115: 1064-1070.
28. Stanford SC,. Prozac: panacea or puzzle? Trends Pharmacol Sci 1996; 17: 150-154.
29. Barbany G, Persson H,. Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids. Eur J Neurosci 1992; 4: 396-403.
30. Schaaf MJ, et al. Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training. Stress 1999; 3: 173-183.
31. Heisler LK, et al. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci 2007; 27: 6956-6964.
32. Murakami S, et al. Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly. Neurosci Res 2005; 53: 129-139.
33. Smith MA, et al. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995; 15: 1768-1777.
34. Vaidya VA, et al. Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett 1999; 262: 1-4.
35. Ge J, Barnes NM,. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. Br J Pharmacol 1996; 117: 1475-1480.
36. Maksay G,. Distinct thermodynamic parameters of serotonin 5-HT3 agonists and antagonists to displace [3H]granisetron binding. J Neurochem 1996; 67: 407-412.
37. Vaidya VA, et al. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J Neurosci 1997; 17: 2785-2795.
38. Freund TF, Buzsaki G,. Interneurons of the hippocampus. Hippocampus 1996; 6: 347-470.
39. Piguet P Galvan M,. Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J Physiol 1994; 481: 629-639.
40. Bijak M, Misgeld U,. Effects of serotonin through serotonin1A and serotonin4 receptors on inhibition in the guinea-pig dentate gyrus in vitro. Neuroscience 1997; 78: 1017-1026.
41. Marmigere F, et al. GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. Neurochem Int 2003; 42: 353-358.
42. Zafra F, et al. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc Natl Acad Sci U S A 1991; 88: 10037-10041.
43. Sairanen M, et al. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 2005; 25: 1089-1094.
44. Rantamäki T, et al. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS ONE 2011; 6: e20567.
45. Madhav TR, et al. Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF). Brain Res Mol Brain Res 2001; 93: 56-63.
46. Mamounas LA, et al. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 1995; 15: 7929-7939.
47. Zhou J, et al. The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Brain Res Dev Brain Res 1996; 97: 297-303.