Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor

International Journal of Pharmaceutics

Volumn 461, Issue 1-2, 2014, Pages 203-213

  Zhang, Wei ^a,b   Parniak, Michael A ^c   Sarafianos, Stefan G ^d   Cost, Marilyn R ^a   Rohan, Lisa C ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d University of Missouri   (United States)

Author keywords

EFdA; HIV prevention; Microbicide; Polymeric film; Vaginal delivery

Indexed keywords

EFDA; MACROGOL 400; PLASTICIZER; POLYMER; POLYVINYL ALCOHOL; PROPYLENE GLYCOL; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 4'-ETHYNYL-2-FLUORO-2'-DEOXYADENOSINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DEOXYADENOSINE DERIVATIVE; EXCIPIENT;

ADULT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CASE REPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; EX VIVO STUDY; FACTORIAL DESIGN; FEMALE; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; INFECTION PREVENTION; MIDDLE AGED; MOISTURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUALITY CONTROL; SCANNING ELECTRON MICROSCOPY; SEXUAL TRANSMISSION; SOLID STATE; TENSILE STRENGTH; X RAY DIFFRACTION; YOUNG MODULUS; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; HIV INFECTIONS; INTRAVAGINAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PERMEABILITY; PROCEDURES; SOLUBILITY; TIME;

ADMINISTRATION, INTRAVAGINAL; ANTI-HIV AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DEOXYADENOSINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; EXCIPIENTS; FEMALE; HIV INFECTIONS; HUMANS; MIDDLE AGED; PERMEABILITY; PLASTICIZERS; POLYMERS; REVERSE TRANSCRIPTASE INHIBITORS; SOLUBILITY; TIME FACTORS;

EID: 84890925412     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.056     Document Type: Article

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