Hypomethylation of the IL17RC Promoter in Peripheral Blood Leukocytes Is Not A Hallmark of Age-Related Macular Degeneration

Cell Reports

Volumn 5, Issue 6, 2013, Pages 1527-1535

  Oliver, Verity F ^a   Franchina, Maria ^b   Jaffe, Andrew E ^c   Branham, Kari E ^d   Othman, Mohammad ^d   Heckenlively, John R ^d   Swaroop, Anand ^e   Campochiaro, Betsy ^a   Vote, Brendan J ^f   Craig, Jamie E ^g   Saffery, Richard ^h   Mackey, David A ^b   Qian, Jiang ^a   Zack, Donald J ^a,i,j   Hewitt, Alex W ^b,h   Merbs, Shannath L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e NATIONAL EYE INSTITUTE   (United States)

^f UNIVERSITY OF TASMANIA   (Australia)

^g FLINDERS UNIVERSITY   (Australia)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ Institute of Genetic Medicine   (United States)

^j INSTITUT DE LA VISION   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GRANULOCYTE; HUMAN; IL17RC GENE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING; QUANTITATIVE ANALYSIS; RETINA MACULA AGE RELATED DEGENERATION;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; HUMANS; LEUKOCYTES; MACULAR DEGENERATION; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RECEPTORS, INTERLEUKIN;

EID: 84890897918     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.11.042     Document Type: Article

References (36)

