-
1
-
-
84861963413
-
Structure and pharmacology of pentameric receptor channels: From bacteria to brain
-
Corringer, P.-J. et al. Structure and pharmacology of pentameric receptor channels: from bacteria to brain. Structure 20, 941-956 (2012).
-
(2012)
Structure
, vol.20
, pp. 941-956
-
-
Corringer, P.-J.1
-
2
-
-
79957953215
-
Principles of activation and permeation in an anionselective Cys-loop receptor
-
Hibbs, R. E. & Gouaux, E. Principles of activation and permeation in an anionselective Cys-loop receptor. Nature 474, 54-60 (2011).
-
(2011)
Nature
, vol.474
, pp. 54-60
-
-
Hibbs, R.E.1
Gouaux, E.2
-
3
-
-
84875220675
-
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
-
Sauguet, L. et al. Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J. 32, 728-741 (2013).
-
(2013)
EMBO J.
, vol.32
, pp. 728-741
-
-
Sauguet, L.1
-
4
-
-
84859173541
-
Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
-
Pan, J. et al. Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat. Commun. 3, 714 (2012).
-
(2012)
Nat. Commun.
, vol.3
, pp. 714
-
-
Pan, J.1
-
5
-
-
58149267953
-
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
-
Bocquet, N. et al. X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457, 111-114 (2009).
-
(2009)
Nature
, vol.457
, pp. 111-114
-
-
Bocquet, N.1
-
6
-
-
41149168686
-
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
-
DOI 10.1038/nature06717, PII NATURE06717
-
Hilf, R. J. C. & Dutzler, R. X-ray structure of a prokaryotic pentameric ligandgated ion channel. Nature 452, 375-379 (2008). (Pubitemid 351430790)
-
(2008)
Nature
, vol.452
, Issue.7185
, pp. 375-379
-
-
Hilf, R.J.C.1
Dutzler, R.2
-
7
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
-
Unwin, N. Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution. J. Mol. Biol. 346, 967 (2005).
-
(2005)
J. Mol. Biol.
, vol.346
, pp. 967
-
-
Unwin, N.1
-
8
-
-
0022628717
-
Kinetics of unliganded acetylcholine receptor channel gating
-
Jackson, M. B. Kinetics of unliganded acetylcholine receptor channel gating. Biophys. J. 49, 663-672 (1986). (Pubitemid 16166911)
-
(1986)
Biophysical Journal
, vol.49
, Issue.3
, pp. 663-672
-
-
Jackson, M.B.1
-
9
-
-
58549118250
-
Unliganded gating of acetylcholine receptor channels
-
Purohit, P. & Auerbach, A. Unliganded gating of acetylcholine receptor channels. Proc. Natl Acad. Sci. 106, 115-120 (2009).
-
(2009)
Proc. Natl Acad. Sci.
, vol.106
, pp. 115-120
-
-
Purohit, P.1
Auerbach, A.2
-
10
-
-
84861145025
-
The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel
-
Nayak, T. K., Purohit, P. G. & Auerbach, A. The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel. J. Gen. Physiol. 139, 349-358 (2012).
-
(2012)
J. Gen. Physiol.
, vol.139
, pp. 349-358
-
-
Nayak, T.K.1
Purohit, P.G.2
Auerbach, A.3
-
11
-
-
0028958601
-
Characterizing transition states in protein folding: An essential step in the puzzle
-
Fersht, A. R. Characterizing transition states in protein folding: an essential step in the puzzle. Curr. Opin. Struct. Biol. 5, 79-84 (1995).
-
(1995)
Curr. Opin. Struct. Biol.
, vol.5
, pp. 79-84
-
-
Fersht, A.R.1
-
12
-
-
84876411224
-
The energy and work of a ligand-gated ion channel
-
Auerbach, A. The energy and work of a ligand-gated ion channel. J. Mol. Biol. 425, 1461-1475 (2013).
-
(2013)
J. Mol. Biol.
, vol.425
, pp. 1461-1475
-
-
Auerbach, A.1
-
13
-
-
79951824109
-
Design and control of acetylcholine receptor conformational change
-
Jadey, S. V., Purohit, P., Bruhova, I., Gregg, T. M. & Auerbach, A. Design and control of acetylcholine receptor conformational change. Proc Natl Acad. Sci. 108, 4328-4333 (2011).
-
(2011)
Proc Natl Acad. Sci.
