Improving the enantioselectivity of an esterase toward (S)-ketoprofen ethyl ester through protein engineering

Journal of Molecular Catalysis B: Enzymatic

Volumn 100, Issue , 2014, Pages 25-31

  Yoon, Sangyoung ^a   Kim, Seungbum ^a   Park, Songyi ^a   Hong, Eunsoo ^a   Kim, Jinyeong ^a   Kim, Sangchul ^a   Yoo, Tae Hyeon ^a   Ryu, Yeonwoo ^a  

^a Ajou University   (South Korea)

Author keywords

(S) ketoprofen; Enantioselectivity; Esterase; Protein engineering; rac Ketoprofen ethyl ester

Indexed keywords

ESTERASE; ETHYL ESTERS; KETOPROFEN; OPTICALLY PURE COMPOUNDS; POLAR ORGANIC SOLVENTS; PROTEIN ENGINEERING; STRUCTURAL STABILITIES; SUBSTRATE SPECIFICITY;

BIOCHEMICAL ENGINEERING; ENANTIOSELECTIVITY; ENZYMES; ESCHERICHIA COLI; ESTERIFICATION; GENETIC ENGINEERING; HYDROLYSIS; STABILITY; SUBSTRATES;

ESTERS;

ALCOHOL; ARYLACETIC ACID DERIVATIVE; BREFELDIN A; ENZYME VARIANT; EST25 ENZYME; ESTERASE; KETOPROFEN DERIVATIVE; L255W ENZYME; METHANOL; ORGANIC SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STABILITY; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROLYSIS; MICHAELIS MENTEN KINETICS; MOLECULAR LIBRARY; PH; PROTEIN ENGINEERING; RACEMIC MIXTURE; THERMOSTABILITY; WILD TYPE;

EID: 84890845827     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2013.11.008     Document Type: Article

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