Design, synthesis and molecular docking of some new 1,2,4- triazolobenzimidazol-3-yl acetohydrazide derivatives with anti-inflammatory- analgesic activities

Archives of Pharmacal Research

Volumn 36, Issue 12, 2013, Pages 1465-1479

  Mohammed, Anber F ^a   Abdel Moty, Samia G ^a   Hussein, Mostafa A ^a   Abdel Alim, Abdel Alim M ^a  

^a Assiut University   (Egypt)

Author keywords

1,2,4 Triazolobenzimidazole; Anti inflammatory analgesic; COX enzyme; Molecular docking; Ulcerogenecity

Indexed keywords

2 (ACETYLSULFANYL) 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOLE; 2 (N PROPYLSULFANYL) 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOLE; 2 [(2 PHENYLETHYL)SULFANYL] 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOLE; 4 AMINO 3 [(2 PHENYLETHYL)SULFANYL] 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 4H 1,2,4 TRIAZOLE; 4 AMINO 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] ACETATE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' (1 PHENYLETHYLIDENE)ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' (3 CHLOROPHENYLMETHYLIDENE)ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' (4 ISOPROPYLPHENYLMETHYLIDENE)ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' (4 NITROPHENYLMETHYLIDENE)ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' [1 (4 BROMOPHENYL)ETHYLIDENE]ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' [1 (4 CHLOROPHENYL)ETHYLIDENE]ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL] N' [1 (4 METHOXYPHENYL)ETHYLIDENE]ACETOHYDRAZIDE; [2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOLE 3 YL]ACETOHYDRAZIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; HYDRAZIDE DERIVATIVE; INDOMETACIN; METHYL[[5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOL 2 YL]SULFANYL]ACETATE; N (4 BROMOPHENYL) 2 [[5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 1,3,4 OXADIAZOL 2 YL]SULFANYL]ACETAMIDE; N [3 [(2 PHENYLETHYL)SULFANYL] 5 [[2 (METHYLSULFANYL) 3H 1,2,4 TRIAZOLO(1,5 A)BENZIMIDAZOL 3 YL]METHYL] 4H 1,2,4 TRIAZOL 4 YL]4 CHLOROBENZAMIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ADULT ANIMAL; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; INFRARED SPECTROSCOPY; LD 50; MALE; MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPE; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZIMIDAZOLES; DRUG DESIGN; EDEMA; MALE; MICE; MOLECULAR DOCKING SIMULATION; PAIN; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84890800650     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0153-z     Document Type: Article

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