, vol.108
, pp. 4328-4333
-
-
Jadey, S.V.1
Purohit, P.2
Bruhova, I.3
Gregg, T.M.4
Auerbach, A.5
-
14
-
-
84877133114
-
Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor
-
Gupta, S., Purohit, P. & Auerbach, A. Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J. Biol. Chem. 288, 12667-12679 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 12667-12679
-
-
Gupta, S.1
Purohit, P.2
Auerbach, A.3
-
15
-
-
0033811476
-
The extracellular linker of muscle acetylcholine receptor channels is a gating control element
-
Grosman, C., Salamone, F. N., Sine, S. M. & Auerbach, A. The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J. Gen. Physiol. 116, 327-340 (2000).
-
(2000)
J. Gen. Physiol.
, vol.116
, pp. 327-340
-
-
Grosman, C.1
Salamone, F.N.2
Sine, S.M.3
Auerbach, A.4
-
16
-
-
68049143193
-
Energy and structure of the M2 helix in acetylcholine receptor-channel gating
-
Jha, A., Purohit, P. & Auerbach, A. Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophys. J. 96, 4075-4084 (2009).
-
(2009)
Biophys. J.
, vol.96
, pp. 4075-4084
-
-
Jha, A.1
Purohit, P.2
Auerbach, A.3
-
17
-
-
78751673139
-
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
-
Nury, H. et al. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature 469, 428-431 (2011).
-
(2011)
Nature
, vol.469
, pp. 428-431
-
-
Nury, H.1
-
18
-
-
49649099967
-
Gating at the mouth of the acetylcholine receptor channel: Energetic consequences of mutations in the alpha M2-Cap
-
Bafna, P. A., Purohit, P. G. & Auerbach, A. Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alpha M2-Cap. PLoS One 3 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Bafna, P.A.1
Purohit, P.G.2
Auerbach, A.3
-
19
-
-
27744608733
-
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel
-
DOI 10.1038/nature04130, PII N04130
-
Lummis, S. C. et al. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature 438, 248-252 (2005). (Pubitemid 41599879)
-
(2005)
Nature
, vol.438
, Issue.7065
, pp. 248-252
-
-
Lummis, S.C.R.1
Beene, D.L.2
Lee, L.W.3
Lester, H.A.4
Broadhurst, R.W.5
Dougherty, D.A.6
-
20
-
-
36549043834
-
Acetylcholine receptor gating at extracellular transmembrane domain interface: The Cys-Loop and M2-M3 linker
-
DOI 10.1085/jgp.200709856
-
Jha, A., Cadugan, D. J., Purohit, P. & Auerbach, A. Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. J. Gen. Physiol. 130, 547-558 (2007). (Pubitemid 350179573)
-
(2007)
Journal of General Physiology
, vol.130
, Issue.6
, pp. 547-558
-
-
Jha, A.1
Cadugan, D.J.2
Purohit, P.3
Auerbach, A.4
-
21
-
-
67650470848
-
Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor
-
Paulsen, I. M., Martin, I. L. & Dunn, S. M. Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor. J. Neurochem. 110, 870-878 (2009).
-
(2009)
J. Neurochem.
, vol.110
, pp. 870-878
-
-
Paulsen, I.M.1
Martin, I.L.2
Dunn, S.M.3
-
22
-
-
34247375206
-
A stepwise mechanism for acetylcholine receptor channel gating
-
DOI 10.1038/nature05721, PII NATURE05721
-
Purohit, P., Mitra, A. & Auerbach, A. A stepwise mechanism for acetylcholine receptor channel gating. Nature 446, 930-933 (2007). (Pubitemid 46633166)
-
(2007)
Nature
, vol.446
, Issue.7138
, pp. 930-933
-
-
Purohit, P.1
Mitra, A.2
Auerbach, A.3
-
23
-
-
84886057632
-
Energetic contributions to channel gating of residues in the muscle nicotinic receptor b1 subunit
-
Akk, G. et al. Energetic contributions to channel gating of residues in the muscle nicotinic receptor b1 subunit. PLoS One 8, e78539 (2013).
