Age-related macular degeneration and DNA methylation

Epigenomics

Volumn 5, Issue 3, 2013, Pages 239-241

  Baird, Paul N ^a   Wei, Lai ^b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NATIONAL EYE INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

age related macular degeneration; discordant twin; gene; genome wide; immune; interleukin; methylation

Indexed keywords

ADAMTS9 PROTEIN; APOLIPOPROTEIN E; ARMS2 PROTEIN; B3GALTL PROTEIN; BF PROTEIN; COLLAGEN TYPE 8; COLLAGEN TYPE 8A1; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; COMPLEMENT FACTOR H RELATED 1; COMPLEMENT FACTOR H RELATED 2; COMPLEMENT FACTOR H RELATED 3; COMPLEMENT FACTOR H RELATED 4; COMPLEMENT FACTOR H RELATED 5; HTRA1 PROTEIN; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17 RECEPTOR C; INTERLEUKIN 22; MONOCARBOXYLATE TRANSPORTER 3; PROTEIN; RAD51B PROTEIN; TGFBR1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGING; ATTRIBUTABLE RISK; CD4+ T LYMPHOCYTE; DIET; DNA METHYLATION; DNA SEQUENCE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC RISK; GENETIC VARIABILITY; GEOGRAPHIC ATROPHY; HERITABILITY; HISTONE MODIFICATION; HUMAN; INFLAMMATION; MEDITERRANEAN DIET; MONOZYGOTIC TWINS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; SMOKING; SUBRETINAL NEOVASCULARIZATION;

DNA METHYLATION; EPIGENOMICS; HUMANS; MACULAR DEGENERATION; PROMOTER REGIONS, GENETIC; RECEPTORS, INTERLEUKIN;

EID: 84879120175     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.13.19     Document Type: Review

References (16)

1. Macular Degeneration Foundation. Eyes on the Future: a Clear Outlook on Age-Related Macular Degeneration. Deloitte Access Economics, Canberra, Australia (2011).
2. Friedman DS, O'Colmain BJ, Muñoz B et al. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 122(4), 564-572 (2004).
3. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104(1), 7-21 (1997).
4. Klein R, Klein BE, Tomany SC, Moss SE. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am. J. Epidemiol. 156(7), 589-598 (2002).
5. Baird PN, Hageman GS, Guymer RH. New era for personalized medicine: the diagnosis and management of age-related macular degeneration. Clin. Experiment. Ophthalmol. 37(8), 814-821 (2009).
6. Fritsche LG, Chen W, Schu M et al.; The AMD Gene Consortium. Seven new loci associated with age-related macular degeneration. Nat. Genet. 45(4), 433-439 (2013).
7. Smith W, Assink J, Klein R et al. Risk factors for age-related macular degeneration: pooled findings from three continents. Ophthalmology 108(4), 697-704 (2001).
8. Thornton J, Edwards R, Mitchell P, Harrison RA, Buchan I, Kelly SP. Smoking and age-related macular degeneration: a review of association. Eye (Lond.) 19(9), 935-944 (2005).
9. Kaushik S, Wang JJ, Flood V et al. Dietary glycemic index and the risk of age-related macular degeneration. Am. J. Clin. Nutr. 88(4), 1104-1110 (2008).
10. Mares JA, Voland RP, Sondel SA et al. Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Arch. Ophthalmol. 129(4), 470-480 (2011).
11. Tan JS, Wang JJ, Flood V, Rochtchina E, Smith W, Mitchell P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology 115(2), 334-341 (2008).
12. Hjelmeland LM. Dark matters in AMD genetics: epigenetics and stochasticity. Invest. Ophthalmol. Vis. Sci. 52(3), 1622-1631 (2011).
13. Kaminsky ZA, Tang T, Wang SC et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet. 41(2), 240-245 (2009).
14. Gordon L, Joo JE, Powell JE et al. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res. 22(8), 1395-1406 (2012).
15. Wei L, Liu B, Tuo J et al. Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep. 2(5), 1151-1158 (2012).
16. Liu B, Wei L, Meyerle C et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J. Transl. Med. 9, 1-12 (2011).