1. Adwan L., Zawia N.H. Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease. Pharmacol. Ther. 2013, 139:41-50.
2. Almén M.S., Jacobsson J.A., Moschonis G., Benedict C., Chrousos G.P., Fredriksson R., Schiöth H.B. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics 2012, 99:132-137.
3. Baird P.N., Wei L. Age-related macular degeneration and DNA methylation. Epigenomics 2013, 5:239-241.
4. Chen W., Stambolian D., Edwards A.O., Branham K.E., Othman M., Jakobsdottir J., Tosakulwong N., Pericak-Vance M.A., Campochiaro P.A., Klein M.L., et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc. Natl. Acad. Sci. USA 2010, 107:7401-7406. Complications of Age-Related Macular Degeneration Prevention Trial Research Group.
5. Choy K.W., Pang C.P., To K.F., Yu C.B., Ng J.S., Lam D.S. Impaired expression and promotor hypermethylation of O6-methylguanine-DNA methyltransferase in retinoblastoma tissues. Invest. Ophthalmol. Vis. Sci. 2002, 43:1344-1349.
6. Coleman H.R., Chan C.C., Ferris F.L., Chew E.Y. Age-related macular degeneration. Lancet 2008, 372:1835-1845.
7. Deaton A.M., Bird A. CpG islands and the regulation of transcription. Genes Dev. 2011, 25:1010-1022.
8. Delcourt C., Diaz J.L., Ponton-Sanchez A., Papoz L. Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l'Age. Arch. Ophthalmol. 1998, 116:1031-1035.
9. Delcourt C., Delyfer M.N., Rougier M.B., Amouyel P., Colin J., Le Goff M., Malet F., Dartigues J.F., Lambert J.C., Korobelnik J.F. Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study. Invest. Ophthalmol. Vis. Sci. 2011, 52:5955-5962.
10. Fritsche L.G., Chen W., Schu M., Yaspan B.L., Yu Y., Thorleifsson G., Zack D.J., Arakawa S., Cipriani V., Ripke S., et al. Seven new loci associated with age-related macular degeneration. Nat. Genet. 2013, 45:433-439. AMD Gene Consortium, e1-e2.
11. Hackler L., Masuda T., Oliver V.F., Merbs S.L., Zack D.J. Use of laser capture microdissection for analysis of retinal mRNA/miRNA expression and DNA methylation. Methods Mol. Biol. 2012, 884:289-304.
12. Hansen K.D., Timp W., Bravo H.C., Sabunciyan S., Langmead B., McDonald O.G., Wen B., Wu H., Liu Y., Diep D., et al. Increased methylation variation in epigenetic domains across cancer types. Nat. Genet. 2011, 43:768-775.
13. Haudenschild D., Moseley T., Rose L., Reddi A.H. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J.Biol. Chem. 2002, 277:4309-4316.
14. Hunter A., Spechler P.A., Cwanger A., Song Y., Zhang Z., Ying G.S., Hunter A.K., Dezoeten E., Dunaief J.L. DNA methylation is associated with altered gene expression in AMD. Invest. Ophthalmol. Vis. Sci. 2012, 53:2089-2105.
15. Irizarry R.A., Ladd-Acosta C., Wen B., Wu Z., Montano C., Onyango P., Cui H., Gabo K., Rongione M., Webster M., et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 2009, 41:178-186.
16. Jiang Y., Liu S., Chen X., Cao Y., Tao Y. Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer. Biochim. Biophys. Acta 2013, 1835:155-163.
17. Jones P.A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 2012, 13:484-492.
18. Ladd-Acosta C., Hansen K.D., Briem E., Fallin M.D., Kaufmann W.E., Feinberg A.P. Common DNA methylation alterations in multiple brain regions in autism. Mol. Psychiatry 2013, Published online September 3, 2013. 10.1038/mp.2013.114.
19. Lee K.W., Pausova Z. Cigarette smoking and DNA methylation. Front Genet 2013, 4:132-143.
20. Maat W., van der Velden P.A., Out-Luiting C., Plug M., Dirks-Mulder A., Jager M.J., Gruis N.A. Epigenetic inactivation of RASSF1a in uveal melanoma. Invest. Ophthalmol. Vis. Sci. 2007, 48:486-490.
21. Martin D.F., Maguire M.G., Ying G.S., Grunwald J.E., Fine S.L., Jaffe G.J. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N.Engl. J. Med. 2011, 364:1897-1908. CATT Research Group.
22. Merbs S.L., Khan M.A., Hackler L., Oliver V.F., Wan J., Qian J., Zack D.J. Cell-specific DNA methylation patterns of retina-specific genes. PLoS ONE 2012, 7:e32602.
23. Miao C.G., Yang Y.Y., He X., Li J. New advances of DNA methylation and histone modifications in rheumatoid arthritis, with special emphasis on MeCP2. Cell. Signal. 2013, 25:875-882.
24. Nasonkin I.O., Merbs S.L., Lazo K., Oliver V.F., Brooks M., Patel K., Enke R.A., Nellissery J., Jamrich M., Le Y.Z., et al. Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis. Development 2013, 140:1330-1341.
25. Oliver V.F., Wan J., Agarwal S., Zack D.J., Qian J., Merbs S.L. A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples. Epigenetics Chromatin 2013, 6:17.
26. Roessler J., Ammerpohl O., Gutwein J., Hasemeier B., Anwar S.L., Kreipe H., Lehmann U. Quantitative cross-validation and content analysis of the 450k DNA methylation array from Illumina, Inc. BMC Res. Notes 2012, 5:210-217.
27. Rung L., Lövestam-Adrian M. Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration. Clin Ophthalmol 2013, 7:395-401.
28. Sui G.Y., Liu G.C., Liu G.Y., Gao Y.Y., Deng Y., Wang W.Y., Tong S.H., Wang L. Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br. J. Ophthalmol. 2013, 97:389-394.
29. Tan J.S., Wang J.J., Flood V., Mitchell P. Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. Arch. Ophthalmol. 2009, 127:656-665.
30. Tost J., Gut I.G. DNA methylation analysis by pyrosequencing. Nat. Protoc. 2007, 2:2265-2275.
31. Tost J., El abdalaoui H., Gut I.G. Serial pyrosequencing for quantitative DNA methylation analysis. Biotechniques 2006, 40:721-722. 724, 726.
32. van Leeuwen R., Boekhoorn S., Vingerling J.R., Witteman J.C., Klaver C.C., Hofman A., de Jong P.T. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 2005, 294:3101-3107.
33. Wan J., Oliver V.F., Zhu H., Zack D.J., Qian J., Merbs S.L. Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs. Nucleic Acids Res. 2013, 41:8503-8514.
34. Wei L., Liu B., Tuo J., Shen D., Chen P., Li Z., Liu X., Ni J., Dagur P., Sen H.N., et al. Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep 2012, 2:1151-1158.
35. Yang Z., Stratton C., Francis P.J., Kleinman M.E., Tan P.L., Gibbs D., Tong Z., Chen H., Constantine R., Yang X., et al. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N.Engl. J. Med. 2008, 359:1456-1463.
36. Yang Z., Tong Z., Chen Y., Zeng J., Lu F., Sun X., Zhao C., Wang K., Davey L., Chen H., et al. Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet. 2010, 6:e1000836.