-
(2013)
PLoS One
, vol.8
-
-
Akk, G.1
-
24
-
-
0037197654
-
Structure of the transition state of gating in the acetylcholine receptor channel pore: A Φ-value analysis
-
DOI 10.1021/bi011864f
-
Cymes, G. D., Grosman, C. & Auerbach, A. Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry 41, 5548-5555 (2002). (Pubitemid 34429388)
-
(2002)
Biochemistry
, vol.41
, Issue.17
, pp. 5548-5555
-
-
Cymes, G.D.1
Grosman, C.2
Auerbach, A.3
-
25
-
-
0036304564
-
Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits
-
DOI 10.1016/S0022-2836(02)00381-9
-
Unwin, N., Miyazawa, A., Li, J. & Fujiyoshi, Y. Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits. J. Mol. Biol. 319, 1165-1176 (2002). (Pubitemid 34729426)
-
(2002)
Journal of Molecular Biology
, vol.319
, Issue.5
, pp. 1165-1176
-
-
Unwin, N.1
Miyazawa, A.2
Li, J.3
Fujiyoshi, Y.4
-
26
-
-
0346365092
-
Free-Energy Landscapes of Ion-Channel Gating Are Malleable: Changes in the Number of Bound Ligands Are Accompanied by Changes in the Location of the Transition State in Acetylcholine-Receptor Channels
-
DOI 10.1021/bi0354334
-
Grosman, C. Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels. Biochemistry 42, 14977-14987 (2003). (Pubitemid 37553528)
-
(2003)
Biochemistry
, vol.42
, Issue.50
, pp. 14977-14987
-
-
Grosman, C.1
-
27
-
-
0001060616
-
Structure-energy relations, reaction mechanism, and disparity of progress of concerted reaction events
-
Grunwald, E. Structure-energy relations, reaction mechanism, and disparity of progress of concerted reaction events. J. Am. Chem. Soc. 107, 125-133 (1985).
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 125-133
-
-
Grunwald, E.1
-
28
-
-
27744443715
-
Plasticity of acetylcholine receptor gating motions via rate-energy relationships
-
DOI 10.1529/biophysj.105.068783
-
Mitra, A., Tascione, R., Auerbach, A. & Licht, S. Plasticity of acetylcholine receptor gating motions via rate-energy relationships. Biophys. J. 89, 3071-3078 (2005). (Pubitemid 41636063)
-
(2005)
Biophysical Journal
, vol.89
, Issue.5
, pp. 3071-3078
-
-
Mitra, A.1
Tascione, R.2
Auerbach, A.3
Licht, S.4
-
29
-
-
1842686239
-
Gating Dynamics of the Acetylcholine Receptor Extracellular Domain
-
DOI 10.1085/jgp.200309004
-
Chakrapani, S., Bailey, T. D. & Auerbach, A. Gating dynamics of the acetylcholine receptor extracellular domain. J. Gen. Physiol. 123, 341-356 (2004). (Pubitemid 38469279)
-
(2004)
Journal of General Physiology
, vol.123
, Issue.4
, pp. 341-356
-
-
Chakrapani, S.1
Bailey, T.D.2
Auerbach, A.3
-
30
-
-
77950282036
-
Energetics of gating at the apo-acetylcholine receptor transmitter binding site
-
Purohit, P. & Auerbach, A. Energetics of gating at the apo-acetylcholine receptor transmitter binding site. J. Gen. Physiol. 135, 321-331 (2010).
-
(2010)
J. Gen. Physiol.
, vol.135
, pp. 321-331
-
-
Purohit, P.1
Auerbach, A.2
-
31
-
-
79951834831
-
Temperature dependence of acetylcholine receptor channels activated by different agonists
-
Gupta, S. & Auerbach, A. Temperature dependence of acetylcholine receptor channels activated by different agonists. Biophys. J. 100, 895-903 (2011).
-
(2011)
Biophys. J.
, vol.100
, pp. 895-903
-
-
Gupta, S.1
Auerbach, A.2
-
33
-
-
27744499937
-
Φ-value analysis of a linear, sequential reaction mechanism: Theory and application to ion channel gating
-
DOI 10.1529/biophysj.105.067215
-
Zhou, Y., Pearson, J. E. & Auerbach, A. F-Value analysis of a linear, sequential reaction mechanism: Theory and application to ion channel gating. Biophys. J. 89, 3680-3685 (2005). (Pubitemid 41725593)
-
(2005)
Biophysical Journal
, vol.89
, Issue.6
, pp. 3680-3685
-
-
Zhou, Y.1
Pearson, J.E.2
Auerbach, A.3
-
34
-
-
49649102025
-
On the nature of partial agonism in the nicotinic receptor superfamily
-
Lape, R., Colquhoun, D. & Sivilotti, L. G. On the nature of partial agonism in the nicotinic receptor superfamily. Nature 454, 722-727 (2008).
