Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling

Food and Chemical Toxicology

Volumn 64, Issue , 2014, Pages 307-313

  Wu, Jinfeng ^a   Xu, Hailin ^a   Wong, Pok Fai ^b   Xia, Shijin ^a   Xu, Jinhua ^a   Dong, Jingcheng ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cigarette smoke; Icaritin; Lung epithelial cells; Nrf2; Oxidative stress; PI3K AKT

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIOXIDANT; CIGARETTE SMOKE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; ICARITIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ASSAY; CELL PROTECTION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; EXPOSURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SMOKING; STRUCTURE ANALYSIS; UPREGULATION;

CIGARETTE SMOKE; ICARITIN; LUNG EPITHELIAL CELLS; NRF2; OXIDATIVE STRESS; PI3K-AKT;

CELLS, CULTURED; CHROMONES; ENZYME ACTIVATION; EPITHELIAL CELLS; FLAVONOIDS; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; LUNG; MORPHOLINES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOKE; TRANSCRIPTION, GENETIC;

EID: 84890962623     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.12.006     Document Type: Article

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