-
(2008)
Nature
, vol.454
, pp. 722-727
-
-
Lape, R.1
Colquhoun, D.2
Sivilotti, L.G.3
-
35
-
-
84864009008
-
An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors
-
Jadey, S. & Auerbach, A. An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors. J. Gen. Physiol. 140, 17-28 (2012).
-
(2012)
J. Gen. Physiol.
, vol.140
, pp. 17-28
-
-
Jadey, S.1
Auerbach, A.2
-
36
-
-
6344219895
-
Is allostery an intrinsic property of all dynamic proteins?
-
DOI 10.1002/prot.20232
-
Gunasekaran, K., Ma, B. & Nussinov, R. Is allostery an intrinsic property of all dynamic proteins? Proteins 57, 433-443 (2004). (Pubitemid 39390799)
-
(2004)
Proteins: Structure, Function and Genetics
, vol.57
, Issue.3
, pp. 433-443
-
-
Gunasekaran, K.1
Ma, B.2
Nussinov, R.3
-
37
-
-
0034760077
-
Dynamic activation of protein function: A view emerging from NMR spectroscopy
-
DOI 10.1038/nsb1101-926
-
Wand, A. J. Dynamic activation of protein function: a view emerging from NMR spectroscopy. Nat. Struct. Biol. 8, 926-931 (2001). (Pubitemid 33032359)
-
(2001)
Nature Structural Biology
, vol.8
, Issue.11
, pp. 926-931
-
-
Wand, A.J.1
-
38
-
-
22244438519
-
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
-
DOI 10.1529/biophysj.104.050229
-
Taly, A. et al. Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. Biophys. J. 88, 3954-3965 (2005). (Pubitemid 40991108)
-
(2005)
Biophysical Journal
, vol.88
, Issue.6
, pp. 3954-3965
-
-
Taly, A.1
Delarue, M.2
Grutter, T.3
Nilges, M.4
Le Novere, N.5
Corringer, P.-J.6
Changeux, J.-P.7
-
39
-
-
79551615831
-
Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model
-
Zheng, W. & Auerbach, A. Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model. PLoS Comput. Biol. 7, e1001046 (2011).
-
(2011)
PLoS Comput. Biol.
, vol.7
-
-
Zheng, W.1
Auerbach, A.2
-
40
-
-
1542285356
-
Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling
-
Qin, F. Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. Biophys. J. 86, 1488 (2004).
-
(2004)
Biophys. J.
, vol.86
, pp. 1488
-
-
Qin, F.1
-
41
-
-
84861856196
-
A locally closed conformation of a bacterial pentameric proton-gated ion channel
-
Prevost, M. S. et al. A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat. Struct. Mol. Biol. 19, 642-649 (2012).
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 642-649
-
-
Prevost, M.S.1
-
42
-
-
77955693995
-
Linking the acetylcholine receptor-channel agonist-binding sites with the gate
-
Cadugan, D. J. & Auerbach, A. Linking the acetylcholine receptor-channel agonist-binding sites with the gate. Biophys. J. 99, 798-807 (2010).
-
(2010)
Biophys. J.
, vol.99
, pp. 798-807
-
-
Cadugan, D.J.1
Auerbach, A.2
-
43
-
-
84855162755
-
The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels
-
Jha, A., Gupta, S., Zucker, S. N. & Auerbach, A. The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels. J. Physiol. 590, 119-129 (2012).
-
(2012)
J. Physiol.
, vol.590
, pp. 119-129
-
-
Jha, A.1
Gupta, S.2
Zucker, S.N.3
Auerbach, A.4
-
44
-
-
36549039473
-
Acetylcholine receptor gating at extracellular transmembrane domain interface: The "pre-M1" linker
-
DOI 10.1085/jgp.200709857
-
Purohit, P. & Auerbach, A. Acetylcholine receptor gating at extracellular transmembrane domain interface: the 'pre-M1' linker. J. Gen. Physiol. 130, 559-568 (2007). (Pubitemid 350179574)
-
(2007)
Journal of General Physiology
, vol.130
, Issue.6
, pp. 559-568
-
-
Purohit, P.1
Auerbach, A.2
-
45
-
-
79951992408
-
Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site
-
Purohit, P. & Auerbach, A. Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site. Mol. Pharmacol. 79, 351-359 (2011).
-
(2011)
Mol. Pharmacol.
, vol.79
, pp. 351-359
-
-
Purohit, P.1
Auerbach, A.2
|